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Synthesis, DNA-Binding, Cleavage, and Cytotoxic Activity of New 1,7-Dioxa-4,10-diazacyclododecane Artificial Receptors Containing Bisguanidinoethyl or Diaminoethyl Double Side Arms

Chemistry : a European journal, v.13 no.34, 2007년, pp.9703 - 9712  

Sheng, Xin (Department of Chemistry, State Key Laboratory of Coordination, Chemistry, Nanjing University, Nanjing 210093 (P. R. China), Fax: (+86) 025-8332-1884) ,  Lu, Xiao-Min (State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093 (P. R. China), Fax: (+86) 025-8359-7620) ,  Chen, Yue-Ting (Department of Chemistry, State Key Laboratory of Coordination, Chemistry, Nanjing University, Nanjing 210093 (P. R. China), Fax: (+86) 025-8332-1884) ,  Lu, Guo-Yuan (Department of Chemistry, State Key Laboratory of Coordination, Chemistry, Nanjing University, Nanjing 210093 (P. R. China), Fax: (+86) 025-8332-1884) ,  Zhang, Jing-Jing (Department of Chemistry, State Key Laboratory of Coordination, Chemistry, Nanjing University, Nanjing 210093 (P. R. China), Fax: (+86) 025-8332-1884) ,  Shao, Ying (Department of Chemistry, State Key Laboratory of Coordination, Chemistry, Nanjing University, Nanjing 210093 (P. R. China), Fax: (+86) 025-8332-1884) ,  Liu, Fang (Department of Chemistry, State Key Laboratory of Coordination, Chemistry, Nanjing University, Nanjing 210093 (P. R) ,  Xu, Qiang

Abstract AI-Helper 아이콘AI-Helper

Novel 1,7-dioxa-4,10-diazacyclododecane artificial receptors with two pendant aminoethyl (3) or guanidinoethyl (4) side arms have been synthesized. Spectroscopy, including fluorescence and CD spectroscopy, of the interactions of 3, 4, and their copper(II) complexes with calf thymus DNA indicated tha...

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