van den Broeke, Emanuel N.
(Department of Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands)
,
van Heck, Casper H.
,
Ceelen, Linda A. J. M.
(Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands)
,
van Rijn, Clementina M.
(and)
,
van Goor, Harry
(Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands)
,
Wilder-Smith, Oliver H. G.
(and)
High-frequency conditioning electrical stimulation (HFS) of human skin induces an increased pain sensitivity to mechanical stimuli in the surrounding nonconditioned skin. The aim of this study was to investigate the effect of HFS on reported pain sensitivity to single electrical stimuli applied wit...
High-frequency conditioning electrical stimulation (HFS) of human skin induces an increased pain sensitivity to mechanical stimuli in the surrounding nonconditioned skin. The aim of this study was to investigate the effect of HFS on reported pain sensitivity to single electrical stimuli applied within the area of conditioning stimulation. We also investigated the central nervous system responsiveness to these electrical stimuli by measuring event-related potentials (ERPs). Single electrical test stimuli were applied in the conditioned area before and 30 min after HFS. During electrical test stimulation, the reported pain intensity (numerical rating scale) and EEG (ERPs) were measured. Thirty minutes after conditioning stimulation, we observed a decrease of reported pain intensity at both the conditioned and control (opposite arm) skin site in response to the single electrical test stimuli. In contrast, we observed enhanced ERP amplitudes after HFS at the conditioned skin site, compared with control site, in response to the single electrical test stimuli. Recently, it has been proposed that ERPs, at least partly, reflect a saliency detection system. Therefore, the enhanced ERPs might reflect enhanced saliency to potentially threatening stimuli.
High-frequency conditioning electrical stimulation (HFS) of human skin induces an increased pain sensitivity to mechanical stimuli in the surrounding nonconditioned skin. The aim of this study was to investigate the effect of HFS on reported pain sensitivity to single electrical stimuli applied within the area of conditioning stimulation. We also investigated the central nervous system responsiveness to these electrical stimuli by measuring event-related potentials (ERPs). Single electrical test stimuli were applied in the conditioned area before and 30 min after HFS. During electrical test stimulation, the reported pain intensity (numerical rating scale) and EEG (ERPs) were measured. Thirty minutes after conditioning stimulation, we observed a decrease of reported pain intensity at both the conditioned and control (opposite arm) skin site in response to the single electrical test stimuli. In contrast, we observed enhanced ERP amplitudes after HFS at the conditioned skin site, compared with control site, in response to the single electrical test stimuli. Recently, it has been proposed that ERPs, at least partly, reflect a saliency detection system. Therefore, the enhanced ERPs might reflect enhanced saliency to potentially threatening stimuli.
참고문헌 (19)
Beissner, Florian, Brandau, Amadeus, Henke, Christian, Felden, Lisa, Baumgärtner, Ulf, Treede, Rolf-Detlef, Oertel, Bruno G., Lötsch, Jörn.
Quick Discrimination of A delta and C Fiber Mediated Pain Based on Three Verbal Descriptors.
PloS one,
vol.5,
no.9,
e12944-.
Boyle, Y., El-Deredy, W., Martinez Montes, E., Bentley, D.E., Jones, A.K.P..
Selective modulation of nociceptive processing due to noise distraction.
Pain,
vol.138,
no.3,
630-640.
Dowman, R..
SEP topographies elicited by innocuous and noxious sural nerve stimulation. II. Effects of stimulus intensity on topographic pattern and amplitude.
Electroencephalography and clinical neurophysiology, Evoked potentials,
vol.92,
no.4,
303-315.
Gratton, G., Coles, M.G.H., Donchin, E..
A new method for off-line removal of ocular artifact.
Electroencephalography and clinical neurophysiology,
vol.55,
no.4,
468-484.
Hansen, Niels, Klein, Thomas, Magerl, Walter, Treede, Rolf-Detlef.
Psychophysical Evidence for Long-Term Potentiation of C-Fiber and Aδ-Fiber Pathways in Humans by Analysis of Pain Descriptors.
Journal of neurophysiology,
vol.97,
no.3,
2559-2563.
Klein, Thomas, Magerl, Walter, Hopf, Hanns-Christian, Sandkühler, Jürgen, Treede, Rolf-Detlef.
Perceptual Correlates of Nociceptive Long-Term Potentiation and Long-Term Depression in Humans.
The Journal of neuroscience : the official journal of the Society for Neuroscience,
vol.24,
no.4,
964-971.
Klein, T., Stahn, S., Magerl, W., Treede, R.D..
The role of heterosynaptic facilitation in long-term potentiation (LTP) of human pain sensation.
Pain,
vol.139,
no.3,
507-519.
Lang, S., Klein, T., Magerl, W., Treede, R.D..
Modality-specific sensory changes in humans after the induction of long-term potentiation (LTP) in cutaneous nociceptive pathways.
Pain,
vol.128,
no.3,
254-263.
Legrain, Valéry, Iannetti, Gian Domenico, Plaghki, Léon, Mouraux, André.
The pain matrix reloaded : A salience detection system for the body.
Progress in neurobiology,
vol.93,
no.1,
111-124.
Pfau, D.B., Klein, T., Putzer, D., Pogatzki-Zahn, E.M., Treede, R.D., Magerl, W..
Analysis of hyperalgesia time courses in humans after painful electrical high-frequency stimulation identifies a possible transition from early to late LTP-like pain plasticity.
Pain,
vol.152,
no.7,
1532-1539.
Rankin, Catharine H., Abrams, Thomas, Barry, Robert J., Bhatnagar, Seema, Clayton, David F., Colombo, John, Coppola, Gianluca, Geyer, Mark A., Glanzman, David L., Marsland, Stephen, McSweeney, Frances K., Wilson, Donald A., Wu, Chun-Fang, Thompson, Richard F..
Habituation revisited: An updated and revised description of the behavioral characteristics of habituation.
Neurobiology of learning and memory,
vol.92,
no.2,
135-138.
Sandkühler, J., Chen, J. G., Cheng, G., Randić, M..
Low-Frequency Stimulation of Afferent Aδ-Fibers Induces Long-Term Depression at Primary Afferent Synapses with Substantia Gelatinosa Neurons in the Rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience,
vol.17,
no.16,
6483-6491.
van den Broeke , Emanuel N, van Heck, Casper H, van Rijn, Clementina M, Wilder-Smith , Oliver HG.
Neural correlates of heterotopic facilitation induced after high frequency electrical stimulation of nociceptive pathways.
Molecular pain,
vol.7,
28-28.
van den Broeke, Emanuel N., van Rijn, Clementina M., Biurrun Manresa, José A., Andersen, Ole K., Arendt-Nielsen, Lars, Wilder-Smith, Oliver H. G..
Neurophysiological Correlates of Nociceptive Heterosynaptic Long-Term Potentiation in Humans.
Journal of neurophysiology,
vol.103,
no.4,
2107-2113.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.