$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Aspirin, salicylates, and cancer

The Lancet, v.373 no.9671 = no.9671, 2009년, pp.1301 - 1309  

Elwood, P.C. (School of Biomedical Sciences, University of Ulster, Coleraine, UK) ,  Gallagher, A.M. ,  Duthie, G.G. ,  Mur, L.A. ,  Morgan, G.

Abstract AI-Helper 아이콘AI-Helper

Evidence from a wide range of sources suggests that individuals taking aspirin and related non-steroidal anti-inflammatory drugs have reduced risk of large bowel cancer. Work in animals supports cancer reduction with aspirin, but no long-term randomised clinical trials exist in human beings, and ran...

참고문헌 (116)

  1. Proc Natl Acad Sci USA Gasic 61 46 1968 10.1073/pnas.61.1.46 Anti-metastatic effects associated with platelet reduction 

  2. Lancet Gasic 2 932 1972 10.1016/S0140-6736(72)92581-0 Anti-metastatic effect of aspirin 

  3. Lancet Kolenich 2 714 1972 10.1016/S0140-6736(72)92124-1 Haematological effects of aspirin 

  4. Prostaglandins Jaffe 6 453 1974 10.1016/S0090-6980(74)80055-9 Prostaglandin and cancer: an update 

  5. Gut Bennett 16 409 1975 Proceedings: prostaglandins in human colonic carcinoma 

  6. Cancer Res Kune 48 4399 1988 Colorectal cancer risk, chronic illnesses, operations and medications: case control results from the Melbourne Colorectal Cancer Study 

  7. vol 1 1997 

  8. Cancer Epidemiol Biomarkers Prev Vainio 6 749 1997 An international evaluation of the cancer-preventive potential of nonsteroidal anti-inflammatory drugs 

  9. Prog Exp Tumor Res Baron 37 1 2003 10.1159/000071364 Epidemiology of non-steroidal anti-inflammatory drugs and cancer 

  10. Cell Prolif Mahdi 39 249 2006 10.1111/j.1365-2184.2006.00390.x Calcium salicylate-mediated apoptosis in human HT01080 fibrosarcoma cells 

  11. J Natl Cancer Inst Gann 85 1220 1993 10.1093/jnci/85.15.1220 Low-dose aspirin and incidence of colorectal tumors in a randomised trial 

  12. BMJ Peto 296 313 1988 10.1136/bmj.296.6618.313 Randomised trial of prophylactic daily aspirin in British male doctors 

  13. JAMA Cook 294 47 2005 10.1001/jama.294.1.47 Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomised controlled trial 

  14. Br J Cancer Zhang 98 989 2008 10.1038/sj.bjc.6604240 Low-dose aspirin and breast cancer risk: results by tumour characteristics from a randomised trial 

  15. N Engl J Med Giovannucci 333 609 1995 10.1056/NEJM199509073331001 Aspirin and the risk of colorectal cancer in women 

  16. Br J Cancer Collet 81 62 1999 10.1038/sj.bjc.6690651 Colorectal cancer prevention by non-steroidal anti-inflammatory drugs: effects of dosage and timing 

  17. Cancer Res Harris 63 6096 2003 Breast cancer and nonsteroidal anti-inflammatory drugs: prospective results from the Women's Health Initiative 

  18. Arch Intern Med Chan 167 562 2007 10.1001/archinte.167.6.562 Long-term aspirin use and mortality in women 

  19. Lancet Flossmann 369 1603 2007 10.1016/S0140-6736(07)60747-8 Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies 

  20. N Engl J Med Sandler 348 883 2003 10.1056/NEJMoa021633 A randomised trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer 

  21. N Engl J Med Baron 348 891 2003 10.1056/NEJMoa021735 A randomised trial of aspirin to prevent colorectal adenomas 

  22. Int J Epidemiol Smith 33 30 2004 10.1093/ije/dyh132 Mendelian randomisation: prospects, potential and limitations 

  23. Cancer Epidemiol Biomarkers Prev Lin 11 1305 2002 Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia 

  24. Br J Cancer Powles 28 316 1973 10.1038/bjc.1973.154 The inhibition by aspirin and indomethacin of osteolytic tumour deposits and hypercalcaemia in rats with Walker tumour, and its possible application to human breast cancer 

