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Evidence-based Complementary and Alternative Medicine : eCAM, v.2014, 2014년, pp.289264 -
Li, Zheng (Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China) , Geng, Ya-Na (Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China) , Jiang, Jian-Dong (State Key Laboratory of Bioactive Natural Products and Function, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China) , Kong, Wei-Jia (Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China)
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Oxidative stress and inflammation are proved to be critical for the pathogenesis of diabetes mellitus. Berberine (BBR) is a natural compound isolated from plants such as Coptis chinensis and Hydrastis canadensis and with multiple pharmacological activities. Recent studies showed that BBR had antioxi...
1 Evans JL Maddux BA Goldfine ID The molecular basis for oxidative stress-induced insulin resistance Antioxidants and Redox Signaling 2005 7 7-8 1040 1052 2-s2.0-22044443268 15998259
2 Donath MY Shoelson SE Type 2 diabetes as an inflammatory disease Nature Reviews Immunology 2011 11 2 98 107 2-s2.0-79151478555
3 Furukawa S Fujita T Shimabukuro M Increased oxidative stress in obesity and its impact on metabolic syndrome The Journal of Clinical Investigation 2004 114 12 1752 1761 2-s2.0-15244342531 15599400
4 Bonnefont-Rousselot D Glucose and reactive oxygen species Current Opinion in Clinical Nutrition and Metabolic Care 2002 5 5 561 568 2-s2.0-0036725547 12172481
5 Alberici LC Vercesi AE Oliveira HCF Mitochondrial energy metabolism and redox responses to hypertriglyceridemia Journal of Bioenergetics and Biomembranes 2011 43 1 19 23 2-s2.0-79952311179 21258853
6 Rösen P Nawroth PP King G Möller W Tritschler H-J Packer L The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a congress series sponsored by UNESCO-MCBN, the American diabetes association and the German diabetes society Diabetes/Metabolism Research and Reviews 2001 17 3 189 212 2-s2.0-0034939115 11424232
7 Evans JL Goldfine ID Maddux BA Grodsky GM Are oxidative stress—activated signaling pathways mediators of insulin resistance and β -cell dysfunction? Diabetes 2003 52 1 1 8 2-s2.0-0037219409 12502486
8 Kaneto H Xu G Fujii N Kim S Bonner-Weir S Weir GC Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression Journal of Biological Chemistry 2002 277 33 30010 30018 2-s2.0-0037119417 12011047
9 Scivittaro V Ganz MB Weiss MF AGEs induce oxidative stress and activate protein kinase C- β (II) in neonatal mesangial cells American Journal of Physiology 2000 278 4 F676 F683 2-s2.0-0033996388 10751230
10 Goldin A Beckman JA Schmidt AM Creager MA Advanced glycation end products: sparking the development of diabetic vascular injury Circulation 2006 114 6 597 605 2-s2.0-33746920337 16894049
11 Xie W Du L Diabetes is an inflammatory disease: evidence from traditional Chinese medicines Diabetes, Obesity and Metabolism 2011 13 4 289 301 2-s2.0-79951931336
12 Crook M Type 2 diabetes mellitus: a disease of the innate immune system? An update Diabetic Medicine 2004 21 3 203 207 2-s2.0-1542344902 15008827
13 Donath MY Targeting inflammation in the treatment of type 2 diabetes Diabetes, Obesity and Metabolism 2013 15 supplement 3 193 196
14 Gratas-Delamarche A Derbré F Vincent S Cillard J Physical inactivity, insulin resistance, and the oxidative-inflammatory loop Free Radical Research 2014 48 1 93 108 24060092
15 Mahmoud F Al-Ozairi E Inflammatory cytokines and the risk of cardiovascular complications in type 2 diabetes Disease Markers 2013 35 4 235 241 24167372
16 Patel PS Buras ED Balasubramanyam A The role of the immune system in obesity and insulin resistance Journal of Obesity 2013 616193
