[논문]Anti-inflammatory Effect of Triterpenoic Acids of Eriobotrya japonica (Thunb.) Lindl. Leaf on Rat Model of Chronic Bronchitis

Ge, Jin-Fang; Wang, Ting-Yu; Zhao, Bin; Lv, Xiong-Wen; Jin, Yong; Peng, Lei; Yu, Shi-Chun; Li, Jun

doi:10.1142/S0192415X09006862

[해외논문] Anti-inflammatory Effect of Triterpenoic Acids of Eriobotrya japonica (Thunb.) Lindl. Leaf on Rat Model of Chronic Bronchitis

The American journal of Chinese medicine, v.37 no.2, 2009년, pp.309 - 321

Ge, Jin-Fang (School of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China) , Wang, Ting-Yu (School of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China) , Zhao, Bin (School of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China) , Lv, Xiong-Wen (School of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China) , Jin, Yong (School of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China) , Peng, Lei (School of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China) , Yu, Shi-Chun (Anhui An-tai Medical Company, Hefei 230032, Anhui, China) , Li, Jun (School of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China)

Abstract ▼ AI-Helper

This study was designed to investigate the anti-inflammatory effect of Triterpenoic Acids from Eriobotrya japonica (Thunb.) Lindl. (TAL) on chronic bronchitis (CB) in rats. CB model was established by combination of Bacillus Calmette-Guerin (BCG, 5 mg/kg, injected through the caudal vein) and lipopolysaccharide (LPS, 1 g/L, injected through endotracheal intubation). Rats with CB model were treated with TAL (50, 150 and 450 mg/kg) for 3 weeks. The leukocytes in bronchoalveolar lavage fluid (BALF) were counted after Wright staining, the levels of cytokine tumor necrosis factor alpha (TNF-α), interleukin (IL)-8, and IL-10 in the supernatants of lung homogenate were assessed by enzyme-linked immunosorbent assay (ELISA), and the protein expression of nuclear factor kappaB (NF-κB) and intercellular adhesion molecule-1 (ICAM-1) on bronchial epithelium were tested by immunohistochemical staining. As compared to the normal and sham groups, the total number of leukocyte, the differential counts of neutrophils and alveolar macrophage (AM) in BALF, the levels of TNF-α and IL-8 in the supernatants of lung homogenate, and the expression of NF-κB and ICAM-1 on bronchial epithelium in CB rats were significantly increased, while the level of IL-10 was decreased. TAL (50, 150 and 450 mg/kg) attenuated these alterations in model CB rats, which indicates that TAL has anti-inflammatory effect in the rats with CB.

참고문헌 (27)

Abe, Shuichi, Nakamura, Hidenori, Inoue, Sumito, Takeda, Hiroaki, Saito, Hiroshi, Kato, Shuichi, Mukaida, Naofumi, Matsushima, Kouji, Tomoike, Hitonobu. Interleukin-8 Gene Repression by Clarithromycin Is Mediated by the Activator Protein-1 Binding Site in Human Bronchial Epithelial Cells. American journal of respiratory cell and molecular biology : an official journal of the american thoracic society, medical section of the american lung association, vol.22, no.1, 51-60.

상세보기
Banno, Norihiro, Akihisa, Toshihiro, Tokuda, Harukuni, Yasukawa, Ken, Taguchi, Yosuke, Akazawa, Hiroyuki, Ukiya, Motohiko, Kimura, Yumiko, Suzuki, Takashi, Nishino, Hoyoku. Anti-inflammatory and Antitumor-Promoting Effects of the Triterpene Acids from the Leaves of Eriobotrya japonica. Biological & pharmaceutical bulletin, vol.28, no.10, 1995-1999.

상세보기
BRESSER, PAUL, OUT, THEO A., van ALPHEN, LOEK, JANSEN, HENK M., LUTTER, RENÉ. Airway Inflammation in Nonobstructive and Obstructive Chronic Bronchitis with Chronic Haemophilus influenzae Airway Infection : Comparison with Noninfected Patients with Chronic Obstructive Pulmonary Disease. American journal of respiratory and critical care medicine : an official journal of the American Thoracic Society, medical section of the American Lung Association, vol.162, no.3, 947-952.

상세보기
Christman, John W., Sadikot, Ruxana T., Blackwell, Timothy S.. The Role of Nuclear Factor-κ B in Pulmonary Diseases. Chest : official publication of the American College of Chest Physicians, vol.117, no.5, 1482-1487.

상세보기
Chung, K. F.. Cytokines in chronic obstructive pulmonary disease. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology, vol.18, no.suppl34, 50s-59s.

상세보기
Eraso, Alberto Jorge, Albesa, Inés. Eriobotrya japonica Counteracts Reactive Oxygen Species and Nitric Oxide Stimulated by Chloramphenicol. The American journal of Chinese medicine, vol.35, no.5, 875-885.

