[논문]Effects of 1,8-cineole on hypertension induced by chronic exposure to nicotine in rats

Moon, Hea Kyung; Kang, Purum; Lee, Hui Su; Min, Sun Seek; Seol, Geun Hee

doi:10.1111/jphp.12195

[해외논문] Effects of 1,8-cineole on hypertension induced by chronic exposure to nicotine in rats 원문보기

Journal of pharmacy and pharmacology, v.66 no.5, 2014년, pp.688 - 693

Moon, Hea Kyung (Department of Basic Nursing Science, School of Nursing, Korea University, Seoul, Republic of Korea) , Kang, Purum (Department of Basic Nursing Science, School of Nursing, Korea University, Seoul, Republic of Korea) , Lee, Hui Su (Department of Basic Nursing Science, School of Nursing, Korea University, Seoul, Republic of Korea) , Min, Sun Seek (Department of Physiology and Biophysics, School of Medicine, Eulji University, Daejeon, Republic of Korea) , Seol, Geun Hee (Department of Basic Nursing Science, School of Nursing, Korea University, Seoul, Republic of Korea)

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AbstractObjectivesThe monoterpenic oxide 1,8-cineole is a major component of many essential oils. We investigated its effects on systolic blood pressure (SBP) and oxidative stress in rats chronically exposed to nicotine.MethodsMale Sprague-Dawley rats (100-120 g) were intraperitoneally injected with 0.8 mg/kg/day nicotine for 21 days, followed by 3 mg/kg nicotine the next day. Rats were subsequently injected intraperitoneally with 0.01, 0.1 and 1 mg/kg 1,8-cineole, or 10 mg/kg nifedipine. SBP was measured using a tail cuff transducer, plasma nitrite concentration was measured colorimetrically, and plasma corticosterone concentration was measured by enzyme immunoassay.Key findingsWe found that 0.1 mg/kg 1,8-cineole significantly reduced SBP, and that 1.0 mg/kg 1,8-cineole significantly increased plasma nitrite concentrations, compared with rats chronically exposed to nicotine alone. Rats chronically exposed to nicotine showed a significant increase in lipid peroxidation levels, an elevation significantly antagonized by treatment with 0.01 mg/kg and 0.1 mg/kg 1,8-cineole. Chronic exposure to nicotine also significantly increased plasma corticosterone levels, but this effect was not diminished by treatment with 1,8-cineole.ConclusionsThese results indicate that 1,8-cineole may lower blood pressure, and that this antihypertensive effect may be associated with the regulation of nitric oxide and oxidative stress in rats chronically exposed to nicotine.

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[논문] Protective effects of 1,8-cineole on cardiovascular function in a rat model of chronic exposure to nicotine

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