17 Hung H-Y Qian K Morris-Natschke SL Hsu C-S Lee K-H Recent discovery of plant-derived anti-diabetic natural products Natural Product Reports 2012 29 5 580 606 2-s2.0-84859868815 22491825
18 Yin J Zhang H Ye J Traditional Chinese medicine in treatment of metabolic syndrome Endocrine, Metabolic and Immune Disorders 2008 8 2 99 111 2-s2.0-47249158048
19 Yao J Kong W Jiang J Learning from berberine: treating chronic diseases through multiple targets Science China Life Science 2013
20 Yin J Ye J Jia W Effects and mechanisms of berberine in diabetes treatment Acta Pharmaceutica Sinica B 2012 2 4 327 334
21 Zhang M Chen L Berberine in type 2 diabetes therapy: a new perspective for an old antidiarrheal drug Acta Pharmaceutica Sinica B 2012 2 4 379 386,
22 Liu Y Zhang L Song H Ji G Update on berberine in nonalcoholic Fatty liver disease Evidence-Based Complementary and Alternative Medicine 2013 2013 8 pages 308134
23 Dong H Wang N Zhao L Lu F Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis Evidence-Based Complementary and Alternative Medicine 2012 2012 12 pages 591654
24 Zhang H Wei J Xue R Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression Metabolism 2010 59 2 285 292 2-s2.0-74049139484 19800084
25 Kong W-J Zhang H Song D-Q Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression Metabolism 2009 58 1 109 119 2-s2.0-57049090579 19059538
26 Zhang H Kong W-J Shan Y-Q Protein kinase D activation stimulates the transcription of the insulin receptor gene Molecular and Cellular Endocrinology 2010 330 1-2 25 32 2-s2.0-77957667482 20674666
27 Liu W-H Hei Z-Q Nie H Berberine ameliorates renal injury in streptopzotocin-induced diabetic rats by suppression of both oxidative stress and aldose reductase Chinese Medical Journal 2008 121 8 706 712 2-s2.0-51149101181 18701023
28 Xie X Chang X Chen L Berberine ameliorates experimental diabetes-induced renal inflammation and fibronectin by inhibiting the activation of RhoA/ROCK signaling Molecular and Cellular Endocrinology 2013 381 56 65 23896433
29 Zhou J-Y Zhou S-W Protective effect of berberine on antioxidant enzymes and positive transcription elongation factor b expression in diabetic rat liver Fitoterapia 2011 82 2 184 189 2-s2.0-79952362196 20828602
30 Lao-ong T Chatuphonprasert W Nemoto N Jarukamjorn K Alteration of hepatic glutathione peroxidase and superoxide dismutase expression in streptozotocin-induced diabetic mice by berberine Pharmaceutical Biology 2012 50 8 1007 1012 22775417
31 Wang Y Campbell T Perry B Beaurepaire C Qin L Hypoglycemic and insulin-sensitizing effects of berberine in high-fat diet- and streptozotocin-induced diabetic rats Metabolism 2011 60 2 298 305 2-s2.0-78751647742 20304443
32 Chatuphonprasert W Lao-Ong T Jarukamjorn K Improvement of superoxide dismutase and catalase in streptozotocin-nicotinamide-induced type 2-diabetes in mice by berberine and glibenclamide Pharmaceutical Biology 2013
33 Wu D Wen W Qi C-L Ameliorative effect of berberine on renal damage in rats with diabetes induced by high-fat diet and streptozotocin Phytomedicine 2012 19 8-9 712 718 2-s2.0-84859168971 22483555
34 Zhou J Zhou S Tang J Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats European Journal of Pharmacology 2009 606 1–3 262 268 2-s2.0-60949108484 19374872
35 Tang L-Q Wei W Chen L-M Liu S Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats Journal of Ethnopharmacology 2006 108 1 109 115 2-s2.0-33749327046 16759828
36 Bhutada P Mundhada Y Bansod K Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes Behavioural Brain Research 2011 220 1 30 41 2-s2.0-79952758240 21262264
