[논문]Hydrogels With Integrin-Binding Angiopoietin-1–Derived Peptide, QHREDGS, for Treatment of Acute Myocardial Infarction

Reis, Lewis A.; Chiu, Loraine L.Y.; Wu, Jun; Feric, Nicole; Laschinger, Carol; Momen, Abdul; Li, Ren-Ke; Radisic, Milica

doi:10.1161/CIRCHEARTFAILURE.114.001881

[해외논문] Hydrogels With Integrin-Binding Angiopoietin-1–Derived Peptide, QHREDGS, for Treatment of Acute Myocardial Infarction 원문보기

Circulation. an American Heart Association Journal Heart failure, v.8 no.2, 2015년, pp.333 - 341

Reis, Lewis A. (From the Institute of Biomaterials and Biomedical Engineering (L.A.R., N.F., C.L., M.R.) and Department of Chemical Engineering and Applied Chemistry (L.L.Y.C., M.R.), University of Toronto, Canada) , Chiu, Loraine L.Y. (and Toronto General Research Institute, University Health Network, Canada (J.W., A.M., R.-K.L.).) , Wu, Jun (From the Institute of Biomaterials and Biomedical Engineering (L.A.R., N.F., C.L., M.R.) and Department of Chemical Engineering and Applied Chemistry (L.L.Y.C., M.R.), University of Toronto, Canada) , Feric, Nicole (and Toronto General Research Institute, University Health Network, Canada (J.W., A.M., R.-K.L.).) , Laschinger, Carol (From the Institute of Biomaterials and Biomedical Engineering (L.A.R., N.F., C.L., M.R.) and Department of Chemical Engineering and Applied Chemistry (L.L.Y.C., M.R.), University of Toronto, Canada) , Momen, Abdul (and Toronto General Research Institute, University Health Network, Canada (J.W., A.M., R.-K.L.).) , Li, Ren-Ke (From the Institute of Biomaterials and Biomedical Engineering (L.A.R., N.F., C.L., M.R.) and Department of) , Radisic, Milica

Abstract ▼ AI-Helper

Background—Hydrogels are being actively investigated for direct delivery of cells or bioactive molecules to the heart after myocardial infarction (MI) to prevent cardiac functional loss. We postulate that immobilization of the prosurvival angiopoietin-1–derived peptide, QHREDGS, to a chitosan-collagen hydrogel could produce a clinically translatable thermoresponsive hydrogel to attenuate post-MI cardiac remodeling.Methods and Results—In a rat MI model, QHREDGS-conjugated hydrogel (QHG213H), control gel, or PBS was injected into the peri-infarct/MI zone. By in vivo tracking and chitosan staining, the hydrogel was demonstrated to remain in situ for 2 weeks and was cleared in ≈3 weeks. By echocardiography and pressure–volume analysis, the QHG213H hydrogel significantly improved cardiac function compared with the controls. Scar thickness and scar area fraction were also significantly improved with QHG213H gel injection compared with the controls. There were significantly more cardiomyocytes, determined by cardiac troponin-T staining, in the MI zone of the QHG213H hydrogel group; and hydrogel injection did not induce a significant inflammatory response as assessed by polymerase chain reaction and an inflammatory cytokine assay. The interaction of cardiomyocytes and cardiac fibroblasts with QHREDGS was found to be mediated by β1-integrins.Conclusions—We demonstrated for the first time that the QHG213H peptide–modified hydrogel can be injected in the beating heart where it remains localized for a clinically effective period. Moreover, the QHG213H hydrogel induced significant cardiac functional and morphological improvements after MI relative to the controls.

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참고문헌 (46)

Mayfield, A.E., Tilokee, E.L., Latham, N., McNeill, B., Lam, B.K., Ruel, M., Suuronen, E.J., Courtman, D.W., Stewart, D.J., Davis, D.R.. The effect of encapsulation of cardiac stem cells within matrix-enriched hydrogel capsules on cell survival, post-ischemic cell retention and cardiac function. Biomaterials, vol.35, no.1, 133-142.

상세보기
Nelson, Devin M., Ma, Zuwei, Leeson, Cory E., Wagner, William R.. Extended and sequential delivery of protein from injectable thermoresponsive hydrogels. Journal of biomedical materials research. Part A, vol.a100, no.3, 776-785.

상세보기
Menasché, Philippe. Current Status and Future Prospects for Cell Transplantation to Prevent Congestive Heart Failure. Seminars in thoracic and cardiovascular surgery, vol.20, no.2, 131-137.

