$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

The CcpA regulon of Streptococcus suis reveals novel insights into the regulation of the streptococcal central carbon metabolism by binding of CcpA to two distinct binding motifs

Molecular microbiology, v.92 no.1, 2014년, pp.61 - 83  

Willenborg, Jörg (Institute of Microbiology, University of Veterinary Medicine, Hannover, Germany) ,  de Greeff, Astrid (Central Veterinary Institute, Wageningen University, Lelystad, The Netherlands) ,  Jarek, Michael (Genome Analytics, Helmholtz Centre for Infection Research, Braunschweig, Germany) ,  Valentin‐Weigand, Peter (Institute of Microbiology, University of Veterinary Medicine, Hannover, Germany) ,  Goethe, Ralph (Institute of Microbiology, University of Veterinary Medicine, Hannover, Germany)

Abstract AI-Helper 아이콘AI-Helper

SummaryStreptococcus suis (S. suis) is a neglected zoonotic streptococcus causing fatal diseases in humans and in pigs. The transcriptional regulator CcpA (catabolite control protein A) is involved in the metabolic adaptation to different carbohydrate sources and virulence of S. suis a...

참고문헌 (45)

  1. Abranches , J. , Nascimento , M.M. , Zeng , L. , Browngardt , C.M. , Wen , Z.T. , Rivera , M.F. , and Burne , R.A. ( 2008 ) CcpA regulates central metabolism and virulence gene expression in Streptococcus mutans . J Bacteriol 190 : 2340 – 2349 . 

  2. Antunes , A. , Camiade , E. , Monot , M. , Courtois , E. , Barbut , F. , Sernova , N. , V , et al . ( 2012 ) Global transcriptional control by glucose and carbon regulator CcpA in Clostridium difficile . Nucleic Acids Res 40 : 10701 – 10718 . 

  3. Arends , J.P. , and Zanen , H.C. ( 1988 ) Meningitis caused by Streptococcus suis in humans . Rev Infect Dis 10 : 131 – 137 . 

  4. Bailey , T.L. , Williams , N. , Misleh , C. , and Li , W.W. ( 2006 ) MEME: discovering and analyzing DNA and protein sequence motifs . Nucleic Acids Res 34 : W369 – W373 . 

  5. Battke , F. , Symons , S. , and Nieselt , K. ( 2010 ) Mayday‐integrative analytics for expression data . BMC Bioinformatics 11 : 121 . 

  6. Buescher , J.M. , Liebermeister , W. , Jules , M. , Uhr , M. , Muntel , J. , Botella , E. , et al . ( 2012 ) Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism . Science 335 : 1099 – 1103 . 

  7. Carvalho , S.M. , Kloosterman , T.G. , Kuipers , O.P. , and Neves , A.R. ( 2011 ) CcpA ensures optimal metabolic fitness of Streptococcus pneumoniae . PLoS ONE 6 : e26707 . 

  8. Carver , T. , Thomson , N. , Bleasby , A. , Berriman , M. , and Parkhill , J. ( 2009 ) DNAPlotter: circular and linear interactive genome visualization . Bioinformatics 25 : 119 – 120 . 

  9. Chaix , D. , Ferguson , M.L. , Atmanene , C. , Van Dorsselaer , A. , Sanglier‐Cianferani , S. , Royer , C.A. , and Declerck , N. ( 2010 ) Physical basis of the inducer‐dependent cooperativity of the central glycolytic genes repressor/DNA complex . Nucleic Acids Res 38 : 5944 – 5957 . 

  10. Chanter , N. , Jones , P.W. , and Alexander , T.J. ( 1993 ) Meningitis in pigs caused by Streptococcus suis – a speculative review . Vet Microbiol 36 : 39 – 55 . 

  11. Clifton‐Hadley , F.A. , and Alexander , T.J. ( 1980 ) The carrier site and carrier rate of Streptococcus suis type II in pigs . Vet Rec 107 : 40 – 41 . 

  12. Deutscher , J. , Kuster , E. , Bergstedt , U. , Charrier , V. , and Hillen , W. ( 1995 ) Protein kinase‐dependent HPr/CcpA interaction links glycolytic activity to carbon catabolite repression in gram‐positive Bacteria . Mol Microbiol 15 : 1049 – 1053 . 

  13. Deutscher , J. , Francke , C. , and Postma , P.W. ( 2006 ) How phosphotransferase system‐related protein phosphorylation regulates carbohydrate metabolism in bacteria . Microbiol Mol Biol Rev 70 : 939 – 1031 . 

