$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Insulin induces C2C12 cell proliferation and apoptosis through regulation of cyclin D1 and BAD expression

Journal of cellular biochemistry, v.114 no.12, 2013년, pp.2708 - 2717  

Xiong, Cheng‐Juan (Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou City, Henan, 450001, China) ,  Li, Ping‐Fa (Department of Laboratory Medicine, Xinxiang Medical University, Xinxiang City, Henan, 453003, China) ,  Song, Yang‐Liu (Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou City, Henan, 450001, China) ,  Xue, Li‐Xiang (Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China) ,  Jia, Zhu‐Qing (Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China) ,  Yao, Chun‐Xia (Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou City, Henan, 450001, China) ,  Wei, Qing‐Xia (Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou City, Henan, 450001, China) ,  Zhang, Shu‐Feng (The People's Hospital of Henan Province, Zhengzhou University,) ,  Zhang, Shan‐Feng ,  Zhang, Yan‐Yan ,  Zhao, Ji‐Min ,  Wang, Tian‐Qi ,  Guo, Mao‐Feng ,  Zang, Ming‐Xi

Abstract AI-Helper 아이콘AI-Helper

ABSTRACTInsulin is a secreted peptide hormone identified in human pancreas to promote glucose utilization. Insulin has been observed to induce cell proliferation and myogenesis in C2C12 cells. The precise mechanisms underlying the proliferation of C2C12 cells induced by insulin remain unclear. In th...

주제어

참고문헌 (29)

  1. Asai T , Okumura K , Takahashi R , Matsui H , Numaguchi Y , Murakami H , Murakami R , Murohara T . 2006 . Combined therapy with PPARalpha agonist and l ‐carnitine rescues lipotoxic cardiomyopathy due to systemic carnitine deficiency . Cardiovasc Res 70 : 566 – 577 . 

  2. Burri L , Thoresen GH , Berge RK . 2010 . The role of PPARalpha activation in liver and muscle . PPAR Res 2010 : 1 – 11 . 

  3. Chan SH , Kikkawa U , Matsuzaki H , Chen JH , Chang WC . 2012 . Insulin receptor substrate‐1 prevents autophagy‐dependent cell death caused by oxidative stress in mouse NIH/3T3 cells . J Biomed Sci 19 : 64 . 

  4. Cirri P , Taddei ML , Chiarugi P , Buricchi F , Caselli A , Paoli P , Giannoni E , Camici G , Manao G , Raugei G , Ramponi G . 2005 . Insulin inhibits platelet‐derived growth factor‐induced cell proliferation . Mol Biol Cell 16 : 73 – 83 . 

  5. Conejo R , Valverde AM , Benito M , Lorenzo M . 2001 . Insulin produces myogenesis in C2C12 myoblasts by induction of NF‐kappaB and downregulation of AP‐1 activities . J Cell Physiol 186 : 82 – 94 . 

  6. Dandekar AA , Wallach BJ , Barthel A , Roth RA . 1998 . Comparison of the signaling abilities of the cytoplasmic domains of the insulin receptor and the insulin receptor‐related receptor in 3T3‐L1 adipocytes . Endocrinology 139 : 3578 – 3584 . 

  7. Deng JY , Hsieh PS , Huang JP , Lu LS , Hung LM . 2008 . Activation of estrogen receptor is crucial for resveratrol‐stimulating muscular glucose uptake via both insulin‐dependent and ‐independent pathways . Diabetes 57 : 1814 – 1823 . 

  8. Gerin I , Bommer GT , Lidell ME , Cederberg A , Enerback S , Macdougald OA . 2009 . On the role of FOX transcription factors in adipocyte differentiation and insulin‐stimulated glucose uptake . J Biol Chem 284 : 10755 – 10763 . 

  9. Gezginci‐Oktayoglu S , Karatug A , Bolkent S . 2012 . The relation among NGF, EGF and insulin is important for triggering pancreatic beta cell apoptosis . Diabetes Metab Res Rev 28 : 654 – 662 . 

  10. Kahn CR , White MF . 1988 . The insulin receptor and the molecular mechanism of insulin action . J Clin Invest 82 : 1151 – 1156 . 

  11. Kim EJ , Kho JH , Kang MR , Um SJ . 2007 . Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity . Mol Cell 28 : 277 – 290 . 

  12. Nakajima K , Inagawa M , Uchida C , Okada K , Tane S , Kojima M , Kubota M , Noda M , Ogawa S , Shirato H , Sato M , Suzuki‐Migishima R , Hino T , Satoh Y , Kitagawa M , Takeuchi T . 2011 . Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)‐cyclin D1 pathway . Development 138 : 1771 – 1782 . 

