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[해외논문] The effect of gut microbiota on drug metabolism

Expert opinion on drug metabolism & toxicology, v.9 no.10, 2013년, pp.1295 - 1308  

Kang, Mi Jeong (Yeungnam University, College of Pharmacy, Gyeongsan, 712-749, South Korea) ,  Kim, Hyung Gyun (Chungnam National University, College of Pharmacy, Daejeon, 305-764, South Korea) ,  Kim, Jin Sung (Yeungnam University, College of Pharmacy, Gyeongsan, 712-749, South Korea) ,  Oh, Do Gyeong (Yeungnam University, College of Pharmacy, Gyeongsan, 712-749, South Korea) ,  Um, Yeon Ji (Yeungnam University, College of Pharmacy, Gyeongsan, 712-749, South Korea) ,  Seo, Chae Shin (Yeungnam University, College of Pharmacy, Gyeongsan, 712-749, South Korea) ,  Han, Ji Won (Yeungnam University, College of Pharmacy, Gyeongsan, 712-749, South Korea) ,  Cho, Hyun Ji (Yeungnam University, College of Pharmacy, Gyeongsan, 712-749, South Korea) ,  Kim, Ghee Hwan (Yeungnam University, College of Pharmacy, Gyeongsan, 712-749, South Korea) ,  Jeong, Tae Cheon (Yeungnam University, College of Pharmacy, Gyeongsan, 712-749, South Korea) ,  Jeong, Hye Gwang

Abstract AI-Helper 아이콘AI-Helper

Introduction: Numerous drugs and toxicants must be metabolized to an active form. Metabolic activation by host tissues, such as the liver, has been well studied. However, drug and toxicant metabolism by the intestinal microbiota is an unexplored, but essential, field of study in pharmacology and tox...

Keyword

참고문헌 (115)

  1. Wienkers, Larry C., Heath, Timothy G.. Predicting in vivo drug interactions from in vitro drug discovery data. Nature reviews. Drug discovery, vol.4, no.10, 825-833.

  2. Williams, J. Andrew, Hyland, Ruth, Jones, Barry C., Smith, Dennis A., Hurst, Susan, Goosen, Theunis C., Peterkin, Vincent, Koup, Jeffrey R., Ball, Simon E.. DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS. Drug metabolism and disposition: the biological fate of chemicals, vol.32, no.11, 1201-1208.

  3. Bjornsson, Thorir D., Callaghan, John T., Einolf, Heidi J., Fischer, Volker, Gan, Lawrence, Grimm, Scott, Kao, John, King, S. Peter, Miwa, Gerald, Ni, Lan, Kumar, Gondi, McLeod, James, Obach, R. Scott, Roberts, Stanley, Roe, Amy, Shah, Anita, Snikeris, Fred, Sullivan, John T., Tweedie, Donald, Vega, Jose M., Walsh, John, Wrighton, Steven A.. THE CONDUCT OF IN VITRO AND IN VIVO DRUG-DRUG INTERACTION STUDIES: A PHARMACEUTICAL RESEARCH AND MANUFACTURERS OF AMERICA (PhRMA) PERSPECTIVE. Drug metabolism and disposition: the biological fate of chemicals, vol.31, no.7, 815-832.

  4. Structure, Function and Diversity of the Healthy Human Microbiome. Nature, vol.486, no.7402, 207-214.

  5. Nature Yatsunenko T 222 486 2012 

  6. Kang, Mi-Jeong, Ha, Hyun-Woo, Kim, Ghee-Hwan, Lee, Sang-Kyu, Ahn, Young-Tae, Kim, Dong-Hyun, Jeong, Hye-Gwang, Jeong, Tae-Cheon. Role of Metabolism by Intestinal Bacteria in Arbutin-Induced Suppression of Lymphoproliferative Response in vitro. Biomolecules & therapeutics, vol.20, no.2, 196-200.