상세보기
Zhong Yao Xin Yao Yu Lin Chuang Yao Li Gao F. H. 266 12
Chin. Pharmacol. Bull. Ge J. F. 830 20
HILL, ADAM T., BAYLEY, DARREN, STOCKLEY, ROBERT A.. The Interrelationship of Sputum Inflammatory Markers in Patients with Chronic Bronchitis. American journal of respiratory and critical care medicine : an official journal of the American Thoracic Society, medical section of the American Lung Association, vol.160, no.3, 893-898.

상세보기
HUANG, SONG-LIH, SU, CHERN-HUEY, CHANG, SHI-CHUAN. Tumor Necrosis Factor- α Gene Polymorphism in Chronic Bronchitis. American journal of respiratory and critical care medicine : an official journal of the American Thoracic Society, medical section of the American Lung Association, vol.156, no.5, 1436-1439.

상세보기
Huang, Yan, Li, Jun, Cao, Qi, Yu, Shi-Chun, Lv, Xiong-Wen, Jin, Yong, Zhang, Lei, Zou, Yu-Hong, Ge, Jin-Fang. Anti-oxidative effect of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. leaf in chronic bronchitis rats. Life sciences, vol.78, no.23, 2749-2757.

상세보기
Ito, H., Kobayashi, E., Li, S.-H., Hatano, T., Sugita, D., Kubo, N., Shimura, S., Itoh, Y., Tokuda, H., Nishino, H., Yoshida, T.. Antitumor Activity of Compounds Isolated from Leaves ofEriobotrya japonica. Journal of agricultural and food chemistry, vol.50, no.8, 2400-2403.

상세보기
Klin. Med. Kalinina E. P. 25 81
Acta Univ. Med. Anhui Li J. 174 42
MIKAMI, MISHASHI, LLEWELLYN-JONES, CAROL G., BAYLEY, DARREN, HILL, SUSAN L., STOCKLEY, ROBERT A.. The Chemotactic Activity of Sputum from Patients with Bronchiectasis. American journal of respiratory and critical care medicine : an official journal of the American Thoracic Society, medical section of the American Lung Association, vol.157, no.3, 723-728.

상세보기
Nikula, Kristen J., Green, Francis H. Y.. ANIMAL MODELS OF CHRONIC BRONCHITIS AND THEIR RELEVANCE TO STUDIES OF PARTICLE-INDUCED DISEASE. Inhalation toxicology, vol.12, no.suppl4, 123-153.

상세보기
10.1136/thorax.56.6.432
POSTMA, DIRKJE S., KERSTJENS, HUIB A. M.. Are Inhaled Glucocorticosteroids Effective in Chronic Obstructive Pulmonary Disease?. American journal of respiratory and critical care medicine : an official journal of the American Thoracic Society, medical section of the American Lung Association, vol.160, no.1, S66-S71.

상세보기
Profita, M. Effect of cilomilast (Ariflo) on TNF- , IL-8, and GM-CSF release by airway cells of patients with COPD. Thorax, vol.58, no.7, 573-579.

상세보기
SAETTA, MARINA, TURATO, GRAZIELLA, MAESTRELLI, PIERO, MAPP, CRISTINA E., FABBRI, LEONARDO M.. Cellular and Structural Bases of Chronic Obstructive Pulmonary Disease. American journal of respiratory and critical care medicine : an official journal of the American Thoracic Society, medical section of the American Lung Association, vol.163, no.6, 1304-1309.

상세보기
SAULEDA, JAUME, GARCÍA-PALMER, FRANCISCO JOSÉ, GONZÁLEZ, GERMAN, PALOU, ANDREU, AGUSTÍ, ALVAR G. N.. The Activity of Cytochrome Oxidase Is Increased in Circulating Lymphocytes of Patients with Chronic Obstructive Pulmonary Disease, Asthma, and Chronic Arthritis. American journal of respiratory and critical care medicine : an official journal of the American Thoracic Society, medical section of the American Lung Association, vol.161, no.1, 32-35.

상세보기
Chin. Med. J. Song W. 1140 114
Syrovets, Tatiana, Büchele, Berthold, Krauss, Christine, Laumonnier, Yves, Simmet, Thomas. Acetyl-Boswellic Acids Inhibit Lipopolysaccharide-Mediated TNF-α Induction in Monocytes by Direct Interaction with IκB Kinases. The journal of immunology : official journal of the American Association of Immunologists, vol.174, no.1, 498-506.

상세보기
Takanashi, S, Hasegawa, Y, Kanehira, Y, Yamamoto, K, Fujimoto, K, Satoh, K, Okamura, K. Interleukin-10 level in sputum is reduced in bronchial asthma, COPD and in smokers. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology, vol.14, no.2, 309-314.

상세보기
J. Beijing Univ. Tradit. Chin. Med. Tang G. H. 26 25
Zhongguo Zhong Xi Yi Jie He Za Zhi Zhao C. Y. 843 21
Zhonghua Jie He He Hu Xi Za Zhi Zhong X. N. 750 26

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[해외논문] Anti-inflammatory Effect of Triterpenoic Acids of Eriobotrya japonica (Thunb.) Lindl. Leaf on Rat Model of Chronic Bronchitis

Abstract ▼ AI-Helper

참고문헌 (27)

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