[논문]The prevalence of testicular adrenal rest tumors and associated factors in postpubertal patients with congenital adrenal hyperplasia caused by 21-hydroxylase deficiency

Kang, Min Jae; Kim, Jae Hyun; Lee, Sun Hee; Lee, Young Ah; Shin, Choong Ho; Yang, Sei Won

doi:10.1507/endocrj.K11E-034

The prevalence of testicular adrenal rest tumors and associated factors in postpubertal patients with congenital adrenal hyperplasia caused by 21-hydroxylase deficiency 원문보기

Endocrine journal, v.58 no.6, 2011년, pp.501 - 508

Kang, Min Jae (Department of Pediatrics, Seoul National University College of Medicine, Seoul, 110-769, Korea) , Kim, Jae Hyun (Department of Pediatrics, Inje University Ilsan Paik Hospital, Goyang, 411-706, Korea) , Lee, Sun Hee (Department of Pediatrics, Inje University Pusan Paik Hospital, Pusan, 614-735, Korea) , Lee, Young Ah (Department of Pediatrics, Seoul National University College of Medicine, Seoul, 110-769, Korea) , Shin, Choong Ho (Department of Pediatrics, Seoul National University College of Medicine, Seoul, 110-769, Korea) , Yang, Sei Won (Department of Pediatrics, Seoul National University College of Medicine, Seoul, 110-769, Korea)

Abstract ▼ AI-Helper

Development of a testicular adrenal rest tumor (TART) is common in males with congenital adrenal hyperplasia, and it can be an important cause of infertility. In the present study, we observed the prevalence of TARTs, and analyzed its associated factors in patients with 21-hydroxylase deficiency. Testicular ultrasonography was performed in 48 postpubertal male patients aged 10.6 to 27.1 years. To determine whether patients were undertreated, we analyzed the serum 17-hydroxyprogesterone (17-OHP) levels to the time of ultrasonographic measurement and calculated the percentage of measurements when serum 17-OHP level was >10 ng/mL relative to the total number of measurements during the follow-up period. We divided the 6-year period before ultrasonographic measurement (time 0) into three 2-year intervals and calculated the average concentration of serum 17-OHP in each interval to give a -2nd to 0 year-average concentration (-2-0YAC), -4-2YAC and -6-4YAC. A TART was detected by ultrasonography in 31 of 48 patients (64.6%) and the median maximal cross-sectional area of the TARTs was 0.71 (0.03, 4.95) cm2. The corrected final adult height was lower, and -4-2YAC and body mass index were higher in patients with TART than in those without. After controlling for the type of 21-hydroxylase deficiency, hydrocortisone-equivalent dose, age, and -6-4YAC, the size of TART was associated with a high undertreatment percentage with a marginal statistical significance. These results suggest that strict disease control is mandatory and regular examination with testicular ultrasonography is recommended in male patients, regardless of the type of 21-hydroxylase deficiency.

주제어

참고문헌 (33)

10.1159/000110585 1. Hughes IA (2007) Congenital adrenal hyperplasia: a lifelong disorder. Horm Res 68: 84-89.

상세보기
10.1210/jc.2006-1311 2. Claahsen-van der Grinten HL, Otten BJ, Takahashi S, Meuleman EJ, Hulsbergen-van de Kaa C, Sweep FC, Hermus AR (2007) Testicular adrenal rest tumors in adult males with congenital adrenal hyperplasia: evaluation of pituitary-gonadal function before and after successful testis-sparing surgery in eight patients. J Clin Endocrinol Metab 92: 612-615.

상세보기
10.1016/j.beem.2008.09.007 3. Claahsen-van der Grinten HL, Otten BJ, Stikkelbroeck MM, Sweep FC, Hermus AR (2009) Testicular adrenal rest tumours in congenital adrenal hyperplasia. Best Practic Res Clin Endocrinol Metab 23: 209-220.

상세보기
Martinez-Aguayo, A., Rocha, A., Rojas, N., García, C., Parra, R., Lagos, M., Valdivia, L., Poggi, H., Cattani, A.. Testicular Adrenal Rest Tumors and Leydig and Sertoli Cell Function in Boys with Classical Congenital Adrenal Hyperplasia. The Journal of clinical endocrinology & metabolism, vol.92, no.12, 4583-4589.