  7. Larsen, Nadja, Vogensen, Finn K., van den Berg, Frans W. J., Nielsen, Dennis Sandris, Andreasen, Anne Sofie, Pedersen, Bente K., Al-Soud, Waleed Abu, Sørensen, Søren J., Hansen, Lars H., Jakobsen, Mogens. Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults. PloS one, vol.5, no.2, e9085-.

  8. Khanal, T., Kim, H.G., Hwang, Y.P., Kong, M.J., Kang, M.J., Yeo, H.K., Kim, D.H., Jeong, T.C., Jeong, H.G.. Role of metabolism by the human intestinal microflora in arbutin-induced cytotoxicity in HepG2 cell cultures. Biochemical and biophysical research communications, vol.413, no.2, 318-324.

  9. Khanal, Tilak. Protective role of intestinal bacterial metabolism against baicalin-induced toxicity in HepG2 cell cultures. The Journal of toxicological sciences, vol.37, no.2, 363-371.

  10. Khanal, T., Kim, H.G., Choi, J.H., Do, M.T., Kong, M.J., Kang, M.J., Noh, K., Yeo, H.K., Ahn, Y.T., Kang, W., Kim, D.H., Jeong, T.C., Jeong, H.G.. Biotransformation of geniposide by human intestinal microflora on cytotoxicity against HepG2 cells. Toxicology letters, vol.209, no.3, 246-254.

  11. Khanal, Tilak, Kim, Hyung Gyun, Jin, Sun Woo, Shim, Eol, Han, Hwa Jeong, Noh, Keumhan, Park, Sunkyoung, Lee, Dae Hun, Kang, Wonku, Yeo, Hee Kyung, Kim, Dong Hyun, Jeong, Tae Cheon, Jeong, Hye Gwang. Protective role of metabolism by intestinal microflora in butyl paraben-induced toxicity in HepG2 cell cultures. Toxicology letters, vol.213, no.2, 174-183.

  12. Jeong, Hye Gwang, Kang, Mi Jeong, Kim, Hyung Gyun, Oh, Do Gyeong, Kim, Jin Sung, Lee, Sang Kyu, Jeong, Tae Cheon. Role of intestinal microflora in xenobiotic‐induced toxicity. Molecular nutrition & food research, vol.57, no.1, 84-99.

  13. Sousa, T., Paterson, R., Moore, V., Carlsson, A., Abrahamsson, B., Basit, A.W.. The gastrointestinal microbiota as a site for the biotransformation of drugs. International journal of pharmaceutics, vol.363, no.1, 1-25.

  14. Hooper, Lora V., Gordon, Jeffrey I.. Commensal Host-Bacterial Relationships in the Gut. Science, vol.292, no.5519, 1115-1118.

  15. Saad, Rama, Rizkallah, Mariam R, Aziz, Ramy K. Gut Pharmacomicrobiomics: the tip of an iceberg of complex interactions between drugs and gut-associated microbes. Gut pathogens, vol.4, 16-16.

  16. Haiser, H.J., Turnbaugh, P.J.. Developing a metagenomic view of xenobiotic metabolism. Pharmacological research : the official journal of the Italian Pharmacological Society, vol.69, no.1, 21-31.

  17. Yeo, Hee-Kyung, Hyun, Yang-Jin, Jang, Se-Eun, Han, Myung-Joo, Lee, Yong-Sup, Kim, Dong-Hyun. Development of Fecal Microbial Enzyme Mix for Mutagenicity Assay of Natural Products. Journal of microbiology and biotechnology, vol.22, no.6, 838-848.

  18. AKAO, Teruaki, CHE, QingMing, KOBASHI, Kyoichi, HATTORI, Masao, NAMBA, Tsuneo. A Purgative Action of Barbaloin Is Induced by Eubacterium sp. Strain BAR, a Human Intestinal Anaerobe, Capable of Transforming Barbaloin to Aloe-Emodin Anthrone.. Biological & pharmaceutical bulletin, vol.19, no.1, 136-138.