37 Moghaddam HK Baluchnejadmojarad T Roghani M Berberine ameliorate oxidative stress and astrogliosis in the hippocampus of STZ-induced diabetic rats Molecular Neurobiology 2013
38 Liu W Liu P Tao S Berberine inhibits aldose reductase and oxidative stress in rat mesangial cells cultured under high glucose Archives of Biochemistry and Biophysics 2008 475 2 128 134 2-s2.0-44949179681 18471986
39 Del Rio D Stewart AJ Pellegrini N A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress Nutrition, Metabolism and Cardiovascular Diseases 2005 15 4 316 328 2-s2.0-23944478990
40 Ceballos-Picot I Witko-Sarsat V Merad-Boudia M Glutathione antioxidant system as a marker of oxidative stress in chronic renal failure Free Radical Biology and Medicine 1996 21 6 845 853 2-s2.0-0037839029 8902530
41 Maritim AC Sanders RA Watkins JB III Diabetes, oxidative stress, and antioxidants: a review Journal of Biochemical and Molecular Toxicology 2003 17 1 24 38 2-s2.0-0037253073 12616644
42 Choi B-H Ahn I-S Kim Y-H Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte Experimental and Molecular Medicine 2006 38 6 599 605 2-s2.0-33846185097 17202835
43 Lou T Zhang Z Xi Z Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes Inflammation 2011 34 6 659 667 2-s2.0-82955235212 21110076
44 Jeong HW Hsu KC Lee J-W Berberine suppresses proinflammatory responses through AMPK activation in macrophages American Journal of Physiology - Endocrinology and Metabolism 2009 296 4 E955 E964 2-s2.0-65649108647 19208854
45 Lin W-C Lin J-Y Five bitter compounds display different anti-inflammatory effects through modulating cytokine secretion using mouse primary splenocytes in vitro Journal of Agricultural and Food Chemistry 2011 59 1 184 192 2-s2.0-78651085721 21155568
46 Wang Y Attenuation of berberine on lipopolysaccharide-induced inflammatory and apoptosis responses in β -cells via TLR4-independent JNK/NF- κ B pathway Pharmaceutical Biology 2013
47 Shang W Liu J Yu X Zhao J Effects of berberine on serum levels of inflammatory factors and inflammatory signaling pathway in obese mice induced by high fat diet Zhongguo Zhongyao Zazhi 2010 35 11 1474 1477 2-s2.0-77956108839 20822024
48 Chen Y Wang Y Zhang J Sun C Lopez A Berberine improves glucose homeostasis in streptozotocin-induced diabetic rats in association with multiple factors of insulin resistance ISRN Endocrinology 2011 2011 519371
49 Xing L-J Zhang L Liu T Hua Y-Q Zheng P-Y Ji G Berberine reducing insulin resistance by up-regulating IRS-2 mRNA expression in nonalcoholic fatty liver disease (NAFLD) rat liver European Journal of Pharmacology 2011 668 3 467 471 2-s2.0-80053572802 21839075
50 Cui G Qin X Zhang Y Gong Z Ge B Zang YQ Berberine differentially modulates the activities of ERK, p38 MAPK, and JNK to suppress Th17 and Th1 T cell differentiation in type 1 diabetic mice Journal of Biological Chemistry 2009 284 41 28420 28429 2-s2.0-70350518829 19661066
51 Chueh W-H Lin J-Y Protective effect of isoquinoline alkaloid berberine on spontaneous inflammation in the spleen, liver and kidney of non-obese diabetic mice through downregulating gene expression ratios of pro-/anti-inflammatory and Th1/Th2 cytokines Food Chemistry 2012 131 4 1263 1271 2-s2.0-81855221952
52 Majithiya JB Balaraman R Time-dependent changes in antioxidant enzymes and vascular reactivity of aorta in streptozotocin-induced diabetic rats treated with curcumin Journal of Cardiovascular Pharmacology 2005 46 5 697 705 2-s2.0-27344449941 16220078
53 Hill C Flyvbjerg A Grønbæk H The renal expression of transforming growth factor- β isoforms and their receptors in acute and chronic experimental diabetes in rats Endocrinology 2000 141 3 1196 1208 2-s2.0-0034465487 10698197
