[논문]Long-Lasting Reduction of Blood Pressure by Electroacupuncture in Patients with Hypertension: Randomized Controlled Trial

Li, Peng; Tjen-A-Looi, Stephanie C.; Cheng, Ling; Liu, Dongmei; Painovich, Jeannette; Vinjamury, Sivarama; Longhurst, John C.

doi:10.1089/acu.2015.1106

[해외논문] Long-Lasting Reduction of Blood Pressure by Electroacupuncture in Patients with Hypertension: Randomized Controlled Trial 원문보기

Medical acupuncture, v.27 no.4, 2015년, pp.253 - 266

Li, Peng (Susan-Samueli Center for Integrative Medicine, University of California , Irvine, School of Medicine, Irvine, CA.) , Tjen-A-Looi, Stephanie C. (Susan-Samueli Center for Integrative Medicine, University of California , Irvine, School of Medicine, Irvine, CA.) , Cheng, Ling (East Hospital , Shanghai, China .) , Liu, Dongmei (Susan-Samueli Center for Integrative Medicine, University of California , Irvine, School of Medicine, Irvine, CA.) , Painovich, Jeannette (Susan-Samueli Center for Integrative Medicine, University of California , Irvine, School of Medicine, Irvine, CA.) , Vinjamury, Sivarama (Southern California University of Health Sciences , Whittier, CA.) , Longhurst, John C. (Susan-Samueli Center for Integrative Medicine, University of California , Irvine, School of Medicine, Irvine, CA.)

Abstract ▼ AI-Helper

AbstractBackground: Acupuncture at specific acupoints has experimentally been found to reduce chronically elevated blood pressure.Objective: To examine effectiveness of electroacupuncture (EA) at select acupoints to reduce systolic blood pressure (SBP) and diastolic blood pressures (DBP) in hypertensive patients.Design: Two-arm parallel study.Patients: Sixty-five hypertensive patients not receiving medication were assigned randomly to one of the two acupuncture intervention (33 versus 32 patients).Intervention: Patients were assessed with 24-hour ambulatory blood pressure monitoring. They were treated with 30-minutes of EA at PC 5-6+ST 36-37 or LI 6-7+GB 37-39 once weekly for 8 weeks. Four acupuncturists provided single-blinded treatment.Main outcome measures: Primary outcomes measuring effectiveness of EA were peak and average SBP and DBP. Secondary outcomes examined underlying mechanisms of acupuncture with plasma norepinephrine, renin, and aldosterone before and after 8 weeks of treatment. Outcomes were obtained by double-blinded evaluation.Results: After 8 weeks, 33 patients treated with EA at PC 5-6+ST 36-37 had decreased peak and average SBP and DBP, compared with 32 patients treated with EA at LI 6-7+GB 37-39 control acupoints. Changes in blood pressures significantly differed between the two patient groups. In 14 patients, a long-lasting blood pressure–lowering acupuncture effect was observed for an additional 4 weeks of EA at PC 5-6+ST 36-37. After treatment, the plasma concentration of norepinephrine, which was initially elevated, was decreased by 41%; likewise, renin was decreased by 67% and aldosterone by 22%.Conclusions: EA at select acupoints reduces blood pressure. Sympathetic and renin-aldosterone systems were likely related to the long-lasting EA actions.

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[해외논문] Long-Lasting Reduction of Blood Pressure by Electroacupuncture in Patients with Hypertension: Randomized Controlled Trial 원문보기

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