  13. Nemer M , Horb ME . 2007 . The KLF family of transcriptional regulators in cardiomyocyte proliferation and differentiation . Cell Cycle 6 : 117 – 121 . 

  14. Pawlikowska P , Gajkowska B , Hocquette JF , Orzechowski A . 2006 . Not only insulin stimulates mitochondriogenesis in muscle cells, but mitochondria are also essential for insulin‐mediated myogenesis . Cell Prolif 39 : 127 – 145 . 

  15. Ryder JW , Bassel‐Duby R , Olson EN , Zierath JR . 2003 . Skeletal muscle reprogramming by activation of calcineurin improves insulin action on metabolic pathways . J Biol Chem 278 : 44298 – 44304 . 

  16. Sermeus A , Genin M , Maincent A , Fransolet M , Notte A , Leclere L , Riquier H , Arnould T , Michiels C . 2012 . Hypoxia‐induced modulation of apoptosis and BCL‐2 family proteins in different cancer cell types . PLoS ONE 7 : e47519 . 

  17. Spizzo R , Nicoloso MS , Lupini L , Lu Y , Fogarty J , Rossi S , Zagatti B , Fabbri M , Veronese A , Liu X , Davuluri R , Croce CM , Mills G , Negrini M , Calin GA . 2010 . miR‐145 participates with TP53 in a death‐promoting regulatory loop and targets estrogen receptor‐alpha in human breast cancer cells . Cell Death Differ 17 : 246 – 254 . 

  18. Sun C , Zhou J . 2008 . Trichostatin A improves insulin stimulated glucose utilization and insulin signaling transduction through the repression of HDAC2 . Biochem Pharmacol 76 : 120 – 127 . 

  19. Tamamori‐Adachi M , Goto I , Yamada K , Kitajima S . 2008a . Differential regulation of cyclin D1 and D2 in protecting against cardiomyocyte proliferation . Cell Cycle 7 : 3768 – 3774 . 

  20. Tamamori‐Adachi M , Takagi H , Hashimoto K , Goto K , Hidaka T , Koshimizu U , Yamada K , Goto I , Maejima Y , Isobe M , Nakayama KI , Inomata N , Kitajima S . 2008b . Cardiomyocyte proliferation and protection against post‐myocardial infarction heart failure by cyclin D1 and Skp2 ubiquitin ligase . Cardiovasc Res 80 : 181 – 190 . 

  21. Tsao TS , Burcelin R , Katz EB , Huang L , Charron MJ . 1996 . Enhanced insulin action due to targeted GLUT4 overexpression exclusively in muscle . Diabetes 45 : 28 – 36 . 

  22. White MF , Kahn CR . 1994 . The insulin signaling system . J Biol Chem 269 : 1 – 4 . 

  23. Yang W , Zhang Y , Li Y , Wu Z , Zhu D . 2007 . Myostatin induces cyclin D1 degradation to cause cell cycle arrest through a phosphatidylinositol 3‐kinase/AKT/GSK‐3 beta pathway and is antagonized by insulin‐like growth factor 1 . J Biol Chem 282 : 3799 – 3808 . 

  24. Yang Y , Yee D . 2012 . Targeting insulin and insulin‐like growth factor signaling in breast cancer . J Mammary Gland Biol Neoplasia 17 : 251 – 261 . 

  25. Yao CX , Wei QX , Zhang YY , Wang WP , Xue LX , Yang F , Zhang SF , Xiong CJ , Li WY , Wei ZR , Zou Y , Zang MX . 2013 . miR‐200b targets GATA‐4 during cell growth and differentiation . RNA Biol 10 : 465 – 480 . 

  26. Yao CX , Xiong CJ , Wang WP , Yang F , Zhang SF , Wang TQ , Wang SL , Yu HL , Wei ZR , Zang MX . 2012 . Transcription factor GATA‐6 recruits PPARalpha to cooperatively activate Glut4 gene expression . J Mol Biol 415 : 143 – 158 . 

  27. Zang MX , Li Y , Wang H , Wang JB , Jia HT . 2004 . Cooperative interaction between the basic helix–loop–helix transcription factor dHAND and myocyte enhancer factor 2C regulates myocardial gene expression . J Biol Chem 279 : 54258 – 54263 . 

  28. Zick Y , Grunberger G , Podskalny JM , Moncada V , Taylor SI , Gorden P , Roth J . 1983a . Insulin stimulates phosphorylation of serine residues in soluble insulin receptors . Biochem Biophys Res Commun 116 : 1129 – 1135 . 

  29. Zick Y , Rees‐Jones RW , Grunberger G , Taylor SI , Moncada V , Gorden P , Roth J . 1983b . The insulin‐stimulated receptor kinase is a tyrosine‐specific casein kinase . Eur J Biochem 137 : 631 – 637 . 

관련 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로