AbstractObjective-To determine the body condition score (BCS) distribution for dogs examined at a teaching hospital and examine whether the BCS distribution for dogs with cancer differed significantly from the distribution for dogs without cancer.Sample Population-1,777 dogs with cancer and 12,893 d...
AbstractObjective-To determine the body condition score (BCS) distribution for dogs examined at a teaching hospital and examine whether the BCS distribution for dogs with cancer differed significantly from the distribution for dogs without cancer.Sample Population-1,777 dogs with cancer and 12,893 dogs without cancer.Procedures-A retrospective prevalence case-control study was conducted that used medical records from 1999 to 2004. Information was collected on BCS (9-point system), age, breed, sex, neuter status, diagnosis, and corticosteroid administration. Body condition score at the time of examination for cancer (dogs with cancer) or first chronologic visit (dogs without cancer) was recorded. Logistic regression was used to compare BCS prevalence distributions between groups.Results-The overall prevalence of obese dogs (BCS ≥ 7/9) was 14.8% (2,169/14,670), and the overall prevalence of overweight dogs (BCS ≥ 6/9 to < 7/9) was 21.6% (3,174/14,670). There was a significant difference in the BCS distribution between dogs with and without cancer, with a slightly lower prevalence of being overweight and obese in dogs with cancer. The prevalence of obese and overweight dogs varied with specific cancer types when compared with the prevalence for dogs without cancer.Conclusions and Clinical Relevance-Differences in obesity prevalence among cancer types is suggestive of an incongruous effect of this variable on cancer expression or a differential effect of specific cancer types on weight status. Systematic use of BCSs will help elucidate the association between obesity and cancer development.
AbstractObjective-To determine the body condition score (BCS) distribution for dogs examined at a teaching hospital and examine whether the BCS distribution for dogs with cancer differed significantly from the distribution for dogs without cancer.Sample Population-1,777 dogs with cancer and 12,893 dogs without cancer.Procedures-A retrospective prevalence case-control study was conducted that used medical records from 1999 to 2004. Information was collected on BCS (9-point system), age, breed, sex, neuter status, diagnosis, and corticosteroid administration. Body condition score at the time of examination for cancer (dogs with cancer) or first chronologic visit (dogs without cancer) was recorded. Logistic regression was used to compare BCS prevalence distributions between groups.Results-The overall prevalence of obese dogs (BCS ≥ 7/9) was 14.8% (2,169/14,670), and the overall prevalence of overweight dogs (BCS ≥ 6/9 to < 7/9) was 21.6% (3,174/14,670). There was a significant difference in the BCS distribution between dogs with and without cancer, with a slightly lower prevalence of being overweight and obese in dogs with cancer. The prevalence of obese and overweight dogs varied with specific cancer types when compared with the prevalence for dogs without cancer.Conclusions and Clinical Relevance-Differences in obesity prevalence among cancer types is suggestive of an incongruous effect of this variable on cancer expression or a differential effect of specific cancer types on weight status. Systematic use of BCSs will help elucidate the association between obesity and cancer development.
참고문헌 (53)
Flegal Prevalence and trends in obesity among US adults, 1999-2000 JAMA 2002 288 723
Calle Body-mass index and mortality in a prospective cohort of US adults N Engl J Med 1999 341 1097 10.1056/NEJM199910073411501
Calle Obesity and cancer Oncogene 2004 23 6365 10.1038/sj.onc.1207751
Wei Comparison of risk factors for colon and rectal cancer Int J Cancer 2004 108 433 10.1002/ijc.11540
van den Brandt Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk Am J Epidemiol 2000 152 514 10.1093/aje/152.6.514
Wang Potential involvement of leptin in carcinogenesis of hepatocellular carcinoma World J Gastroenterol 2004 10 2478 10.3748/wjg.v10.i17.2478
Potischman Reversal of relationship between body mass and endogenous estrogen concentration with menopausal status J Natl Cancer Inst 1996 88 756 10.1093/jnci/88.11.756
Porter Obesity and the risk of prostate cancer Prostate 2005 62 316 10.1002/pros.20121
Presti Obesity and prostate cancer Curr Opin Urol 2005 15 13 10.1097/00042307-200501000-00004
Dunn Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice Cancer Res 1997 57 4667
Yin Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin Cancer Res 2004 64 5870 10.1158/0008-5472.CAN-04-0655
Gayet Insulin resistance and changes in plasma concentration of TNFA, IGF1, and NEFA in dogs during weight gain and obesity J Anim Physiol Anim Nutr 2004 88 157 10.1111/j.1439-0396.2003.00473.x
Martin Hormonal disturbances associated with obesity in dogs J Anim Physiol Anim Nutr 2006 90 355 10.1111/j.1439-0396.2005.00589.x
