[논문]Glycine Inhibits Melanogenesis in Vitro and Causes Hypopigmentation in Vivo

Ishikawa, Masago; Kawase, Ichiro; Ishii, Fumio

doi:10.1248/bpb.30.2031

[해외논문] Glycine Inhibits Melanogenesis in Vitro and Causes Hypopigmentation in Vivo 원문보기

Biological & pharmaceutical bulletin, v.30 no.11, 2007년, pp.2031 - 2036

Ishikawa, Masago (Drug Evaluation Department, Life Science Institute, SSP CO., LTD.) , Kawase, Ichiro (Drug Evaluation Department, Life Science Institute, SSP CO., LTD.) , Ishii, Fumio (Drug Evaluation Department, Life Science Institute, SSP CO., LTD.)

Abstract ▼ AI-Helper

The simplest amino acid, glycine, is important in protein composition and plays a significant role in numerous physiological events in mammals. Despite the inhibitory effect of glycine on spontaneous melanogenesis in B16F0 melanoma cells, the details of the underlying mechanisms remain unknown. The present study was conducted to investigate the further effects and the mechanisms of inhibitory effect of glycine on melanogenesis using B16F0 melanoma cells and hair follicle melanogenesis in C57BL/6J mice. Treatment with glycine (1—16 mM) for 72 h inhibited α-melanocyte stimulating hormone (α-MSH)-induced melanogenesis in a concentration-dependent manner without any effects on cell proliferation in B16F0 melanoma cells. Treatment with kojic acid (2.5 mM) for 72 h also inhibited α-MSH-induced melanogenesis in B16F0 melanoma cells. The highest dose of glycine inhibited the α-MSH-induced increment of tyrosinase protein levels in B16F0 melanoma cells. In hair follicle melanogenesis in C57BL/6J mice, treatment with glycine (1250 or 2500 mg/kg, i.p.) for 5 d prevented the decrement of L* and C* values and inhibited the increment of tyrosinase protein levels and melanin content within the skin. Treatment with hydroquinone (100 mg/kg, i.p.) for 5 d had a similar hypopigmenting effect to that of high dose glycine. These results suggest that glycine has an inhibitory effect on melanogenesis that is mediated by down-regulation of tyrosinase protein levels, leading to a hypopigmenting effect in C57BL/6J mice.

주제어

참고문헌 (37)

0027-5107 Mutat. Res. AGAR NITA 571 1/2 121 2005 10.1016/j.mrfmmm.2004.11.016

상세보기
1087-0024 J. Invest. Dermatol. Symp. Proc. Hearing V. J. 4 24 1999 10.1038/sj.jidsp.5640176

상세보기
0893-5785 Pigment Cell Res. Naish-Byfield S., Riley P. A. 11 94 1998 10.1111/j.1600-0749.1998.tb00716.x

상세보기
Hearing, V.J., Jimenez, M.. Mammalian tyrosinase-The critical regulatory control point in melanocyte pigmentation. The International journal of biochemistry, vol.19, no.12, 1141-1147.

상세보기
0021-9258 J. Biol. Chem. Lerner A. B. 181 281 1949 10.1016/S0021-9258(18)56648-5

상세보기
0031-9333 Physiol. Rev. Lerner A. B., Fitzpatrick T. B. 30 91 1950 10.1152/physrev.1950.30.1.91

상세보기
Kasraee, Behrooz. Peroxidase-Mediated Mechanisms Are Involved in the Melanocytotoxic and Melanogenesis-Inhibiting Effects of Chemical Agents. Dermatology : international journal for clinical and investigational dermatology, vol.205, no.4, 329-339.

상세보기
Lim, Joyce Teng Ee, Frcpi,, Fams,. Treatment of Melasma Using Kojic Acid in a Gel Containing Hydroquinone and Glycolic Acid :. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], vol.25, no.4, 282-284.

상세보기
10.1001/archderm.135.4.407
Takizawa, Tamotsu, Imai, Toshio, Onose, Jun-ichi, Ueda, Makoto, Tamura, Toru, Mitsumori, Kunitoshi, Izumi, Keisuke, Hirose, Masao. Enhancement of Hepatocarcinogenesis by Kojic Acid in Rat Two-Stage Models after Initiation with N-bis(2-hydroxypropyl)nitrosamine or N-diethylnitrosamine. Toxicological sciences : an official journal of the Society of Toxicology, vol.81, no.1, 43-49.

상세보기
Liver Int. Bruck R., Wardi J., Aeed H., Avni Y 23 276 2003 10.1034/j.1600-0676.2003.00839.x

상세보기
Ishizaki-Koizumi, S., Sonaka, I., Takei, Y., Ikejima, K., Sato, N.. The glycine analogue, aminomethanesulfonic acid, inhibits LPS-induced production of TNF-α in isolated rat Kupffer cells and exerts hepatoprotective effects in mice. Biochemical and biophysical research communications, vol.322, no.2, 514-519.

상세보기
Carcinogenesis Rose M. L., Madren J., Bunzendahl H 20 793 1999 10.1093/carcin/20.5.793

상세보기
Ishikawa, Masago, Kawase, Ichiro, Ishii, Fumio. Combination of Amino Acids Reduces Pigmentation in B16F0 Melanoma Cells. Biological & pharmaceutical bulletin, vol.30, no.4, 677-681.