  14. Drzewiecki , K. , Eymann , C. , Mittenhuber , G. , and Hecker , M. ( 1998 ) The yvyD gene of Bacillus subtilis is under dual control of sigmaB and sigmaH . J Bacteriol 180 : 6674 – 6680 . 

  15. Dubreuil , J.D. , Jacques , M. , Brochu , D. , Frenette , M. , and Vadeboncoeur , C. ( 1996 ) Surface location of HPr, a phosphocarrier of the phosphoenolpyruvate:sugar phosphotransferase system in Streptococcus suis . Microbiology 142 : 837 – 843 . 

  16. Fittipaldi , N. , Segura , M. , Grenier , D. , and Gottschalk , M. ( 2012 ) Virulence factors involved in the pathogenesis of the infection caused by the swine pathogen and zoonotic agent Streptococcus suis . Future Microbiol 7 : 259 – 279 . 

  17. Fujita , Y. ( 2009 ) Carbon catabolite control of the metabolic network in Bacillus subtilis . Biosci Biotechnol Biochem 73 : 245 – 259 . 

  18. Fulde , M. , Willenborg , J. , de Greeff , A. , Benga , L. , Smith , H.E. , Valentin‐Weigand , P. , and Goethe , R. ( 2011 ) ArgR is an essential local transcriptional regulator of the arc ABC operon in Streptococcus suis and is crucial for biological fitness in an acidic environment . Microbiology 157 : 572 – 582 . 

  19. Giammarinaro , P. , and Paton , J.C. ( 2002 ) Role of RegM, a homologue of the catabolite repressor protein CcpA, in the virulence of Streptococcus pneumoniae . Infect Immun 70 : 5454 – 5461 . 

  20. Gruening , P. , Fulde , M. , Valentin‐Weigand , P. , and Goethe , R. ( 2006 ) Structure, regulation, and putative function of the arginine deiminase system of Streptococcus suis . J Bacteriol 188 : 361 – 369 . 

  21. Holden , M.T.G. , Hauser , H. , Sanders , M. , Thi , H.N. , Cherevach , I. , Cronin , A. , et al . ( 2009 ) Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis . PLoS ONE 4 : e6072 . 

  22. Iyer , R. , Baliga , N.S. , and Camilli , A. ( 2005 ) Catabolite control protein A (CcpA) contributes to virulence and regulation of sugar metabolism in Streptococcus pneumoniae . J Bacteriol 187 : 8340 – 8349 . 

  23. Ji , H. , Jiang , H. , Ma , W. , Johnson , D.S. , Myers , R.M. , and Wong , W.H. ( 2008 ) An integrated software system for analyzing ChIP‐chip and ChIP‐seq data . Nat Biotechnol 26 : 1293 – 1300 . 

  24. Kruger , S. , Gertz , S. , and Hecker , M. ( 1996 ) Transcriptional analysis of bglPH expression in Bacillus subtilis : evidence for two distinct pathways mediating carbon catabolite repression . J Bacteriol 178 : 2637 – 2644 . 

  25. Landmann , J.J. , Werner , S. , Hillen , W. , Stulke , J. , and Gorke , B. ( 2012 ) Carbon source control of the phosphorylation state of the Bacillus subtilis carbon‐flux regulator Crh in vivo . FEMS Microbiol Lett 327 : 47 – 53 . 

  26. Li , H. , and Durbin , R. ( 2010 ) Fast and accurate long‐read alignment with Burrows‐Wheeler transform . Bioinformatics 26 : 589 – 595 . 

  27. Li , H. , Handsaker , B. , Wysoker , A. , Fennell , T. , Ruan , J. , Homer , N. , et al . ( 2009 ) The sequence alignment/map format and SAMtools . Bioinformatics 25 : 2078 – 2079 . 

  28. Lulko , A.T. , Buist , G. , Kok , J. , and Kuipers , O.P. ( 2007 ) Transcriptome analysis of temporal regulation of carbon metabolism by CcpA in Bacillus subtilis reveals additional target genes . J Mol Microbiol Biotechnol 12 : 82 – 95 . 

  29. Mai , N.T. , Hoa , N.T. , Nga , T.V. , Linh , L.D. , Chau , T.T. , Sinh , D. , X , et al . ( 2008 ) Streptococcus suis meningitis in adults in Vietnam . Clin Infect Dis 46 : 659 – 667 . 

