[논문]Retinyl palmitate polymeric nanocapsules as carriers of bioactives

doi:10.1016/j.jcis.2012.05.042

Retinyl palmitate polymeric nanocapsules as carriers of bioactives 원문보기

Journal of colloid and interface science, v.382 no.1, 2012년, pp.36 - 47

Teixeira, Zaine (Instituto de Quí) , Dreiss, Cécile A. (mica, Universidade Estadual de Campinas, P.O. Box 6154, Brazil) , Lawrence, M.J. (Institute of Pharmaceutical Science, King&rsquo) , Heenan, Richard K. (s College London, 150 Stamford Street, London SE1 9NH, United Kingdom) , Machado, Daisy (Institute of Pharmaceutical Science, King&rsquo) , Justo, Giselle Z. (s College London, 150 Stamford Street, London SE1 9NH, United Kingdom) , Guterres, Sílvia S. (ISIS-STFC, Rutherford Appleton Laboratory, Chilton, Oxon OX11 0QX, United Kingdom) , Durán, Nelson (Instituto de Biologia, Universidade Estadual de Campinas, P.O. Box 6109, Brazil)

Abstract ▼ AI-Helper

Graphical abstractHighlights► A simple and reproducible poly(D,L-lactide) nanocapsule system. ► A delivery system for retinyl palmitate in association with other bioactives. ► High drug skin permeation from nanocapsules, attributed to their deformability. ► A bimodal distribution of sizes as measured by SANS in shell-matched conditions. ► Different wall thicknesses, where smaller particles show thinner wall thicknesses. AbstractNanocapsules containing poly(D,L-lactide) shell and retinyl palmitate core have been prepared by the pre-formed polymer interfacial deposition method. Dynamic light scattering measurements yielded an average hydrodynamic diameter of ∼220nm and a polydispersity index of ∼0.12. Small-angle neutron scattering experiments revealed the presence of two populations of nanocapsules of core diameters ∼192 and 65nm. Freeze fracture transmission electron microscopy showed a polydisperse population of nanocapsules (NC), with a poly(D,L-lactide) shell thickness between 11 and 3nm. For comparison purposes, nanoemulsions (NE, no polymer) and nanospheres (NS, polymer matrix) were also prepared. Each type of nanoparticles exhibited a different morphology (when examined by electron microscopy), in particular NC showed deformability by capillary adhesion. All three types of nanoparticles successfully encapsulated the poorly water-soluble molecules baicalein and benzophenone-3. The thermal behavior of the various nanoparticles was different to a physical mixture of its individual components. Cytotoxicity and phototoxicity assays, performed in human keratinocytes (HaCaT) and murine fibroblasts (BALB/c 3T3), showed that the NC were only cytotoxic at high concentrations. In vitro release studies of benzophenone-3, by the dialysis bag method using NC and NS, showed a sustained release; however, permeation studies using plastic surgery human abdominal skin in Franz diffusion cells showed that a higher amount of benzophenone-3 from NC penetrated into the skin, most probably due to the deformable nature of these nanoparticles.

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Retinyl palmitate polymeric nanocapsules as carriers of bioactives 원문보기

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