  19. ISHII, Yasuko, TANIZAWA, Hisayuki, TAKINO, Yoshio. Studies of Aloe. V. Mechanism of Cathartic Effect. (4).. Biological & pharmaceutical bulletin, vol.17, no.5, 651-653.

  20. Liu, Jun, Nguyen, Mary D.H., Andya, James D., Shire, Steven J.. Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution. Journal of pharmaceutical sciences : a publication of the American Pharmaceutical Association, vol.95, no.1, 234-235.

  21. Akao, Teruaki, Kawabata, Kiyoshi, Yanagisawa, Erika, Ishihara, Kazuhisa, Mizuhara, Yasuharu, Wakui, Yoko, Sakashita, Yoko, Kobashi, Kyoichi. Balicalin, the Predominant Flavone Glucuronide of Scutellariae Radix, is Absorbed from the Rat Gastrointestinal Tract as the Aglycone and Restored to its Original Form. Journal of pharmacy and pharmacology, vol.52, no.12, 1563-1568.

  22. Xing, Jie, Chen, Xiaoyan, Zhong, Dafang. Absorption and enterohepatic circulation of baicalin in rats. Life sciences, vol.78, no.2, 140-146.

  23. 10.1038/aps.2010.42 

  24. Jung, Myung-Ah, Jang, Se-Eun, Hong, Sung-Woon, Hana, Myung-Joo, Kim, Dong-Hyun. The Role of Intestinal Microflora in Anti-Inflammatory Effect of Baicalin in Mice. Biomolecules & therapeutics, vol.20, no.1, 36-42.

  25. Zhang, Li, Lin, Ge, Zuo, Zhong. Involvement of UDP-Glucuronosyltransferases in the Extensive Liver and Intestinal First-Pass Metabolism of Flavonoid Baicalein. Pharmaceutical research, vol.24, no.1, 81-.

  26. Chao, Jui-I, Su, Wen-Chi, Liu, Huei-Fang. Baicalein induces cancer cell death and proliferation retardation by the inhibition of CDC2 kinase and survivin associated with opposite role of p38 mitogen-activated protein kinase and AKT. Molecular cancer therapeutics, vol.6, no.11, 3039-3048.

  27. Gao, Zhonghong, Huang, Kaixun, Yang, Xiangliang, Xu, Huibi. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Biochimica et biophysica acta, General subjects, vol.1472, no.3, 643-650.

  28. PLoS One Dou W 1 7 2012 

  29. Matthies, Anastasia, Clavel, Thomas, Gütschow, Michael, Engst, Wolfram, Haller, Dirk, Blaut, Michael, Braune, Annett. Conversion of Daidzein and Genistein by an Anaerobic Bacterium Newly Isolated from the Mouse Intestine. Applied and environmental microbiology, vol.74, no.15, 4847-4852.

  30. Decroos, Karel, Vanhemmens, Steffi, Cattoir, Sofie, Boon, Nico, Verstraete, Willy. Isolation and characterisation of an equol-producing mixed microbial culture from a human faecal sample and its activity under gastrointestinal conditions. Archives of microbiology, vol.183, no.1, 45-55.

  31. Bowey, E., Adlercreutz, H., Rowland, I.. Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, vol.41, no.5, 631-636.

  32. Kang, Nam Joo, Lee, Ki Won, Rogozin, Evgeny A., Cho, Yong-Yeon, Heo, Yong-Seok, Bode, Ann M., Lee, Hyong Joo, Dong, Zigang. Equol, a Metabolite of the Soybean Isoflavone Daidzein, Inhibits Neoplastic Cell Transformation by Targeting the MEK/ERK/p90RSK/Activator Protein-1 Pathway. The Journal of biological chemistry, vol.282, no.45, 32856-32866.

  33. Liu, Xiaoping, Suzuki, Naomi, Laxmi, Y.R. Santosh, Okamoto, Yoshinori, Shibutani, Shinya. Anti-breast cancer potential of daidzein in rodents. Life sciences, vol.91, no.11, 415-419.

