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Oxidation Potentials of N‐Modified Derivatives of the Analgesic Flupirtine Linked to Potassium KV7 Channel Opening Activity But Not Hepatocyte Toxicity

ChemMedChem : Chemistry Enabling Drug Discovery, v.10 no.2, 2015년, pp.368 - 379  

Lemmerhirt, Christian J. ,  Rombach, Mirko ,  Bodtke, Anja ,  Bednarski, Patrick J. ,  Link, Andreas

Abstract ▼ AI-Helper 아이콘AI-Helper

AbstractOpeners of neuronal voltage‐gated potassium channels (KV) are of interest as therapeutic agents for treating pain (flupirtine) and epilepsy (retigabine). In an effort to better understand the mechanisms of action and toxicity of flupirtine, we synthesized nine novel analogues with var...

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