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Intranasal Piperine‐Loaded Chitosan Nanoparticles as Brain‐Targeted Therapy in Alzheimer's Disease: Optimization, Biological Efficacy, and Potential Toxicity

Journal of pharmaceutical sciences : a publication of the American Pharmaceutical Association, v.104 no.10, 2015년, pp.3544 - 3556  

Elnaggar, Yosra S. R. (Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt) ,  Etman, Samar M. (Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt) ,  Abdelmonsif, Doaa A. (Department of Medical Biochemistry, Faculty of Medicine, Alexandria University, Alexandria, Egypt) ,  Abdallah, Ossama Y. (Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt)

Abstract AI-Helper 아이콘AI-Helper

Piperine (PIP) is a phytopharmaceutical with reported neuroprotective potential in Alzheimer's disease (AD). Oral PIP delivery suffers from its hydrophobicity and pre‐systemic metabolism. In this article, mono‐disperse intranasal chitosan nanoparticles (CS‐NPs) were elaborated for ...

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참고문헌 (86)

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