  25. Cancer Res Rao 55 1462 1995 Chemoprevention of colon carcinogenesis by sulindac, a non-steroidal anti-inflammatory agent 

  26. Gastroenterol Barnes 114 873 1998 10.1016/S0016-5085(98)70305-1 Chemoprotection of spontaneous intestinal adenomas in the adenomatous polyposis coli Min mouse model with aspirin 

  27. Carcinogenesis Reddy 20 1645 1999 10.1093/carcin/20.8.1645 Chemopreventive effect of S-methylmethane thiosulfonate and sulindac administered together during the promotion/progression stages of colon carcinogenesis 

  28. Tech Coloproctol Miliaras 8 suppl 1 S59 2004 10.1007/s10151-004-0113-1 The effect of aspirin and high fibre diet on colorectal carcinoma: a comparative experimental study 

  29. J Natl Cancer Inst Thun 94 252 2002 10.1093/jnci/94.4.252 Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic and clinical issues 

  30. Proc Nutr Soc Mathers 62 51 2003 10.1079/PNS2002236 Can resistant starch and/or aspirin prevent the development of colonic neoplasia? The Concerted Action Polyp Prevention (CAPP) 1 study 

  31. Epidemiology Garcia Rodriguez 11 376 2000 10.1097/00001648-200007000-00003 Reduced incidence of colorectal adenomas among long term users of nonsteroidal antiinflammatory drugs: a pooled analysis of published studies and a new population-based study 

  32. Cancer Causes Control Bosetti 17 871 2006 10.1007/s10552-006-0033-7 Aspirin and cancer risk: an update quantitative review to 2005 

  33. Dis Colon Rectum Asano 47 665 2004 10.1007/s10350-003-0111-9 Non-steroidal anti-inflammatory drugs and aspirin for the prevention of colo-rectal adenomas and cancer: a systematic review 

  34. Am J Gastroenterol Velayos 100 1345 2005 10.1111/j.1572-0241.2005.41442.x Effect of 5-aminosalicylate use on colorectal cancer and dysplasia risk: a systematic review and metaanalysis of observational studies 

  35. J Natl Cancer Inst Jacobs 99 608 2007 10.1093/jnci/djk132 A large cohort study of long-term daily use of adult-strength aspirin and cancer incidence 

  36. Br J Cancer Khuder 84 1188 2001 10.1054/bjoc.2000.1709 Breast cancer and NSAID use: a meta-analysis 

  37. BMC Cancer González-Pérez 3 28 2003 10.1186/1471-2407-3-28 Effects of non-steroidal anti inflammatory drugs on cancer sites other than the colon and rectum: a meta-analysis 

  38. Int J Clin Pract Agrawal 62 444 2008 10.1111/j.1742-1241.2007.01668.x NSAIDs and breast cancer: a possible prevention and treatment strategy 

  39. Int J Cancer Friis 97 96 2002 10.1002/ijc.1581 Cancer risk in persons receiving prescriptions for paracetamol: a Danish cohort study 

  40. J Natl Cancer Inst Ruffin 89 1152 1997 10.1093/jnci/89.15.1152 Suppression of colorectal mucosal prostaglandins: determining the lowest effective aspirin dose 

  41. JAMA Terry 291 2433 2004 10.1001/jama.291.20.2433 Association of frequency and duration of aspirin use and hormone receptor status with breast cancer risk 

  42. J Natl Cancer Inst Jacobs 97 975 2005 10.1093/jnci/dji173 A large cohort study of aspirin and other nonsteroidal anti-inflammatory drugs and prostate cancer incidence 

  43. Arch Intern Med Smalley 159 161 1999 10.1001/archinte.159.2.161 Use of nonsteroidal anti-inflammatory drugs and incidence of colorectal cancer: a population-based study 

  44. Interdiscip Sci Rev Pierpoint 22 45 1997 10.1179/isr.1997.22.1.45 The natural plant product and mammalian tissue 

  45. Eur J Nutr Baxter 40 289 2001 10.1007/s394-001-8358-x Salicylic acid in soups prepared from organically and non-organically grown vegetables 

