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Recombinant Human Erythropoietin in Amyotrophic Lateral Sclerosis: A Pilot Study of Safety and Feasibility 원문보기

Journal of clinical neurology, v.10 no.4, 2014년, pp.342 - 347  

Kim, Hyun Young (Department of Neurology, College of Medicine, Hanyang University, Seoul, Korea.) ,  Moon, Chanil (Department of Neurology, College of Medicine, Hanyang University, Seoul, Korea.) ,  Kim, Kyung Suk (Bioengineering Institute, Corestem Inc., Seoul, Korea.) ,  Oh, Ki Wook (Department of Neurology, College of Medicine, Hanyang University, Seoul, Korea.) ,  Oh, Seong-il (Department of Neurology, College of Medicine, Hanyang University, Seoul, Korea.) ,  Kim, Juhan (Department of Neurology, College of Medicine, Hanyang University, Seoul, Korea.) ,  Kim, Seung Hyun (Department of Neurology, College of Medicine, Hanyang University, Seoul, Korea.)

Abstract AI-Helper 아이콘AI-Helper

Background and PurposeIt has been shown that erythropoietin is neuroprotective in animal models of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). The aim of this study was to determine the safety and feasibility of repetitive high-dose recombinant human erythropoietin (rhE...

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참고문헌 (32)

  1. 1 Cleveland DW Rothstein JD From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS Nat Rev Neurosci 2001 2 806 819 11715057 

  2. 2 Rowland LP Shneider NA Amyotrophic lateral sclerosis N Engl J Med 2001 344 1688 1700 11386269 

  3. 3 de Carvalho M Costa J Swash M Clinical trials in ALS: a review of the role of clinical and neurophysiological measurements Amyotroph Lateral Scler Other Motor Neuron Disord 2005 6 202 212 16319023 

  4. 4 Bensimon G Lacomblez L Meininger V ALS/Riluzole Study Group A controlled trial of riluzole in amyotrophic lateral sclerosis N Engl J Med 1994 330 585 591 8302340 

  5. 5 Miller RG Mitchell JD Lyon M Moore DH Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND) Amyotroph Lateral Scler Other Motor Neuron Disord 2003 4 191 206 13129806 

  6. 6 Assaraf MI Diaz Z Liberman A Miller WH Jr Arvanitakis Z Li Y Brain erythropoietin receptor expression in Alzheimer disease and mild cognitive impairment J Neuropathol Exp Neurol 2007 66 389 398 17483696 

  7. 7 Maiese K Chong ZZ Hou J Shang YC New strategies for Alzheimer's disease and cognitive impairment Oxid Med Cell Longev 2009 2 279 289 20716915 

  8. 8 Xue YQ Zhao LR Guo WP Duan WM Intrastriatal administration of erythropoietin protects dopaminergic neurons and improves neurobehavioral outcome in a rat model of Parkinson's disease Neuroscience 2007 146 1245 1258 17363174 

  9. 9 Ehrenreich H Fischer B Norra C Schellenberger F Stender N Stiefel M Exploring recombinant human erythropoietin in chronic progressive multiple sclerosis Brain 2007 130 Pt 10 2577 2588 17728357 

  10. 10 Akdemir Ozisik P Oruckaptan H Ozdemir Geyik P Misirlioglu M Sargon MF Kilinc K Effect of erythropoietin on brain tissue after experimental head trauma in rats Surg Neurol 2007 68 547 555 discussion 555 17586022 

  11. 11 Ehrenreich H Hinze-Selch D Stawicki S Aust C Knolle-Veentjer S Wilms S Improvement of cognitive functions in chronic schizophrenic patients by recombinant human erythropoietin Mol Psychiatry 2007 12 206 220 17033631 

  12. 12 Krebs M Leopold K Hinzpeter A Schaefer M Neuroprotective agents in schizophrenia and affective disorders Expert Opin Pharmacother 2006 7 837 848 16634707 

  13. 13 Koh SH Kim Y Kim HY Cho GW Kim KS Kim SH Recombinant human erythropoietin suppresses symptom onset and progression of G93A-SOD1 mouse model of ALS by preventing motor neuron death and inflammation Eur J Neurosci 2007 25 1923 1930 17439481 