54 Mulder H Ahrén B Sundler F Islet amyloid polypeptide (amylin) and insulin are differentially expressed in chronic diabetes induced by streptozotocin in rats Diabetologia 1996 39 6 649 657 2-s2.0-0029951865 8781760
55 Shirwaikar A Shirwaikar A Rajendran K Punitha ISR In vitro antioxidant studies on the benzyl tetra isoquinoline alkaloid berberine Biological and Pharmaceutical Bulletin 2006 29 9 1906 1910 2-s2.0-33748362019 16946507
56 Zhu X Guo X Mao G Hepatoprotection of berberine against hydrogen peroxide-induced apoptosis by upregulation of Sirtuin 1 Phytotherapy Research 2013 27 3 417 421 22628222
57 Salminen A Kaarniranta K Kauppinen A Crosstalk between oxidative stress and SIRT1: impact on the aging process International Journal of Molecular Sciences 2013 14 2 3834 3859 23434668
58 van der Horst A Tertoolen LGJ De Vries-Smits LMM Frye RA Medema RH Burgering BMT FOXO 4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir SIRT 1 The Journal of Biological Chemistry 2004 279 28 28873 28879 2-s2.0-3142742707 15126506
59 Sarna LK Wu N Hwang S-Y Siow YL Karmin O Berberine inhibits NADPH oxidase mediated superoxide anion production in macrophages Canadian Journal of Physiology and Pharmacology 2010 88 3 369 378 2-s2.0-77950900334 20393601
60 Cheng F Wang Y Li J Berberine improves endothelial function by reducing endothelial microparticles-mediated oxidative stress in humans International Journal of Cardiology 2013 167 3 936 942 22465347
61 Gray SP Di Marco E Okabe J NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis Circulation 2013 127 18 1888 1902 23564668
62 Li J-M Shah AM ROS generation by nonphagocytic NADPH oxidase: potential relevance in diabetic nephropathy Journal of the American Society of Nephrology 2003 14 supplement 3 S221 S226 2-s2.0-0041865372 12874435
63 Eid AA Ford BM Block K AMP-activated Protein Kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes The Journal of Biological Chemistry 2010 285 48 37503 37512 2-s2.0-78549248891 20861022
64 Wang S Zhang M Liang B AMPK α 2 Deletion causes aberrant expression and activation of NAD(P)H Oxidase and consequent endothelial dysfunction in vivo : role of 26S proteasomes Circulation Research 2010 106 6 1117 1128 2-s2.0-77950989801 20167927
65 Kukidome D Nishikawa T Sonoda K Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells Diabetes 2006 55 1 120 127 2-s2.0-33644749330 16380484
66 Xie Z Zhang J Wu J Viollet B Zou M-H Upregulation of mitochondrial uncoupling protein-2 by the AMP-Activated protein kinase in endothelial cells attenuates oxidative stress in diabetes Diabetes 2008 57 12 3222 3230 2-s2.0-58149358854 18835932
67 Wang Q Zhang M Liang B Shirwany N Zhu Y Zou M-H Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2 PLoS ONE 2011 6 9 2-s2.0-80053196866 e25436
68 Nègre-Salvayre A Hirtz C Carrera G A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation The FASEB Journal 1997 11 10 809 815 2-s2.0-0038061012 9271366
69 Arsenijevic D Onuma H Pecqueur C Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production Nature Genetics 2000 26 4 435 439 2-s2.0-0033667705 11101840
70 Yang Q-H Hu S-P Zhang Y-P Effect of berberine on expressions of uncoupling protein-2 mRNA and protein in hepatic tissue of non-alcoholic fatty liver disease in rats Chinese Journal of Integrative Medicine 2011 17 3 205 211 2-s2.0-79952547920 21359922
71 de Souza BM Assmann TS Kliemann LM Gross JL Canani LH Crispim D The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications Arquivos Brasileiros de Endocrinologia e Metabologia 2011 55 4 239 248 2-s2.0-79960534188 21779625
72 Mo C Wang L Zhang J The crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice Antioxidants & Redox Signaling 2013
