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Abstract ▼ AI-Helper

The folding structure of RNA determines its biological function, and therefore predicting the folding structure is important for understanding RNA. This paper describes a modeling system called Folder which automates the process of model-building and simulation of RNA secondary structure formation ...

The folding structure of RNA determines its biological function, and therefore predicting the folding structure is important for understanding RNA. This paper describes a modeling system called Folder which automates the process of model-building and simulation of RNA secondary structure formation in a unified framework. Folder does not make a commitment to the numeric values of the energy model, but uses approximation of the model and combines it with knowledge from other sources. The structure formation process of RNA is simulated by producing a series of structures at intermediate stage of the RNA chain's growth Major strengths of Folder are. (1) its prediction is not sensitive to imperfect data, (2) it is made general so as to be widely applicable to many different types of RNAs, and (3) it predicts secondary structures common to multiple RNA sequences in the same amount of time and space as those for folding a single sequence by conventional methods.