[논문]Measurement of Nasal Nitric Oxide Is Useful for the Diagnosis of Sinusitis-Induced Prolonged Cough

Kim, Sang-Heon; Jeong, Jin Hyeok; Kwak, Hyun Jung; Song, Sung Heon; Kim, Tae Hyung; Sohn, Jang Won; Shin, Dong Ho; Yoon, Ho Joo; Park, Sung Soo

doi:10.1620/tjem.223.145

Measurement of Nasal Nitric Oxide Is Useful for the Diagnosis of Sinusitis-Induced Prolonged Cough 원문보기

The Tohoku journal of experimental medicine, v.223 no.2, 2011년, pp.145 - 151

Kim, Sang-Heon (Department of Internal Medicine, Hanyang University College of Medicine) , Jeong, Jin Hyeok (Department of Otolaryngology-Head & Neck Surgery, Hanyang University College of Medicine) , Kwak, Hyun Jung (Department of Internal Medicine, Hanyang University College of Medicine) , Song, Sung Heon (Department of Internal Medicine, Hanyang University College of Medicine) , Kim, Tae Hyung (Department of Internal Medicine, Hanyang University College of Medicine) , Sohn, Jang Won (Department of Internal Medicine, Hanyang University College of Medicine) , Shin, Dong Ho (Department of Internal Medicine, Hanyang University College of Medicine) , Yoon, Ho Joo (Department of Internal Medicine, Hanyang University College of Medicine) , Park, Sung Soo (Department of Internal Medicine, Hanyang University College of Medicine)

Abstract ▼ AI-Helper

Upper airway cough syndrome (UACS), the most common cause of prolonged cough, is diagnosed based on clinical findings without specific diagnostic test. The concentration of nitric oxide in nasal cavity air (nNO) is influenced by allergic rhinitis and/or sinusitis, both of which are common causes of UACS. We measured nNO levels in patients with UACS and those with other causes. We also examined the usefulness of measuring nNO for differentiating patients with sinusitis from those without sinusitis. The study included 93 adult patients with prolonged cough lasting more than threeweeks. Etiologies of cough were identified and nNO was measured at the initial investigation. UACS was diagnosed in 58 patients (62.4%), and sinusitis was identified in 11 (19.0%) of the 58 patients with UACS. Levels of nNO in UACS did not differ from non-UACS etiologies (316.2 ± 129.2 vs. 334.9 ± 88.2 ppb; p = 0.452), suggesting that the measurement of nNO could not discriminate UACS from other etiologies of prolonged cough. However, patients with sinusitis showed significantly decreased nNO levels (190.1 ± 114.8ppb) compared with patients with UACS without sinusitis (345.7 ± 114.6ppb; p<0.001) and non-UACS patients (334.9 ± 88.2 ppb; p<0.001). In a receiver operating characteristic curve analysis for the diagnosis of sinusitis in prolonged cough, the best sensitivity (73.2%) and specificity (81.8%) were obtained with a nNO cutoff value of 279.0 ppb. These findings imply that the measurement of nNO could be useful for diagnosis of prolonged cough associated with sinusitis.

주제어

참고문헌 (46)

10.1183/09031936.93.06091368 Alving, K., Weitzberg, E. & Lundberg, J.M. (1993) Increased amount of nitric oxide in exhaled air of asthmatics. Eur. Respir. J. , 6 , 1368-1370.

상세보기
10.1111/j.1365-2222.1997.tb00719.x Arnal, J.F., Didier, A., Rami, J., M'Rini, C., Charlet, J.P., Serrano, E. & Besombes, J.P. (1997) Nasal nitric oxide is increased in allergic rhinitis. Clin. Exp. Allergy , 27 , 358-362.

상세보기
10.1034/j.1399-3003.1999.13b15.x Arnal, J.F., Flores, P., Rami, J., Murris-Espin, M., Bremont, F., Pasto, I.A.M., Serrano, E. & Didier, A. (1999) Nasal nitric oxide concentration in paranasal sinus inflammatory diseases. Eur. Respir. J. , 13 , 307-312.

상세보기
American Thoracic Society. (2005) ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am. J. Respir. Crit. Care Med. , 171 , 912-930.
10.1136/adc.75.4.319 Balfour-Lynn, I.M., Laverty, A. & Dinwiddie, R. (1996) Reduced upper airway nitric oxide in cystic fibrosis. Arch. Dis. Child. , 75 , 319-322.

