$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences 원문보기

Proceedings of the National Academy of Sciences of the United States of America, v.112 no.9, 2015년, pp.2876 - 2881  

Zhu, Xiao-Hong ,  Lu, Ming ,  Lee, Byeong-Yeul ,  Ugurbil, Kamil ,  Chen, Wei

Abstract AI-Helper 아이콘AI-Helper

SignificanceDecline in NAD+ availability and abnormal NAD+/NADH redox state are tightly linked to age-related metabolic diseases and neurodegenerative disorders. To better understand the roles of NAD metabolism and redox state in health and disease, it is important to assess the intracellular NAD an...

주제어

참고문헌 (47)

  1. The alcoholic ferment of yeast-juice. Proceedings of the Royal Society of London. Series B, Containing papers of a biological character, vol.77, no.519, 405-420.

  2. CHANCE, BRITTON, ITO, TAKERU. Control of Endogenous Adenosine Triphosphatase Activity by Energy-Linked Pyridine Nucleotide Reduction in Mitochondria. Nature, vol.195, no.4837, 150-153.

  3. Belenky, Peter, Bogan, Katrina L., Brenner, Charles. NAD+ metabolism in health and disease. Trends in biochemical sciences, vol.32, no.1, 12-19.

  4. Houtkooper, Riekelt H., Cantó, Carles, Wanders, Ronald J., Auwerx, Johan. The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways. Endocrine reviews, vol.31, no.2, 194-223.

  5. Lin, Su-Ju, Guarente, Leonard. Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease. Current opinion in cell biology, vol.15, no.2, 241-246.

  6. Canto, C., Houtkooper, Riekelt H., Pirinen, E., Youn, Dou Y., Oosterveer, Maaike H., Cen, Y., Fernandez-Marcos, Pablo J., Yamamoto, H., Andreux, Penelope A., Cettour-Rose, P., Gademann, K., Rinsch, C., Schoonjans, K., Sauve, Anthony A., Auwerx, J.. The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity. Cell metabolism, vol.15, no.6, 838-847.

  7. Houtkooper, Riekelt H., Auwerx, Johan. Exploring the therapeutic space around NAD +. The Journal of cell biology, vol.199, no.2, 205-209.

  8. Mouchiroud, L., Houtkooper, Riekelt H., Moullan, N., Katsyuba, E., Ryu, D., Canto, C., Mottis, A., Jo, Y.S., Viswanathan, M., Schoonjans, K., Guarente, L., Auwerx, J.. The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell, vol.154, no.2, 430-441.

  9. Oka, Shin-ichi, Hsu, Chiao-Po, Sadoshima, Junichi. Regulation of Cell Survival and Death by Pyridine Nucleotides. Circulation research : a journal of the American Heart Association, vol.111, no.5, 611-627.

  10. Pittelli, Maria, Felici, Roberta, Pitozzi, Vanessa, Giovannelli, Lisa, Bigagli, Elisabetta, Cialdai, Francesca, Romano, Giovanni, Moroni, Flavio, Chiarugi, Alberto. Pharmacological Effects of Exogenous NAD on Mitochondrial Bioenergetics, DNA Repair, and Apoptosis. Molecular pharmacology, vol.80, no.6, 1136-1146.

  11. Wang, Suping, Xing, Zili, Vosler, Peter S., Yin, Hannah, Li, Wenjin, Zhang, Feng, Signore, Armando P., Stetler, R. Anne, Gao, Yanqin, Chen, Jun. Cellular NAD Replenishment Confers Marked Neuroprotection Against Ischemic Cell Death : Role of Enhanced DNA Repair. Stroke, vol.39, no.9, 2587-2595.

  12. Wiley, Christopher, Campisi, Judith. NAD+ controls neural stem cell fate in the aging brain. The EMBO journal, vol.33, no.12, 1289-1291.

  13. Chance, B., Cohen, P., Jobsis, F., Schoener, B.. Localized Fluorometry of Oxidation-Reduction States of Intracellular Pyridine Nucleotide in Brain and Kidney Cortex of the Anesthetized Rat. Science, vol.136, no.3513, 325-325.

  14. Lowry, Oliver H., Passonneau, Janet V., Schulz, Demoy W., Rock, Martha K.. The Measurement of Pyridine Nucleotides by Enzymatic Cycling. The Journal of biological chemistry, vol.236, no.10, 2746-2755.