  30. Miwa , Y. , Nakata , A. , Ogiwara , A. , Yamamoto , M. , and Fujita , Y. ( 2000 ) Evaluation and characterization of catabolite‐responsive elements ( cre ) of Bacillus subtilis . Nucleic Acids Res 28 : 1206 – 1210 . 

  31. Munch , R. , Hiller , K. , Grote , A. , Scheer , M. , Klein , J. , Schobert , M. , and Jahn , D. ( 2005 ) Virtual footprint and PRODORIC: an integrative framework for regulon prediction in prokaryotes . Bioinformatics 21 : 4187 – 4189 . 

  32. van Opijnen , T. , and Camilli , A. ( 2010 ) Genome‐wide fitness and genetic interactions determined by Tn‐seq, a high‐throughput massively parallel sequencing method for microorganisms . Curr Protoc Microbiol Chapter 1 : Unit1E . 

  33. Postma , P.W. , Lengeler , J.W. , and Jacobson , G.R. ( 1993 ) Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria . Microbiol Rev 57 : 543 – 594 . 

  34. Robitaille , D. , Gauthier , L. , and Vadeboncoeur , C. ( 1991 ) The presence of two forms of the phosphocarrier protein HPr of the phosphoenolpyruvate:sugar phosphotransferase system in streptococci . Biochimie 73 : 573 – 581 . 

  35. Rutherford , K. , Parkhill , J. , Crook , J. , Horsnell , T. , Rice , P. , Rajandream , M.A. , and Barrell , B. ( 2000 ) Artemis: sequence visualization and annotation . Bioinformatics 16 : 944 – 945 . 

  36. Seshasayee , A.S.N. , Bertone , P. , Fraser , G.M. , and Luscombe , N.M. ( 2006 ) Transcriptional regulatory networks in bacteria: from input signals to output responses . Curr Opin Microbiol 9 : 511 – 519 . 

  37. Shelburne , S.A. , Keith , D. , Horstmann , N. , Sumby , P. , Davenport , M.T. , Graviss , E.A. , et al . ( 2008 ) A direct link between carbohydrate utilization and virulence in the major human pathogen group A Streptococcus . Proc Natl Acad Sci USA 105 : 1698 – 1703 . 

  38. Shelburne , S.A. , Olsen , R.J. , Suber , B. , Sahasrabhojane , P. , Sumby , P. , Brennan , R.G. , and Musser , J.M. ( 2010 ) A Combination of independent transcriptional regulators shapes bacterial virulence gene expression during infection . PLoS Pathog 6 : e1000817 . 

  39. Stulke , J. , and Hillen , W. ( 2000 ) Regulation of carbon catabolism in Bacillus species . Annu Rev Microbiol 54 : 849 – 880 . 

  40. Tagami , K. , Nanamiya , H. , Kazo , Y. , Maehashi , M. , Suzuki , S. , Namba , E. , et al . ( 2012 ) Expression of a small (p)ppGpp synthetase, YwaC, in the (p)ppGpp(0) mutant of Bacillus subtilis triggers YvyD‐dependent dimerization of ribosome . Microbiologyopen 1 : 115 – 134 . 

  41. Titgemeyer , F. , and Hillen , W. ( 2002 ) Global control of sugar metabolism: a Gram‐positive solution . Antonie Van Leeuwenhoek 82 : 59 – 71 . 

  42. Vadeboncoeur , C. , and Pelletier , M. ( 1997 ) The phosphoenolpyruvate:sugar phosphotransferase system of oral streptococci and its role in the control of sugar metabolism . FEMS Microbiol Rev 19 : 187 – 207 . 

  43. Willenborg , J. , Fulde , M. , de Greeff , A. , Rohde , M. , Smith , H.E. , Valentin‐Weigand , P. , and Goethe , R. ( 2011 ) Role of glucose and CcpA in capsule expression and virulence of Streptococcus suis . Microbiology 157 : 1823 – 1833 . 

  44. Zeng , L. , and Burne , R.A. ( 2010 ) Seryl‐phosphorylated HPr regulates CcpA‐independent carbon catabolite repression in conjunction with PTS permeases in Streptococcus mutans . Mol Microbiol 75 : 1145 – 1158 . 

  45. Zomer , A.L. , Buist , G. , Larsen , R. , Kok , J. , and Kuipers , O.P. ( 2007 ) Time‐resolved determination of the CcpA regulon of Lactococcus lactis subsp. cremoris MG1363 . J Bacteriol 189 : 1366 – 1381 . 

섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로