[논문]The effects of pyridoxine deficiency and supplementation on hematological profiles, lymphocyte function, and hepatic cytochrome P450 in B6C3F1mice

Tangjarukij, Chanthana; Navasumrit, Panida; Zelikoff, Judith T.; Ruchirawat, Mathuros

doi:10.1080/15476910903083866

The effects of pyridoxine deficiency and supplementation on hematological profiles, lymphocyte function, and hepatic cytochrome P450 in B6C3F1mice 원문보기

Journal of immunotoxicology, v.6 no.3, 2009년, pp.147 - 160

Tangjarukij, Chanthana , Navasumrit, Panida , Zelikoff, Judith T. , Ruchirawat, Mathuros

Abstract ▼ AI-Helper

Pyridoxine, a B(6) vitamin, is a co-factor in a variety of enzymatic reactions involved in intermediary metabolism. The effects of pyridoxine deficiency and supplementation on hematological profiles, lymphocyte function, and hepatic CYP1A1 and CYP2E1 were investigated in B(6)C(3)F(1) mice fed a diet containing either 0 (i.e., pyridoxine-deficient diet, [PD]); or 7 mg pyridoxine-HCl/kg (i.e., control diet, [CD]) for 8 or 13 weeks followed by administration of 500 mug pyridoxine-HCl (IP) daily for either 2 (PD-S2 and CD-S2) or 3 (PD-S3 and CD-S3) consecutive days. Results demonstrated that erythrocyte aspartate aminotransferase activity coefficient (EAST-AC) values, which reflect host pyridoxine status, were significantly higher in PD mice than in CD mice, and dropped to control levels after supplementation. PD mice had significantly reduced weight gains, mean corpuscular volume (MCV), hemoglobin (HGB), and hematocrit (HCT) levels compared to CD mice after 8 and 13 weeks on the prescribed diet. In addition, PD mice had significantly lower circulating levels of total white blood cells, but higher red blood cell numbers after 8 weeks (compared to CD mice). Pyridoxine supplementation for 3 days restored HGB levels in PD mice to that of the unsupplemented CD controls; HCT, MCV and MCH levels were also increased in PD-S3 mice compared to their unsupplemented PD counterparts, but failed to reach comparable levels to those seen in mice fed a control diet. The pyridoxine-deficient diet also resulted in decreased mitogen stimulated T-lymphocyte proliferation after a 13-week feeding regimen and increased hepatic CYP1A1 activity that was reversed by pyridoxine supplementation. These studies demonstrate in a murine model that pyridoxine deficiency can cause multiple alterations that, in many cases, can be reversed by supplementation.

참고문헌 (66)

J. Nutr. Sci. Vitaminol. (Tokyo) Aramphongphan A. 105 40 1994 10.3177/jnsv.40.105

상세보기
Adv. Exp. Med. Biol Axelrod A. E. 93 135 1981
Bellec, G, Dréano, Y, Lozach, P, Ménez, J F, Berthou, F. Cytochrome P450 metabolic dealkylation of nine N-nitrosodialkylamines by human liver microsomes.. Carcinogenesis, vol.17, no.9, 2029-2034.

상세보기
Anal. Biochem Bisp M. R. 82 305 2002 10.1006/abio.2002.5638

상세보기
Anal. Biochem Bradford M. M. 248 72 1976 10.1016/0003-2697(76)90527-3

상세보기
Blood Cartwright G. E. 111 2 1947 10.1182/blood.V2.2.111.111

상세보기
Anat. Rec Cassel S. 47 191 1978 10.1002/ar.1091910105

상세보기
Can. J. Physiol. Pharmacol Chandra R. K. 290 61 1983 10.1139/y83-044

상세보기
Biochemistry with Clinical Correlations Chaney S. G 1126 1993 3
Int. J. Vitam. Nutr. Res Changbumrung S. 149 54 1984
Am. J. Clin. Nutr Changbumrung S. 770 41 1985 10.1093/ajcn/41.4.770

상세보기
Arthritis Res. Ther Chiang E. P. 1404 7 2005 10.1186/ar1839

상세보기
FASEB J Coon M. J. 428 10 1996 10.1096/fasebj.10.4.8647341

상세보기
J. Nutr Costello A. M. 1757S 133 2 2003 10.1093/jn/133.5.1757S

상세보기
Mol. Pharmacol Crawford R. B. 921 52 1997 10.1124/mol.52.6.921

상세보기
J. Nutr Dirige O. V. 109 97 1969 10.1093/jn/97.1.109

상세보기
DOKE, Shoko, INAGAKI, Naoki, HAYAKAWA, Takashi, TSUGE, Haruhito. Effects of Vitamin B₆ Deficiency on Cytokine Levels and Lymphocytes in Mice. Bioscience, biotechnology, and biochemistry, vol.62, no.5, 1008-1010.

상세보기
Blood Foy H. 1054 13 1958 10.1182/blood.V13.11.1054.1054

상세보기
Mol. Cell. Biochem Frydas S. 79 197 1999 10.1023/A:1006958310081

상세보기
Drug Metab. Dispos Gonzalez F. J. 1 35 2007 10.1124/dmd.106.012492

상세보기
González-Jasso, Eva, López, Tomás, Lucas, Daniele, Berthou, Francois, Manno, Maurizio, Ortega, Arturo, Albores, Arnulfo. CYP2E1 regulation by benzene and other small organic chemicals in rat liver and peripheral lymphocytes. Toxicology letters, vol.144, no.1, 55-67.

