Lee, Jae Hoon
(Departments of Surgery and College of Medicine, Hanyang University, Seoul, Korea)
,
Lee, Kyeong Geun
(Departments of Surgery and College of Medicine, Hanyang University, Seoul, Korea)
,
Ha, Tae Kyung
(Departments of Surgery and College of Medicine, Hanyang University, Seoul, Korea)
,
Jun, Young Jin
(Departments of Pathology, College of Medicine, Hanyang University, Seoul, Korea)
,
Pair, Seung Sam
(Departments of Pathology, College of Medicine, Hanyang University, Seoul, Korea)
,
Park, Hwon Kyum
(Departments of Surgery and College of Medicine, Hanyang University, Seoul, Korea)
,
Lee, Kwang Soo
(Departments of Surgery and College of Medicine, Hanyang University, Seoul, Korea)
The aims of this study were to clarify the distribution and spread pattern of metastatic nodes and to evaluate the importance of the number, ratio, and location of positive nodes in ampullary adenocarcinoma. We analyzed the clinicopathologic data and survival of 52 patients who received curative pan...
The aims of this study were to clarify the distribution and spread pattern of metastatic nodes and to evaluate the importance of the number, ratio, and location of positive nodes in ampullary adenocarcinoma. We analyzed the clinicopathologic data and survival of 52 patients who received curative pancreatoduodenectomy for ampullary adenocarcinoma between June 1994 and May 2009. Metastatic lymph nodes were found in 32 (61.5%) patients. The median number of evaluated nodes and positive nodes were 26 (range 10-60) and two (range 1-15), respectively. The most commonly involved nodes were the posterior pancreaticoduodenal nodes (26 patients) followed by the anterior pancreaticoduodenal nodes (11 patients). No positive hepatoduodenal and common hepatic artery nodes were found. In univariate analysis, number of positive nodes, and their ratio and location were significantly associated with survival. Only the factor of three or more metastatic nodes had the independent power in predicting a poor outcome in multivariate analysis ( P < 0.001). Ampullary adenocarcinoma first spreads to the posterior pancreaticoduodenal nodes and then the anterior nodes. The number of positive lymph nodes, rather than their ratio and location, independently affects survival after curative resection in patients with ampullary carcinoma.
The aims of this study were to clarify the distribution and spread pattern of metastatic nodes and to evaluate the importance of the number, ratio, and location of positive nodes in ampullary adenocarcinoma. We analyzed the clinicopathologic data and survival of 52 patients who received curative pancreatoduodenectomy for ampullary adenocarcinoma between June 1994 and May 2009. Metastatic lymph nodes were found in 32 (61.5%) patients. The median number of evaluated nodes and positive nodes were 26 (range 10-60) and two (range 1-15), respectively. The most commonly involved nodes were the posterior pancreaticoduodenal nodes (26 patients) followed by the anterior pancreaticoduodenal nodes (11 patients). No positive hepatoduodenal and common hepatic artery nodes were found. In univariate analysis, number of positive nodes, and their ratio and location were significantly associated with survival. Only the factor of three or more metastatic nodes had the independent power in predicting a poor outcome in multivariate analysis ( P < 0.001). Ampullary adenocarcinoma first spreads to the posterior pancreaticoduodenal nodes and then the anterior nodes. The number of positive lymph nodes, rather than their ratio and location, independently affects survival after curative resection in patients with ampullary carcinoma.
참고문헌 (35)
Yeo, Charles J., Cameron, John L., Sohn, Taylor A., Lillemoe, Keith D., Pitt, Henry A., Talamini, Mark A., Hruban, Ralph H., Ord, Sarah E., Sauter, Patricia K., Coleman, JoAnn, Zahurak, Marianna L., Grochow, Louise B., Abrams, Ross A..
Six Hundred Fifty Consecutive Pancreaticoduodenectomies in the 1990s : Pathology, Complications, and Outcomes.
Annals of surgery,
vol.226,
no.3,
248-260.
Bouvet, Michael, Gamagami, Reza A, Gilpin, Elizabeth A, Romeo, Oreste, Sasson, Aaron, Easter, David W, Moossa, A.R.
Factors influencing survival after resection for periampullary neoplasms.
The American journal of surgery,
vol.180,
no.1,
13-17.