  34. AKAO, Teruaki, KOBASHI, Kyoichi, ABURADA, Masaki. Enzymic Studies on the Animal and Intestinal Bacterial Metabolism of Geniposide.. Biological & pharmaceutical bulletin, vol.17, no.12, 1573-1576.

  35. Kim, Byung-Chul, Kim, Hong-Gyum, Lee, Sin-Ae, Lim, Seunghwan, Park, Eun-Hee, Kim, Seong-Jin, Lim, Chang-Jin. Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway. Biochemical pharmacology, vol.70, no.9, 1398-1407.

  36. Jin, Jong-Sik, Nishihata, Tomohiro, Kakiuchi, Nobuko, Hattori, Masao. Biotransformation of C-Glucosylisoflavone Puerarin to Estrogenic (3S)-Equol in Co-culture of Two Human Intestinal Bacteria. Biological & pharmaceutical bulletin, vol.31, no.8, 1621-1625.

  37. Choi, E.J., Kim, T., Lee, M.S.. Pro-apoptotic effect and cytotoxicity of genistein and genistin in human ovarian cancer SK-OV-3 cells. Life sciences, vol.80, no.15, 1403-1408.

  38. Leung, Kar Wah, Wong, Alice Sze-Tsai. Pharmacology of ginsenosides: a literature review. Chinese medicine, vol.5, 20-20.

  39. Wakabayashi, C., Murakami, K., Hasegawa, H., Murata, J., Saiki, I.. An Intestinal Bacterial Metabolite of Ginseng Protopanaxadiol Saponins Has the Ability to Induce Apoptosis in Tumor Cells. Biochemical and biophysical research communications, vol.246, no.3, 725-730.

  40. Bae, Eun-Ah, Shin, Ji-eun, Kim, Dong-Hyun. Metabolism of Ginsenoside Re by Human Intestinal Microflora and Its Estrogenic Effect. Biological & pharmaceutical bulletin, vol.28, no.10, 1903-1908.

  41. Biosci Microflora Kobashi K 1 16 1997 

  42. Teruaki Akao, Taiko Akao, Masao Hattori, Matao Kanaoka, Keiichi Yamamoto, Tsuneo Namba, Kyoichi Kobashi. Hydrolysis of glycyrrhizin to 18β-glycyrrhetyl monoglucuronide by lysosomal β-D-glucuronidase of animal livers. Biochemical pharmacology, vol.41, no.6, 1025-1029.

  43. Oyo Yakuri Fujita H 637 16 1978 

  44. Shim, S B, Kim, N J, Kim, D H. Beta-glucuronidase inhibitory activity and hepatoprotective effect of 18 beta-glycyrrhetinic acid from the rhizomes of Glycyrrhiza uralensis.. Planta medica, vol.66, no.1, 40-43.

  45. KIM, Dong-Hyun, SHONG, In-Seok, KOBASHI, Kyoichi, HAN, Myung Joo. Purification and Characterization of .BETA.-Glucosidase from Bacteroides JY-6, a Human Intestinal Bacterium.. Biological & pharmaceutical bulletin, vol.19, no.9, 1121-1125.

  46. Labib, Samira, Erb, Annette, Kraus, Michael, Wickert, Thomas, Richling, Elke. The pig caecum model: A suitable tool to study the intestinal metabolism of flavonoids. Molecular nutrition & food research, vol.48, no.4, 326-332.

  47. Roowi, Suri, Mullen, William, Edwards, Christine A., Crozier, Alan. Yoghurt impacts on the excretion of phenolic acids derived from colonic breakdown of orange juice flavanones in humans. Molecular nutrition & food research, vol.53, no.suppl1, S68-S75.

  48. Jin, Ming Ji, Kim, Unyong, Kim, In Sook, Kim, Yuri, Kim, Dong-Hyun, Han, Sang Beom, Kim, Dong-Hyun, Kwon, Oh-Seung, Yoo, Hye Hyun. Effects of Gut Microflora on Pharmacokinetics of Hesperidin: A Study on Non-Antibiotic and Pseudo-Germ-Free Rats. Journal of toxicology and environmental health. Part A, vol.73, no.21, 1441-1450.

