Shivananda Nayak, B.
(Department of Pre Clinical Sciences, Biochemistry Unit,Faculty of Medical Sciences, The University of the West Indies, St. Augustine,Trinidad)
,
Sivachandra Raju, S.
(Department of Para Clinical Sciences, Faculty of MedicalSciences, The University of the West Indies, St. Augustine, Trinidad)
,
Orette, F.A.
(Department of Para Clinical Sciences, Faculty of MedicalSciences, The University of the West Indies, St. Augustine, Trinidad)
,
Chalapathi Rao, A.V.
(Department of Para Clinical Sciences, Faculty of MedicalSciences, The University of the West Indies, St. Augustine, Trinidad)
Hibiscus rosa sinensis (H rosa sinensis), a plant product, has been used for the treatment of a variety of diseases as well as to promote wound healing. The wound-healing activity of the ethanol extract of H rosa sinensis flower was determined in rats, using excision, incision, and dead space wo...
Hibiscus rosa sinensis (H rosa sinensis), a plant product, has been used for the treatment of a variety of diseases as well as to promote wound healing. The wound-healing activity of the ethanol extract of H rosa sinensis flower was determined in rats, using excision, incision, and dead space wound models and is presented in this report. The animals were randomly divided into 2 groups of 6 each in all the models. Test group animals in each model were treated with the ethanol extract of H rosa sinensis orally by mixing in drinking water (120 mg kgU2014;1 dayU2014;1), and the control group animals were maintained with plain drinking water. Healing was assessed by the rate of wound contraction, period of epithelialization, tensile strength (skin breaking strength), granulation tissue weight, and hydroxyproline content. The antimicrobial activity of the flower extract against selected microorganisms that infect the wounds was also assessed. Animals treated with the extract exhibited an 86% reduction in the wound area compared with controls, who exhibited a 75% reduction. The extract-treated animals were found to epithelize their wounds significantly faster than controls (P U003C; .002) and have shown significantly higher skin-breaking strength than controls (P U003C; .002). The dry and wet weight of granulation tissue and hydroxyproline content were also increased significantly when compared with controls. The reported observations suggest H rosa sinensis aids wound healing in the rat model.
Hibiscus rosa sinensis (H rosa sinensis), a plant product, has been used for the treatment of a variety of diseases as well as to promote wound healing. The wound-healing activity of the ethanol extract of H rosa sinensis flower was determined in rats, using excision, incision, and dead space wound models and is presented in this report. The animals were randomly divided into 2 groups of 6 each in all the models. Test group animals in each model were treated with the ethanol extract of H rosa sinensis orally by mixing in drinking water (120 mg kgU2014;1 dayU2014;1), and the control group animals were maintained with plain drinking water. Healing was assessed by the rate of wound contraction, period of epithelialization, tensile strength (skin breaking strength), granulation tissue weight, and hydroxyproline content. The antimicrobial activity of the flower extract against selected microorganisms that infect the wounds was also assessed. Animals treated with the extract exhibited an 86% reduction in the wound area compared with controls, who exhibited a 75% reduction. The extract-treated animals were found to epithelize their wounds significantly faster than controls (P U003C; .002) and have shown significantly higher skin-breaking strength than controls (P U003C; .002). The dry and wet weight of granulation tissue and hydroxyproline content were also increased significantly when compared with controls. The reported observations suggest H rosa sinensis aids wound healing in the rat model.
Stadelmann, W.K., Digenis, A.G., Tobin, G.R..
Physiology and healing dynamics of chronic cutaneous wounds - role of matrix metalloproteinases in tumor invasion and metastasis.
The American journal of surgery,
vol.176,
no.2,
26S-38S.
Iba, Yoshinori, Shibata, Aya, Kato, Mizuho, Masukawa, Tohru.
Possible involvement of mast cells in collagen remodeling in the late phase of cutaneous wound healing in mice.
International immunopharmacology,
vol.4,
no.14,
1873-1880.
Midwood, Kim S., Williams, Leyla Valenick, Schwarzbauer, Jean E..
Tissue repair and the dynamics of the extracellular matrix.
The international journal of biochemistry & cell biology,
vol.36,
no.6,
1031-1037.
Gauthaman, Karunakaran K, Saleem, Mohamed TS, Thanislas, Peter T, Prabhu, Vinoth V, Krishnamoorthy, Karthikeyan K, Devaraj, Niranjali S, Somasundaram, Jayaprakash S.
Cardioprotective effect of the Hibiscus rosa sinensis flowers in an oxidative stress model of myocardial ischemic reperfusion injury in rat.
Bmc complementary and alternative medicine,
vol.6,
32-32.
Sachdewa, Archana, Khemani, L.D.
Effect of Hibiscus rosa sinensis Linn. ethanol flower extract on blood glucose and lipid profile in streptozotocin induced diabetes in rats.
Journal of ethnopharmacology,
vol.89,
no.1,
61-66.
Lee, K.H..
Studies on the Mechanism of Action of Salicylate II. Retardation of Wound Healing by Aspirin.
Journal of pharmaceutical sciences : a publication of the American Pharmaceutical Association,
vol.57,
no.6,
1042-1043.
Henriques, Ana, Jackson, Simon, Cooper, Rose, Burton, Neil.
Free radical production and quenching in honeys with wound healing potential.
The Journal of antimicrobial chemotherapy,
vol.58,
no.4,
773-777.
Gilliver, Stephen C., Ashworth, Jason J., Mills, Stuart J., Hardman, Matthew J., Ashcroft, Gillian S..
Androgens modulate the inflammatory response during acute wound healing.
Journal of cell science,
vol.119,
no.4,
722-732.
Adhirajan, N, Ravi Kumar, T, Shanmugasundaram, N, Babu, Mary.
In vivo and in vitro evaluation of hair growth potential of Hibiscus rosa-sinensis Linn..
Journal of ethnopharmacology,
vol.88,
no.2,
235-239.
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