  46. J Sci Food Agric Robertson 32 833 1981 10.1002/jsfa.2740320813 Salicylic acid in fresh and canned fruit and vegetables 

  47. J Am Diet Assoc Swain 85 950 1985 10.1016/S0002-8223(21)03743-3 Salicylates in foods 

  48. J Agric Food Chem Paterson 54 2891 2006 10.1021/jf058158w Salicylic acid content of spices and its implications 

  49. Plant J Curtis 38 244 2004 10.1111/j.1365-313X.2004.02040.x The victorin-induced mitochondrial permeability transition precedes cell shrinkage and biochemical markers of cell death, and shrinkage occurs without loss of membrane integrity 

  50. J Exp Bot Neill 53 1237 2002 10.1093/jexbot/53.372.1237 Hydrogen peroxide and nitric oxide as signalling molecules in plants 

  51. Plant J Mur 23 609 2000 10.1046/j.1365-313x.2000.00825.x A loss of resistance to avirulent bacterial pathogens in tobacco is associated with the attenuation of a salicylic acid-potentiated oxidative burst 

  52. Plant Physiol Mehdy 105 467 1994 10.1104/pp.105.2.467 Active oxygen species in plant defense against pathogens 

  53. Ann Rev Plant Physiol Plant Mol Biol Lamb 48 251 1997 10.1146/annurev.arplant.48.1.251 The oxidative burst in plant disease resistance 

  54. Free Radic Biol Med Chung 34 434 2003 10.1016/S0891-5849(02)01301-1 Molecular ordering of ROS production, mitochondrial changes, and caspase activation during sodium salicylate-induced apoptosis 

  55. Plant Physiol Norman 134 492 2004 10.1104/pp.103.031039 Salicylic acid is an uncoupler and inhibitor of mitochondrial electron transport 

  56. J Biol Chem Battaglia 280 33864 2005 10.1074/jbc.M502391200 Oxidative stress is responsible for mitochondrial permeability transition induction by salicylate in liver mitochondria 

  57. Am J Epidemiol Genkinger 160 1223 2004 10.1093/aje/kwh339 Fruit, vegetable, and antioxidant intake and all-cause, cancer, and cardiovascular disease mortality in a community-dwelling population in Washington County, Maryland 

  58. QJM Paterson 94 445 2001 10.1093/qjmed/94.8.445 Salicylic acid: a link between aspirin, diet and the prevention of colorectal cancer 

  59. Cancer Lett Janssen 114 163 1997 10.1016/S0304-3835(97)04650-8 Acetylsalicylic and salicylates in foods 

  60. J Clin Pathol Blacklock 54 553 2001 10.1136/jcp.54.7.553 Salicylic acid in the serum of subjects not taking aspirin. Comparison of salicylic acid concentrations in the serum of vegetarians, non-vegetarians and patients taking low-dose aspirin 

  61. J Clin Pathol Lawrence 56 651 2003 10.1136/jcp.56.9.651 Urinary excretion of salicyluric and salicylic acids by non-vegetarians, vegetarians, and patients taking low dose aspirin 

  62. Gastroenterol Hawk 126 1423 2004 10.1053/j.gastro.2004.03.002 Colorectal cancer chemoprevention-an overview of the science 

  63. Biochim Biophys Acta Herschman 1299 125 1996 10.1016/0005-2760(95)00194-8 Prostaglandin synthase 2 

  64. Nat New Biol Vane 231 232 1971 10.1038/newbio231232a0 Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs 

  65. Biochim Biophys Acta Chell 1766 104 2006 Mediators of PGE2 synthesis and signalling downstream of COX-2 represent potential targets for the prevention/treatment of cancer 

  66. Gut Wang 55 115 2006 10.1136/gut.2004.047100 Prostaglandins and cancer 

  67. J Biol Chem Morita 270 10902 1995 10.1074/jbc.270.18.10902 Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2 

  68. Am J Health Syst Pharm Gonzalez 55 S4 1998 10.1093/ajhp/55.suppl_1.S4 Atherosclerosis: a unifying disorder with diverse manifestations 

  69. Proc Natl Acad Sci USA Xu 96 5292 1999 10.1073/pnas.96.9.5292 Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate 

