[논문]Protective Effects of Human Placenta Extract on Cartilage Degradation in Experimental Osteoarthritis

Kim, Joon-ki; Kim, Tae-hoon; Park, Sang-won; Kim, Hyo-yeon; Kim, Sang hoon; Lee, Sung youl; Lee, Sun-mee

doi:10.1248/bpb.33.1004

Protective Effects of Human Placenta Extract on Cartilage Degradation in Experimental Osteoarthritis 원문보기

Biological & pharmaceutical bulletin, v.33 no.6, 2010년, pp.1004 - 1010

Kim, Joon-ki (School of Pharmacy, Sungkyunkwan University) , Kim, Tae-hoon (School of Pharmacy, Sungkyunkwan University) , Park, Sang-won (School of Pharmacy, Sungkyunkwan University) , Kim, Hyo-yeon (School of Pharmacy, Sungkyunkwan University) , Kim, Sang hoon (Business Development, Green Cross Corporation) , Lee, Sung youl (Business Development, Green Cross Corporation) , Lee, Sun-mee (School of Pharmacy, Sungkyunkwan University)

Abstract ▼ AI-Helper

This study investigated the effect of human placenta extract (HPE) on cartilage degradation in vitro MG-63 cells, articular cartilage explants, and in vivo monoiodoacetate (MIA)-induced osteoarthritis (OA). Matrix metalloproteinase (MMP)-2 activity was measured in HPE-treated osteoblastic MG-63 cells. Articular cartilage explants in rabbit were cultured, and the degree of proteoglycan (PG) degradation was assessed by measuring the amount of glycosaminoglycan (GAG) released into the culture medium. Experimental osteoarthritis was induced by intra-articular injection of 3 mg MIA in rats. Beginning 14 d post-MIA injection, HPE was administered intra-articularly once a day for 14 d. The knee joints were assessed by roentgenography, histology, and gelatinase activity. HPE inhibited PG degradation in articular cartilage explants. HPE significantly reduced deformity of knee joints and suppressed the histological change in MIA-induced OA. HPE inhibited MMP-2 activity in MG-63 cells. MMP-2 and -9 activities were also reduced in the cartilages of HPE-treated knee joints. Our results indicate that HPE has therapeutic effects on OA by protecting cartilage.

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참고문헌 (24)

Park, Kyoung Chul, Park, Eun Jin, Kim, Eun Ran, Kim, Yeonran, Chung, Suk Hee, Cho, Byoung Wook, Kim, Sunyoung, Jin, Mirim. Therapeutic effects of PG201, an ethanol extract from herbs, through cartilage protection on collagenase-induced arthritis in rabbits. Biochemical and biophysical research communications, vol.331, no.4, 1469-1477.

상세보기
10.1186/ar2339 2) Poitras S., Avouac J., Rossignol M., Avouac B., Cedraschi C., Nordin M., Rousseaux C., Rozenberg S., Savarieau B., Thoumie P., Valat J. P., Vignon E., Hilliquin P., Arthritis Res. Ther. , 9 , R126 (2007).

상세보기
Tonello, Giuseppe, Daglio, Marcello, Zaccarelli, Nadia, Sottofattori, Enzo, Mazzei, Mauro, Balbi, Alessandro. Characterization and quantitation of the active polynucleotide fraction (PDRN) from human placenta, a tissue repair stimulating agent. Journal of pharmaceutical and biomedical analysis, vol.14, no.11, 1555-1560.

상세보기
0022-3751 J. Physiol. Hooper K. C. 148 283 1959 10.1113/jphysiol.1959.sp006288

상세보기
0049-3848 Thromb. Res. Uszynski M. 16 689 1979 10.1016/0049-3848(79)90212-3

상세보기
Mochizuki, H., Kada, T.. Antimutagenic action of mammalian placental extracts on mutations induced in Escherichia coli by UV radiation, γ-rays and N-methyl-N'-nitro-N-nitrosoguanidine. Mutation research, vol.95, no.2, 457-474.

상세보기
10.1111/j.1600-0897.2006.00435.x 7) Sabapatha A., Gercel-Taylor C., Taylor D. D., Am. J. Reprod. Immunol. , 56 , 345—355 (2006).

