자궁 경부암의 임상 조직학적 요인들과 T 조절 림프구 분포와의 상관 분석 Relation between clinicopathological factors and the proportion of regulatory T Lymphocytes in patients with cervical cancers
목적: 자궁 경부암과 T 조절 림프구 특이 Forkhead Box Transcription Factor FoxP3과의 상관 분석을 통해 T 조절 림프구 특이 Forkhead Box Transcription Factor FoxP3의 임상적 의의를 찾고자 한다. 방법: 17명의 자궁 경부암 환자의 말초 혈액을 항 CD4, CD25 mAb 그리고 항 Foxp3 mAb와 결합하는 림프구 세포를 획득하여, flow cytometry을 이용한 Foxp3를 정량화 한다. 이후 자궁 경부암의 임상적, 인구 통계학적 특성과의 상관 분석을 실시한다. 분석된 특성들은 연령, 신장, 체중, 비만도, 최대 종양 직경, 자궁 방 침범 유무, 임파절 침범 유무, 그리고 림프관 종양 침범 유무 등으로 이루어진다. 결과: 여러 자궁경부암의 임상적, 인구 통계학적 특성들 중 T 조절 림프구 특이 Forkhead Box Transcription Factor FoxP3는 최대 종양 직경과 통계적 유의한 상관성을 갖는다 (p value = 0.012, Spearman’s rho 상관 계수 = 0.593). 결론: 진행된 자궁 경부암의 초기 종양의 크기와 말초 혈액의 T 조절 림프구 특이 Forkhead Box Transcription Factor FoxP3 사이에는 통계적 유의한 상관관계를 나타내며, 이는 종양 크기와 항 종양 면역 체계와의 유의한 상관성을 지님을 시사한다.
목적: 자궁 경부암과 T 조절 림프구 특이 Forkhead Box Transcription Factor FoxP3과의 상관 분석을 통해 T 조절 림프구 특이 Forkhead Box Transcription Factor FoxP3의 임상적 의의를 찾고자 한다. 방법: 17명의 자궁 경부암 환자의 말초 혈액을 항 CD4, CD25 mAb 그리고 항 Foxp3 mAb와 결합하는 림프구 세포를 획득하여, flow cytometry을 이용한 Foxp3를 정량화 한다. 이후 자궁 경부암의 임상적, 인구 통계학적 특성과의 상관 분석을 실시한다. 분석된 특성들은 연령, 신장, 체중, 비만도, 최대 종양 직경, 자궁 방 침범 유무, 임파절 침범 유무, 그리고 림프관 종양 침범 유무 등으로 이루어진다. 결과: 여러 자궁경부암의 임상적, 인구 통계학적 특성들 중 T 조절 림프구 특이 Forkhead Box Transcription Factor FoxP3는 최대 종양 직경과 통계적 유의한 상관성을 갖는다 (p value = 0.012, Spearman’s rho 상관 계수 = 0.593). 결론: 진행된 자궁 경부암의 초기 종양의 크기와 말초 혈액의 T 조절 림프구 특이 Forkhead Box Transcription Factor FoxP3 사이에는 통계적 유의한 상관관계를 나타내며, 이는 종양 크기와 항 종양 면역 체계와의 유의한 상관성을 지님을 시사한다.
Objective: The aim of this study is to determine which clinicopathological factors have the significance in proportion of regulatory T lymphocytes in patients with cervical cancers. Methods: Blood samples were collected preoperatively from 17 patients with uterine cervical cancers (stage: IB, IIA) d...
Objective: The aim of this study is to determine which clinicopathological factors have the significance in proportion of regulatory T lymphocytes in patients with cervical cancers. Methods: Blood samples were collected preoperatively from 17 patients with uterine cervical cancers (stage: IB, IIA) diagnosed at Asan medical center from May 2006 to October 2006. Patients were limited to who never been treated after diagnosis. We analyzed phenotypes of lymphocytes through flow cytometry by using anti CD3 antibodies, anti CD4 antibodies, anti CD25 antibodies and anti Transcription Factor Foekhead Box P3 (FoxP3) antibodies. Following analysis by flow cytometry, it was determined the relation between the proportion of regulatory T lymphocytes and clinicopathological factors of patients, including age, height, weight, BMI, maximum tumor diameter, lymphovascular tumor emboli, parametrial invasion, and lymph node metastasis. Results: Among many clinicopathological factors in patients with cervical cancer, only maximum tumor diameter was significantly correlated with the proportion of CD4+CD25+highFoxP3+ regulatory T lymphocytes (p=0.012, Spearman’s rho Correlation Coefficient=0.593). Conclusion: This is the first report to document the relation between uterine cervical cancer and the proportion of regulatory T lymphocytes in peripheral blood. In terms of positive correlation between the primary tumor size and the proportion of regulatory T lymphocytes in peripheral blood, we suggest that the spread mechanism of uterine cervical caner, especially direct invasion, will be related with the anti-tumor immune tolerance state. Further studies are necessary to explain the specific spread mechanisms and systemic antitumor immunity in cervical cancer.
Objective: The aim of this study is to determine which clinicopathological factors have the significance in proportion of regulatory T lymphocytes in patients with cervical cancers. Methods: Blood samples were collected preoperatively from 17 patients with uterine cervical cancers (stage: IB, IIA) diagnosed at Asan medical center from May 2006 to October 2006. Patients were limited to who never been treated after diagnosis. We analyzed phenotypes of lymphocytes through flow cytometry by using anti CD3 antibodies, anti CD4 antibodies, anti CD25 antibodies and anti Transcription Factor Foekhead Box P3 (FoxP3) antibodies. Following analysis by flow cytometry, it was determined the relation between the proportion of regulatory T lymphocytes and clinicopathological factors of patients, including age, height, weight, BMI, maximum tumor diameter, lymphovascular tumor emboli, parametrial invasion, and lymph node metastasis. Results: Among many clinicopathological factors in patients with cervical cancer, only maximum tumor diameter was significantly correlated with the proportion of CD4+CD25+highFoxP3+ regulatory T lymphocytes (p=0.012, Spearman’s rho Correlation Coefficient=0.593). Conclusion: This is the first report to document the relation between uterine cervical cancer and the proportion of regulatory T lymphocytes in peripheral blood. In terms of positive correlation between the primary tumor size and the proportion of regulatory T lymphocytes in peripheral blood, we suggest that the spread mechanism of uterine cervical caner, especially direct invasion, will be related with the anti-tumor immune tolerance state. Further studies are necessary to explain the specific spread mechanisms and systemic antitumor immunity in cervical cancer.
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