상세보기
10.1210/endo-26-3-385 5. Wilkins L, Fleishmann W, Howard JE (1940) Macrogenitosomia precox associated with hyperplasia of the androgenic tissue of the adrenal and death from corticoadrenal insufficiency. Endocrinology 26: 385-395.

상세보기
10.1016/j.crad.2005.04.006 6. Barwick TD, Malhotra A, Webb JA, Savage MO, Reznek RH (2005) Embryology of the adrenal glands and its relevance to diagnostic imaging. Clin Radiol 60: 953-959.

상세보기
10.1093/humrep/16.2.263 7. Murphy H, George C, de Kretser D, Judd S (2001) Successful treatment with ICSI of infertility caused by azoospermia associated with adrenal rests in the testes: case report. Hum Reprod 16: 263-267.

상세보기
10.1210/jc.2007-0337 8. Claahsen-van der Grinten HL, Otten BJ, Sweep FC, Span PN, Ross HA, Meuleman EJ, Hermus AR (2007) Testicular tumors in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency show functional features of adrenocortical tissue. J Clin Endocrinol Metab 92: 3674-3680.

상세보기
10.1148/radiology.198.1.8539414 9. Avila NA, Premkumar A, Shawker TH, Jones JV, Laue L, Cutler GB Jr. (1996) Testicular adrenal rest tissue in congenital adrenal hyperplasia: findings at Gray-scale and color Doppler US. Radiology 198: 99-104.
10.7863/jum.2005.24.12.1717 10. Nagamine WH, Mehta SV, Vade A (2005) Testicular adrenal rest tumors in a patient with congenital adrenal hyperplasia: sonographic and magnetic resonance imaging findings. J Ultrasound Med 24: 1717-1720.

상세보기
Benvenga, S, Smedile, G, Lo Giudice, F, Trimarchi, F. Testicular adrenal rests: evidence for luteinizing hormone receptors and for distinct types of testicular nodules differing for their autonomization. European journal of endocrinology, vol.141, no.3, 231-237.

상세보기
10.2214/ajr.172.4.10587136 12. Avila NA, Premkumar A, Merke DP (1999) Testicular adrenal rest tissue in congenital adrenal hyperplasia: comparison of MR imaging and sonographic findings. AJR Am J Roentgenol 172: 1003-1006.

상세보기
10.1210/jc.86.12.5721
10.1111/j.1365-2605.2009.00967.x 14. Mouritsen A, Jorgensen N, Main KM, Schwartz M, Juul A (2009) Testicular adrenal rest tumours in boys, adolescents and adult men with congenital adrenal hyperplasia may be associated with the CYP21A2 mutation. Int J Androl 33: 521-527.

상세보기
10.1186/1687-9856-2010-298937 15. Nebesio TD, Eugster EA (2010) Growth and reproductive outcomes in congenital adrenal hyperplasia. Int J Pediatr Endocrinol 2010: 298937. (Epub 2010 Feb1)
Speiser, Phyllis W., White, Perrin C.. Congenital Adrenal Hyperplasia. The New England journal of medicine, vol.349, no.8, 776-788.

상세보기
10.1530/EJE-07-0201 17. Claahsen-van der Grinten HL, Sweep FC, Blickman JG, Hermus AR, Otten BJ (2007) Prevalence of testicular adrenal rest tumours in male children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Eur J Endocrinol 157: 339-344.

상세보기
10.1210/jc.2008-1414 18. Reisch N, Flade L, Scherr M, Rottenkolber M, Pedrosa Gil F, Bidlingmaier M, Wolff H, Schwarz HP, Quinkler M, Beuschlein F, Reincke M (2009) High prevalence of reduced fecundity in men with congenital adrenal hyperplasia. J Clin Endocrinol Metab 94: 1665-1670.