73 Hsu Y-Y Chen C-S Wu S-N Jong Y-J Lo Y-C Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cells European Journal of Pharmaceutical Sciences 2012 46 5 415 425 2-s2.0-84859389458 22469516
74 Hsu YY Tseng YT Lo YC Berberine, a natural antidiabetes drug, attenuates glucose neurotoxicity and promotes Nrf2-related neurite outgrowth Toxicology and Applied Pharmacology 2013 272 3 787 796 23954465
75 Bae J Lee D Kim YK Gil M Lee JY Lee KJ Berberine protects 6-hydroxydopamine-induced human dopaminergic neuronal cell death through the induction of heme oxygenase-1 Molecules and Cells 2013 35 2 151 157 23329300
76 Vomhof-Dekrey EE Picklo Sr MJ The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism Journal of Nutritional Biochemistry 2012 23 10 1201 1206 22819548
77 Zhang Y Li X Zou D Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine The Journal of Clinical Endocrinology and Metabolism 2008 93 7 2559 2565 2-s2.0-47549100864 18397984
78 Perreault M Marette A Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle Nature Medicine 2001 7 10 1138 1143 2-s2.0-0034770292
79 DuBois RN Abramson SB Crofford L Cyclooxygenase in biology and disease The FASEB Journal 1998 12 12 1063 1073 2-s2.0-0031689543 9737710
80 Mima A Inflammation and oxidative stress in diabetic nephropathy: new insights on its inhibition as new therapeutic targets Journal of Diabetes Research 2013 2013 8 pages 248563
81 Wang Q Qi J Hu R Chen Y Kijlstra A Yang P Effect of berberine on proinflammatory cytokine production by ARPE-19 cells following stimulation with tumor necrosis factor- α Investigative Ophthalmology & Visual Science 2012 53 4 2395 2402 22427564
82 Jia L Liu J Song Z Berberine suppresses amyloid-beta-induced inflammatory response in microglia by inhibiting nuclear factor-kappaB and mitogen-activated protein kinase signalling pathways Journal of Pharmcy and Pharmacology 2012 64 10 1510 1521
83 Lee D Bae J Kim YK Inhibitory effects of berberine on lipopolysaccharide-induced inducible nitric oxide synthase and the high-mobility group box 1 release in macrophages Biochemical and Biophysical Research Communications 2013 431 3 506 511 23333393
84 Cheng Z Pang T Gu M Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK Biochimica et Biophysica Acta 2006 1760 11 1682 1689 2-s2.0-33750519660 17049164
85 Zhou L Yang Y Wang X Berberine stimulates glucose transport through a mechanism distinct from insulin Metabolism 2007 56 3 405 412 2-s2.0-33846845952 17292731
86 Ndisang JF Role of heme oxygenase in inflammation, insulin-signalling, diabetes and obesity Mediators of Inflammation 2010 2010 2-s2.0-77953527349 359732
87 Son Y Lee JH Chung HT Pae HO Therapeutic roles of heme oxygenase-1 in metabolic diseases: curcumin and resveratrol analogues as possible Inducers of heme oxygenase-1 Oxidative Medicine and Cellular Longevity 2013 2013 12 pages 639541
88 Mercurio F Zhu H Murray BW IKK-1 and IKK-2: cytokine-activated I κ B kinases essential for NF- κ B activation Science 1997 278 5339 860 866 2-s2.0-0030685825 9346484
89 Karin M Positive and negative regulation of I κ B kinase activity through IKK β subunit phosphorylation Science 1999 284 5412 309 313 2-s2.0-0033537719 10195894
90 Yi P Lu F-E Xu L-J Chen G Dong H Wang K-F Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKK β World Journal of Gastroenterology 2008 14 6 876 883 2-s2.0-40149095921 18240344
91 Pandey MK Sung B Kunnumakkara AB Sethi G Chaturvedi MM Aggarwal BB Berberine modifies cysteine 179 of I κ B α kinase, suppresses nuclear factor- κ B-regulated antiapoptotic gene products, and potentiates apoptosis Cancer Research 2008 68 13 5370 5379 2-s2.0-48549105216 18593939
