$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

[해외논문] Structural determination of sildenafil and its analogues in dietary supplements by fast-atom bombardment collision-induced dissociation tandem mass spectrometry

Rapid communications in mass spectrometry : RCM, v.23 no.19, 2009년, pp.3158 - 3166  

Ahn, Sungho (College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea) ,  Hong, Joo Yeon (College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea) ,  Hong, Moo Ki (Korea Food & Drug Administration, Seoul 122-704, Korea) ,  Jang, Young Pyo (College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea) ,  Oh, Myung Sook (College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea) ,  Jung, Jee H. (College of Pharmacy, Pusan National University, Busan 609-735, Korea) ,  Hong, Jongki (College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea)

Abstract AI-Helper 아이콘AI-Helper

Sildenafil and its analogues, which are used as illegal additives in several dietary supplements, were isolated by liquid-liquid extraction and column chromatography and analyzed by fast-atom bombardment mass spectrometry (FAB-MS). Structures of sildenafil and its derivatives were elucidated by FAB-...

참고문헌 (20)

  1. Sung, Byung-Je, Yeon Hwang, Kwang, Ho Jeon, Young, Lee, Jae Il, Heo, Yong-Seok, Hwan Kim, Jin, Moon, Jinho, Min Yoon, Jung, Hyun, Young-Lan, Kim, Eunmi, Jin Eum, Sung, Park, Sam-Yong, Lee, Jie-Oh, Gyu Lee, Tae, Ro, Seonggu, Myung Cho, Joong. Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules. Nature, vol.425, no.6953, 98-102.

  2. 10.1210/edrv-16-3-370 

  3. Shin, M.-H., Hong, M.-K., Kim, W.-S., Lee, Y.-J., Jeoung, Y.-C.. Identification of a new analogue of sildenafil added illegally to a functional food marketed for penile erectile dysfunction. Food additives and contaminants : analysis, surveillance, evaluation, control, vol.20, no.9, 793-796.

  4. Blok-Tip, L., Zomer, B., Bakker, F., Hartog, K. D., Hamzink, M., ten Hove, J., Vredenbregt, M., de Kaste, D.. Structure elucidation of sildenafil analogues in herbal products. Food additives and contaminants : analysis, surveillance, evaluation, control, vol.21, no.8, 737-748.

  5. Kim, Dae-Kee, Ryu, Do Hyun, Lee, Namkyu, Lee, Ju Young, Kim, Jae-Sun, Lee, Sukho, Choi, Jin-Young, Ryu, Je-Ho, Kim, Nam-Ho, Im, Guang-Jin, Choi, Won-Son, Kim, Tae-Kon. Synthesis and phosphodiesterase 5 inhibitory activity of new 5-phenyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one derivatives containing an N-acylamido group on a phenyl ring. Bioorganic & medicinal chemistry, vol.9, no.7, 1895-1899.

  6. Bischoff, E. Vardenafil preclinical trial data: potency, pharmacodynamics, pharmacokinetics, and adverse events. International journal of impotence research : official journal of the International Society for Impotence Research, vol.16, no.suppl1, S34-S37.

  7. Hou, Peiling, Zou, Peng, Low, Min-Yong, Chan, Eli, Koh, Hwee-Ling. Structural identification of a new acetildenafil analogue from pre-mixed bulk powder intended as a dietary supplement. Food additives and contaminants : analysis, surveillance, evaluation, control, vol.23, no.9, 870-875.

  8. Zou, Peng, Oh, Sharon Sze-Yin, Hou, Peiling, Low, Min-Yong, Koh, Hwee-Ling. Simultaneous determination of synthetic phosphodiesterase-5 inhibitors found in a dietary supplement and pre-mixed bulk powders for dietary supplements using high-performance liquid chromatography with diode array detection and liquid chromatography–electrospray ionization tandem mass spectrometry. Journal of chromatography A, vol.1104, no.1, 113-122.

  9. Reepmeyer, J.C., Woodruff, J.T.. Use of liquid chromatography-mass spectrometry and a chemical cleavage reaction for the structure elucidation of a new sildenafil analogue detected as an adulterant in an herbal dietary supplement. Journal of pharmaceutical and biomedical analysis, vol.44, no.4, 887-893.

  10. Balayssac, S., Trefi, S., Gilard, V., Malet-Martino, M., Martino, R., Delsuc, M.A.. 2D and 3D DOSY 1H NMR, a useful tool for analysis of complex mixtures: Application to herbal drugs or dietary supplements for erectile dysfunction. Journal of pharmaceutical and biomedical analysis, vol.50, no.4, 602-612.

  11. Wang, Yiling, Chen, Guiliang, Zhu, Ziqiang, Zhu, Jianzhong, Lu, Wei. Study on Infrared Transmission Spectrum of Sildenafil Citrate Mixed in Traditional Chinese Medicine. International journal of infrared and millimeter waves, vol.24, no.7, 1177-1185.

  12. Zhong, Dafang, Xing, Jie, Zhang, Shuqiu, Sun, Lu. Study of the electrospray ionization tandem mass spectrometry of sildenafil derivatives. Rapid communications in mass spectrometry : RCM, vol.16, no.19, 1836-1843.

  13. Zhu, Xiaolan, Xiao, Song, Chen, Bo, Zhang, Fei, Yao, Shouzhuo, Wan, Zutian, Yang, Dajin, Han, Hongwei. Simultaneous determination of sildenafil, vardenafil and tadalafil as forbidden components in natural dietary supplements for male sexual potency by high-performance liquid chromatography–electrospray ionization mass spectrometry. Journal of chromatography A, vol.1066, no.1, 89-95.

  14. 10.1093/jat/27.2.88 

  15. Gratz, Samuel R., Flurer, Cheryl L., Wolnik, Karen A.. Analysis of undeclared synthetic phosphodiesterase-5 inhibitors in dietary supplements and herbal matrices by LC–ESI–MS and LC–UV. Journal of pharmaceutical and biomedical analysis, vol.36, no.3, 525-533.

  16. Bogusz, Maciej J., Hassan, Huda, Al-Enazi, Eid, Ibrahim, Zuhour, Al-Tufail, Mohammed. Application of LC–ESI–MS–MS for detection of synthetic adulterants in herbal remedies. Journal of pharmaceutical and biomedical analysis, vol.41, no.2, 554-564.

  17. Venhuis, B.J., Zomer, G., de Kaste, D.. Structure elucidation of a novel synthetic thiono analogue of sildenafil detected in an alleged herbal aphrodisiac. Journal of pharmaceutical and biomedical analysis, vol.46, no.4, 814-817.

  18. Gratz, Samuel R., Gamble, Bryan M., Flurer, Rick A.. Accurate mass measurement using Fourier transform ion cyclotron resonance mass spectrometry for structure elucidation of designer drug analogs of tadalafil, vardenafil and sildenafil in herbal and pharmaceutical matrices. Rapid communications in mass spectrometry : RCM, vol.20, no.15, 2317-2327.

  19. Reepmeyer, J.C., Woodruff, J.T., d'Avignon, D.A.. Structure elucidation of a novel analogue of sildenafil detected as an adulterant in an herbal dietary supplement. Journal of pharmaceutical and biomedical analysis, vol.43, no.5, 1615-1621.

  20. Annual Repot of Korea Food & Drug Administration ‘Identification of Illegal Additives contained in Foods’. KFDA: Seoul Korea 2004. 

LOADING...

활용도 분석정보

상세보기
다운로드
내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

관련 콘텐츠

유발과제정보 저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로