[논문]In vivo study of four preparative extracts of Clematis terniflora DC. for antinociceptive activity and anti-inflammatory activity in rat model of carrageenan-induced chronic non-bacterial prostatitis

Chen, R.Z.; Cui, L.; Guo, Y.J.; Rong, Y.M.; Lu, X.H.; Sun, M.Y.; Zhang, L.; Tian, J.K.

doi:10.1016/j.jep.2011.01.004

In vivo study of four preparative extracts of Clematis terniflora DC. for antinociceptive activity and anti-inflammatory activity in rat model of carrageenan-induced chronic non-bacterial prostatitis

Journal of ethnopharmacology, v.134 no.3, 2011년, pp.1018 - 1023

Chen, R.Z. , Cui, L. , Guo, Y.J. , Rong, Y.M. , Lu, X.H. , Sun, M.Y. , Zhang, L. , Tian, J.K.

Abstract ▼ AI-Helper

Aim of the study: The present study was conducted to evaluate the anti-inflammatory and antinociceptive activities of Clematis terniflora DC. extracts and fractions and to further support its traditional use as Chinese folk medicine in treatment of urinary infections, especially the disease of prostatitis. Materials and methods: The antinociceptive activity of its water extract (WE), 70% ethanol extract (EE), water eluted part of EE from AB-8 macroporous resin (WEPMR) and 70% ethanol eluted part of EE from AB-8 macroporous resin (EEPMR) was conducted using mice writhing test with different doses. Then the anti-inflammatory activity of the four parts was evaluated on rat models of carrageenan-induced chronic non-bacterial prostatitis (CNP). Preliminary study was taken to determine the phytochemical compositions of the four preparative extracts. Results: Significant writhing inhibitory effect was found with EE at small (7.5g/kg body wt.), moderate (15g/kg body wt.) and large (30g/kg body wt.) doses (doses here are presented as crude herbs) as well as EEPMR at moderate and large doses by oral administration (OA) (p@?0.01). Data from prostatic index, lecithin microsome density and white blood cell level showed that moderate dose of EE and EEPMR both had significant (p@?0.05 or p@?0.01) inhibition effect on carrageenan-induced inflammation in rat prostate. The HPLC analytical results showed that flavonoids were the main active compounds in WE, EE and EEPMR. And most flavonoids were accumulated into the part of EEPMR by AB-8 macroporous resin leaving only few compounds in WEPMR. No acute toxicity was identified in oral administration of the four parts at a dose of 100g/kg body wt. Conclusions: The results described here suggest that extracts of the aerial part of Clematis terniflora DC. might be of therapeutic interest in the treatment of prostatitis.

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참고문헌 (19)

Journal of Ethnopharmacology Bremner 124 295 2009 10.1016/j.jep.2009.04.035 Assessing medicinal plants from South-Eastern Spain for potential anti-inflammatory effects targeting nuclear factor-Kappa B and other pro-inflammatory mediators

상세보기
British Journal of Pharmacology and Chemotherapy Collier 32 295 1968 10.1111/j.1476-5381.1968.tb00973.x The abdominal constriction response and its suppression by analgesic drugs in the mouse

상세보기
Annals of Internal Medicine Collins 133 367 2000 10.7326/0003-4819-133-5-200009050-00013 Diagnosis and treatment of chronic abacterial prostatitis: a systematic review

상세보기
Phytomedicine Gonzalez 9 125 2002 10.1078/0944-7113-00096 Anti-ulcerogenic and analgesic activities of the leaves of Wilbrandia ebracteata in mice

상세보기
Urology He 75 654 2010 10.1016/j.urology.2009.09.061 Clinical significance of IL-2, IL-10, and TNF-α in prostatic secretion of patients with chronic prostatitis

상세보기
Asian Journal of Andrology Huang 2 311 2000 Clinical classification of chronic prostatitis: a preliminary investigation

상세보기
Chemical and Pharmaceutical Bulletin Kawata 46 1891 1998 10.1248/cpb.46.1891 Studies on the constituents of Clematis species VII, triterpenoid saponins from the roots of Clematis terniflora DC. var. robusta

상세보기
Fitoterapia Khan 72 575 2001 10.1016/S0367-326X(01)00258-1 Antimicrobial activity of Clematis papuasica and Nauclea obversifolia

상세보기
Journal of Ethnopharmacology Lee 101 294 2005 10.1016/j.jep.2005.05.009 Clematis mandshurica protected to apoptosis of rat chondrocytes

상세보기
Journal of Ethnopharmacology Li 104 138 2006 10.1016/j.jep.2005.08.061 Inhibition of COXs and 5-LOX and activation of PPARs by Australian Clematis species (Ranunculaceae)

상세보기
Archives of Toxicology Lorke 54 275 1983 10.1007/BF01234480 A new approach to practical acute toxicity testing

상세보기
Journal of Ethnopharmacology Mekonnen 127 433 2010 10.1016/j.jep.2009.10.020 Evaluation of the diuretic and analgesic activities of the rhizomes of Rumex abyssinicus Jacq in mice

상세보기
Shoyakugaku Zasshi Mikage 37 334 1983 Pharmacognostic studies on the Clematis plants and related crude drugs: the botanical origin of “Wei-ling-xian” from northeast China
Peptides Peng 30 1805 2009 10.1016/j.peptides.2009.06.027 Clematis montana lectin, a novel mannose-binding lectin from traditional Chinese medicine with antiviral and apoptosis-inducing activities

상세보기
Inflammopharmacology Radhakrishnan 17 23 2009 10.1007/s10787-008-8051-6 Development and characterisation of a novel animal model of prostate inflammation-induced chronic pelvic pain

상세보기
Genitourinary Medicine Thin 67 279 1991 The diagnosis of prostatitis: a review

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Acta Phytotaxonomica Sinica Wang 43 431 2005 A new system of classification of the genus Clematis (Ranunculaceae)

상세보기
Journal of Ethnopharmacology Yesilada 110 504 2007 10.1016/j.jep.2006.10.016 Clematis vitalba L. aerial part exhibits potent anti-inflammatory, antinociceptive and antipyretic effects

상세보기
Pain Zimmermann 16 109 1983 10.1016/0304-3959(83)90201-4 Ethical guidelines for investigations of experimental pain in conscious animals

상세보기

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In vivo study of four preparative extracts of Clematis terniflora DC. for antinociceptive activity and anti-inflammatory activity in rat model of carrageenan-induced chronic non-bacterial prostatitis

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