92 Lee C-H Chen J-C Hsiang C-Y Wu S-L Wu H-C Ho T-Y Berberine suppresses inflammatory agents-induced interleukin-1 β and tumor necrosis factor- α productions via the inhibition of I κ B degradation in human lung cells Pharmacological Research 2007 56 3 193 201 2-s2.0-34548206790 17681786
93 Jiang Q Liu P Wu X Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: involvement of NF- κ B signaling pathway Molecular and Cellular Endocrinology 2011 331 1 34 40 2-s2.0-78149410755 20674665
94 Wan X Chen X Liu L Berberine ameliorates chronic kidney injury caused by atherosclerotic renovascular disease through the suppression of NF κ B signaling pathway in rats PLoS ONE 2013 8 3 e59794
95 Shi J Wei L Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil Journal of Cardiovascular Pharmacology 2013 62 4 341 354 23921309
96 Xie X Peng J Chang X Activation of RhoA/ROCK regulates NF- κ B signaling pathway in experimental diabetic nephropathy Molecular and Cellular Endocrinology 2013 369 1-2 86 97 23376009
97 Remppis A Bea F Greten HJ Rhizoma coptidis inhibits LPS-induced MCP-1/CCL2 production in murine macrophages via an AP-1 and NF B-dependent pathway Mediators of Inflammation 2010 2010 8 pages 2-s2.0-77955406469 194896
98 Kuo C-L Chi C-W Liu T-Y The anti-inflammatory potential of berberine in vitro and in vivo Cancer Letters 2004 203 2 127 137 2-s2.0-0346724714 14732220
99 Schonthaler HB Guinea-Viniegra J Wagner EF Targeting inflammation by modulating the Jun/AP-1 pathway Annals of the Rheumatic Diseases 2011 70 1 i109 i112 2-s2.0-79953014066 21339212
100 Ricote M Li AC Willson TM Kelly CJ Glass CK The peroxisome proliferator-activated receptor- γ is a negative regulator of macrophage activation Nature 1998 391 6662 79 82 2-s2.0-0031886864 9422508
101 Delerive P Martin-Nizard F Chinetti G Peroxisome proliferator-activated receptor activators inhibit thrombin- induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway Circulation Research 1999 85 5 394 402 2-s2.0-0033520304 10473669
102 Pasceri V Wu HD Willerson JT Yeh ETH Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor- γ activators Circulation 2000 101 3 235 238 2-s2.0-0034711678 10645917
103 Chen FL Yang ZH Liu Y Berberine inhibits the expression of TNFalpha, MCP-1, and IL-6 in AcLDL-stimulated macrophages through PPARgamma pathway Endocrine 2008 33 3 331 337 2-s2.0-67449096759 19034703
104 Feng A-W Gao W Zhou G-R Berberine ameliorates COX-2 expression in rat small intestinal mucosa partially through PPAR γ pathway during acute endotoxemia International Immunopharmacology 2012 12 1 182 188 2-s2.0-84856093248 22155099
105 Zhou J Zhou S Berberine regulates peroxisome proliferator-activated receptors and positive transcription elongation factor b expression in diabetic adipocytes European Journal of Pharmacology 2010 649 1–3 390 397 2-s2.0-78049235146 20868663
106 Li G-S Liu X-H Zhu H Berberine-improved visceral white adipose tissue insulin resistance associated with altered sterol regulatory element-binding proteins, liver X receptors, and peroxisome proliferator-activated receptors transcriptional programs in diabetic hamsters Biological and Pharmaceutical Bulletin 2011 34 5 644 654 2-s2.0-79955666243 21532151
107 Yang J Yin J Gao H Berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokines profile in human preadipocytes and metabolic syndrome patients Evidence-based Complementary and Alternative Medicine 2012 2012 9 pages 2-s2.0-84859726719 363845
108 Huang C Zhang Y Gong Z Berberine inhibits 3T3-L1 adipocyte differentiation through the PPAR γ pathway Biochemical and Biophysical Research Communications 2006 348 2 571 578 2-s2.0-33747079990 16890192
109 Chen QM Xie MZ Studies on the hypoglycemic effect of Coptis chinensis and berberine Acta Pharmaceutica Sinica 1986 21 6 401 406 2-s2.0-0022739343 3811923