  15. Lowry, Oliver H., Passonneau, Janet V., Rock, Martha K.. The Stability of Pyridine Nucleotides. The Journal of biological chemistry, vol.236, no.10, 2756-2759.

  16. Avi-Dor, Y., Olson, John M., Doherty, Mary D., Kaplan, Nathan O.. Fluorescence of Pyridine Nucleotides in Mitochondria. The Journal of biological chemistry, vol.237, no.7, 2377-2383.

  17. Lu, Ming, Zhu, Xiao‐Hong, Zhang, Yi, Chen, Wei. Intracellular redox state revealed by in vivo 31P MRS measurement of NAD+ and NADH contents in brains. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine, vol.71, no.6, 1959-1972.

  18. Evans, Frederick E., Kaplan, Nathan O.. 31 P nuclear magnetic resonance studies of HeLa cells. Proceedings of the National Academy of Sciences of the United States of America, vol.74, no.11, 4909-4913.

  19. Lei, Hao, Zhu, Xiao-Hong, Zhang, Xiao-Liang, Ugurbil, Kamil, Chen, Wei. In vivo 31P magnetic resonance spectroscopy of human brain at 7 T: An initial experience. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine, vol.49, no.2, 199-205.

  20. Navon, G, Ogawa, S, Shulman, R G, Yamane, T. High-resolution 31P nuclear magnetic resonance studies of metabolism in aerobic Escherichia coli cells.. Proceedings of the National Academy of Sciences of the United States of America, vol.74, no.3, 888-891.

  21. Du, Fei, Zhu, Xiao-Hong, Zhang, Yi, Friedman, Michael, Zhang, Nanyin, Uğurbil, Kâmil, Chen, Wei. Tightly coupled brain activity and cerebral ATP metabolic rate. Proceedings of the National Academy of Sciences of the United States of America, vol.105, no.17, 6409-6414.

  22. BK Siesjo Brain Energy Metabolism (John Wiley & Sons New York). (1978). 

  23. Lu, Ming, Chen, Wei, Zhu, Xiao‐Hong. Field dependence study of in vivo brain 31P MRS up to 16.4 T. NMR in biomedicine, vol.27, no.9, 1135-1141.

  24. NMR and Chemistry: An Introduction to the Fourier Transform-Multinuclear Ear Akitt JW 45 1983 10.1007/978-1-4899-3097-2 2 JW Akitt NMR and Chemistry: An Introduction to the Fourier Transform-Multinuclear Ear (Chapman and Hall Ltd, 2nd Ed, London), pp. 45-49 (1983). 

  25. Alano, Conrad C., Tran, Alexandra, Tao, Rong, Ying, Weihai, Karliner, Joel S., Swanson, Raymond A.. Differences among cell types in NAD+ compartmentalization: A comparison of neurons, astrocytes, and cardiac myocytes. Journal of neuroscience research, vol.85, no.15, 3378-3385.

  26. McKenna, Mary C., Waagepetersen, Helle S., Schousboe, Arne, Sonnewald, Ursula. Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: Current evidence and pharmacological tools. Biochemical pharmacology, vol.71, no.4, 399-407.

  27. Williamson, DH, Lund, P, Krebs, HA. The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver. The Biochemical journal, vol.103, no.2, 514-527.

  28. Tischler, Marc E., Friedrichs, Dagmar, Coll, Kathleen, Williamson, John R.. Pyridine nucleotide distributions and enzyme mass action ratios in hepatocytes from fed and starved rats. Archives of biochemistry and biophysics, vol.184, no.1, 222-236.

  29. Balaban, R. S.. Regulation of oxidative phosphorylation in the mammalian cell. American journal of physiology. Cell physiology, vol.258, no.3, C377-C389.

  30. Circ Res Chance B I31 38 1976 Pyridine nucleotide as an indicator of the oxygen requirements for energy-linked functions of mitochondria B Chance, Pyridine nucleotide as an indicator of the oxygen requirements for energy-linked functions of mitochondria. Circ Res 38, I31-I38 (1976). 

  31. Vaishnavi, S. Neil, Vlassenko, Andrei G., Rundle, Melissa M., Snyder, Abraham Z., Mintun, Mark A., Raichle, Marcus E.. Regional aerobic glycolysis in the human brain. Proceedings of the National Academy of Sciences of the United States of America, vol.107, no.41, 17757-17762.

