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Fluoxetine (Prozac) Binding to Serotonin Transporter Is Modulated by Chloride and Conformational Changes 원문보기

The Journal of neuroscience : the official journal of the Society for Neuroscience, v.29 no.30, 2009년, pp.9635 - 9643  

Tavoulari, Sotiria ,  Forrest, Lucy R. ,  Rudnick, Gary

Abstract AI-Helper 아이콘AI-Helper

Serotonin transporter (SERT) is the main target for widely used antidepressant agents. Several of these drugs, including imipramine, citalopram, sertraline, and fluoxetine (Prozac), bound more avidly to SERT in the presence of Cl−. In contrast, Cl−did not enhance cocaine or paroxetine ...

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