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[해외논문] Skeletal Growth and IGF Levels in Rats after HT042 Treatment

Phytotherapy research : PTR, v.26 no.12, 2012년, pp.1771 - 1778  

Kim, Mi‐Yeon (Department of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University, Hoegi‐) ,  Kim, Ji Young (dong, Dongdaemun‐) ,  Lim, Dongwook (gu, Seoul, 130‐) ,  Lee, Donghun (701, Republic of Korea) ,  Kim, Yoonjung (Department of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University, Hoegi‐) ,  Chang, Gyu Tae (dong, Dongdaemun‐) ,  Choi, Ho‐Young (gu, Seoul, 130‐) ,  Kim, Hocheol (701, Republic of Korea)

Abstract

HT042, a new herbal prescription consisting of Astragalus membranaceus, Phlomis umbrosa and Eleutherococcus senticosus, is used in traditional Korean medicine to stimulate growth in children. This study was conducted to investigate the effects of HT042 on skeletal growth, insulin‐like growth factor‐1 (IGF‐1) and insulin‐like growth factor binding protein‐3 (IGFBP‐3) levels, and oestrogenic activity in female rats. Female Sprague–Dawley rats were divided into control, recombinant human growth hormone (rhGH; 20 µg/kg/day), and HT042 (100 mg/kg/day) groups and treated for 3 weeks. Axial skeletal growth, femur length, and growth plate length were measured every 3 weeks. The serum IGF‐1 and IGFBP‐3 levels were analysed. Moreover, the oestrogenic activity of the herbal extracts in the immature and ovariectomized rats was tested. The nose–anus, nose–tail, femur and growth‐plate lengths were increased significantly in the HT042 group. Both IGF‐1 and IGFBP‐3 were highly expressed in the hypertrophic zone of the growth plate. The serum IGF‐1 levels were increased. Moreover, HT042 had no uterotrophic effects in the rats. Consequently, HT042 promoted longitudinal bone growth by stimulating cell proliferation in the epiphyseal plate and inducing the expression of IGF‐1 without an oestrogenic response. HT042 may be helpful in stimulating growth in children with short stature. Copyright © 2012 John Wiley & Sons, Ltd.

주제어

#HT042   #herbal extract   #skeletal growth   #IGF‐1   #uterotrophic assay  

참고문헌 (48)

  1. Baker J , Liu JP , Robertson EJ , Efstratiadis A . 1993 . Role of insulin‐like growth factors in embryonic and postnatal growth . Cell 75 : 73 – 82 . 

    상세보기

  2. Bar RS , Clemmons DR , Boes M , et al . 1990 . Transcapillary permeability and subendothelial distribution of endothelial and amniotic fluid insulin‐like growth factor binding proteins in the rat heart . Endocrinology 127 : 1078 – 1086 . 

    상세보기

  3. Bass S , Delmas PD , Pearce G , Hendrich E , Tabensky A , Seeman E . 1999 . The differing tempo of growth in bone size, mass, and density in girls is region‐specific . J Clin Invest 104 : 795 – 804 . 

    상세보기

  4. Binoux M , Hossenlopp P . 1988 . Insulin‐like growth factor (IGF) and IGF‐binding proteins: comparison of human serum and lymph . J Clin Endocrinol Metab 67 : 509 – 514 . 

  5. Booth AN , Bickoff EM , Kohler GO . 1960 . Estrogen‐like activity in vegetable oils and mill by‐products . Science 131 : 1807 – 1808 . 

    상세보기

  6. Bordas E , Bretter E , Uray Z . 1981 . Effect of spironolactone (Aldactone‐A) on the function of the thyroid gland in white rats . Endocrinologie 19 : 33 – 37 . 

  7. Bryant J , Baxter L , Cave CB , Milne R . 2007 . Recombinant growth hormone for idiopathic short stature in children and adolescents . Cochrane Database Syst Rev 18 : CD004440 . 

  8. Bulbring E , Burn JH . 1935 . The estimation of oestrin and of male hormone in oily solution . J Physiol 85 : 320 – 333 . 

    상세보기

  9. Cernich J , Jacobson JD , Moore WV , Popovic J . 2004 . Use of aromatase inhibitors in children with short stature . Pediatr Endocrinol Rev 2 : 2 – 7 . 