상세보기
1015-2008 Pathobiology 58 4 193 1990 10.1159/000163583

상세보기
Chakraborty, Ashok K., Funasaka, Yoko, Slominski, Andrzej, Ermak, Gennady, Hwang, Jim, Pawelek, John M., Ichihashi, Masamitsu. Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: regulation by ultraviolet B. Biochimica et biophysica acta, Molecular cell research, vol.1313, no.2, 130-138.

상세보기
0893-5785 Pigment Cell Res. Kippenberger S., Bernd A., Bereiter 9 179 1996 10.1111/j.1600-0749.1996.tb00107.x

상세보기
0021-9738 J. Clin. Invest. Schauer E., Trautinger F., Kock A., 93 2258 1994 10.1172/JCI117224

상세보기
Plonka, P.M., Handjiski, B., Michalczyk, D., Popik, M., Paus, R.. Oral zinc sulphate causes murine hair hypopigmentation and is a potent inhibitor of eumelanogenesis in vivo. British journal of dermatology : BJD, vol.155, no.1, 39-49.

상세보기
Tobin, D.J, Paus, R. Graying: gerontobiology of the hair follicle pigmentary unit. Experimental gerontology, vol.36, no.1, 29-54.

상세보기
0022-202X J. Invest. Dermatol. Slominski A., Wortsman J., Plonka P 124 13 2005 10.1111/j.0022-202X.2004.23528.x

상세보기
0022-202X J. Invest. Dermatol. Alena F., Dixon W., Thomas P., Jimb 104 792 1995 10.1111/1523-1747.ep12606994

상세보기
0022-3565 J. Pharmacol. Exp. Ther. Moss K. G., Toner G. C., Cherringto 307 476 2003 10.1124/jpet.103.052530

상세보기
Park, Hee-Young, Lee, Jin, González, Salvador, Middelkamp-Hup, Maritza A., Kapasi, Sameer, Peterson, Shaun, Gilchrest, Barbara A.. Topical Application of a Protein Kinase C Inhibitor Reduces Skin and Hair Pigmentation. The Journal of investigative dermatology, vol.122, no.1, 159-166.

상세보기
0893-5785 Pigment Cell Res. Tobiishi M., Haratake A., Kaminaga 17 651 2004 10.1111/j.1600-0749.2004.00183.x

상세보기
Kageyama, Akiko, Oka, Masahiro, Okada, Taro, Nakamura, Shun-ichi, Ueyama, Takehiko, Saito, Naoaki, Hearing, Vincent J., Ichihashi, Masamitsu, Nishigori, Chikako. Down-regulation of Melanogenesis by Phospholipase D2 through Ubiquitin Proteasome-mediated Degradation of Tyrosinase. The Journal of biological chemistry, vol.279, no.26, 27774-27780.

상세보기
BILSLAND, D., FERGUSON, J.. (7) Homozygous variegate porphyria. British journal of dermatology : BJD, vol.127, no.suppl40, 48-49.

상세보기
0007-0963 Br. J. Dermatol. Ortonne J. P. 122 141 1990 10.1111/j.1365-2133.1990.tb16121.x

상세보기
0011-9059 Int. J. Dermatol. Ber Rahman S., Bhawan J. 35 229 1996 10.1111/j.1365-4362.1996.tb02994.x

상세보기
Ando, Hideya, Watabe, Hidenori, Valencia, Julio C., Yasumoto, Ken-ichi, Furumura, Minao, Funasaka, Yoko, Oka, Masahiro, Ichihashi, Masamitsu, Hearing, Vincent J.. Fatty Acids Regulate Pigmentation via Proteasomal Degradation of Tyrosinase. The Journal of biological chemistry, vol.279, no.15, 15427-15433.

상세보기
Park, S. -H., Kim, D. -S., Kim, W. -G., Ryoo, I. -J., Lee, D. -H., Huh, C. -H., Youn, S. -W., Yoo, I. -D., Park, K. -C.. Terrein: a new melanogenesis inhibitor and its mechanism. Cellular and molecular life sciences : CMLS, vol.61, no.22, 2878-2885.

상세보기
0022-202X J. Invest. Dermatol. Slominski A., Paus R. 101 90S 1993 10.1016/0022-202X(93)90507-E

상세보기
0077-8923 Ann. N.Y. Acad. Sci. Hochstein P., Cohen G. 100 876 1963 10.1111/j.1749-6632.1963.tb42938.x

상세보기
1201-5989 Skin Therapy Lett. Halder R. M., Richards G. M. 9 1 2004
0893-5785 Pigment Cell Res. Granholm D. E., Reese R. N., Granho 8 302 1995 10.1111/j.1600-0749.1995.tb00678.x

상세보기
0007-0963 Br. J. Dermatol. Horii I., Nakayama Y., Obata M., Ta 121 587 1989 10.1111/j.1365-2133.1989.tb08190.x

상세보기
0340-3696 Arch. Dermatol. Res. Denda M., Hori J., Koyama J., Yoshi 284 363 1992 10.1007/BF00372041

상세보기

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

[해외논문] Glycine Inhibits Melanogenesis in Vitro and Causes Hypopigmentation in Vivo 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (37)

이 논문을 인용한 문헌

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트