  49. Lee, Neung-Kee, Choi, Seung-Hoon, Park, Sung-Hwan, Park, Eun-Kyung, Kim, Dong-Hyun. Antiallergic Activity of Hesperidin Is Activated by Intestinal Microflora. Pharmacology, vol.71, no.4, 174-180.

  50. Kim, Dong-Hyun, Jung, Eun-Ah, Sohng, In-Suk, Han, Jung-Ah, Kim, Tae-Hyung, Han, Myung-Joo. Intestinal Bacterial Metabolism of Flavonoids and Its Relation to Some Biological Activities. Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, vol.21, no.1, 17-23.

  51. Shin, Ji-eun, Bae, Eun-Ah, Lee, Young Chul, Ma, Jin-Youl, Kim, Dong-Hyun. Estrogenic Effect of Main Components Kakkalide and Tectoridin of Puerariae Flos and Their Metabolites. Biological & pharmaceutical bulletin, vol.29, no.6, 1202-1206.

  52. 10.1254/jphs.93.331 

  53. Schoefer, Lilian, Mohan, Ruchika, Schwiertz, Andreas, Braune, Annett, Blaut, Michael. Anaerobic Degradation of Flavonoids by Clostridium orbiscindens. Applied and environmental microbiology, vol.69, no.10, 5849-5854.

  54. Schneider, H., Blaut, M.. Anaerobic degradation of flavonoids by Eubacterium ramulus. Archives of microbiology, vol.173, no.1, 71-75.

  55. Jeon, Seon-Min, Kim, Hae Kyung, Kim, Hye-Jin, Do, Gyeong-Min, Jeong, Tae-Sook, Park, Yong Bok, Choi, Myung-Sook. Hypocholesterolemic and antioxidative effects of naringenin and its two metabolites in high-cholesterol fed rats. Translational research : the journal of laboratory and clinical medicine, vol.149, no.1, 15-21.

  56. Lee, Chul-Ho, Jeong, Tae-Sook, Choi, Yang-Kyu, Hyun, Byung-Hwa, Oh, Goo-Taeg, Kim, Eun-Hee, Kim, Ju-Ryoung, Han, Jang-Il, Bok, Song-Hae. Anti-Atherogenic Effect of Citrus Flavonoids, Naringin and Naringenin, Associated with Hepatic ACAT and Aortic VCAM-1 and MCP-1 in High Cholesterol-Fed Rabbits. Biochemical and biophysical research communications, vol.284, no.3, 681-688.

  57. KIM, Dong-Hyun, BAE, Eun-Ah, HAN, Myung Joo. Anti-Helicobacter pylori Activity of the Metabolites of Poncirin from Poncirus trifoliata by Human Intestinal Bacteria.. Biological & pharmaceutical bulletin, vol.22, no.4, 422-424.

  58. J Microbiol Biotechnol Kim JM 46 16 2006 

  59. Prasain, J. K., Jones, K., Brissie, N., Moore, R., Wyss, J. M., Barnes, S.. Identification of Puerarin and Its Metabolites in Rats by Liquid Chromatography−Tandem Mass Spectrometry. Journal of agricultural and food chemistry, vol.52, no.12, 3708-3712.

  60. Park, Eun-Kyung, Shin, Jieun, Bae, Eun-Ah, Lee, Young-Chul, Kim, Dong-Hyun. Intestinal Bacteria Activate Estrogenic Effect of Main Constituents Puerarin and Daidzin of Pueraria thunbergiana. Biological & pharmaceutical bulletin, vol.29, no.12, 2432-2435.

  61. Choo, Min-Kyung, Park, Eun-Kyung, Yoon, Hae-Kyung, Kim, Dong-Hyun. Antithrombotic and Antiallergic Activities of Daidzein, a Metabolite of Puerarin and Daidzin Produced by Human Intestinal Microflora. Biological & pharmaceutical bulletin, vol.25, no.10, 1328-1332.

