[논문]Feeding tolerance of preterm infants appropriate for gestational age (AGA) as compared to those small for gestational age (SGA)

Bozzetti, Valentina; Paterlini, Giuseppe; DeLorenzo, Paola; Meroni, Valeria; Gazzolo, Diego; Van Bel, Frank; Visser, Gerard HA; Valsecchi, Maria Grazia; Tagliabue, Paolo E

doi:10.3109/14767058.2012.746303

Feeding tolerance of preterm infants appropriate for gestational age (AGA) as compared to those small for gestational age (SGA)

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International So, v.26 no.16, 2013년, pp.1610 - 1615

Bozzetti, Valentina (Neonatal Intensive Care Unit, MBBM Foundation, San Gerardo Hospital) , Paterlini, Giuseppe (Neonatal Intensive Care Unit, MBBM Foundation, San Gerardo Hospital) , DeLorenzo, Paola (Department of Clinical and Preventive Medicine, Center of Biostatistics for Clinical Epidemiology, University of Milano-Bicocca) , Meroni, Valeria (Neonatal Intensive Care Unit, MBBM Foundation, San Gerardo Hospital) , Gazzolo, Diego (Department of Maternal, Fetal and Neonatal Medicine, C. Arrigo Children's Hospital , Alessandria , Italy , and) , Van Bel, Frank (Department of Neonatology, Wilhelmina Children's Hospital , AB Utrecht , the Netherlands) , Visser, Gerard HA (Department of Neonatology, Wilhelmina Children's Hospital , AB Utrecht , the Netherlands) , Valsecchi, Maria Grazia (Department of Clinical and Preventive Medicine, Cent) , Tagliabue, Paolo E

Abstract ▼ AI-Helper

Preterm infants are often considered too unstable to be fed enterally so they are exposed to complications related to a prolonged enteral fasting. Our study aims to compare feeding tolerance of adequate for gestational age (AGA) versus small for gestational age (SGA) infants and to evaluate which perinatal factors affect feeding tolerance (measured as time to achieve full enteral feeding, FEF). Inborn infants with a gestational age (GA) less than 32 weeks, born from January 2006 to December 2010, were eligible for this study. We enrolled 310 infants. The time to FEF was longer for SGA infants than for AGA, while a longer GA was associated to a reduced time to FEF. A beneficial effect was observed for antenatal steroids, while Apgar score below 7, the administration of inotrops or caffeine, the occurrence of sepsis or NEC and the presence of PDA were associated to a longer time to FEF. When evaluated jointly with a multivariate analysis, GA (p < 0.0001), antenatal steroids prophylaxis (p = 0.002), SGA (p < 0.0001) and occurrence of NEC (p = 0.0002) proved to have independent prognostic impact on the time to FEF. Feeding tolerance is better as GA increases, and worsen in SGA infants. Antenatal betamethasone is effective in reducing the time to FEF in both AGA and SGA.

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Feeding tolerance of preterm infants appropriate for gestational age (AGA) as compared to those small for gestational age (SGA)

Abstract ▼ AI-Helper

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