[논문]The Kv7 potassium channel activator retigabine decreases alcohol consumption in rats

Knapp, Clifford M.; O’Malley, Matthew; Datta, Subimal; Ciraulo, Domenic A.

doi:10.3109/00952990.2014.892951

The Kv7 potassium channel activator retigabine decreases alcohol consumption in rats

The American journal of drug and alcohol abuse, v.40 no.3, 2014년, pp.244 - 250

Knapp, Clifford M. (BUPA Clinical Studies Unit ,) , O’Malley, Matthew (Laboratory of Sleep and Cognitive Neuroscience, Department of Psychiatry ,) , Datta, Subimal (Laboratory of Sleep and Cognitive Neuroscience, Department of Psychiatry ,) , Ciraulo, Domenic A. (Department of Psychiatry, Boston University School of Medicine , Boston, MA , USA)

Abstract ▼ AI-Helper

Background: Activation of Kv7 potassium channels may decrease the reactivity of mesolimbic dopaminergic neurons that are implicated in mediating the reinforcing effects of ethanol. Objectives: The objective of this study was to determine whether the administration of the Kv7 potassium channel opener retigabine would decrease ethanol intake in Long Evans rats. Methods: A limited access two-bottle choice model of alcohol (10% solution) consumption was used in this study. A separate group of animals was tested to evaluate the actions of retigabine on sucrose (5% solution) consumption to determine whether this drug might produce non-selective impairment of the ability of rats to drink liquids. Animals were treated with either vehicle or increasing doses (2.5-7.5 mg/kg SC) of retigabine administered over a 3-day period. Results: Compared to vehicle, retigabine at a dose of 7.5 mg/kg produced a reduction in the amount of ethanol consumed. These effects did not occur in association with significant changes in water consumption. A significant time effect was found for the actions of retigabine in sucrose-drinking rats with a trend for an increase in sucrose intake with the highest dose of retigabine administered. Conclusions: These results indicate that the administration of retigabine may produce a decrease in ethanol consumption by rats at doses that do not significantly reduce the drinking of either water or a sucrose solution. These findings are consistent with the hypothesis that activation of Kv7 channels facilitates the reduction of alcohol consumption in the rat.

주제어

참고문헌 (36)

Weiss, Friedbert, Porrino, Linda J.. Behavioral Neurobiology of Alcohol Addiction: Recent Advances and Challenges. The Journal of neuroscience : the official journal of the Society for Neuroscience, vol.22, no.9, 3332-3337.

상세보기
Pharmacopsychiatry Söderpalm B S87 42 2009 10.1055/s-0029-1220690

상세보기
Alc Clin Exp Res Crosby SJ 36A 32 2008 10.1111/j.1530-0277.2007.00543.x

상세보기
Alcohol Clin Exp Res Fish EW 81 34 2010 10.1111/j.1530-0277.2009.01069.x

상세보기
Alcohol Moolten M 221 7 1990 10.1016/0741-8329(90)90008-Z

상세보기
Handbook of neuroscience for the behavioral sciences Knapp C 2009
J Pharmacol Exp Ther Imperato A 219 239 1986

상세보기
Alcohol Clin Exp Res Ding ZM 1571 33 2009 10.1111/j.1530-0277.2009.00985.x

상세보기
Brodie, Mark S.. Increased Ethanol Excitation of Dopaminergic Neurons of the Ventral Tegmental Area After Chronic Ethanol Treatment. Alcoholism: clinical and experimental research, vol.26, no.7, 1024-1030.

상세보기
Alcohol Clin Exp Res Brodie MS 1848 23 1999 10.1111/j.1530-0277.1999.tb04082.x

상세보기
Gessa, G.L., Muntoni, F., Collu, M., Vargiu, L., Mereu, G.. Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area. Brain research, vol.348, no.1, 201-203.

상세보기
J Pharmacol Exp Ther Hansen HH 1006 318 2006 10.1124/jpet.106.106757

상세보기
J Physiol Hansen HH 1823 586 2008 10.1113/jphysiol.2007.149450

상세보기
Delmas, Patrick, Brown, David A.. Pathways modulating neural KCNQ/M (Kv7) potassium channels. Nature reviews. Neuroscience, vol.6, no.11, 850-862.