  62. Lin, Ying-Ju, Hou, Yu Chi, Lin, Chia-Hung, Hsu, Yu-An, Sheu, Jim J.C., Lai, Chih-Ho, Chen, Bing-Hung, Lee Chao, Pei-Dawn, Wan, Lei, Tsai, Fuu-Jen. Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells. Biochemical and biophysical research communications, vol.378, no.4, 683-688.

  63. Park, Eun-Kyung, Choo, Min-Kyung, Yoon, Hae-Kyung, Kim, Dong-Hyun. Antithrombotic and Antiallergic Activities of Rhaponticin from Rhei Rhizoma Are Activated by Human Intestinal Bacteria. Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, vol.25, no.4, 528-533.

  64. Drug Metab Dispos Chun YJ 389 29 2001 

  65. Yang, Jing, Qian, Dawei, Jiang, Shu, Shang, Er-xin, Guo, Jianming, Duan, Jin-ao. Identification of rutin deglycosylated metabolites produced by human intestinal bacteria using UPLC–Q-TOF/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, vol.898, 95-100.

  66. Guardia, Teresita, Rotelli, Alejandra Ester, Juarez, Américo Osvaldo, Pelzer, Lilian Eugenia. Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Il Farmaco, vol.56, no.9, 683-687.

  67. Chow, Jyh-Ming, Shen, Shing-Chuan, Huan, Steven K., Lin, Hui-Yi, Chen, Yen-Chou. Quercetin, but not rutin and quercitrin, prevention of H2O2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages. Biochemical pharmacology, vol.69, no.12, 1839-1851.

  68. Zhu, Ji Xiao, Wang, Ying, Kong, Ling Dong, Yang, Cheng, Zhang, Xin. Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver. Journal of ethnopharmacology, vol.93, no.1, 133-140.

  69. 10.1248/cpb.30.1338 

  70. Matsumoto, Mitsuharu, Ishige, Atsushi, Yazawa, Yuka, Kondo, Manami, Muramatsu, Koji, Watanabe, Kenji. Promotion of Intestinal Peristalsis by Bifidobacterium spp. Capable of Hydrolysing Sennosides in Mice. PloS one, vol.7, no.2, e31700-.

  71. Choi, Jongwon, Shin, Kyoung-Min, Park, Hee-Juhn, Jung, Hyun-Ju, Kim, Hyoung Ja, Lee, Yong Sup, Rew, Jae-Hwan, Lee, Kyung-Tae. Anti-inflammatory and antinociceptive effects of sinapyl alcohol and its glucoside syringin.. Planta medica, vol.70, no.11, 1027-1032.

  72. Kim, Yong Pil, Yamada, Masateru, Lim, Soon Sung, Lee, Sang Hyun, Ryu, Nama, Shin, Kuk Hyun, Ohuchi, Kazuo. Inhibition by tectorigenin and tectoridin of prostaglandin E2 production and cyclooxygenase-2 induction in rat peritoneal macrophages. Biochimica et biophysica acta, Molecular and cell biology of lipids, vol.1438, no.3, 399-407.

  73. Han, T., Cheng, G., Liu, Y., Yang, H., Hu, Y.t., Huang, W.. In vitro evaluation of tectoridin, tectorigenin and tectorigenin sodium sulfonate on antioxidant properties. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, vol.50, no.2, 409-414.

  74. Lee, Soo Hyun, An, Ji Hye, Lee, Hwa Jeong, Jung, Byung Hwa. Evaluation of pharmacokinetic differences of acetaminophen in pseudo germ‐free rats. Biopharmaceutics & drug disposition, vol.33, no.6, 292-303.

  75. Mikov, M.. The metabolism of drugs by the gut flora. European journal of drug metabolism and pharmacokinetics, vol.19, no.3, 201-207.

