[논문]The influence of a cream containing 20% glycerin and its vehicle on skin barrier properties

Lodé; n, M; Wessman, W

doi:10.1046/j.1467-2494.2001.00060.x

[해외논문] The influence of a cream containing 20% glycerin and its vehicle on skin barrier properties

International journal of cosmetic science, v.23 no.2, 2001년, pp.115 - 119

Lodén, M , Wessman, W

Abstract ▼ AI-Helper

SynopsisGlycerin is widely used in cosmetics and well as in pharmaceutical formulations, mainly as humectant. In vitro studies have shown glycerin to prevent crystallization of stratum corneum model lipid mixture at low room humidity. Whether this may affect the skin barrier function during repeated application of glycerin in a cream base to normal skin is not known. Therefore, the influence of a cream containing 20% glycerin was compared with its placebo cream in a bilateral, double‐blind study on 17 healthy volunteers. The effect was evaluated as influence on hydration with a corneometer and on skin barrier function. Skin barrier function was assessed as permeability to water with an evaporimeter (transepidermal water loss; TEWL) and as sensitivity to an irritating surfactant by measuring the biological response (measured as TEWL and skin blood flow).Ten days treatment of normal skin with 20% glycerin significantly increased skin corneometer values, indicating an increased hydration. However, our study failed to show an influence of glycerin on human skin, in terms of TEWL and skin sensitivity to SLS‐induced irritation.RésuméLa glycérine est largement utilisée dans les formulations cosmétiques aussi bien que pharmaceutiques, principalement en tant qu’humectant. Des tests in vitro ont montré que la glycérine empèche la cristallization de la structure lipidique du Stratum Corneumà humidité ambiante basse. La question de savoir si ceci peut affecter la fonction barrière de la peau durant des applications répetées d’une crème pour peau normale contenant de la glycérine n’a pas été demontrée. Par conséquent, une crème contenant 20% de glycérine a été comparée avec son placebo dans un test bilatéral en double aveugle sur 17 volontaires en bonne santé. L’effet hydratant de la glycérine a étéévalué avec l’aide d’un cornéomètre, son influence sur la fonction barrière de la peau avec l’aide d’un évaporimètre (mesurant la Perte Trans‐Epidermal en eau) et son effet protecteur après irritation á l’aide d’un agent de surface par la réponse biologique de la peau (mesure de la PTEL et du flux sanguin).Dix jours de traitement sur une peau normale avec une crème contenant 20% de glycérine ont augmenté les mesures du cornéomètre de manière significative, indiquant une augmentation de l’hydration de la peau. Cependant notre étude n’a pas pu démontré l’influence de la glycérine sur la peau en terme de PTEL et la réduction du potentiel irritant du Sodium Lauryl Sulphate.

참고문헌 (18)

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[해외논문] The influence of a cream containing 20% glycerin and its vehicle on skin barrier properties

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