Feng, Rongxiu
(School of Chemical Engineering and Technology, Tianjin University)
,
Chen, Ligong
(School of Chemical Engineering and Technology, Tianjin University)
,
Zhang, Shunxia
(School of Chemical Engineering and Technology, Tianjin University)
,
Song, Jian
(School of Chemical Engineering and Technology, Tianjin University)
3-Iodothiophene was synthesized from 3-bromothiophene and KI by coordination catalytic iodination using CuI/different 1,2-diamine ligands as catalysts.Under the optimal conditions:n-butanol as solvent,reaction temperature 120 ℃,time 3 h,CuI/N,N'-dimethylethylenediamine as catalytic system and n(3-br...
3-Iodothiophene was synthesized from 3-bromothiophene and KI by coordination catalytic iodination using CuI/different 1,2-diamine ligands as catalysts.Under the optimal conditions:n-butanol as solvent,reaction temperature 120 ℃,time 3 h,CuI/N,N'-dimethylethylenediamine as catalytic system and n(3-bromothiophene)?n(KI)?n(CuI)?n(N,N'-dimethylethylenediamine)20 ?40 ?1 ?2,yield of 3-iodothiophene can reach 91.73%.The product was analyzed by gas chromatography and its purity is 97.28%.The coordination catalytic synthesizing method is mild under the above reaction conditions,with smaller amount of catalyst and less waste disposal than traditional process.Several other compounds including iodobenzene,diphenyl ether,3-thienyl phenyl ether,N-pheny1 piperidine and N-(3-thienyl)piperidine can also be synthesized with good yield by coordination catalytic iodination and coupling reaction.
3-Iodothiophene was synthesized from 3-bromothiophene and KI by coordination catalytic iodination using CuI/different 1,2-diamine ligands as catalysts.Under the optimal conditions:n-butanol as solvent,reaction temperature 120 ℃,time 3 h,CuI/N,N'-dimethylethylenediamine as catalytic system and n(3-bromothiophene)?n(KI)?n(CuI)?n(N,N'-dimethylethylenediamine)20 ?40 ?1 ?2,yield of 3-iodothiophene can reach 91.73%.The product was analyzed by gas chromatography and its purity is 97.28%.The coordination catalytic synthesizing method is mild under the above reaction conditions,with smaller amount of catalyst and less waste disposal than traditional process.Several other compounds including iodobenzene,diphenyl ether,3-thienyl phenyl ether,N-pheny1 piperidine and N-(3-thienyl)piperidine can also be synthesized with good yield by coordination catalytic iodination and coupling reaction.
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