  14. 14 Konishi Y Chui DH Hirose H Kunishita T Tabira T Trophic effect of erythropoietin and other hematopoietic factors on central cholinergic neurons in vitro and in vivo Brain Res 1993 609 29 35 7685231 

  15. 15 Ehrenreich H Aust C Krampe H Jahn H Jacob S Herrmann M Erythropoietin: novel approaches to neuroprotection in human brain disease Metab Brain Dis 2004 19 195 206 15554415 

  16. 16 Janik P Kwiecinski H Sokolowska B Niebroj-Dobosz I Erythropoietin concentration in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis J Neural Transm 2010 117 343 347 20012656 

  17. 17 Ehrenreich H Hasselblatt M Dembowski C Cepek L Lewczuk P Stiefel M Erythropoietin therapy for acute stroke is both safe and beneficial Mol Med 2002 8 495 505 12435860 

  18. 18 Lipsic E van der Meer P Voors AA Westenbrink BD van den Heuvel AF de Boer HC A single bolus of a long-acting erythropoietin analogue darbepoetin alfa in patients with acute myocardial infarction: a randomized feasibility and safety study Cardiovasc Drugs Ther 2006 20 135 141 16761193 

  19. 19 Brooks BR Miller RG Swash M Munsat TL World Federation of Neurology Research Group on Motor Neuron Diseases El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis Amyotroph Lateral Scler Other Motor Neuron Disord 2000 1 293 299 11464847 

  20. 20 Henry DH Bowers P Romano MT Provenzano R Epoetin alfa. Clinical evolution of a pleiotropic cytokine Arch Intern Med 2004 164 262 276 14769622 

  21. 21 Stohlawetz PJ Dzirlo L Hergovich N Lackner E Mensik C Eichler HG Effects of erythropoietin on platelet reactivity and thrombopoiesis in humans Blood 2000 95 2983 2989 10779449 

  22. 22 Maschio G Erythropoietin and systemic hypertension Nephrol Dial Transplant 1995 10 Suppl 2 74 79 7644110 

  23. 23 Smith KJ Bleyer AJ Little WC Sane DC The cardiovascular effects of erythropoietin Cardiovasc Res 2003 59 538 548 14499855 

  24. 24 Cheung WK Goon BL Guilfoyle MC Wacholtz MC Pharmacokinetics and pharmacodynamics of recombinant human erythropoietin after single and multiple subcutaneous doses to healthy subjects Clin Pharmacol Ther 1998 64 412 423 9797798 

  25. 25 Katavetin P Inagi R Miyata T Shao J Sassa R Adler S Erythropoietin induces heme oxygenase-1 expression and attenuates oxidative stress Biochem Biophys Res Commun 2007 359 928 934 17560935 

  26. 26 Villa P Bigini P Mennini T Agnello D Laragione T Cagnotto A Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis J Exp Med 2003 198 971 975 12975460 

  27. 27 Chong ZZ Kang JQ Maiese K Erythropoietin: cytoprotection in vascular and neuronal cells Curr Drug Targets Cardiovasc Haematol Disord 2003 3 141 154 12769640 

  28. 28 Agnello D Bigini P Villa P Mennini T Cerami A Brines ML Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis Brain Res 2002 952 128 134 12363412 

  29. 29 Cho GW Koh SH Kim MH Yoo AR Noh MY Oh S The neuroprotective effect of erythropoietin-transduced human mesenchymal stromal cells in an animal model of ischemic stroke Brain Res 2010 1353 1 13 20547143 

  30. 30 Genc S Akhisaroglu M Kuralay F Genc K Erythropoietin restores glutathione peroxidase activity in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine-induced neurotoxicity in C57BL mice and stimulates murine astroglial glutathione peroxidase production in vitro Neurosci Lett 2002 321 73 76 11872260 

  31. 31 Grignaschi G Zennaro E Tortarolo M Calvaresi N Bendotti C Erythropoietin does not preserve motor neurons in a mouse model of familial ALS Amyotroph Lateral Scler 2007 8 31 35 17364433 

  32. 32 Lauria G Campanella A Filippini G Martini A Penza P Maggi L Erythropoietin in amyotrophic lateral sclerosis: a pilot, randomized, double-blind, placebo-controlled study of safety and tolerability Amyotroph Lateral Scler 2009 10 410 415 19922132 

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