상세보기
10.1164/ajrccm.155.5.9154876 Baraldi, E., Azzolin, N.M., Biban, P. & Zacchello, F. (1997) Effect of antibiotic therapy on nasal nitric oxide concentration in children with acute sinusitis. Am. J. Respir. Crit. Care Med. , 155 , 1680-1683.

상세보기
10.1016/S1081-1206(10)60310-9 Bommarito, L., Guida, G., Heffler, E., Badiu, I., Nebiolo, F., Usai, A., De Stefani, A. & Rolla, G. (2008) Nasal nitric oxide concentration in suspected chronic rhinosinusitis. Ann. Allergy Asthma Immunol. , 101 , 358-362.

상세보기
10.1164/ajrccm.159.6.9809047 Chatkin, J.M., Ansarin, K., Silkoff, P.E., McClean, P., Gutierrez, C., Zamel, N. & Chapman, K.R. (1999) Exhaled nitric oxide as a noninvasive assessment of chronic cough. Am. J. Respir. Crit. Care Med. , 159 , 1810-1813.

상세보기
10.1016/S0140-6736(08)60595-4 Chung, K.F. & Pavord, I.D. (2008) Prevalence, pathogenesis, and causes of chronic cough. Lancet , 371 , 1364-1374.

상세보기
10.1378/chest.128.3.1699 Degano, B., Genestal, M., Serrano, E., Rami, J. & Arnal, J.F. (2005) Effect of treatment on maxillary sinus and nasal nitric oxide concentrations in patients with nosocomial maxillary sinusitis. Chest , 128 , 1699-1705.

상세보기
10.1164/rccm.200207-640OC Deja, M., Busch, T., Bachmann, S., Riskowski, K., Campean, V., Wiedmann, B., Schwabe, M., Hell, B., Pfeilschifter, J., Falke, K.J. & Lewandowski, K. (2003) Reduced nitric oxide in sinus epithelium of patients with radiologic maxillary sinusitis and sepsis. Am. J. Respir. Crit. Care Med. , 168 , 281-286.

상세보기
10.1378/chest.129.1_suppl.75S Dicpinigaitis, P.V. (2006) Chronic cough due to asthma: ACCP evidence-based clinical practice guidelines. Chest , 129 , 75S-79S.

상세보기
FUJIMURA, Masaki, OHKURA, Noriyuki, ABO, Miki, FURUSHO, Shiho, WASEDA, Yuko, ICHIKAWA, Yukari, HARA, Johsuke. Exhaled nitric oxide levels in patients with atopic cough and cough variant asthma. Respirology : official journal of the Asian Pacific Society of Respirology, vol.13, no.3, 359-364.

상세보기
10.4065/82.11.1350 Hahn, P.Y., Morgenthaler, T.Y. & Lim, K.G. (2007) Use of exhaled nitric oxide in predicting response to inhaled corticosteroids for chronic cough. Mayo Clin. Proc. , 82 , 1350-1355.

상세보기
Henriksen, A.h., Sue-Chu, M., Lingaas Holmen, T., Langhammer, A., Bjermer, L.. Exhaled and nasal NO levels in allergic rhinitis: relation to sensitization, pollen season and bronchial hyperresponsiveness. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology, vol.13, no.2, 301-306.

상세보기
10.1378/chest.129.1_suppl.1S Irwin, R.S., Baumann, M.H., Bolser, D.C., Boulet, L.P., Braman, S.S., Brightling, C.E., Brown, K.K., Canning, B.J., Chang, A.B., Dicpinigaitis, P.V., Eccles, R., Glomb, W.B., Goldstein, L.B., Graham, L.M., Hargreave, F.E., Kvale, P.A., Lewis, S.Z., McCool, F.D., McCrory, D.C., Prakash, U.B., Pratter, M.R., Rosen, M.J., Schulman, E., Shannon, J.J., Smith Hammond, C. & Tarlo, S.M. (2006) Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines. Chest , 129 , 1S-23S.

상세보기
10.1001/archinte.1997.00440380091009 Irwin, R.S., French, C.T., Smyrnios, N.A. & Curley, F.J. (1997) Interpretation of positive results of a methacholine inhalation challenge and 1 week of inhaled bronchodilator use in diagnosing and treating cough-variant asthma. Arch. Intern. Med. , 157 , 1981-1987.