Duffy, John P..
Improved Survival for Adenocarcinoma of the Ampulla of Vater : Fifty-five Consecutive Resections.
Archives of surgery : official publication for the Central Surgical Association and the Western Surgical Association,
vol.138,
no.9,
941-.
Fisher, William E., Bakey, Michael E..
Differences between Ampullary, Periampullary and Pancreatic Cancer.
World journal of surgery,
vol.31,
no.1,
144-146.
Böttger, Thomas C., Boddin, Jörg, Heintz, Achim, Junginger, T..
Clinicopathologic Study for the Assessment of Resection for Ampullary Carcinoma.
World journal of surgery,
vol.21,
no.4,
379-383.
Talamini, Mark A., Moesinger, Robert C., Pitt, Henry A., Sohn, Taylor A., Hruban, Ralph H., Lillemoe, Keith D., Yeo, Charles J., Cameron, John L..
Adenocarcinoma of the Ampulla of Vater : A 28-Year Experience.
Annals of surgery,
vol.225,
no.5,
590-600.
Howe, James R., Klimstra, David S., Moccia, Roger D., Conlon, Kevin C., Brennan, Murray F..
Factors Predictive of Survival in Ampullary Carcinoma :.
Annals of surgery,
vol.228,
no.1,
87-94.
Qiao, Qi‐lu, Zhao, Yi‐guo, Ye, Mu‐lin, Yang, Yin‐mo, Zhao, Jian‐xun, Huang, Yan‐ting, Wan, Yuan‐lian.
Carcinoma of the Ampulla of Vater: Factors Influencing Long‐term Survival of 127 Patients with Resection.
World journal of surgery,
vol.31,
no.1,
137-143.
Kayahara, Masato, Nagakawa, Takukazu, Ohta, Tetsuo, Kitagawa, Hirohisa, Miyazaki, Itsuo.
Surgical strategy for carcinoma of the papilla of vater on the basis of lymphatic spread and mode of recurrence.
Surgery,
vol.121,
no.6,
611-617.
Shirai, Y, Ohtani, T, Tsukada, K, Hatakeyama, K.
Patterns of lymphatic spread of carcinoma of the ampulla of Vater.
British journal of surgery : BJS,
vol.84,
no.7,
1012-1016.
Moriya, Toshiyuki, Kimura, Wataru, Hirai, Ichiro, Mizutani, Masaomi, Ma, Jingfeng, Kamiga, Masahiro, Fuse, Akira.
Nodal involvement as an indicator of postoperative liver metastasis in carcinoma of the papilla of Vater.
Journal of hepato-biliary-pancreatic surgery,
vol.13,
no.6,
549-555.
Pawlik, Timothy M., Gleisner, Ana L., Cameron, John L., Winter, Jordan M., Assumpcao, Lia, Lillemoe, Keith D., Wolfgang, Christopher, Hruban, Ralph H., Schulick, Richard D., Yeo, Charles J., Choti, Michael A..
Prognostic relevance of lymph node ratio following pancreaticoduodenectomy for pancreatic cancer.
Surgery,
vol.141,
no.5,
610-618.
Sierzega, Marek, Popiela, Tadeusz, Kulig, Jan, Nowak, Krystyna.
The Ratio of Metastatic/Resected Lymph Nodes is an Independent Prognostic Factor in Patients With Node-positive Pancreatic Head Cancer.
Pancreas,
vol.33,
no.3,
240-245.
Riediger, Hartwig, Keck, Tobias, Wellner, Ulrich, zur Hausen, Axel, Adam, Ulrich, Hopt, Ulrich T., Makowiec, Frank.
The Lymph Node Ratio is the Strongest Prognostic Factor after Resection of Pancreatic Cancer.
Journal of gastrointestinal surgery : official journal of the society for surgery of the alimentary tract,
vol.13,
no.7,
1337-1344.
Schwarz, Roderich E., Smith, David D..
Extent of Lymph Node Retrieval and Pancreatic Cancer Survival: Information from a Large US Population Database.
Annals of surgical oncology,
vol.13,
no.9,
1189-1200.
Sakata, J., Shirai, Y., Wakai, T., Yokoyama, N., Sakata, E., Akazawa, K., Hatakeyama, K..