  10. Cohick WS , Clemmons DR . 1993 . The insulin‐like growth factors . Annu Rev Physiol 55 : 131 – 153 . 

    상세보기

  11. Cutler GB Jr. 1997 . The role of estrogen in bone growth and maturation during childhood and adolescence . J Steroid Biochem Mol Biol 61 : 141 – 144 . 

  12. Dorfman RI . 1962 . Methods in Hormone Research, Vol. II, Part IV: Standard Methods Adopted by Official Organization . Academic Press : New York 

  13. Dunkel L . 2006 . Use of aromatase inhibitors to increase final height . Mol Cell Endocrinol 254–255 : 207 – 216 . 

  14. Dunkel L . 2009 . Update on the role of aromatase inhibitors in growth disorders . Horm Res 71 ( Suppl 1 ): 57 – 63 . 

  15. Engelhard K , Werner C , Kaspar S , et al . 2002 . Effect of the alpha2‐agonist dexmedetomidine on cerebral neurotransmitter concentrations during cerebral ischemia in rats . Anesthesiology 96 : 450 – 457 . 

  16. Ha H , Lee HY , Lee JH , et al . 2010 . Formononetin prevents ovariectomy‐induced bone loss in rats . Arch Pharm Res 33 : 625 – 632 . 

    원문보기 상세보기

  17. Hochberg Z . 2002 . Clinical physiology and pathology of the growth plate . Best Pract Res Clin Endocrinol Metab 16 : 399 – 419 . 

    상세보기

  18. Huh JE , Kwon NH , Baek YH , et al . 2009 . Formononetin promotes early fracture healing through stimulating angiogenesis by up‐regulating VEGFR‐2/Flk‐1 in a rat fracture model . Int Immunopharmacol 9 : 1357 – 1365 . 

    상세보기

  19. Hwa V , Oh Y , Rosenfeld RG . 1999 . The insulin‐like growth factor‐binding protein (IGFBP) superfamily . Endocr Rev 20 : 761 – 787 . 

  20. Jeong YH , Kim YH , Yoo DY . 1999 . The literatual study on the growth disorder . J Korean Oriental Pediatr 13 : 17 – 62 . 

  21. Kato H , Ota T , Furuhashi T , Ohta Y , Iguchi T . 2003 . Changes in reproductive organs of female rats treated with bisphenol A during the neonatal period . Reprod Toxicol 17 : 283 – 288 . 

  22. Kelley KM , Oh Y , Gargosky SE , et al . 1996 . Insulin‐like growth factor‐binding proteins (IGFBPs) and their regulatory dynamics . Int J Biochem Cell Biol 28 : 619 – 637 . 

  23. Kim CS , Ha HK , Song KY . 2002 . Astragali Radix extract as a therapeutics on osteoporosis . J Pharm Soc Kor 2 : 387.381 . 

  24. Kim CS , Ha HK , Lee JH , Kim JS , Song KY , Park SW . 2003a . Herbal extract prevents bone loss in ovariectomized rats . J Pharm Soc Kor 26 : 917 – 924 . 

  25. Kim HS , Nagalla SR , Oh Y , Wilson E , Roberts Jr CT , Rosenfeld RG . 1997 . Identification of a family of low‐affinity insulin‐like growth factor binding proteins(IGFBPs): Characterization of connective tissue growth factor as a member of the IGFBP superfamily . Proc Natl Acad Sci USA 94 : 12981 . 

    상세보기

  26. Kim MY , Park Y , Pandit NR , et al . 2010 . The herbal formula HT042 induces longitudinal bone growth in adolescent female rats . J Med Food 13 : 1376 – 1384 . 

  27. Kim SH , Ku SY , Jee BC , et al . 2003b . Clinical efficacy of serum insulin‐like growth factor‐I (IGF‐I), IGF‐II, and IGF binding protein‐3(IGFBP‐3) in predicting the prognosis of in vitro fertilization and embryo transfer . Korean J Obstet Gynecol 46 : 802 – 809 . 

  28. Kurokawa N , Nakai K , Suzuki K , et al . 2008 . Trends in growth status among schoolchildren in Sendai, Japan, 1994–2003: leveling‐off of mean body height and weight . Tohoku J Exp Med 216 : 371 – 375 . 

    상세보기

  29. Lee CJ , Lee HJ , Yoon YD . 2001 . Effects of endocrine disruptors on reproductive system . J Korean Soc Endocrinol 16 : 596 – 623 . 

