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NTIS 바로가기Biomedical chromatography : BMC, v.29 no.3, 2015년, pp.373 - 378
Ouyang, Hui (Jiangxi University of Traditional Chinese Medicine, 56 Yangmin Road, Nanchang, 330006, China) , Guo, Yicheng (Jiangxi University of Traditional Chinese Medicine, 56 Yangmin Road, Nanchang, 330006, China) , He, Mingzhen (Jiangxi University of Traditional Chinese Medicine, 56 Yangmin Road, Nanchang, 330006, China) , Zhang, Jinlian (Jiangxi University of Traditional Chinese Medicine, 56 Yangmin Road, Nanchang, 330006, China) , Huang, Xiaofang (Jiangxi University of Traditional Chinese Medicine, 56 Yangmin Road, Nanchang, 330006, China) , Zhou, Xin (The Research Center for Quality Control of Natural Medicine, Guizhou Normal University, Guiyang, 550001, China) , Jiang, Hongliang (Tongji School of Pharmacy, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, China) , Feng, Yulin (Jiangxi University of Traditional Chinese Medicine, 56 Yangmin Road, Nanchang, 330006, China) , Yang, Shilin (Jiangxi University of Traditional Chinese Medicine, 56 Yangmin Road, Nanchang, 330006, China)
AbstractA simple, sensitive and specific liquid chromatography–tandem mass spectrometry method was developed and validated for the determination of Pulsatilla saponin D, a potential antitumor constituent isolated from Pulsatilla chinensis in rat plasma. Rat plasma samples were pretreated by pr...
Bang SC , Kim Y , Lee JH and Ahn BZ . Triterpenoid saponins from the roots of Pulsatilla koreana . Journal of Natural Products 2005 ; 68 : 268 – 272 .
Cai F , Sun L , Gao S , Yang Y , Yang Q and Chen W . A rapid and sensitive liquid chromatography–tandem mass spectrometric method for the determination of timosaponin B‐II in blood plasma and a study of the pharmacokinetics of saponin in the rat . Journal of Pharmaceutical and Biomedical Analysis 2008 ; 48 : 1411 – 1416 .
Chen W , Dang YJ and Zhu CY . Simultaneous determination of three major bioactive saponins of Panax notoginseng using liquid chromatography–tandem mass spectrometry and a pharmacokinetic study . Chinese Medicine 2010 ; 5 : 12 .
Editorial Committee of Chinese Pharmacopeia . Pharmacopeia of the People's Republic of China , Section A. Chemical Industry Press : Beijing , 2010 .
Hu ZY , Yang JL , Cheng C , Huang YH , Du FF , Wang FQ , Niu W , Xu F , Jiang RR , Gao XM and Li C . Combinatorial metabolism notably affects human systemic exposure to ginsenosides from orally administered extract of Panax notoginseng roots (Sanqi) . Drug Metabolism and Disposition 2013a ; 41 : 1457 – 1469 .
Hu ZY , Parker RB , Herring VL and Laizure SC . Conventional liquid chromatography/triple quadrupole mass spectrometry based metabolite identification and semi‐quantitative estimation approach in the investigation of in vitro dabigatran etexilate metabolism . Analytical and Bioanalytical Chemistry 2013b ; 405 : 1695 – 1704 .
Hu ZY , Laizure SC , Herring VL and Parker RB . Identification of alcohol‐dependent clopidogrel metabolites using conventional liquid chromatography/triple quadrupole mass spectrometry . Rapid Communications in Mass Spectrometry 2014 ; 28 : 1285 – 1292 .
Ji XM , Shu Z , Xu QM , Liu YL and Yang SL . Simultaneous determination of eight saponins in alkali hydrolysate of total saponins from Pulsatilla chinensis by HPLC‐ELSD . Chinese Traditional and Herbal Drugs 2013 ; 44 : 1416 – 1419 .
Kim MK , Lim EY and Jung MK . First total synthesis of natural pulsatilla saponin D via highly stereospecific glycosylation . Tetrahedron 2013 ; 69 : 5481 – 5486 .
Lee KY , Cho YW , Park J , Lee DY , Kim SH , Kim YC and Sung SH . Quality control of Pulsatilla koreana based on the simultaneous determination of triterpenoidal saponins by HPLC‐ELSD and principal component analysis . Plant Physiology 2010 ; 21 : 314 – 321 .
Li SX , Yang M and Zheng FY . Influence of gastrointestinal digestion and edible plant combination on oral bioavailability of triterpene saponins, using a biomimetic digestion and absorption system and determination by HPLC . Journal of Agricultural and Food Chemistry 2013 ; 61 : 10599 – 10603 .
Liu JY , Guan YL , Zou LB , Gong YX , Hua HM , Xu YN , Zhang H , Yu ZG and Fan WH . Saponins with neuroprotective effects from the roots of Pulsatilla cernua . Molecules 2012 ; 17 : 5520 – 5531 .
