[논문]Glycine ameliorates liver injury and vitamin D deficiency induced by bile duct ligation

Chen, C.Y.; Wang, B.T.; Wu, Z.C.; Yu, W.T.; Lin, P.J.; Tsai, W.L.; Shiesh, S.C.

doi:10.1016/j.cca.2012.10.016

Glycine ameliorates liver injury and vitamin D deficiency induced by bile duct ligation

Clinica chimica acta, v.420, 2013년, pp.150 - 154

Chen, C.Y. , Wang, B.T. , Wu, Z.C. , Yu, W.T. , Lin, P.J. , Tsai, W.L. , Shiesh, S.C.

Abstract ▼ AI-Helper

Background: Patients with chronic liver disease had lower serum concentrations 25-hydroxyvitamin D (25OHD). Glycine, a nonessential amino acid, exerts anti-inflammatory, cytoprotective, and immunomodulatory properties. This study aimed to establish a tandem mass spectrometry assay to measure 25OHD in guinea pigs serum and to investigate the effects of glycine against the liver damage induced by bile duct ligation (BDL). Methods: BDL was performed on male guinea pigs. Glycine, alanine, serine or tyrosine was given by intraperitoneal injection. The animals were sacrificed and examined at 7 and 14days after BDL. Serum concentrations of total bilirubin and aminotransferase were measured. Serum concentrations of 25OHD2 and 25OHD3 were measured by API 5000 mass spectrometer. In addition, oxidative stress was assessed by serum ischemia-modified albumin (IMA) and hepatic malondialdehyde (MDA), and apoptosis by hepatic caspase 3 activities. Results: Serum 25OHD concentrations were decreased around 50% in the BDL group at days 7 and 14 post ligation, compared to sham (mean 65.3ng/ml, p<0.005). Glycine but not other amino acid treatment blunted the reduced serum 25OHD (52.6ng/ml, p<0.05) resulting from BDL. The concentrations of 25OHD were negatively associated with concentrations of IMA (r=-0.305, p<0.05) and caspase 3 (r=-0.562, p<0.0001). At day-14 post ligation, glycine treatment also ameliorated liver damage indicated by serum AST (p<0.005), ALT (p<0.05) and hepatic caspase 3 activities (p<0.05) and oxidative stress. Conclusion: Our results indicate that glycine may protect against BDL-induced liver injury through attenuation of oxidative stress, apoptosis and the vitamin D deficiency.

주제어

참고문헌 (35)

N Engl J Med Trauner 339 1217 1998 10.1056/NEJM199810223391707 Molecular pathogenesis of cholestasis

상세보기
Gastroenterology Greim 63 837 1972 10.1016/S0016-5085(19)33225-1 Mechanism of cholestasis. 5. Bile acids in normal rat livers and in those after bile duct ligation

상세보기
J Clin Invest Patel 94 2183 1994 10.1172/JCI117579 Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes

상세보기
Am J Physiol Kwo 268 G613 1995 Nuclear serine protease activity contributes to bile acid-induced apoptosis in hepatocytes
Antioxid Redox Signal Ryter 9 49 2007 10.1089/ars.2007.9.49 Mechanisms of cell death in oxidative stress

상세보기
Hepatology Marsh 17 91 1993 10.1002/hep.1840170117 Glycine protects hepatocytes from injury caused by anoxia, cold ischemia and mitochondrial inhibitors, but not injury caused by calcium ionophores or oxidative stress

상세보기
Gastroenterology Nichols 106 168 1994 10.1016/S0016-5085(94)95147-0 Inhibition of nonlysosomal calcium- dependent proteolysis by glycine during anoxic injury of rat hepatocytes

상세보기
Am J Physiol Zhong 270 G332 1996 Glycine minimizes reperfusion injury in a low-flow, reflow liver perfusion model in the rat
Mol Pharmacol Zhong 56 455 1999 10.1124/mol.56.3.455 Dietary glycine and renal denervation prevents cyclosporine A-induced hydroxyl radical production in rat kidney

상세보기
Am J Physiol Schemmer 276 G924 1999 Intravenous glycine improves survival in rat liver transplantation
Free Radic Biol Med Mauriz 31 1236 2001 10.1016/S0891-5849(01)00716-X Dietary glycine inhibits activation of nuclear factor kappa B and prevents liver injury in hemorrhagic shock in the rat

상세보기
Curr Opin Clin Nutr Metab Care El Hafidi 9 26 2006 10.1097/01.mco.0000196143.72985.9a Is glycine against elevated blood pressure?

