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[해외논문] Mouse model of enlarged vestibular aqueducts defines temporal requirement of Slc26a4 expression for hearing acquisition 원문보기

The Journal of clinical investigation, v.121 no.11, 2011년, pp.4516 - 4525  

Choi, Byung Yoon ,  Kim, Hyoung-Mi ,  Ito, Taku ,  Lee, Kyu-Yup ,  Li, Xiangming ,  Monahan, Kelly ,  Wen, Yaqing ,  Wilson, Elizabeth ,  Kurima, Kiyoto ,  Saunders, Thomas L. ,  Petralia, Ronald S. ,  Wangemann, Philine ,  Friedman, Thomas B. ,  Griffith, Andrew J.

Abstract AI-Helper 아이콘AI-Helper

Mutations in human SLC26A4 are a common cause of hearing loss associated with enlarged vestibular aqueducts (EVA). SLC26A4 encodes pendrin, an anion-base exchanger expressed in inner ear epithelial cells that secretes HCO3- into endolymph. Studies of Slc26a4-null mice indicate that pendrin is essent...

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