상세보기
Irwin, Richard S., Madison, J. Mark. The Diagnosis and Treatment of Cough. The New England journal of medicine, vol.343, no.23, 1715-1721.

상세보기
10.1016/S0091-6749(97)70301-4 Kharitonov, S.A., Rajakulasingam, K., O'Connor, B., Durham, S.R. & Barnes, P.J. (1997) Nasal nitric oxide is increased in patients with asthma and allergic rhinitis and may be modulated by nasal glucocorticoids. J. Allergy Clin. Immunol. , 99 , 58-64.

상세보기
10.3109/02770901003702840 Kim, S.H., Kim, T.H., Sohn, J.W., Yoon, H.J., Shin, D.H. & Park, S.S. (2010) Reference values and determinants of exhaled nitric oxide in healthy korean adults. J. Asthma , 47 , 563-567.

상세보기
10.1378/chest.129.5.1142 Kwon, N.H., Oh, M.J., Min, T.H., Lee, B.J. & Choi, D.C. (2006) Causes and clinical features of subacute cough. Chest , 129 , 1142-1147.

상세보기
10.3109/00016489709118001 Lindberg, S., Cervin, A. & Runer, T. (1997) Nitric oxide (no) production in the upper airways is decreased in chronic sinusitis. Acta Otolaryngol. , 117 , 113-117.

상세보기
10.1001/jama.289.3.302-b Lundberg, J.O., Maniscalco, M., Sofia, M., Lundblad, L. & Weitzberg, E. (2003) Humming, nitric oxide, and paranasal sinus obstruction. JAMA , 289 , 302-303.

상세보기
10.1136/thx.54.10.947 Lundberg, J.O. & Weitzberg, E. (1999) Nasal nitric oxide in man. Thorax , 54 , 947-952.

상세보기
Maniscalco, M., Sofia, M., Carratù, L., Higenbottam, T.. Effect of nitric oxide inhibition on nasal airway resistance after nasal allergen challenge in allergic rhinitis. European journal of clinical investigation, vol.31, no.5, 462-466.

상세보기
10.1007/s00011-006-6111-1 Maniscalco, M., Sofia, M. & Pelaia, G. (2007) Nitric oxide in upper airways inflammatory diseases. Inflamm. Res. , 56 , 58-69.

상세보기
10.1183/09031936.00101006 Morice, A.H., Fontana, G.A., Belvisi, M.G., Birring, S.S., Chung, K.F., Dicpinigaitis, P.V., Kastelik, J.A., McGarvey, L.P., Smith, J.A., Tatar, M. & Widdicombe, J. (2007) ERS guidelines on the assessment of cough. Eur. Respir. J. , 29 , 1256-1276.

상세보기
10.1136/thx.2006.065144 Morice, A.H., McGarvey, L. & Pavord, I. (2006) Recommendations for the management of cough in adults. Thorax , 61 Suppl 1 , i1-24.

상세보기
10.1378/chest.07-2541 Oh, M.J., Lee, J.Y., Lee, B.J. & Choi, D.C. (2008) Exhaled nitric oxide measurement is useful for the exclusion of nonasthmatic eosinophilic bronchitis in patients with chronic cough. Chest , 134 , 990-995.

상세보기
10.1378/chest.06-2928 Olin, A.C., Bake, B. & Toren, K. (2007) Fraction of exhaled nitric oxide at 50 ml/s: Reference values for adult lifelong never-smokers. Chest , 131 , 1852-1856.

상세보기
10.1034/j.1398-9995.2003.00098.x Palm, J.P., Alving, K. & Lundberg, J.O. (2003) Characterization of airway nitric oxide in allergic rhinitis: the effect of intranasal administration of L-NAME. Allergy , 58 , 885-892.

상세보기
10.1378/chest.116.5.1287 Pratter, M.R., Bartter, T. & Lotano, R. (1999) The role of sinus imaging in the treatment of chronic cough in adults. Chest , 116 , 1287-1291.

상세보기
10.1378/chest.129.1_suppl.63S Pratter, M.R. (2006a) Chronic upper airway cough syndrome secondary to rhinosinus diseases (previously referred to as postnasal drip syndrome): ACCP evidence-based clinical practice guidelines. Chest , 129 , 63S-71S.

