[논문]Ostreae Testa prevent ovariectomy-induced bone loss in mice by osteoblast activations

Han, Sang Yeob; Lee, Jong Rok; Kwon, Young Kyu; Jo, Mi Jeong; Park, Sook Jahr; Kim, Sang Chan; Lee, Hyeung Sik; Ku, Sae Kwang

doi:10.1016/j.jep.2007.08.019

[해외논문] Ostreae Testa prevent ovariectomy-induced bone loss in mice by osteoblast activations

Journal of ethnopharmacology, v.114 no.3, 2007년, pp.400 - 405

Han, Sang Yeob (College of Oriental Medicine, Daegu Haany University, Gyeongsan 712-715, Republic of Korea) , Lee, Jong Rok (College of Oriental Medicine, Daegu Haany University, Gyeongsan 712-715, Republic of Korea) , Kwon, Young Kyu (College of Oriental Medicine, Daegu Haany University, Gyeongsan 712-715, Republic of Korea) , Jo, Mi Jeong (College of Oriental Medicine, Daegu Haany University, Gyeongsan 712-715, Republic of Korea) , Park, Sook Jahr (College of Oriental Medicine, Daegu Haany University, Gyeongsan 712-715, Republic of Korea) , Kim, Sang Chan (College of Oriental Medicine, Daegu Haany University, Gyeongsan 712-715, Republic of Korea) , Lee, Hyeung Sik (Department of Herbal Biotechnology, Daegu Haany University, Gyeongsan 712-715, Republic of Korea) , Ku, Sae Kwang (College of Oriental Medicine, Daegu Haany University, Gyeongsan 712-715, Republic of Korea)

Abstract ▼ AI-Helper

AbstractAim of the studyThe anti-osteoporotic effect of heated powder of Ostreae Testa (hPOT), a powder of oyster shell—Ostrea gigas Thumb (Ostrediae) was observed in vitro and in vivo.Materials and methodsThe effects on proliferation and alkaline phosphatase activity of primary osteoblasts, bone nodule formation, pit formation of osteoclasts and osteoclastogenesis were observed in vitro, and to observe the in vivo efficacy hPOT was orally administered once a day for 28 days to bilateral ovariectomy-induced osteoporosis mice at 125, 250 and 500mg/kg (of body weight).ResultsAlthough hPOT did not influence the pit formation and the number of multinucleated osteoclast-like cells, osteoclastogenesis, it enhanced the proliferation of primary osteoblasts, differentiation (ALP activity) and bone nodule formation of osteoblast in vitro. The estrogen-deficient osteoporotic changes were dramatically prevented by hPOT treatment except for osteoclasts/bone perimeter.ConclusionsIn conclusion, hPOT prevents OVX-induced osteoporosis through osteoblasts activation effects.

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참고문헌 (26)

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[해외논문] Ostreae Testa prevent ovariectomy-induced bone loss in mice by osteoblast activations

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[해외논문] Ostreae Testa prevent ovariectomy-induced bone loss in mice by osteoblast activations

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