  70. Circulation Wu 102 2022 2000 10.1161/01.CIR.102.17.2022 Aspirin and salicylate: an old remedy with a new twist 

  71. Proc Nutr Soc Paterson 65 93 2006 10.1079/PNS2005477 Is there a role for dietary salicylates in health? 

  72. Lancet Featherstone 350 418 1997 10.1016/S0140-6736(05)64147-5 Aspirin for bowel cancer: an old friend finds a new role 

  73. N Engl J Med Janne 342 1960 2000 10.1056/NEJM200006293422606 Chemoprevention of colorectal cancer 

  74. Dig Liver Dis Fiorucci 33 Suppl 2 S35 2001 10.1016/S1590-8658(01)80157-2 Mechanism of non-steroidal anti-inflammatory drug gastropathy 

  75. Science Hong 278 1073 1997 10.1126/science.278.5340.1073 Recent advances in chemoprevention of cancer 

  76. Biochem Pharmacol Kashfi 70 969 2005 10.1016/j.bcp.2005.05.004 Non-COX-2 targets and cancer: expanding the molecular target repertoire of chemoprevention 

  77. Cancer Res Shureiqi 61 4879 2001 Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression 

  78. Gastroenterol Zhang 118 1012 2000 10.1016/S0016-5085(00)70352-0 Par-4, a proapoptotic gene, is regulated by NSAIDs in human colon carcinoma cells 

  79. Science Zhang 290 989 2000 10.1126/science.290.5493.989 Role of BAX in the apoptotic response to anticancer agents 

  80. Blood Bellosillo 92 1406 1998 10.1182/blood.V92.4.1406 Aspirin and salicylate induce apoptosis and activation of caspases in B-cell chronic lymphocytic leukaemia cells 

  81. Proc Natl Acad Sci USA Schwenger 94 2869 1997 10.1073/pnas.94.7.2869 Sodium salicylate induces apoptosis via p38 mitogen activated protein kinase but inhibits tumour necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation 

  82. Neoplasia Zimmermann 2 505 2000 10.1038/sj.neo.7900120 Aspirin induces apoptosis through release of cytochrome c from mitochondria 

  83. Proc Natl Acad Sci USA Chan 95 681 1998 10.1073/pnas.95.2.681 Mechanisms underlying non-steroidal anti-inflammatory drug-mediated apoptosis 

  84. Carcinogenesis Zhou 22 1393 2001 10.1093/carcin/22.9.1393 Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through up-regulation of bax and bak 

  85. FASEB J Stark 15 1273 2001 10.1096/fj.00-0529fje Aspirin induced activation of the NF-kappa B signalling pathway; a novel mechanism for aspirin-mediated apoptosis in colon cancer cells 

  86. Br J Cancer Din 91 381 2004 10.1038/sj.bjc.6601913 Evidence for colorectal cancer cell specificity of aspirin effects on NF kappa B signalling and apoptosis 

  87. Med Hypotheses Rigas 54 210 2000 10.1054/mehy.1999.0023 Is inhibition of cyclooxygenase required for the chemopreventive effect of NSAIDs in colon cancer? A model reconciling the current contradiction 

  88. Curr Mol Med Charames 3 589 2003 10.2174/1566524033479456 Genomic instability and cancer 

  89. Ann Rev Biochem Modrich 56 435 1987 10.1146/annurev.bi.56.070187.002251 DNA mismatch correction 

  90. Nat Med Liu 1 348 1995 10.1038/nm0495-348 Genetic instability occurs in the majority of young patients with colorectal cancer 

  91. Trends Biochem Sci Kolodner 20 397 1995 10.1016/S0968-0004(00)89087-8 Mismatch repair: mechanisms and relationship to cancer susceptibility 

  92. Cancer Metastasis Rev Grady 23 11 2004 10.1023/A:1025861527711 Genomic instability and colon cancer 

  93. Proc Natl Acad Sci USA Ruschoff 95 11301 1998 10.1073/pnas.95.19.11301 Aspirin suppresses the mutator phenotype associated with hereditary nonpolyposis colorectal cancer by genetic selection 