상세보기
Endocr Rev Bouillon 29 726 2008 10.1210/er.2008-0004 Vitamin D and human health: lessons from vitamin D receptor null mice

상세보기
Hepatology Bolt 1 436 1981 10.1002/hep.1840010512 Hepatic vitamin D 25-hydroxylase: inhibition by bile duct ligation or bile salts

상세보기
Am J Clin Nutr Holick 80 1678S 2004 10.1093/ajcn/80.6.1678S Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease

상세보기
N Engl J Med Holick 357 266 2007 10.1056/NEJMra070553 Vitamin D, deficiency

상세보기
Hepatology Petta 51 1158 2010 10.1002/hep.23489 Low vitamin D serum concentration is related to severe fibrosis and low responsiveness to interferon-based therapy in genotype 1 chronic hepatitis C

상세보기
Nutr Metab Cardiovasc Dis Targher 17 517 2007 10.1016/j.numecd.2006.04.002 Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease

상세보기
Int Immunopharmacol Zhang 7 1122 2007 10.1016/j.intimp.2007.03.007 Calcitriol inhibits hepatocyte apoptosis in rat allograft by regulating apoptosis-associated genes

상세보기
Gastroenterology Canbay 123 1323 2002 10.1053/gast.2002.35953 Fas enhances fibrogenesis in the bile duct-ligated mouse: a link between apoptosis and fibrosis

상세보기
Hepatology Witek 50 1421 2009 10.1002/hep.23167 Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis

상세보기
Pharm Res Anraku 18 632 2001 10.1023/A:1011029226072 Effect of oxidative stress on the structure and function of human serum albumin

상세보기
Clin Chem Bhagavan 49 581 2003 10.1373/49.4.581 Evaluation of human serum albumin cobalt binding assay for the assessment of myocardial ischemia and myocardial infarction

상세보기
Hepatology Jalan 50 555 2009 10.1002/hep.22913 Alteration in the functional capacity of albumin in patients with decompensated cirrhosis is associated with increased mortality

상세보기
Clin Chem Lab Med Chen 49 1817 2011 10.1515/cclm.2011.675 The value of serum ischemia-modified albumin for assessing liver function in patients with chronic liver disease

상세보기
Clin Chem Maunsell 51 1683 2005 10.1373/clinchem.2005.052936 Routine isotope-dilution liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of the 25-hydroxy metabolites of vitamins D2 and D3

상세보기
Hepatology Shiesh 32 3 455 2000 10.1053/jhep.2000.16332 Melatonin prevents pigment gallstone formation induced by bile duct ligation in guinea pigs

상세보기
Hepatology Heubi 9 258 1989 10.1002/hep.1840090216 Bone disease in chronic childhood cholestasis. I. Vitamin D absorption and metabolism

상세보기
Hepatology Plourde 8 1577 1988 10.1002/hep.1840080618 Severe cholestasis leads to vitamin D depletion without perturbing its C-25 hydroxylation in the dog

상세보기
J Gastroenterol Hepatol Sheth 26 194 2011 10.1111/j.1440-1746.2010.06323.x Glycine maintains mitochondrial activity and bile composition following warm liver ischemia-reperfusion injury

상세보기
Semin Liver Dis Gutierrez 31 387 2011 10.1055/s-0031-1297927 Classical and emerging roles of vitamin D in hepatitis C virus infection

상세보기
J Hepatol Nakano 55 415 2011 10.1016/j.jhep.2010.11.028 Impact of artificial sunlight therapy on the progress of non-alcoholic fatty liver disease in rats

상세보기
J Hepatol Rahman 2012 Vitamin D for your patients with chronic hepatitis C?
Am J Pathol Weinberg 140 457 1992 Protection of human umbilical vein endothelial cells by glycine and structurally similar amino acids against calcium and hydrogen peroxide-induced lethal cell injury

상세보기
Cancer Epidemiol Biomarkers Prev Fedirko 19 280 2010 10.1158/1055-9965.EPI-09-0448 Effects of supplemental vitamin D and calcium on oxidative DNA damage marker in normal colorectal mucosa: a randomized clinical trial

상세보기

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

AI-Helper ※ AI-Helper는 을 사용합니다.

AI-Helper

안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Glycine ameliorates liver injury and vitamin D deficiency induced by bile duct ligation

Abstract ▼ AI-Helper

주제어

참고문헌 (35)

이 논문을 인용한 문헌

관련 콘텐츠

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트