상세보기
10.1378/chest.129.1_suppl.59S Pratter, M.R. (2006b) Overview of common causes of chronic cough: ACCP evidence-based clinical practice guidelines. Chest , 129 , 59S-62S.

상세보기
10.1378/chest.129.1_suppl.222S Pratter, M.R., Brightling, C.E., Boulet, L.P. & Irwin, R.S. (2006c) An empiric integrative approach to the management of cough: ACCP evidence-based clinical practice guidelines. Chest , 129 , 222S-231S.

상세보기
10.1016/j.jaci.2006.07.028 Profita, M., La Grutta, S., Carpagnano, E., Riccobono, L., Di Giorgi, R., Bonanno, A., Pace, E., Bonsignore, G., Bousquet, J., Vignola, A.M. & Gjomarkaj, M. (2006) Noninvasive methods for the detection of upper and lower airway inflammation in atopic children. J. Allergy Clin. Immunol. , 118 , 1068-1074.

상세보기
10.1016/j.rmed.2008.04.018 Sato, S., Saito, J., Sato, Y., Ishii, T., Xintao, W., Tanino, Y., Ishida, T. & Munakata, M. (2008) Clinical usefulness of fractional exhaled nitric oxide for diagnosing prolonged cough. Respir. Med. , 102 , 1452-1459.

상세보기
Scadding, G. & Scadding, G.K. (2009) Update on the use of nitric oxide as a noninvasive measure of airways inflammation. Rhinology , 47 , 115-120.
10.2500/105065899781389803 Silkoff, P.E., Chatkin, J., Qian, W., Chakravorty, S., Gutierrez, C., Furlott, H., McClean, P., Rai, S., Zamel, N. & Haight, J. (1999) Nasal nitric oxide: a comparison of measurement techniques. Am. J. Rhinol. , 13 , 169-178.

상세보기
10.1067/mai.2000.104938 Silkoff, P.E., Robbins, R.A., Gaston, B., Lundberg, J.O. & Townley, R.G. (2000) Endogenous nitric oxide in allergic airway disease. J. Allergy Clin. Immunol. , 105 , 438-448.

상세보기
10.1164/rccm.200310-1376OC Smith, A.D., Cowan, J.O., Filsell, S., McLachlan, C., Monti-Sheehan, G., Jackson, P. & Taylor, D.R. (2004) Diagnosing asthma: comparisons between exhaled nitric oxide measurements and conventional tests. Am. J. Respir. Crit. Care Med. , 169 , 473-478.

상세보기
10.1111/j.1398-9995.2006.01096.x Struben, V.M., Wieringa, M.H., Feenstra, L. & de Jongste, J.C. (2006a) Nasal nitric oxide and nasal allergy. Allergy , 61 , 665-670.

상세보기
10.1007/s00405-006-0059-1 Struben, V.M., Wieringa, M.H., Mantingh, C.J., de Jongste, J.C. & Feenstra, L. (2006b) Nasal no measurement by direct sampling from the nose during breathhold: aspiration flow, nasal resistance and reproducibility. Eur. Arch. Otorhinolaryngol. , 263 , 723-728.

상세보기
Taylor, D R, Pijnenburg, M W, Smith, A D, Jongste, J C D. Exhaled nitric oxide measurements: clinical application and interpretation. Thorax, vol.61, no.9, 817-827.

상세보기
10.1183/09031936.03.00305503 Wodehouse, T., Kharitonov, S.A., Mackay, I.S., Barnes, P.J., Wilson, R. & Cole, P.J. (2003) Nasal nitric oxide measurements for the screening of primary ciliary dyskinesia. Eur. Respir. J. , 21 , 43-47.

상세보기
10.1016/S1081-1206(10)60398-5 Yuksel, H., Kirmaz, C., Yilmaz, O., Pinar, E., Vatansever, S., Degirmenci, P.B. & Ozbilgin, K. (2008) Nasal mucosal expression of nitric oxide synthases in patients with allergic rhinitis and its relation to asthma. Ann. Allergy Asthma Immunol. , 100 , 12-16.

상세보기

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Measurement of Nasal Nitric Oxide Is Useful for the Diagnosis of Sinusitis-Induced Prolonged Cough 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (46)

이 논문을 인용한 문헌

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트