$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Solanine Induces Mitochondria-Mediated Apoptosis in Human Pancreatic Cancer Cells 원문보기

BioMed research international, v.2014, 2014년, pp.805926 -   

Sun, Hongwei (Department of Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China) ,  Lv, Chongqing (Department of Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China) ,  Yang, Longlong (Department of Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China) ,  Wang, Yingxiu (Department of Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China) ,  Zhang, Qingshun (Department of Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China) ,  Yu, Suhui (Department of Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China) ,  Kong, Hongru (Department of Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China) ,  Wang, Meng (Department of Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China) ,  Xie, Jianming (Department of Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China) ,  Zhang, Chunwu (Wenzhou Key Laboratory of Surgery, Department of Surgery, First) ,  Zhou, Mengtao

Abstract AI-Helper 아이콘AI-Helper

Steroid alkaloids have been suggested as potential anticancer compounds. However, the underlying mechanisms of how steroid alkaloids inhibit the tumor growth are largely unknown. Here, we reported that solanine, a substance of steroid alkaloids, has a positive effect on the inhibition of pancreatic ...

참고문헌 (26)

  1. 1 Lam ET Bracci PM Holly EA Mitochondrial DNA sequence variation and risk of pancreatic cancer Cancer Research 2012 72 3 686 695 2-s2.0-84856521481 22174369 

  2. 2 Howard TJ Pancreatic adenocarcinoma Current Problems in Cancer 1996 20 5 281 328 8902402 

  3. 3 Jemal A Siegel R Xu J Ward E Cancer statistics, 2010 CA: Cancer Journal for Clinicians 2010 60 5 277 300 2-s2.0-77955635233 

  4. 4 Norsa’adah B Nur-Zafira A Knight A Pancreatic cancer in Universiti Sains Malaysia Hospital: a retrospective review of years 2001–2008 Asian Pacific Journal of Cancer Prevention 2012 13 6 2857 2860 22938473 

  5. 5 Werner J Büchler MW Management of pancreatic cancer: recent advances Deutsche Medizinische Wochenschrift 2011 136 36 1807 1810 2-s2.0-80052314284 21882139 

  6. 6 Friedman M Lee KR Kim HJ Lee IS Kozukue N Anticarcinogenic effects of glycoalkaloids from potatoes against human cervical, liver, lymphoma, and stomach cancer cells Journal of Agricultural and Food Chemistry 2005 53 15 6162 6169 2-s2.0-23744506485 16029012 

  7. 7 Kuo CI Chao CH Lu MK Effects of auxins on the production of steroidal alkaloids in rapidly proliferating tissue and cell cultures of Solanum lyratum Phytochemical Analysis 2012 23 4 400 404 22009634 

  8. 8 Son YO Kim J Lim JC Chung Y Chung GH Lee JC Ripe fruits of Solanum nigrum L. inhibits cell growth and induces apoptosis in MCF-7 cells Food and Chemical Toxicology 2003 41 10 1421 1428 2-s2.0-0141767071 12909277 

  9. 9 Reddivari L Vanamala J Safe SH Miller JC Jr. The bioactive compounds α -chaconine and gallic acid in potato extracts decrease survival and induce apoptosis in LNCaP and PC3 prostate cancer cells Nutrition and Cancer 2010 62 5 601 610 2-s2.0-77954020000 20574921 

  10. 10 Patil BC Sharma RP Salunkhe DK Salunkhe K Evaluation of solanine toxicity Food and Cosmetics Toxicology 1972 10 3 395 398 2-s2.0-0015357114 5045682 

  11. 11 Yang SA Paek SH Kozukue N Lee KR Kim JA α -Chaconine, a potato glycoalkaloid, induces apoptosis of HT-29 human colon cancer cells through caspase-3 activation and inhibition of ERK 1/2 phosphorylation Food and Chemical Toxicology 2006 44 6 839 846 2-s2.0-33645945275 16387404 

  12. 12 Lu MK Shih YW Chien TTC Fang LH Huang HC Chen PS α -Solanine inhibits human melanoma cell migration and invasion by reducing matrix metalloproteinase-2/9 activities Biological and Pharmaceutical Bulletin 2010 33 10 1685 1691 2-s2.0-77958008016 20930376 

  13. 13 Choi SH Lee SH Kim HJ Changes in free amino acid, phenolic, chlorophyll, carotenoid, and glycoalkaloid contents in tomatoes during 11 stages of growth and inhibition of cervical and lung human cancer cells by green tomato extracts Journal of Agricultural and Food Chemistry 2010 58 13 7547 7556 2-s2.0-77954560979 20560602 

  14. 14 Gao SY Wang QJ Ji YB Effect of solanine on the membrane potential of mitochondria in HepG2 cells and [Ca 2+ ] i in the cells World Journal of Gastroenterology 2006 12 21 3359 3367 2-s2.0-33745320827 16733852 

  15. 15 Ji YB Gao SY Ji CF Zou X Induction of apoptosis in HepG2 cells by solanine and Bcl-2 protein Journal of Ethnopharmacology 2008 115 2 194 202 2-s2.0-37249089342 18022776 

  16. 16 Zhang J Shi GW Inhibitory effect of solanine on prostate cancer cell line PC-3 in vitro National Journal of Andrology 2011 17 3 284 287 2-s2.0-82255191366 21485553 

  17. 17 Muñoz-Pinedo C Signaling pathways that regulate life and cell death: evolution of apoptosis in the context of self-defense Advances in Experimental Medicine and Biology 2012 738 124 143 2-s2.0-84859871133 22399377 

  18. 18 Schultz DR Harrington WJ Jr. Apoptosis: programmed cell death at a molecular level Seminars in Arthritis and Rheumatism 2003 32 6 345 369 2-s2.0-0037633932 12833244 

  19. 19 Shimizu S Narita M Tsujimoto Y Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC Nature 1999 399 6735 483 487 2-s2.0-0033519705 10365962 

  20. 20 Spierings D McStay G Saleh M Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis Science 2005 310 5745 66 67 2-s2.0-26444489119 16210526 

  21. 21 Antonsson B Mitochondria and the Bcl-2 proteins in apoptosis signaling pathways Molecular and Cellular Biochemistry 2004 256-257 1-2 141 155 2-s2.0-0842280583 14977177 

  22. 22 Green DR Kroemer G The pathophysiology of mitochondrial cell death Science 2004 305 5684 626 629 2-s2.0-3442886811 15286356 

  23. 23 Filomeni G Cardaci S Da Costa Ferreira AM Rotilio G Ciriolo MR Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)2] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38MAPK/p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment Biochemical Journal 2011 437 3 443 453 2-s2.0-79960263592 21548882 

  24. 24 Hemann MT Lowe SW The p53-Bcl-2 connection Cell Death and Differentiation 2006 13 8 1256 1259 2-s2.0-33745961862 16710363 

  25. 25 Wu KC Yang ST Hsia TC Suppression of cell invasion and migration by propofol are involved in down-regulating matrix metalloproteinase-2 and p38 MAPK signaling in A549 human lung adenocarcinoma epithelial cells Anticancer Research 2012 32 11 4833 4842 23155249 

  26. 26 Kim YH Kwon HJ Kim DS Matrix metalloproteinase 9 (MMP-9)-dependent processing of betaig-h3 protein regulates cell migration, invasion, and adhesion The Journal of Biological Chemistry 2012 287 46 38957 38969 23019342 

관련 콘텐츠

오픈액세스(OA) 유형

GOLD

오픈액세스 학술지에 출판된 논문

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로