  30. Leem K , Park SY , Lee DH , Kim , H . 2002 . Lovastatin increases longitudinal bone growth and bone morphogenetic protein‐2 levels in the growth plate of Sprague–Dawley rats . Eur J Pediatr 161 : 406 – 407 . 

    상세보기

  31. Leem K , Park SY , Lee DH , et al . 2003 . Effects of Jaoga‐Yukmiwon(R), a Korean herbal medicine, on chondrocyte proliferation and longitudinal bone growth in adolescent male rats . Phytother Res 17 : 1113 – 1116 . 

  32. Leschek EW , Rose SR , Yanovski JA , et al . 2004 . Effect of growth hormone treatment on adult height in peripubertal children with idiopathic short stature: a randomized, double‐blind, placebo‐controlled trial . J Clin Endocrinol Metab 89 : 3140 – 3148 . 

    상세보기

  33. Park SY , Leem K , Kim H . 2003 . Effects of Acanthopanacis Senticosi Radix and its subfractions on longitudinal bone growth of adolescent rats . Kor J Herbol 18 : 87 – 92 . 

  34. Ra JC , Park HG , Choi MK , Lee HY , Kang KS . 2004 . The development of functional food with plant extracts for enhancing growth rate . J Food Hyg Safety 19 : 112 – 118 . 

  35. Reel JR , Lamb IJ , Neal BH . 1996 . Survey and assessment of mammalian estrogen biological assays for hazard characterization . Fundam Appl Toxicol 34 : 288 – 305 . 

    상세보기

  36. Richard D . 1986 . Effects of ovarian hormones on energy balance and brown adipose tissue thermogenesis . Am J Physiol 250 : R245 – 249 . 

  37. Richman C , Kutilek S , Miyakoshi N , et al . 2001 . Postnatal and pubertal skeletal changes contribute predominantly to the differences in peak bone density between C3H/HeJ and C57BL/6J mice . J Bone Miner Res 16 : 386 – 397 . 

    상세보기

  38. Roith DL , Bondy C , Yakar S , Liu JL , Butler A . 2001 . The somatomedin hypothesis: 2001 . Endocr Rev 22 : 53 – 74 . 

    상세보기

  39. Setchell KD , Brown NM , Zimmer‐Nechemias L , et al . 2002 . Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability . Am J Clin Nutr 76 : 447 – 453 . 

    상세보기

  40. Steckel RH . 2008 . Biological measures of the standard of living . J Econ Perspect 22 : 129 – 152 . 

    상세보기

  41. Van Gool SA , Wit JM , De Schutter T , et al . 2010 . Marginal growth increase, altered bone quality and polycystic ovaries in female prepubertal rats after treatment with the aromatase inhibitor exemestane . Horm Res Paediatr 73 : 49 – 60 . 

    상세보기

  42. Wade GN , Gray JM , Bartness TJ . 1985 . Gonadal influences on adiposity . Int J Obes 9 ( Suppl 1 ): 83 – 92 . 

  43. Weedon MN , Lettre G , Freathy RM , et al . 2007 . A common variant of HMGA2 is associated with adult and childhood height in the general population . Nat Genet 39 : 1245 – 1250 . 

    상세보기

  44. Weise M , De‐Levi S , Barnes KM , Gafni RI , Abad V , Baron J . 2001 . Effects of estrogen on growth plate senescence and epiphyseal fusion . Proc Natl Acad Sci USA 98 : 6871 – 6876 . 

    상세보기

  45. Yakar S , Rosen CJ , Beamer WG , et al . 2002 . Circulating levels of IGF‐1 directly regulate bone growth and density . J Clin Invest 110 : 771 – 781 . 

    상세보기

  46. Yang DS , Cha MH , Kang BJ , Oh SW , Kim YE , Yun Y . 2003 . A study on the longitudinal bone growth of growth‐stimulating material with Eleutherococcus senticosus . Korean J Food Sci Technol 35 : 702 – 707 . 

  47. Yanovski JA , Rose SR , Municchi G , et al . 2003 . Treatment with a luteinizing hormone‐releasing hormone agonist in adolescents with short stature . N Engl J Med 348 : 908 – 917 . 

    상세보기

  48. Zou LY , Xiao LB , Wu T . 2007 . Prevention and treatment effect of Qikanggubao on bone loss induced by prednisone in rats . J Shouxi 27 : 443 – 445 . 

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