상세보기
Reisch, Nicole, Scherr, Michael, Flade, Linda, Bidlingmaier, Martin, Schwarz, Hans-Peter, Müller-Lisse, Ullrich, Reincke, Martin, Quinkler, Marcus, Beuschlein, Felix. Total Adrenal Volume But Not Testicular Adrenal Rest Tumor Volume Is Associated with Hormonal Control in Patients with 21-Hydroxylase Deficiency. The Journal of clinical endocrinology & metabolism, vol.95, no.5, 2065-2072.

상세보기
Merke, Deborah P.. Approach to the Adult with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency. The Journal of clinical endocrinology & metabolism, vol.93, no.3, 653-660.

상세보기
Forest, Maguelone G.. Recent advances in the diagnosis and management of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Human reproduction update, vol.10, no.6, 469-485.

상세보기
10.1016/S0022-3476(79)80078-5 22. Cavallo A, Corn C, Bryan GT, Meyer WJ 3 rd (1979) The use of plasma androstenedione in monitoring therapy of patients with congenital adrenal hyperplasia. J Pediatr 95: 33-37.

상세보기
10.1136/adc.56.3.208 23. Frisch H, Parth K, Schober E, Swoboda W (1981) Circadian patterns of plasma cortisol, 17-hydroxyprogesterone, and testosterone in congenital adrenal hyperplasia. Arch Dis Child 56: 208-213.

상세보기
10.1136/adc.77.3.214 24. Silva IN, Kater CE, Cunha CF, Viana MB (1997) Randomised controlled trial of growth effect of hydrocortisone in congenital adrenal hyperplasia. Arch Dis Child 77: 214-218.

상세보기
10.1148/radiology.183.2.1561344 25. Vanzulli A, DelMaschio A, Paesano P, Braggion F, Livieri C, Angeli E, Tomasi G, Gatti C, Severi F, Chiumello G (1992) Testicular masses in association with adrenogenital syndrome: US findings. Radiology 183: 425-429.
10.1016/S0094-0143(05)70099-9 26. Rich MA, Keating MA (2000) Leydig cell tumors and tumors associated with congenital adrenal hyperplasia. Urol Clin North Am 27: 519-528.

상세보기
10.5858/2009-0512-RSR.1 27. Hanson JA, Ambaye AB (2011) Adult testicular granulosa cell tumor: a review of the literature for clinicopathologic predictors of malignancy. Arch Pathol Lab Med 135: 143-146.

상세보기
10.1200/JCO.2005.08.227 28. McGlynn KA, Devesa SS, Graubard BI, Castle PE (2005) Increasing incidence of testicular germ cell tumors among black men in the United States. Clin Oncol 23: 5757-5761.

상세보기
10.1007/BF02018626 29. Willi U, Atares M, Prader A, Zachmann M (1991) Testicular adrenal-like tissue (TALT) in congenital adrenal hyperplasia: detection by ultrasonography. Pediatr Radiol 21: 284-287.

상세보기
10.1016/j.fertnstert.2007.03.051 30. Claahsen-van der Grinten HL, Otten BJ, Hermus AR, Sweep FC, Hulsbergen-van de Kaa CA (2008) Testicular adrenal rest tumors in patients with congenital adrenal hyperplasia can cause severe testicular damage. Fertil Steril 89: 597-601.

상세보기
10.1186/1687-9856-2009-624823 31. Claahsen-van der Grinten HL, Hermus AR, Otten BJ (2009) Testicular adrenal rest tumours in congenital adrenal hyperplasia. Int J Pediatr Endocrinol 2009: 624823. (Epub 2009 Feb 26)
10.1007/s00330-002-1786-3 32. Stikkelbroeck NM, Suliman HM, Otten BJ, Hermus AR, Blickman JG, Jager GJ (2003) Testicular adrenal rest tumours in postpubertal males with congenital adrenal hyperplasia: sonographic and MR features. Eur Radiol 13: 1597-1603.

상세보기
10.1210/er.21.3.245

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

The prevalence of testicular adrenal rest tumors and associated factors in postpubertal patients with congenital adrenal hyperplasia caused by 21-hydroxylase deficiency 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (33)

이 논문을 인용한 문헌

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트