Man S , Gao W , Zhang Y , Huang L and Liu C . Identification of chemical constituents in Rhizoma Paridis Saponins and their oral administration in rat plasma by UPLC/Q‐TOF/MS . Biomedical Chromatography 2011 ; 25 : 712 – 719 .
Shu Z , Chen Z , Ding XJ , Lu BQ , Ji CJ , Xu QM , Li XR and Yang SL . Three new Triterpenoids from Pulsatilla chinensis (bunge) regel and their cytotoxic activities . Heterocycles 2011 ; 83 : 2365 – 2372 .
Son MK , Jung KH , Hong SW , Lee HS , Zheng HM , Choi MJ , Seo JH , Suh JK and Hong SS . SB365, Pulsatilla saponin D suppresses the proliferation of human colon cancer cells and induces apoptosis by modulating the AKT/mTOR signalling pathway . Food Chemistry 2013a ; 136 : 26 – 33 .
Son MK , Jung KH , Lee HS , Lee H , Kim SJ , Yan HH , Ryu YL and Hong SS . SB365, Pulsatilla saponin D suppresses proliferation and induces apoptosis of pancreatic cancer cells . Oncology Reports 2013b ; 30 : 801 – 808 .
Sun YX , Liu JC , Yu HT and Gong CJ . Isolation and evaluation of immunological adjuvant activities of saponins from the roots of Pulsatilla chinensis with less adverse reactions . International Immunopharmacology 2010 ; 10 : 584 – 590 .
US Food and Drug Administration . Guidance for Industry, Bioanalytical Method Validation . Center for Drug Evaluation and Research of the US Department of Health and Human Services (Draft), Food and Drug Administration, 2013 . http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM368107.pdf
Wang WH , Li PY , Wang XL , Jing WG , Chen LM and Liu A . Quantification of saponins in Dioscorea panthaica Prain et Burk rhizomes with monolithic column using rapid resolution liquid chromatography coupled with a triple quadruple electrospray tandem mass spectrometry . Journal of Pharmaceutical and Biomedical Analysis 2012 ; 71 : 152 – 156 .
Wu H , Guo J , Chen S , Liu X , Zhou Y , Zhang X and Xu X . Recent developments in qualitative and quantitative analysis of phytochemical constituents and their metabolites using liquid chromatography–mass spectrometry . Journal of Pharmaceutical and Biomedical Analysis 2013 ; 72 : 267 – 291 .
Xu HJ , Shi XW , Ji X , Du YF , Zhu H and Zhang LT . Qualitative and quantitative determination of nine main active constituents in Pulsatilla cernua by high‐performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry . Journal of Separation Science 2011a ; 34 : 308 – 316 .
Xu HJ , Ji X , Shi XW , Du YF , Zhu H and Zhang LT . Development of a novel method for triterpenoidal saponins in rat plasma by solid‐phase extraction and high‐performance liquid chromatography tandem mass spectrometry . Analytical Biochemistry 2011b ; 419 : 323 – 332 .
Xu LN , Zheng LL , Yin LH , Ji L , Qi Y , Han X , Xu YW , Peng JY and Tang XQ . Multiple compounds determination and fingerprint analysis of Pulsatilla chinensis (Bunge) Regel by HPLC coupled with evaporative light scattering detection for quality control . Journal of Liquid Chromatography and Related Technologies 2011c ; 34 : 2339 – 2359 .
Xu HJ , Shi XW , Ji X , Du YF , Zhu H and Zhang LT . A rapid method for simultaneous determination of triterpenoid saponins in Pulsatilla turczaninovii using microwave‐assisted extraction and high performance liquid chromatography–tandem mass spectrometry . Food Chemistry 2012a ; 135 : 251 – 258 .
Xu QM , Shu Z , He WJ , Chen LY , Yang SL , Yang G , Liu YL and Li XR . Antitumor activity of Pulsatilla chinensis (Bunge) Regel saponins in human liver tumor 7402 cells in vitro and in vivo . Phytomedicine 2012b ; 9 : 293 – 300 .
Yoo HH , Lee SK , Lim SY , Kim Y , Kang MJ , Kim EJ , Park YH , Im GJ , Lee BY and Kim DH . LC‐MS/MS method for determination of hederacolchiside E, a neuroactive saponin from Pulsatilla koreana extract in rat plasma for pharmacokinetic study . Journal of Pharmaceutical and Biomedical Analysis 2008 ; 48 : 1425 – 1429 .
Zhou DD , Tong L , Wan MX , Wang GJ , Ye ZL , Wang ZT and Lin RH . An LC‐MS method for simultaneous determination of nine ginsenosides in rat plasma and its application in pharmacokinetic stuady . Biomedical Chromatography 2010 ; 25 : 720 – 726 .
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