  76. Mikov, M., Caldwell, J., Dolphin, C.T., Smith, R.L.. The role of intestinal microflora in the formation of the methylthio adduct metabolites of paracetamol - Studies in neomycin-pretreated and germ-free mice. Biochemical pharmacology, vol.37, no.8, 1445-1449.

  77. Lindenbaum, John, Rund, Deborah G., Butler Jr., Vincent P., Tse-Eng, Doris, Saha, Jnan Ranjan. Inactivation of Digoxin by the Gut Flora: Reversal by Antibiotic Therapy. The New England journal of medicine, vol.305, no.14, 789-794.

  78. Saha, Butler, VP, Neu, HC, Lindenbaum, J. Digoxin-inactivating bacteria: identification in human gut flora. Science, vol.220, no.4594, 325-327.

  79. Mathan, V I, Wiederman, J, Dobkin, J F, Lindenbaum, J. Geographic differences in digoxin inactivation, a metabolic activity of the human anaerobic gut flora.. Gut: journal of the British Society of Gastroenterology, vol.30, no.7, 971-977.

  80. J Pharmacol Exp Ther Goldin BR 160 186 1973 

  81. SANDLER, M., GOODWIN, B. L., RUTHVEN, C. R. J., CALNE, D. B.. Therapeutic Implications in Parkinsonism of m-Tyramine Formation from L-Dopa in Man. Nature, vol.229, no.5284, 414-416.

  82. Sandler, M., Karoum, F., Ruthven, C. R. J., Calne, D. B.. m-Hydroxyphenylacetic Acid Formation from L-Dopa in Man: Suppression by Neomycin. Science, vol.166, no.3911, 1417-1418.

  83. Harris, B E, Manning, B W, Federle, T W, Diasio, R B. Conversion of 5-fluorocytosine to 5-fluorouracil by human intestinal microflora. Antimicrobial agents and chemotherapy, vol.29, no.1, 44-48.

  84. Vermes, András, Kuijper, Ed J., Guchelaar, Henk-Jan, Dankert, Jacob. An in vitro Study on the Active Conversion of Flucytosine to Fluorouracil by Microorganisms in the Human Intestinal Microflora. Chemotherapy, vol.49, no.1, 17-23.

  85. Vermes, András, Guchelaar, Henk‐Jan, Van Kuilenburg, Andre B.P., Dankert, Jacob. 5‐fluorocytosine‐related bone‐marrow depression and conversion to fluorouracil: a pilot study. Fundamental & clinical pharmacology, vol.16, no.1, 39-47.

  86. Tobin, Peter, Clarke, Stephen, Seale, J Paul, Lee, Soon, Solomon, Michael, Aulds, Sally, Crawford, Michael, Gallagher, James, Eyers, Tony, Rivory, Laurent. The in vitro metabolism of irinotecan (CPT-11) by carboxylesterase and &bgr;-glucuronidase in human colorectal tumours. British journal of clinical pharmacology, vol.62, no.1, 122-129.

  87. Wallace, Bret D., Wang, Hongwei, Lane, Kimberly T., Scott, John E., Orans, Jillian, Koo, Ja Seol, Venkatesh, Madhukumar, Jobin, Christian, Yeh, Li-An, Mani, Sridhar, Redinbo, Matthew R.. Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme. Science, vol.330, no.6005, 831-835.

  88. 10.4161/cbt.7.12.6940 

  89. Drug Metab Dispos Lavrijsen K 354 23 1995 

  90. J Pharmacol Exp Ther Koch RL 406 208 1979 

  91. Rafii, Fatemeh, Wynne, Rebecca, Heinze, Thomas M., Paine, Donald D.. Mechanism of metronidazole-resistance by isolates of nitroreductase-producing Enterococcus gallinarum and Enterococcus casseliflavus from the human intestinal tract. FEMS microbiology letters, vol.225, no.2, 195-200.

  92. Basit, Abdul W., Newton, J.Michael, Lacey, Larry F.. Susceptibility of the H2-receptor antagonists cimetidine, famotidine and nizatidine, to metabolism by the gastrointestinal microflora. International journal of pharmaceutics, vol.237, no.1, 23-33.

