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NTIS 바로가기Bioorganic & medicinal chemistry letters, v.17 no.5, 2007년, pp.1296 - 1301
Angell, Richard M. (GlaxoSmithKline R&) , Atkinson, Francis L. (D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK) , Brown, Murray J. (GlaxoSmithKline R&) , Chuang, Tsu Tshen (D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK) , Christopher, John A. (GlaxoSmithKline R&) , Cichy-Knight, Maria (D, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK) , Dunn, Allison K. (GlaxoSmithKline R&) , Hightower, Kendra E. (D, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK) , Malkakorpi, Susanna (GlaxoSmithKline R&) , Musgrave, James R. (D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK) , Neu, Margarete (GlaxoSmithKline Inc., 1250 South Collegeville Road, Collegeville, PA 19426, USA) , Rowland, Paul (GlaxoSmithKline Inc., 1250 South Collegeville Road, Collegeville, PA 19426, USA) , Shea, Robyn L. (GlaxoSmithKline Inc., 5 Moore Drive, Research Triangle Park, NC 27709, USA) , Smith, Jeffery L. (GlaxoSmithKline R&) , Somers, Donald O. (D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK) , Thomas, Sonia A. (GlaxoSmithKline R&) , Thompson, Gladstone (D, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK) , Wang, Ruolan (GlaxoSmithKline R&)
Graphical abstractThe identification and exploration of a novel, potent and selective series of N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amide inhibitors of JNK2 and JNK3 kinases is described. Compounds 5a and 11a were identified as potent inhibitors of JNK3 (pIC50 6.7 and 6.6, respectively),...
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