[논문]Acupuncture on GB34 activates the precentral gyrus and prefrontal cortex in Parkinson’s disease

Yeo, Sujung; Choe, Il-Hwan; van den Noort, Maurits; Bosch, Peggy; Jahng, Geon-Ho; Rosen, Bruce; Kim, Sung-Hoon; Lim, Sabina

doi:10.1186/1472-6882-14-336

Acupuncture on GB34 activates the precentral gyrus and prefrontal cortex in Parkinson’s disease 원문보기

Bmc complementary and alternative medicine, v.14, 2014년, pp.336 -

Yeo, Sujung (Research Group of Pain and Neuroscience, WHO Collaborating Centre, East–) , Choe, Il-Hwan (west Medical Research Institute, Kyung Hee University, Seoul, Republic of Korea) , van den Noort, Maurits (Research Group of Pain and Neuroscience, WHO Collaborating Centre, East–) , Bosch, Peggy (west Medical Research Institute, Kyung Hee University, Seoul, Republic of Korea) , Jahng, Geon-Ho (Free University of Brussels, Brussels, Belgium) , Rosen, Bruce (Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands) , Kim, Sung-Hoon (College of Medicine, Kyung Hee University, Seoul, Republic of Korea) , Lim, Sabina (Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, USA)

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BackgroundAcupuncture is increasingly used as an additional treatment for patients with Parkinson’s disease (PD).MethodsIn this functional magnetic resonance imaging study, brain activation in response to acupuncture in a group of 12 patients with PD was compared with a group of 12 healthy participants. Acupuncture was conducted on a specific acupoint, the right GB 34 (Yanglingquan), which is a frequently used acupoint for motor function treatment in the oriental medical field.ResultsAcupuncture stimulation on this acupoint activates the prefrontal cortex, precentral gyrus, and putamen in patients with PD; areas that are known to be impaired in patients with PD. Compared with healthy participants, patients with PD showed significantly higher brain activity in the prefrontal cortex and precentral gyrus, especially visible in the left hemisphere.ConclusionsThe neuroimaging results of our study suggest that in future acupuncture research; the prefrontal cortex as well as the precentral gyrus should be treated for symptoms of Parkinson’s disease and that GB 34 seems to be a suitable acupoint. Moreover, acupuncture evoked different brain activations in patients with Parkinson’s disease than in healthy participants in our study, stressing the importance of conducting acupuncture studies on both healthy participants as well as patients within the same study, in order to detect acupuncture efficacy.Trial registrationKCT0001122 at cris.nih.go.kr (registration date: 20140530)Electronic supplementary materialThe online version of this article (doi:10.1186/1472-6882-14-336) contains supplementary material, which is available to authorized users.

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Acupuncture on GB34 activates the precentral gyrus and prefrontal cortex in Parkinson’s disease 원문보기

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