Number of positive lymph nodes independently affects long-term survival after resection in patients with ampullary carcinoma.
European journal of surgical oncology,
vol.33,
no.3,
346-351.
Falconi, Massimo, Crippa, Stefano, Domínguez, Ismael, Barugola, Giuliano, Capelli, Paola, Marcucci, Stefano, Beghelli, Stefania, Scarpa, Aldo, Bassi, Claudio, Pederzoli, Paolo.
Prognostic Relevance of Lymph Node Ratio and Number of Resected Nodes after Curative Resection of Ampulla of Vater Carcinoma.
Annals of surgical oncology,
vol.15,
no.11,
3178-3186.
Kimura, Wataru, Futakawa, Noriaki, Yamagata, Seiichi, Wada, Yoshiyuki, Kuroda, Akira, Muto, Tetsuichiro, Esaki, Yoshiyuki.
Different Clinicopathologic Findings in Two Histologic Types of Carcinoma of Papilla of Vater.
Japanese journal of cancer research : Gann,
vol.85,
no.2,
161-166.
Atlas of Tumor Pathology, 3rd series, fascile 27. Albores-Saavedra J. 259 2000
10.1007/978-1-4757-3656-4
General rules for surgical and pathological studies on cancer of the biliary tract Japanese Society of Biliary Surgery 1997 4
Japanese Society of Biliary Surgery (JSBS) Nagakawa T. 51 2004 2
Winter, Jordan M., Cameron, John L., Olino, Kelly, Herman, Joseph M., de Jong, Mechteld C., Hruban, Ralph H., Wolfgang, Christopher L., Eckhauser, Frederic, Edil, Barish H., Choti, Michael A., Schulick, Richard D., Pawlik, Timothy M..
Clinicopathologic Analysis of Ampullary Neoplasms in 450 Patients: Implications for Surgical Strategy and Long-Term Prognosis.
Journal of gastrointestinal surgery : official journal of the society for surgery of the alimentary tract,
vol.14,
no.2,
379-387.
Schwarz, Roderich E., Smith, David D..
Lymph Node Dissection Impact on Staging and Survival of Extrahepatic Cholangiocarcinomas, Based on U.S. Population Data.
Journal of gastrointestinal surgery : official journal of the society for surgery of the alimentary tract,
vol.11,
no.2,
158-165.
Roder, J D, Schneider, P M, Stein, H J, Siewert, J R.
Number of lymph node metastases is significantly associated with survival in patients with radically resected carcinoma of the ampulla of Vater.
British journal of surgery : BJS,
vol.82,
no.12,
1693-1696.
Sierra, Alejandro, Regueira, Fernando M., Hern?ndez-Lizo?in, Jos� L., Pardo, Fernando, Mart�nez-Gonzalez, Miguel A., A.-Cienfuegos, Javier.
Role of the Extended Lymphadenectomy in Gastric Cancer Surgery: Experience in a Single Institution.
Annals of surgical oncology,
vol.10,
no.3,
219-226.
Rosenberg, Robert, Friederichs, Jan, Schuster, Tibor, Gertler, Ralf, Maak, Matthias, Becker, Karen, Grebner, Anne, Ulm, Kurt, Höfler, Heinz, Nekarda, Hjalmar, Siewert, Jörg-Rüdiger.
Prognosis of Patients With Colorectal Cancer Is Associated With Lymph Node Ratio: A Single-Center Analysis of 3026 Patients Over a 25-Year Time Period.
Annals of surgery,
vol.248,
no.6,
968-978.
Hurtuk, M.G., Hughes, C., Shoup, M., Aranha, G.V..
Does lymph node ratio impact survival in resected periampullary malignancies?.
The American journal of surgery,
vol.197,
no.3,
348-352.
Yeo, Charles J., Cameron, John L., Lillemoe, Keith D., Sohn, Taylor A., Campbell, Kurtis A., Sauter, Patricia K., Coleman, JoAnn, Abrams, Ross A., Hruban, Ralph H..
Pancreaticoduodenectomy With or Without Distal Gastrectomy and Extended Retroperitoneal Lymphadenectomy for Periampullary Adenocarcinoma, Part 2: Randomized Controlled Trial Evaluating Survival, Morbidity, and Mortality.
Annals of surgery,
vol.236,
no.3,
355-368.
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