[논문]Omega-3 index and smoking in patients with acute ST-elevation myocardial infarction taking statins: a case-control study in Korea

Kim, Young Joo; Jeong, Dong Wook; Lee, Jeong Gyu; Lee, Han Cheol; Lee, Sang Yeoup; Kim, Yun Jin; Yi, Yu Hyeon; Park, Yong Soon; Cho, Young Hye; Bae, Mi Jin; Choi, Eun Jung

doi:10.1186/1476-511X-11-43

Omega-3 index and smoking in patients with acute ST-elevation myocardial infarction taking statins: a case-control study in Korea 원문보기

Lipids in health and disease, v.11, 2012년, pp.43 - 43

Kim, Young Joo (Department of Family Medicine, Pusan National University Hospital, Busan, South Korea) , Jeong, Dong Wook (Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea) , Lee, Jeong Gyu (Department of Family Medicine, Pusan National University Hospital, Busan, South Korea) , Lee, Han Cheol (Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, South Korea) , Lee, Sang Yeoup (Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea) , Kim, Yun Jin (Department of Family Medicine, Pusan National University Hospital, Busan, South Korea) , Yi, Yu Hyeon (Department of Family Medicine, Pusan National University Hospital, Busan, South Korea) , Park, Yong Soon (Department of Food & Nutrition, Hanyang University, Seoul, South Korea) , Cho, Young Hye (Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yang) , Bae, Mi Jin , Choi, Eun Jung

Abstract ▼ AI-Helper

Backgroundn-3 fatty acids and lifestyle also are closely related to risk of CVD. Most Koreans have higher fish consumption than people of Western populations. However, little is known about the recommended value of omega-3 index in Korean patients with acute ST-elevation myocardial infarction (STEMI) taking statins. Here, we tested the hypothesis that lower omega-3 fatty acids and/or smoking are associated with acute STEMI, even though patients with dyslipidemia who were taking statins and who attained their LDL-C goals.MethodsWe conducted a case-control study in which omega-3 fatty acids and lifestyle factors were determined in 24 consecutive Korean patients taking statins with angiographically confirmed acute STEMI and 68 healthy controls without acute STEMI. The omega-3 index was calculated by the sum of eicosapentaenoic acid and docosahexaenoic acid in erythrocyte membranes. Multivariable adjusted regression analysis was used to assess independent associations between acute STEMI, omega-3 index, and lifestyle factors after adjusting for age, sex, and body mass index (BMI).ResultsThe mean age of total subjects was 59.9 years, and 57.6% of the subjects were male. The omega-3 index was significantly lower in cases (8.83%) than controls (11.13%; P < 0.001); however, total trans-fatty acids were not different between the two groups. The omega-3 index was inversely associated with odds for being a case (OR 0.16 (95% CI 0.03-1.14); P = 0.047), while smoking was positively associated with odds for being a case (OR 6.67 (95% CI 1.77-25.23); P = 0.005) after adjusting for all confounding variables.ConclusionThis study shows that relative to controls, acute STEMI cases are more likely to be smokers and to have a lower omega-3 index, even though the cases were taking statins. An omega-3 index of at least 11% and abstinence from smoking are associated with cardioprotection for Koreans.

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Omega-3 index and smoking in patients with acute ST-elevation myocardial infarction taking statins: a case-control study in Korea 원문보기

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Omega-3 index and smoking in patients with acute ST-elevation myocardial infarction taking statins: a case-control study in Korea 원문보기

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