상세보기
Lu, Wen-Ning, Lü, Shuang-Hong, Wang, Hai-Bin, Li, De-Xue, Duan, Cui-Mi, Liu, Zhi-Qiang, Hao, Tong, He, Wen-Jun, Xu, Bin, Fu, Qiang, Song, Ying C., Xie, Xiao-Hua, Wang, Chang-Yong. Functional Improvement of Infarcted Heart by Co-Injection of Embryonic Stem Cells with Temperature-Responsive Chitosan Hydrogel. Tissue engineering. Part A, vol.15, no.6, 1437-1447.

상세보기
Rask, Fiona, Dallabrida, Susan M., Ismail, Nesreen S., Amoozgar, Zohreh, Yeo, Yoon, Rupnick, Maria A., Radisic, Milica. Photocrosslinkable chitosan modified with angiopoietin‐1 peptide, QHREDGS, promotes survival of neonatal rat heart cells. Journal of biomedical materials research. Part A, vol.a95, no.1, 105-117.

상세보기
Garbern, J.C., Minami, E., Stayton, P.S., Murry, C.E.. Delivery of basic fibroblast growth factor with a pH-responsive, injectable hydrogel to improve angiogenesis in infarcted myocardium. Biomaterials, vol.32, no.9, 2407-2416.

상세보기
Suuronen, Erik J., Veinot, John P., Wong, Serena, Kapila, Varun, Price, Joel, Griffith, May, Mesana, Thierry G., Ruel, Marc. Tissue-Engineered Injectable Collagen-Based Matrices for Improved Cell Delivery and Vascularization of Ischemic Tissue Using CD133 ⁺ Progenitors Expanded From the Peripheral Blood. Circulation, vol.114, no.1,

상세보기
Zhang, Yan, Thorn, Stephanie, DaSilva, Jean N., Lamoureux, Marc, deKemp, Robert A., Beanlands, Rob S., Ruel, Marc, Suuronen, Erik J.. Collagen-Based Matrices Improve the Delivery of Transplanted Circulating Progenitor Cells : Development and Demonstration by Ex Vivo Radionuclide Cell Labeling and In Vivo Tracking With Positron-Emission Tomography. Circulation. Cardiovascular imaging, vol.1, no.3, 197-204.

상세보기
Wu, J., Zeng, F., Huang, X.P., Chung, J.C.Y., Konecny, F., Weisel, R.D., Li, R.K.. Infarct stabilization and cardiac repair with a VEGF-conjugated, injectable hydrogel. Biomaterials, vol.32, no.2, 579-586.

상세보기
Deng, Chao, Zhang, Pingchuan, Vulesevic, Branka, Kuraitis, Drew, Li, Fengfu, Yang, Ann Fook, Griffith, May, Ruel, Marc, Suuronen, Erik J.. A Collagen-Chitosan Hydrogel for Endothelial Differentiation and Angiogenesis. Tissue engineering. Part A, vol.16, no.10, 3099-3109.

상세보기
Fujita, Masanori, Ishihara, Masayuki, Morimoto, Yuji, Simizu, Masafumi, Saito, Yoshio, Yura, Hirofumi, Matsui, Takemi, Takase, Bonpei, Hattori, Hidemi, Kanatani, Yasuhiro, Kikuchi, Makoto, Maehara, Tadaaki. Efficacy of Photocrosslinkable Chitosan Hydrogel Containing Fibroblast Growth Factor-2 in a Rabbit Model of Chronic Myocardial Infarction. The Journal of surgical research, vol.126, no.1, 27-33.

상세보기
Reis, L.A., Chiu, L.L.Y., Liang, Y., Hyunh, K., Momen, A., Radisic, M.. A peptide-modified chitosan-collagen hydrogel for cardiac cell culture and delivery. Acta Biomaterialia: structure-property-function relationships in biomaterials, vol.8, no.3, 1022-1036.

상세보기
Tan, Wei, Krishnaraj, Raj, Desai, Tejal A.. Evaluation of Nanostructured Composite Collagen-Chitosan Matrices for Tissue Engineering. Tissue engineering, vol.7, no.2, 203-210.

상세보기
Chiu, Loraine L., Y.. Cardiac tissue engineering: current state and perspectives. Frontiers in bioscience (Landmark edition), vol.17, no.4, 1533-.

상세보기
In: Cardiac Regeneration & Repair Volume II: Biomaterials & Tissue Engineering Reis LA 528 2014 1 Reis LA, Chiu LLY, Feric N, Fu L, Radisic M. Injectable biomaterials for cardiac repair. , Li R-K, Weisel RDIn: Cardiac Regeneration & Repair Volume II: Biomaterials & Tissue Engineering. 1st ed. Cambridge, UK: Woodhead Publishing Ltd; 2014:528.
Hayes, A.J., Huang, W.Q., Mallah, J., Yang, D., Lippman, M.E., Li, L.Y.. Angiopoietin-1 and Its Receptor Tie-2 Participate in the Regulation of Capillary-like Tubule Formation and Survival of Endothelial Cells. Microvascular research, vol.58, no.3, 224-237.