상세보기
Eur J Neurosci Drion G 827 31 2010 10.1111/j.1460-9568.2010.07107.x

상세보기
Brain Res Moore SD 222 516 1990 10.1016/0006-8993(90)90922-X

상세보기
J Neurophysiol Koyama S 1977 97 2007 10.1152/jn.00270.2006

상세보기
Eur J Pharmacol Hansen HH 77 570 2007 10.1016/j.ejphar.2007.05.029

상세보기
Sotty, Florence, Damgaard, Trine, Montezinho, Liliana P., Mørk, Arne, Olsen, Christina K., Bundgaard, Christoffer, Husum, Henriette. Antipsychotic-Like Effect of Retigabine [N-(2-Amino-4-(fluorobenzylamino)-phenyl)carbamic Acid Ester], a KCNQ Potassium Channel Opener, via Modulation of Mesolimbic Dopaminergic Neurotransmission. The Journal of pharmacology and experimental therapeutics, vol.328, no.3, 951-962.

상세보기
Basic Clinl Pharmacol Toxicol Jensen MM 339 109 2011 10.1111/j.1742-7843.2011.00730.x

상세보기
J Neurochem Martire M 179 102 2007 10.1111/j.1471-4159.2007.04562.x

상세보기
Alcohol Stromberg MF 281 15 1998 10.1016/S0741-8329(97)00131-6

상세보기
Alcohol Stromberg MF 109 23 2001 10.1016/S0741-8329(00)00137-3

상세보기
Eur J Pharmacol Olive MF 55 15 2002 10.1016/S0014-2999(02)01272-4

상세보기
Knapp, C.M., Mercado, M., Markley, T.L., Crosby, S., Ciraulo, D.A., Kornetsky, C.. Zonisamide decreases ethanol intake in rats and mice. Pharmacology, biochemistry, and behavior, vol.87, no.1, 65-72.

상세보기
Pharmacol Biochem Behav Knapp CM 474 92 2009 10.1016/j.pbb.2009.01.017

상세보기
JAMA Johnson BA 1641 10 2007 10.1001/jama.298.14.1641

상세보기
Arias, Albert J., Feinn, Richard, Oncken, Cheryl, Covault, Jonathan, Kranzler, Henry R.. Placebo-Controlled Trial of Zonisamide for the Treatment of Alcohol Dependence. Journal of clinical psychopharmacology, vol.30, no.3, 318-322.

상세보기
Sarid-Segal, Ofra, Knapp, Clifford M., Burch, William, Richardson, Mark A., Bahtia, Sean, DeQuattro, Kimberly, Afshar, Maryam, Richambault, Courtney, Sickels, Laurie, Devine, Eric, Ciraulo, Domenic A.. The Anticonvulsant Zonisamide Reduces Ethanol Self-Administration by Risky Drinkers. The American journal of drug and alcohol abuse, vol.35, no.5, 316-319.

상세보기
World Neurosurg Voges J S28.e21 80 2013 10.1016/j.wneu.2012.07.011

상세보기
SAS version 9.1.3. SAS Institute Inc., Cary, NC, USA; 2002-2003
Gunthorpe, Martin J., Large, Charles H., Sankar, Raman. The mechanism of action of retigabine (ezogabine), a first‐in‐class K⁺ channel opener for the treatment of epilepsy. Epilepsia : the journal of the International League against Epilepsy, vol.53, no.3, 412-424.

상세보기
Arzneimittelforschung Rundfeldt C 1063 50 2000
J Pharmacol Exper Ther Korsgaard MP 282 314 2005 10.1124/jpet.105.083923

상세보기
Rostock, Angelika, Tober, Christine, Rundfeldt, Chris, Bartsch, Reni, Engel, Jürgen, Polymeropoulos, Emanuele E., Kutscher, Bernhard, Löscher, Wolfgang, Hönack, Dagmar, White, H.Steve, Wolf, Harold H.. D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures. Epilepsy research, vol.23, no.3, 211-223.

상세보기
Hopf, F.W., Simms, J.A., Chang, S.J., Seif, T., Bartlett, S.E., Bonci, A.. Chlorzoxazone, an SK-Type Potassium Channel Activator Used in Humans, Reduces Excessive Alcohol Intake in Rats. Biological psychiatry, vol.69, no.7, 618-624.

상세보기

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

The Kv7 potassium channel activator retigabine decreases alcohol consumption in rats

Abstract ▼ AI-Helper

주제어

참고문헌 (36)

이 논문을 인용한 문헌

관련 콘텐츠

원문 URL 링크

연관된 기능

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트