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3. Mol Nutr Food Res JD Clarke 55 7 999 2011 10.1002/mnfr.201000547 Clarke JD et al. Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells. Mol Nutr Food Res. 2011;55(7):999-1009. 

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4. Epigenetics H Fan 7 12 1379 2012 10.4161/epi.22609 Fan H et al. Sulforaphane causes a major epigenetic repression of myostatin in porcine satellite cells. Epigenetics. 2012;7(12):1379-90. 

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7. PLoS One K Suppipat 7 12 e51251 2012 10.1371/journal.pone.0051251 Suppipat K et al. Sulforaphane induces cell cycle arrest and apoptosis in acute lymphoblastic leukemia cells. PLoS One. 2012;7(12):e51251. SFN is important in the regulation of several biological mechanisms that help prevent the metastasis of cancer. This source is of interest for it reveals that the proliferation of lymphoblastic leukemia cells is adversely affected by the incorporation of SFN suggesting that multiple cancer types are regulated by similar pathways which may allow SFN to serve as a broad therapy. 

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8. J Cell Biochem K Sakao 113 2 599 2012 10.1002/jcb.23386 Sakao K, Singh SV. D,L-sulforaphane-induced apoptosis in human breast cancer cells is regulated by the adapter protein p66Shc. J Cell Biochem. 2012;113(2):599-610. SFN induces apoptosis of more than one cancer type. This source reveals SFN to be affective in the promotion of said apoptosis through the regulation of p66Shc. This information facilitates understanding of the mechanisms by which SFN is able to hinder the growth and spread of cancerous cells. 

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