상세보기
0378-8741 J. Ethnopharmacol. Hong H. T., Kim H. J., Lee T. K., K 79 143 2002 10.1016/S0378-8741(01)00371-3

상세보기
Yeom, Mi-Jung, Lee, Han-Chang, Kim, Gun-Ho, Shim, Insop, Lee, Hye-Jung, Hahm, Dae-Hyun. Therapeutic Effects of Hominis placenta Injection into an Acupuncture Point on the Inflammatory Responses in Subchondral Bone Region of Adjuvant-Induced Polyarthritic Rat. Biological & pharmaceutical bulletin, vol.26, no.10, 1472-1477.

상세보기
10.1016/0304-4165(78)90308-2 10) Sandy J. D., Brown H. L., Lowther D. A., Biochim. Biophys. Acta , 543 , 536—544 (1978).

상세보기
1063-4584 Osteoarthritis Cartilage Bove S. E., Calcaterra S. L., Brook 11 821 2003 10.1016/S1063-4584(03)00163-8

상세보기
Choi, J.H., Choi, J.H., Kim, D.Y., Yoon, J.H., Youn, H.Y., Yi, J.B., Rhee, H.I., Ryu, K.H., Jung, K., Han, C.K., Kwak, W.J., Cho, Y.B.. Effects of SKI 306X, a new herbal agent, on proteoglycan degradation in cartilage explant culture and collagenase-induced rabbit osteoarthritis model. Osteoarthritis and cartilage, vol.10, no.6, 471-478.

상세보기
Sakano, Yoshitaka, Terada, Nobuo, Ueda, Hideho, Fujii, Yasuhisa, Hamada, Yoshiki, Akamatsu, Noriya, Ohno, Shinichi. Histological study of articular cartilage in experimental rat knee arthritis induced by intracapsular injection of cationic polyethyleneimine. Medical electron microscopy : official journal of the Clinical Electron Microscopy Society of Japan, vol.33, no.4, 246-257.

상세보기
KOBAYASHI, Kiyoshi, IMAIZUMI, Rei, SUMICHIKA, Hiroshi, TANAKA, Hideki, GODA, Maki, FUKUNARI, Atsushi, KOMATSU, Hirotsugu. Sodium Iodoacetate-Induced Experimental Osteoarthritis and Associated Pain Model in Rats. The Journal of veterinary medical science, vol.65, no.11, 1195-1199.

상세보기
Dumond, H., Presle, N., Pottie, P., Pacquelet, S., Terlain, B., Netter, P., Gepstein, A., Livne, E., Jouzeau, J.-Y.. Site specific changes in gene expression and cartilage metabolism during early experimental osteoarthritis. Osteoarthritis and cartilage, vol.12, no.4, 284-295.

상세보기
16) Mason R. M., Spencer C. A., Palmer N. T., “Chondrocyte Energy Metabolism and Its Modulation by Iodoacetate and Diclofenac,” Hogrefe and Huber, Toronto, 1989.
1063-4584 Osteoarthritis Cartilage Barve R. A., Minnerly J. C., Weiss 15 1190 2007 10.1016/j.joca.2007.03.014

상세보기
0192-6233 Toxicol. Pathol. Guzman R. E., Evans M. G., Bove S., 31 619 2003 10.1080/01926230390241800

상세보기
1063-4584 Osteoarthritis Cartilage Stevens A. L., Wheeler C. A., Tanne 16 489 2008 10.1016/j.joca.2007.07.015

상세보기
20) Trelstad R., Kemp P., “Matrix Glycoproteins and Proteoglycans,” WB Saunders, Philadelphia, 1993.
0266-4356 Br. J. Oral. Maxillofac. Surg. Mizui T., Ishimaru J., Miyamoto K., 39 310 2001 10.1054/bjom.2001.0634

상세보기
Chu, Shu-Chen, Yang, Shun-Fa, Lue, Ko-Huang, Hsieh, Yih-Shou, Wu, Chih-Lung, Lu, Ko-Hsiu. Regulation of Gelatinases Expression by Cytokines, Endotoxin, and Pharmacological Agents in the Human Osteoarthritic Knee. Connective tissue research, vol.45, no.3, 142-150.

상세보기
0021-9533 J. Cell Sci. 103 4 1093 1992 10.1242/jcs.103.4.1093

상세보기
0749-8063 Arthroscopy Hsieh Y. S., Yang S. F., Chu S. C., 20 482 2004 10.1016/j.arthro.2004.03.010

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DOI : 10.1248/bpb.33.1004 [무료]
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