상세보기
Kim, Injune, Kim, Hwan Gyu, So, June-No, Kim, Joo Heon, Kwak, Hee Jin, Koh, Gou Young. Angiopoietin-1 Regulates Endothelial Cell Survival Through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway. Circulation research : a journal of the American Heart Association, vol.86, no.1, 24-29.

상세보기
Papapetropoulos, Andreas, Fulton, David, Mahboubi, Keyvan, Kalb, Robert G., O'Connor, Daniel S., Li, Fengzhi, Altieri, Dario C., Sessa, William C.. Angiopoietin-1 Inhibits Endothelial Cell Apoptosis via the Akt/Survivin Pathway. The Journal of biological chemistry, vol.275, no.13, 9102-9105.

상세보기
Carlson, Timothy R., Feng, Yuezhong, Maisonpierre, Peter C., Mrksich, Milan, Morla, Alex O.. Direct Cell Adhesion to the Angiopoietins Mediated by Integrins. The Journal of biological chemistry, vol.276, no.28, 26516-26525.

상세보기
Dallabrida, Susan M., Ismail, Nesreen, Oberle, Julianne R., Himes, Blanca E., Rupnick, Maria A.. Angiopoietin-1 Promotes Cardiac and Skeletal Myocyte Survival Through Integrins. Circulation research : a journal of the American Heart Association, vol.96, no.4,

상세보기
Rask, Fiona, Mihic, Anton, Reis, Lewis, Dallabrida, Susan M., Ismail, Nesreen S., Sider, Krista, Simmons, Craig. A., Rupnick, Maria A., Weisel, Richard D., Li, Ren-Ke, Radisic, Milica. Hydrogels modified with QHREDGS peptide support cardiomyocyte survival in vitro and after sub-cutaneous implantation. Soft matter, vol.6, no.20, 5089-5099.

상세보기
Odedra, D., Chiu, L.L.Y., Shoichet, M., Radisic, M.. Endothelial cells guided by immobilized gradients of vascular endothelial growth factor on porous collagen scaffolds. Acta Biomaterialia: structure-property-function relationships in biomaterials, vol.7, no.8, 3027-3035.

상세보기
Chiu, Loraine L.Y., Weisel, Richard D., Li, Ren-Ke, Radisic, Milica. Defining conditions for covalent immobilization of angiogenic growth factors onto scaffolds for tissue engineering. Journal of tissue engineering and regenerative medicine, vol.5, no.1, 69-84.

상세보기
Chiu, Loraine L. Y., Radisic, Milica, Vunjak‐Novakovic, Gordana. Bioactive Scaffolds for Engineering Vascularized Cardiac Tissues. Macromolecular bioscience, vol.10, no.11, 1286-1301.

상세보기
Fan, Vivian H., Au, Ada, Tamama, Kenichi, Littrell, Romie, Richardson, Llewellyn B., Wright, John W., Wells, Alan, Griffith, Linda G.. Tethered Epidermal Growth Factor Provides a Survival Advantage to Mesenchymal Stem Cells. Stem cells^®, vol.25, no.5, 1241-1251.

상세보기
Shen, Y.H., Shoichet, M.S., Radisic, M.. Vascular endothelial growth factor immobilized in collagen scaffold promotes penetration and proliferation of endothelial cells. Acta Biomaterialia: structure-property-function relationships in biomaterials, vol.4, no.3, 477-489.

상세보기
Am J Physiol Patten RD H1812 274 5 1998 Ventricular remodeling in a mouse model of myocardial infarction. Patten RD, Aronovitz MJ, Deras-Mejia L, Pandian NG, Hanak GG, Smith JJ, Mendelsohn ME, Konstam MA. Ventricular remodeling in a mouse model of myocardial infarction. Am J Physiol. 1998;274(5 Pt 2):H1812-H1820.
Krzeminski, T.F., Nozynski, J.K., Grzyb, J., Porc, M.. Wide-spread myocardial remodeling after acute myocardial infarction in rat. Features for heart failure progression. Vascular pharmacology, vol.48, no.2, 100-108.

상세보기
Li, Zhenqing, Guan, Jianjun. Hydrogels for Cardiac Tissue Engineering. Polymers, vol.3, no.4, 740-761.

상세보기
Kan, C.D., Li, S.H., Weisel, R.D., Zhang, S., Li, R.K.. Recipient Age Determines the Cardiac Functional Improvement Achieved by Skeletal Myoblast Transplantation. Journal of the American College of Cardiology, vol.50, no.11, 1086-1092.

