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An interdomain RNA binding site on the hepadnaviral polymerase that is essential for reverse transcription 원문보기

Virology, v.390 no.1, 2009년, pp.130 - 138  

Badtke, M.P. (Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 S. Grand Blvd., St. Louis, MO, USA) ,  Khan, I. ,  Cao, F. ,  Hu, J. ,  Tavis, J.E.

Abstract AI-Helper 아이콘AI-Helper

The T3 motif on the duck hepatitis B virus reverse transcriptase (P) is proposed to be a binding site essential for viral replication, but its ligand and roles in DNA synthesis are unknown. Here, we found that T3 is needed for P to bind the viral RNA, the first step in DNA synthesis. A second motif,...

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