  32. Balaban, Robert S., Nemoto, Shino, Finkel, Toren. Mitochondria, Oxidants, and Aging. Cell, vol.120, no.4, 483-495.

  33. Stein, L.R., Imai, S.i.. The dynamic regulation of NAD metabolism in mitochondria. Trends in endocrinology and metabolism : TEM, vol.23, no.9, 420-428.

  34. Braidy, Nady, Poljak, Anne, Grant, Ross, Jayasena, Tharusha, Mansour, Hussein, Chan-Ling, Tailoi, Guillemin, Gilles J., Smythe, George, Sachdev, Perminder. Mapping NAD+ metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence. Biogerontology, vol.15, no.2, 177-198.

  35. Gomes, Ana P., Price, Nathan L., Ling, Alvin J.Y., Moslehi, Javid J., Montgomery, M.K., Rajman, L., White, James P., Teodoro, Joao S., Wrann, Christiane D., Hubbard, Basil P., Mercken, Evi M., Palmeira, Carlos M., de Cabo, R., Rolo, Anabela P., Turner, N., Bell, Eric L., Sinclair, David A.. Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging. Cell, vol.155, no.7, 1624-1638.

  36. Leenders, K L, Perani, D, Lammertsma, A A, Heather, J D, Buckingham, P, Healy, M J, Gibbs, J M, Wise, R J, Hatazawa, J, Herold, S. Cerebral blood flow, blood volume and oxygen utilization. Normal values and effect of age.. Brain : a journal of neurology, vol.113, no.1, 27-47.

  37. Yamaguchi, T, Kanno, I, Uemura, K, Shishido, F, Inugami, A, Ogawa, T, Murakami, M, Suzuki, K. Reduction in regional cerebral metabolic rate of oxygen during human aging.. Stroke, vol.17, no.6, 1220-1228.

  38. Navarro, Ana, Boveris, Alberto. The mitochondrial energy transduction system and the aging process. American journal of physiology. Cell physiology, vol.292, no.2, C670-C686.

  39. Boumezbeur, Fawzi, Mason, Graeme F, de Graaf, Robin A, Behar, Kevin L, Cline, Gary W, Shulman, Gerald I, Rothman, Douglas L, Petersen, Kitt F. Altered Brain Mitochondrial Metabolism in Healthy Aging as Assessed by in vivo Magnetic Resonance Spectroscopy. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, vol.30, no.1, 211-221.

  40. Petersen, Kitt Falk, Befroy, Douglas, Dufour, Sylvie, Dziura, James, Ariyan, Charlotte, Rothman, Douglas L., DiPietro, Loretta, Cline, Gary W., Shulman, Gerald I.. Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance. Science, vol.300, no.5622, 1140-1142.

  41. Schreiber, Valérie, Dantzer, Fran챌oise, Ame, Jean-Christophe, de Murcia, Gilbert. Poly(ADP-ribose): novel functions for an old molecule. Nature reviews. Molecular cell biology, vol.7, no.7, 517-528.

  42. Wang, J., Fivecoat, H., Ho, L., Pan, Y., Ling, E., Pasinetti, G.M.. The role of Sirt1: At the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology. Biochimica et biophysica acta. Proteins and proteomics, vol.1804, no.8, 1690-1694.

  43. Yoshino, Jun, Mills, Kathryn F., Yoon, Myeong Jin, Imai, Shin-ichiro. Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice. Cell metabolism, vol.14, no.4, 528-536.

  44. Mouchiroud, Laurent, Houtkooper, Riekelt H., Auwerx, Johan. NAD+ metabolism: A therapeutic target for age-related metabolic disease. Critical reviews in biochemistry and molecular biology, vol.48, no.4, 397-408.

  45. Prolla, Tomas A., Denu, John M.. NAD+ Deficiency in Age-Related Mitochondrial Dysfunction. Cell metabolism, vol.19, no.2, 178-180.

  46. Klingenberg, M, Bucher, T. Biological Oxidations. Annual review of biochemistry, vol.29, 669-708.

  47. Unden, G, Bongaerts, J. Alternative respiratory pathways of Escherichia coli: energetics and transcriptional regulation in response to electron acceptors. Biochimica et biophysica acta, Bioenergetics, vol.1320, no.3, 217-234.

관련 콘텐츠

오픈액세스(OA) 유형

BRONZE

출판사/학술단체 등이 한시적으로 특별한 프로모션 또는 일정기간 경과 후 접근을 허용하여, 출판사/학술단체 등의 사이트에서 이용 가능한 논문

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로