상세보기
Matsubayashi, Keiji, Fedak, Paul W.M., Mickle, Donald A.G., Weisel, Richard D., Ozawa, Tsukasa, Li, Ren-Ke. Improved Left Ventricular Aneurysm Repair With Bioengineered Vascular Smooth Muscle Grafts. Circulation, vol.108, no.suppl1,

상세보기
Fan, Ming, Chen, Wei, Liu, Wei, Du, Guo-Qing, Jiang, Shu-Lin, Tian, Wei-Chen, Sun, Lu, Li, Ren-Ke, Tian, Hai. The Effect of Age on the Efficacy of Human Mesenchymal Stem Cell Transplantation after a Myocardial Infarction. Rejuvenation research, vol.13, no.4, 429-438.

상세보기
Dang, L.T.H., Feric, N.T., Laschinger, C., Chang, W.Y., Zhang, B., Wood, G.A., Stanford, W.L., Radisic, M.. Inhibition of apoptosis in human induced pluripotent stem cells during expansion in a defined culture using angiopoietin-1 derived peptide QHREDGS. Biomaterials, vol.35, no.27, 7786-7799.

상세보기
Principles of Regenerative Medicine Atala A 2008 Atala A, Lanza R, Thomson JA, Nerem RMPrinciples of Regenerative Medicine. Amsterdam: Elsevier; 2008.
Feric, Nicole T., Cheng, Calvin C. H., Goh, M. Cynthia, Dudnyk, Vyacheslav, Di Tizio, Val, Radisic, Milica. Angiopoietin-1 peptide QHREDGS promotes osteoblast differentiation, bone matrix deposition and mineralization on biomedical materials. Biomaterials science, vol.2, no.10, 1384-1398.

상세보기
Bouten, C.V.C., Dankers, P.Y.W., Driessen-Mol, A., Pedron, S., Brizard, A.M.A., Baaijens, F.P.T.. Substrates for cardiovascular tissue engineering. Advanced drug delivery reviews, vol.63, no.4, 221-241.

상세보기
10.1007/10_2011_119
Ruggiero, Alessandro, Thorek, Daniel L. J., Guenoun, Jamal, Krestin, Gabriel P., Bernsen, Monique R.. Cell tracking in cardiac repair: what to image and how to image. European radiology, vol.22, no.1, 189-204.

상세보기
Yamaoka, Tetsuji, Tabata, Yasuhiko, Ikada, Yoshito. Body distribution profile of polysaccharides after intravenous administration. Drug delivery, vol.1, no.1, 75-82.

상세보기
Onishi, Hiraku, Machida, Yoshiharu. Biodegradation and distribution of water-soluble chitosan in mice. Biomaterials, vol.20, no.2, 175-182.

상세보기
Takemura, Genzou, Fujiwara, Hisayoshi. Role of apoptosis in remodeling after myocardial infarction. Pharmacology & therapeutics, vol.104, no.1, 1-16.

상세보기
Lang, R.M., Bierig, M., Devereux, R.B., Flachskampf, F.A., Foster, E., Pellikka, P.A., Picard, M.H., Roman, M.J., Seward, J., Shanewise, J., Solomon, S., Spencer, K.T., St. John Sutton, M., Stewart, W.. Recommendations for chamber quantification. European journal of echocardiography : journal of the Working Group on Echocardiography of the European Society of Cardiology, vol.7, no.2, 79-108.

상세보기
Venugopal, Jayarama Reddy, Prabhakaran, Molamma P., Mukherjee, Shayanti, Ravichandran, Rajeswari, Dan, Kai, Ramakrishna, Seeram. Biomaterial strategies for alleviation of myocardial infarction. Journal of the Royal Society, Interface, vol.9, no.66, 1-19.

상세보기
Van Slyke, Paul, Alami, Jennifer, Martin, Daniel, Kuliszewski, Michael, Leong-Poi, Howard, Sefton, Michael V., Dumont, Dan. Acceleration of Diabetic Wound Healing by an Angiopoietin Peptide Mimetic. Tissue engineering. Part A, vol.15, no.6, 1269-1280.

상세보기
Miklas, Jason W., Dallabrida, Susan M., Reis, Lewis A., Ismail, Nesreen, Rupnick, Maria, Radisic, Milica. QHREDGS Enhances Tube Formation, Metabolism and Survival of Endothelial Cells in Collagen-Chitosan Hydrogels. PloS one, vol.8, no.8, e72956-.

상세보기
Ahmad, Shakil, Cudmore, Melissa J., Wang, Keqing, Hewett, Peter, Potluri, Rahul, Fujisawa, Takeshi, Ahmed, Asif. Angiopoietin-1 Induces Migration of Monocytes in a Tie-2 and Integrin-Independent Manner. Hypertension, vol.56, no.3, 477-483.

상세보기

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