Ishioka Experimental and clinical studies on plasma leptin in obese dogs J Vet Med Sci 2002 64 349 10.1292/jvms.64.349
Chang The p53 tumor suppressor gene as a common cellular target in human carcinogenesis Am J Gastroenterol 1993 88 174
Mayr Tumour suppressor gene p53 mutation in a case of haemangiosarcoma of a dog Acta Vet Hung 2002 50 157 10.1556/avet.50.2002.2.4
Johnson Mutation of the p53 tumor suppressor gene in spontaneous occurring osteosarcomas of the dog Carcinogenesis 1998 19 213 10.1093/carcin/19.1.213
Lee Mutation of p53 tumor suppressor gene in spontaneous canine mammary tumors J Vet Sci 2002 3 321 10.4142/jvs.2002.3.4.321
Hursting Diet-gene interactions in p53-deficient mice: insulin-like growth factor I as a mechanistic target J Nutr 2004 134 2482S 10.1093/jn/134.9.2482S
Berrigan Adult onset calorie restriction and fasting delay spontaneous tumorigenesis in p53-deficient mice Carcinogenesis 2002 23 817 10.1093/carcin/23.5.817
Hursting Calorie restriction delays spontaneous tumorigenesis in p53-knockout transgenic mice Proc Natl Acad Sci U S A 1994 91 7036 10.1073/pnas.91.15.7036
Sanderson Owner impressions of three premium diets fed to healthy adult dogs J Am Vet Med Assoc 2005 227 1931 10.2460/javma.2005.227.1931
Mawby Comparison of different methods for determining body fat composition of dogs J Am Anim Hosp Assoc 2004 40 109 10.5326/0400109
Kealy Effects of diet restriction on life span and age-related changes in dogs J Am Vet Med Assoc 2002 220 1315 10.2460/javma.2002.220.1315
Mattheeuws Diabetes mellitus in dogs: relationship of obesity to glucose tolerance and insulin response Am J Vet Res 1984 45 98
Lund Prevalence and risk factors for obesity in adult dogs from private US veterinary practices Int J Appl Res Vet Med 2006 4 177
Bronson Variation in age at death of dogs of different sexes and breeds Am J Vet Res 1982 43 2057
Glickman Epidemiologic study of insecticide exposure, obesity, and risk of bladder cancer in household dogs J Toxicol Environ Health 1989 28 407 10.1080/15287398909531360
Sonnenschein Body confirmation, diet and risk of breast cancer in pet dogs: a case-control study Am J Epidemiol 1991 133 694 10.1093/oxfordjournals.aje.a115944
Perez Alenza Relationship between habitual diet and canine mammary tumors in a case-control study J Vet Intern Med 1998 12 132 10.1111/j.1939-1676.1998.tb02108.x
Philibert Influence of host factors on survival in dogs with malignant mammary gland tumors J Vet Intern Med 2003 17 102 10.1111/j.1939-1676.2003.tb01330.x
Parker Canine genomics and genetics: running with the pack PLoS Genet 2005 1 508
Kronfeld Body condition and energy intake of dogs in a referral teaching hospital J Nutr 1991 121 S157 10.1093/jn/121.suppl_11.S157
McGreevy Prevalence of obesity in dogs examined by Australian veterinary practices and the risk factors involved Vet Rec 2005 156 695 10.1136/vr.156.22.695
Colliard Risk factors for obesity in dogs in France J Nutr 2006 136 1951S 10.1093/jn/136.7.1951S
McElroy Short- and long-term effects of ovariectomy on food intake, body weight, carcass composition, and brown adipose tissue in rats Physiol Behav 1987 39 361 10.1016/0031-9384(87)90235-6
Fettman Effects of neutering on body weight, metabolic rate and glucose tolerance of domestic cats Res Vet Sci 1997 62 133
Edney Study of obesity in dogs visiting veterinary practices in the United Kingdom Vet Rec 1986 118 391 10.1136/vr.118.14.391
Mason Obesity in pet dogs Vet Rec 1970 86 612 10.1136/vr.86.21.612
Modiano Distinct B-cell and T-cell lymphoproliferative disease prevalence among dog breeds indicate heritable risk Cancer Res 2005 65 5654 10.1158/0008-5472.CAN-04-4613
Ru Host related risk factors for canine osteosarcoma Vet J 1998 156 33
Hayes Carcinoma of the nasal cavity and paranasal sinuses in dogs: descriptive epidemiology Cornell Vet 1982 72 168
Reif Cancer of the nasal cavity and paranasal sinuses and exposure to environmental tobacco smoke in pet dogs Am J Epidemiol 1998 147 488 10.1093/oxfordjournals.aje.a009475
Reif Passive smoking and canine lung cancer risk Am J Epidemiol 1992 135 234 10.1093/oxfordjournals.aje.a116276
Hayes Epidemiological features of canine renal neoplasms Cancer Res 1977 37 2553
Dorn Survey of animal neoplasm in Alameda and Contra Costa counties, California. I. Methodology and description of cases J Natl Cancer Inst 1968 40 295
Dorn Survey of animal neoplasm in Alameda and Contra Costa counties, California. II. Cancer morbidity in dogs and cats from Alameda county J Natl Cancer Inst 1968 40 307
Michel Evaluation of body condition score and weight loss in dogs presented to a veterinary oncology service J Vet Intern Med 2004 18 692 10.1111/j.1939-1676.2004.tb02607.x
Willett Recall of remote diets Nutritional epidemiology 1998 148
Vail Hematopoietic tumors, canine lymphoma and lymphoid leukemias Small animal clinical oncology 2001 558
Lawler Influence of lifetime food restriction on causes, time, and predictors of death in dogs J Am Vet Med Assoc 2005 226 225 10.2460/javma.2005.226.225
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