  94. Clin Cancer Res Goel 9 383 2003 A novel mechanism for aspirin-mediated growth inhibition of human colon cancer cells 

  95. J Physiol Nunez 571 57 2006 10.1113/jphysiol.2005.100586 Cell proliferation depends on mitochondrial Ca2+ uptake: inhibition by salicylate 

  96. Biochem Pharmacol Drew 70 888 2005 10.1016/j.bcp.2005.06.011 Salicylic acid modulates oxidative stress and glutathione peroxidase activity in the rat colon 

  97. Oncology Rep Harris 13 559 2005 Aspirin, ibuprofen and other non-steroidal anti-inflammatory drugs in cancer prevention: a critical review of non-selective COX-2 blockade 

  98. FASEB J Borthwick 20 2009 2006 10.1096/fj.06-5987com Therapeutic levels of aspirin and salicylate directly inhibit a model of angiogenesis through a COX-independent mechanism 

  99. J Natl Cancer Inst Jankowski 96 885 2004 10.1093/jnci/djh171 Re: cost-effectiveness of aspirin chemoprevention for Barrett's esophagus 

  100. Aliment Pharmacol Ther Lanas 16 779 2002 10.1046/j.1365-2036.2002.01230.x Helicobacter pylori increases the risk of upper gastrointestinal bleeding in patients taking low-dose aspirin 

  101. N Engl J Med Lai 346 2033 2002 10.1056/NEJMoa012877 Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use 

  102. N Engl J Med Chan 352 238 2005 10.1056/NEJMoa042087 Clopidogrel versus aspirin and esomeparazole to prevent recurrent ulcer bleeding 

  103. 2000 Series DS, vol 2, decennial supplement no 13 

  104. Cancer Iwama 73 2065 1994 10.1002/1097-0142(19940415)73:8<2065::AID-CNCR2820730809>3.0.CO;2-O Mortality in young first degree relatives of patients with familial adenomatous polyposis 

  105. Gut Williams 23 835 1982 10.1136/gut.23.10.835 Polyps and cancer of the large bowel: a necropsy study in Liverpool 

  106. N Engl J Med Marcus 333 656 1995 10.1056/NEJM199509073331011 Aspirin as prophylaxis against colorectal cancer 

  107. Cancer Res Elder 56 2273 1996 Differential growth inhibition by the aspirin metabolite salicylate in human colorectal tumour cell lines: enhanced apoptosis in carcinoma and in-vitro transformed adenoma relative to adenoma cell lines 

  108. JAMA Jacobs 294 105 2005 10.1001/jama.294.1.105 Low-dose aspirin and vitamin E: challenges and opportunities in cancer prevention 

  109. Int J Epidemiol Flossman 36 962 2007 10.1093/ije/dym200 Commentary: aspirin and colorectal cancer-an epidemiological success story 

  110. Drugs Jolly 62 945 2002 10.2165/00003495-200262060-00006 NSAIDs and gastrointestinal cancer prevention 

  111. Heart Sanmuganathan 85 265 2001 10.1136/heart.85.3.265 Aspirin for primary prevention of coronary heart disease: safety and absolute benefit related to coronary risk derived from meta-analysis of randomised trials 

  112. Am J Med McQuaid 119 624 2006 10.1016/j.amjmed.2005.10.039 Systematic review and meta-analysis of adverse events of low-dose aspirin and clopidogrel in randomized controlled trials 

  113. Br J Clin Pharmacol Garcia Rodriquez 52 563 2001 10.1046/j.0306-5251.2001.01476.x Association between aspirin and upper gastrointestinal complications: systematic review of epidemiological studies 

  114. J Clin Epidemiol Hernandez-Dias 55 157 2002 10.1016/S0895-4356(01)00461-9 Incidence of serious upper gastrointestinal bleeding/perforation in the general population: review of epidemiological studies 

  115. JAMA He 280 1930 1998 10.1001/jama.280.22.1930 Aspirin and risk of haemorrhagic stroke: a meta-analysis of randomized controlled trials 

  116. N Engl J Med Kassirer 330 1895 1994 10.1056/NEJM199406303302611 Incorporating patients' preferences into medical decisions 

관련 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로