상세보기
J. Nutr Goswami A. 210 89 1966 10.1093/jn/89.2.210

상세보기
J. Natl. Cancer Inst Gridley D. S. 951 78 1987
J. Nutr Ha C. 938 114 1984 10.1093/jn/114.5.938

상세보기
Am. J. Clin. Nutr Heller S. R. 1339 26 1973 10.1093/ajcn/26.12.1339

상세보기
Cancer Res Hong J. 2973 49 1989

상세보기
J. Austral. Coll. Nutr. Environ. Med Holman P. 5 14 1995
Acta Univ. Oul. D Hukkanen J. 1 621 2000
Am. J. Clin. Nutr Kirksey A. 946 31 1978 10.1093/ajcn/31.6.946

상세보기
J. Nutr Kwak H. K. 3308 132 2002 10.1093/jn/132.11.3308

상세보기
Am. J. Clin. Nutr Ladipo O. A. 280S 72 1 2000 10.1093/ajcn/72.1.280S

상세보기
J. Nutr Leklem J. E. 1503 120 11 1990 10.1093/jn/120.suppl_11.1503

상세보기
J. Nutr Mirone L. 167 67 1959 10.1093/jn/67.1.167

상세보기
J. Biol. Chem Nebert D. W. 23847 279 2004 10.1074/jbc.R400004200

상세보기
Ng, Sheung P., Zelikoff, Judith T.. The Effects of Prenatal Exposure of Mice to Cigarette Smoke on Offspring Immune Parameters. Journal of toxicology and environmental health. Part A, vol.71, no.7, 445-453.

상세보기
Southeast Asian J. Trop. Med. Publ. Health Nontasut P. 47 27 1996
FEBS Lett Oka T. 162 331 1993 10.1016/0014-5793(93)80318-O

상세보기
Nutr. Res. Rev Oka T 257 14 2001 10.1079/095442201108729231

상세보기
Sao Paulo Med. J Oshiro M. 54 123 2005 10.1590/S1516-31802005000200004

상세보기
Casarett & Doull’s Toxicology: The Basic Science of Poison, Sixth Edition Parkinson A 133 2001
Southeast Asian J. Trop. Med. Publ. Health Pongpaew P. 573 24 1993
J. Biochem. Mol. Toxicol Powley M. W. 303 14 2000 10.1002/1099-0461(2000)14:6<303::AID-JBT2>3.0.CO;2-8

상세보기
Nutr. Rev Rall L. C. 217 51 1993 10.1111/j.1753-4887.1993.tb03109.x

상세보기
Am. J. Clin. Nutr Raica N. 67 15 1964 10.1093/ajcn/15.2.67

상세보기
J. Nutr Reeves P. G. 838S 127 5 1997 10.1093/jn/127.5.838S

상세보기
Drug Metab. Disp Reinke L. A. 548 13 1985
Adv. Exp. Med. Biol Reynolds R. D. 339 206 1986
J. Nutr Ronnenberg A. G. 2703 130 2000 10.1093/jn/130.11.2703

상세보기
J. Cancer Res. Clin. Oncol Ruchirawat M. 559 116 1990 10.1007/BF01637080

상세보기
Eur. J. Clin. Nutr Sanchez D. J. 27 53 1999 10.1038/sj.ejcn.1600674

상세보기
Southeast Asian J. Trop. Med. Publ. Health Schreurs W. H. 586 7 1976
J. Nutr Setiawan B. 553 130 2000 10.1093/jn/130.3.553

상세보기
Blood Shen S. C. 679 23 1964 10.1182/blood.V23.5.679.679

상세보기
Blood Shen S. C. 425 30 1967 10.1182/blood.V30.4.425.425

상세보기
Environ. Health Perspect Smith M. T. 1219 104 6 1996 10.1289/ehp.961041219

상세보기
Biochem. Biophys. Res. Commun Soh Y. 541 227 1996 10.1006/bbrc.1996.1542

상세보기
Enzyme Solomon L. R. 262 23 1978 10.1159/000458588

상세보기
Southeast Asian J. Trop. Med. Publ. Health Tada Y. 628 33 2002
Arch. Biochem. Biophys Takada Y. 1 229 1984 10.1016/0003-9861(84)90123-1

상세보기
Proc. Natl. Acad. Sci. USA Towbin H. 4350 76 1979 10.1073/pnas.76.9.4350

상세보기
Arch. Med. Res Tovar A. R. 195 27 1996

상세보기
Post-grad. Med. J Trakatellis A. S70 68 1 1992
J. Med. Assoc. Thai Vudhivai N. 465 74 1991
J. Immunol Willis-Carr J. I. 1153 120 1978 10.4049/jimmunol.120.4.1153

상세보기
Wolters, M., Hermann, S., Hahn, A.. Effect of multivitamin supplementation on the homocysteine and methylmalonic acid blood concentrations in women over the age of 60 years. European journal of nutrition, vol.44, no.3, 183-192.

상세보기
Am. J. Clin. Nutr Woodring M. J. 1385 23 1970 10.1093/ajcn/23.11.1385

상세보기

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

The effects of pyridoxine deficiency and supplementation on hematological profiles, lymphocyte function, and hepatic cytochrome P450 in B6C3F1mice 원문보기

Abstract ▼ AI-Helper

참고문헌 (66)

이 논문을 인용한 문헌

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트