  93. J Pharm Pharm Sci Chourasia MK 33 6 2003 

  94. Sandborn, W. J., Hanauer, S. B.. The pharmacokinetic profiles of oral mesalazine formulations and mesalazine pro-drugs used in the management of ulcerative colitis. Alimentary pharmacology & therapeutics, vol.17, no.1, 29-42.

  95. KNOLL, U., STRAUHS, P., SCHUSSER, G., UNGEMACH, F. R.. Study of the plasma pharmacokinetics and faecal excretion of the prodrug olsalazine and its metabolites after oral administration to horses. Journal of veterinary pharmacology and therapeutics, vol.25, no.2, 135-143.

  96. Ireland, A, Priddle, J D, Jewell, D P. Comparison of 5-aminosalicylic acid and N-acetylaminosalicylic acid uptake by the isolated human colonic epithelial cell.. Gut: journal of the British Society of Gastroenterology, vol.33, no.10, 1343-1347.

  97. Aura, Anna-Marja, Mattila, Ismo, Hyötyläinen, Tuulia, Gopalacharyulu, Peddinti, Bounsaythip, Catherine, Orešič, Matej, Oksman-Caldentey, Kirsi-Marja. Drug metabolome of the Simvastatin formed by human intestinal microbiota in vitro. Molecular bioSystems, vol.7, no.2, 437-446.

  98. 10.1254/jjp.59.1 

  99. Hoy, Sheridan M., Scott, Lesley J., Wagstaff, Antona J.. Sodium Picosulfate/Magnesium Citrate : A Review of its Use as a Colorectal Cleanser. Drugs, vol.69, no.1, 123-136.

  100. 10.1097/00008571-199702000-00005 

  101. J Pharmacol Exp Ther Okuda H 791 287 1998 

  102. Ogura, Kenichiro, Nishiyama, Takahito, Takubo, Hiroaki, Kato, Atsushi, Okuda, Haruhiro, Arakawa, Kazuhito, Fukushima, Masakazu, Nagayama, Sekio, Kawaguchi, Yasuro, Watabe, Tadashi. Suicidal inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil derived from the antiviral, sorivudine. Cancer letters, vol.122, no.1, 107-113.

  103. Renwick, A.G., Evans, S.P., Sweatman, T.W., Cumberland, J., George, C.F.. The role of the gut flora in the reduction of sulphinpyrazone in the rat. Biochemical pharmacology, vol.31, no.16, 2649-2656.

  104. J Pharmacol Exp Ther Strong HA 726 230 1984 

  105. Haemostasis Pay GF 165 10 1981 

  106. Del Maschio, A., Livio, M., Cerletti, C., De Gaetano, G.. Inhibition of human platelet cyclo-oxygenase activity by sulfinpyrazone and three of its metabolites. European journal of pharmacology, vol.101, no.3, 209-214.

  107. 10.3109/00498258709043976 

  108. 10.1038/clpt.1985.192 

  109. J Pharmacol Exp Ther Duggan DE 8 201 1977 

  110. 10.2174/187569210792246326 

  111. Maurice, C., Haiser, H., Turnbaugh, P.. Xenobiotics Shape the Physiology and Gene Expression of the Active Human Gut Microbiome. Cell, vol.152, no.1, 39-50.

  112. Thiele, I., Heinken, A., Fleming, R.M.. A systems biology approach to studying the role of microbes in human health. Current opinion in biotechnology, vol.24, no.1, 4-12.

  113. 10.4161/gmic.22370 

  114. Meinl, Walter, Sczesny, Silke, Brigelius-Flohé, Regina, Blaut, Michael, Glatt, Hansruedi. Impact of Gut Microbiota on Intestinal and Hepatic Levels of Phase 2 Xenobiotic-Metabolizing Enzymes in the Rat. Drug metabolism and disposition: the biological fate of chemicals, vol.37, no.6, 1179-1186.

  115. Cancer Res Takasuna K 3752 56 1996 

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