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76. J. Immunol. JJ Kobie 177 6780 2006 10.4049/jimmunol.177.10.6780 Kobie, J. J. et al. T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5′-adenosine monophosphate to adenosine. J. Immunol. 177, 6780-6786 (2006). References 74-76 collectively revealed the ability of T Reg cells to generate the inhibitory molecule adenosine by selective expression of CD39 and CD73. Reference 79 showed that another inhibitory adenosine nucleoside, cAMP, is directly transferred into effector T cells via gap junctions. 

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77. Blood PE Zarek 111 251 2008 10.1182/blood-2007-03-081646 Zarek, P. E. et al. A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells. Blood 111, 251-259 (2008). 

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79. J. Exp. Med. T Bopp 204 1303 2007 10.1084/jem.20062129 Bopp, T. et al. Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. J. Exp. Med. 204, 1303-1310 (2007). 

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80. Curr. Opin. Immunol. JA Bluestone 17 638 2005 10.1016/j.coi.2005.09.002 Bluestone, J. A. & Tang, Q. How do CD4+CD25+ regulatory T cells control autoimmunity? Curr. Opin. Immunol. 17, 638-642 (2005). 

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81. Nature Immunol. Q Tang 7 83 2006 10.1038/ni1289 Tang, Q. et al. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nature Immunol. 7, 83-92 (2006). 

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82. J. Exp. Med. CE Tadokoro 203 505 2006 10.1084/jem.20050783 Tadokoro, C. E. et al. Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo. J. Exp. Med. 203, 505-511 (2006). References 81 and 82 revealed the importance of T Reg -cell-DC interactions as a mechanism for blocking effector-T-cell activation. 

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