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NTIS 바로가기Chem-bio informatics journal, v.9, 2009년, pp.1 - 11
宮本 秀一 (崇城大学) , 河合 聡人 (薬) , 樋口 成定 (学) , 西 有希 (部) , 谷本 敏子 (崇城大学) , 上梶 友記子 (薬) , 中田 大介 (学) , 福見 宏 (部) , 寺尾 啓二 (崇城大学)
The stability, dispersibility and oral bioavailability of coenzyme Q10 (CoQ10) are known to be improved upon complexing CoQ10 with g-cyclodextrin (γ-CD). However, the details of the three-dimensional structure of the γ-CD/CoQ10 complex are not well understood. Therefore, the molecular co...
Stocker, R, Bowry, V W, Frei, B. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol.. Proceedings of the National Academy of Sciences of the United States of America, vol.88, no.5, 1646-1650.
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Fuller, Bryan, Smith, Dustin, Howerton, Amber, Kern, Dale. Anti-inflammatory effects of CoQ10 and colorless carotenoids. Journal of cosmetic dermatology : the official journal of the European Society for Cosmetic & Aesthetic Dermatology, vol.5, no.1, 30-38.
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Terao, Keiji, Nakata, Daisuke, Fukumi, Hiroshi, Schmid, Gerhard, Arima, Hidetoshi, Hirayama, Fumitoshi, Uekama, Kaneto. Enhancement of oral bioavailability of coenzyme Q10 by complexation with γ-cyclodextrin in healthy adults. Nutrition research, vol.26, no.10, 503-508.
[7] D. Nakata, M. Nakano, and K. Terao, Bioavailability enhancement of Coenzyme Q10 by use of gamma cyclodextrin, The Fifth Conference of the International Coenzyme Q10 Association, 172-173 (2007).
Ding, J., Steiner, T., Saenger, W.. Structure of the γ-cyclodextrin-1-propanol-17H2O inclusion complex. Acta crystallographica. Section B, Structural science, vol.47, no.5, 731-738.
Ferguson, David M., Raber, Douglas J.. A new approach to probing conformational space with molecular mechanics: random incremental pulse search. Journal of the American Chemical Society, vol.111, no.12, 4371-4378.
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Ryckaert, Jean-Paul, Ciccotti, Giovanni, Berendsen, Herman J.C. Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes. Journal of computational physics, vol.23, no.3, 327-341.
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[14] H. Reuscher, Stabilized PUFA triglycerides for nutraceuticals and functional foods using gamma cyclodextrin, Proceeding of the tenth international symposium on cyclodextrin, 609-617 (2000).
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