110 Ni YX Therapeutic effect of berberine on 60 patients with type II diabetes mellitus and experimental research Zhong Xi Yi Jie He Za Zhi 1988 8 12 711 713 2-s2.0-0024253938 3248329
111 Lugrin J Rosenblatt-Velin N Parapanov R Liaudet L The role of oxidative stress during inflammatory processes Biological Chemistry 2013
112 Muñoz A Costa M Nutritionally mediated oxidative stress and inflammation Oxidative Medicine and Cellular Longevity 2013 2013 610950
113 Soskić SS Dobutović BD Sudar EM Regulation of inducible Nitric Oxide synthase (iNOS) and its potential role in insulin resistance, diabetes and heart failure Open Cardiovascular Medicine Journal 2011 5 1 153 163 2-s2.0-80053525165 21792376
114 Zhang X Zhao Y Zhang M Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats PLoS ONE 2012 7 8 e42529
115 Xie W Gu D Li J Cui K Zhang Y Effects and action mechanisms of berberine and rhizoma coptidis on gut microbes and obesity in high-fat diet-fed C57BL/6J mice PLoS ONE 2011 6 9 2-s2.0-80052479571 e24520
116 Han J Lin H Huang W Modulating gut microbiota as an anti-diabetic mechanism of berberine Medical Science Monitor 2011 17 7 RA164 RA167 2-s2.0-79959964544 21709646
117 Shan YQ Zhu YP Pang J Tetrandrine potentiates the hypoglycemic efficacy of berberine by inhibiting P-glycoprotein function Biological and Pharmaceutical Bulletin 2013 36 10 1562 1569 23924821
118 Peng L Li Z-R Green RS Holzman IR Lin J Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers Journal of Nutrition 2009 139 9 1619 1625 2-s2.0-69549114504 19625695
119 Zhang Q Piao X-L Piao X-S Lu T Wang D Kim SW Preventive effect of Coptis chinensis and berberine on intestinal injury in rats challenged with lipopolysaccharides Food and Chemical Toxicology 2011 49 1 61 69 2-s2.0-78650261067 20932871
120 Amasheh M Fromm A Krug SM TNF α -induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NF κ B signaling Journal of Cell Science 2010 123 23 4145 4155 2-s2.0-78649730159 21062898
121 Gu L Li N Gong J Li Q Zhu W Li J Berberine ameliorates intestinal epithelial tight-junction damage and down-regulates myosin light chain kinase pathways in a mouse model of endotoxinemia Journal of Infectious Diseases 2011 203 11 1602 1612 2-s2.0-79956223990 21592990
122 Tan XS Ma JY Feng R Tissue distribution of berberine and its metabolites after oral administration in rats PLoS ONE 2013 8 10 e77969
123 Wang YX Kong WJ Li YH Synthesis and structure-activity relationship of berberine analogues in LDLR up-regulation and AMPK activation Bioorganic & Medicinal Chemistry 2012 20 22 6552 6558 23058107
124 Wang Z-S Lu F-E Xu L-J Dong H Berberine reduces endoplasmic reticulum stress and improves insulin signal transduction in Hep G2 cells Acta Pharmacologica Sinica 2010 31 5 578 584 2-s2.0-77952060625 20383171
125 Wu S Lu FE Dong H Effect of berberine on the endoplasmic reticulum stress-related apoptosis in pancreatic β -cells Chinese Journal of Diabetes 2013 21 6 544 547
126 Xue X Piao J-H Nakajima A Tumor necrosis factor α (TNF α ) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNF α Journal of Biological Chemistry 2005 280 40 33917 33925 2-s2.0-26644450729 16107336
127 Hanada S Harada M Kumemura H Oxidative stress induces the endoplasmic reticulum stress and facilitates inclusion formation in cultured cells Journal of Hepatology 2007 47 1 93 102 2-s2.0-34249669166 17434230
128 Evans-Molina C Hatanaka M Mirmira RG Lost in translation: endoplasmic reticulum stress and the decline of β -cell health in diabetes mellitus Diabetes, Obesity and Metabolism 2013 15 supplement 3 159 169
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