[논문]The Impact of Diet and Lifestyle on Gut Microbiota and Human Health

Conlon, Michael A.; Bird, Anthony R.

doi:10.3390/nu7010017

The Impact of Diet and Lifestyle on Gut Microbiota and Human Health 원문보기

Nutrients, v.7 no.1, 2015년, pp.17 - 44

Conlon, Michael A. , Bird, Anthony R.

Abstract ▼ AI-Helper

There is growing recognition of the role of diet and other environmental factors in modulating the composition and metabolic activity of the human gut microbiota, which in turn can impact health. This narrative review explores the relevant contemporary scientific literature to provide a general perspective of this broad area. Molecular technologies have greatly advanced our understanding of the complexity and diversity of the gut microbial communities within and between individuals. Diet, particularly macronutrients, has a major role in shaping the composition and activity of these complex populations. Despite the body of knowledge that exists on the effects of carbohydrates there are still many unanswered questions. The impacts of dietary fats and protein on the gut microbiota are less well defined. Both short- and long-term dietary change can influence the microbial profiles, and infant nutrition may have life-long consequences through microbial modulation of the immune system. The impact of environmental factors, including aspects of lifestyle, on the microbiota is particularly poorly understood but some of these factors are described. We also discuss the use and potential benefits of prebiotics and probiotics to modify microbial populations. A description of some areas that should be addressed in future research is also presented.

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참고문헌 (175)

1. Backhed F. Ley R.E. Sonnenburg J.L. Peterson D.A. Gordon J.I. Host-bacterial mutualism in the human intestine Science 2005 307 1915 1920 10.1126/science.1104816 15790844

상세보기
2. Scanlan P.D. Shanahan F. Marchesi J.R. Human methanogen diversity and incidence in healthy and diseased colonic groups using mcrA gene analysis BMC Microbiol. 2008 8 79 10.1186/1471-2180-8-79 18492229

상세보기
3. Huttenhower C. Gevers D. Knight R. Abubucker S. Badger J.H. Chinwalla A.T. Creasy H.H. Earl A.M. Fitzgerald M.G. Fulton R.S. Structure, function and diversity of the healthy human microbiome Nature 2012 486 207 214 22699609

상세보기
4. Huse S.M. Ye Y. Zhou Y. Fodor A.A. A core human microbiome as viewed through 16S rRNA sequence clusters PLoS One 2012 7 e34242 10.1371/journal.pone.0034242 22719824

상세보기
5. Manichanh C. Rigottier-Gois L. Bonnaud E. Gloux K. Pelletier E. Frangeul L. Nalin R Jarrin C. Chardon P. Marteau P. Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach Gut 2006 55 205 211 16188921

상세보기
6. Bingham S.A. Day N.E. Luben R. Ferrari P. Slimani N. Norat T. Clavel-Chapelon F. Kesse E. Nieters A. Boeing H. Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): An observational study Lancet 2003 361 1496 1501 12737858
7. Stephen A.M. Cummings J.H. Mechanism of action of dietary fiber in the human colon Nature 1980 284 283 284 10.1038/284283a0 7360261

상세보기
8. Cummings J.H. Bingham S.A. Heaton K.W. Eastwood M.A. Fecal weight, colon cancer risk, and dietary-intake of nonstarch polysaccharides (dietary fiber) Gastroenterology 1992 103 1783 1789 1333426
9. Birkett A.M. Jones G.P. de Silva A.M. Young G.P. Muir J.G. Dietary intake and faecal excretion of carbohydrate by Australians: Importance of achieving stool weights greater than 150 g to improve faecal markers relevant to colon cancer risk Eur. J. Clin. Nutr. 1997 51 625 632 10.1038/sj.ejcn.1600456 9306090

상세보기
10. Duncan S.H. Louis P. Thomson J.M. Flint H.J. The role of pH in determining the species composition of the human colonic microbiota Environ. Microbiol. 2009 11 2112 2122 10.1111/j.1462-2920.2009.01931.x 19397676

상세보기
11. Nicholson J.K. Holmes E. Kinross J. Burcelin R. Gibson G. Jia W. Pettersson S. Host-gut microbiota metabolic interactions Science 2012 336 1262 1267 10.1126/science.1223813 22674330

상세보기
12. Cummings J.H. Macfarlane G.T. The control and consequences of bacterial fermentation in the human colon J. Appl. Bacteriol. 1991 70 443 459 10.1111/j.1365-2672.1991.tb02739.x 1938669

상세보기
13. Topping D.L. Clifton P.M. Short-chain fatty acids and human colonic function: Roles of resistant starch and nonstarch polysaccharides Physiol. Rev. 2001 81 1031 1064 11427691

상세보기
14. Donohoe D.R. Garge N. Zhang X. Sun W. O’Connell T.M. Bunger M.K. Bultman S.J. The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon Cell. Metab. 2011 13 517 526 10.1016/j.cmet.2011.02.018 21531334

상세보기
15. Trompette A. Gollwitzer E.S. Yadava K. Sichelstiel A.K. Sprenger N. Ngom-Bru C. Blanchard C. Junt T. Nicod L.P. Harries N.L. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis Nat. Med. 2014 20 159 168 24390308

상세보기
16. Trent M.S. Stead C.M. Tran A.X. Hankins J.V. Diversity of endotoxin and its impact on pathogenesis J. Endotoxin Res. 2006 12 205 223 10.1179/096805106X118825 16953973
17. Kamada N. Chen G. Nunez G. Harnessing pathogen-commensal relations Nat. Med. 2012 18 1190 1191 10.1038/nm.2900 22869189

상세보기
18. Fukuda S. Toh H. Hase K. Oshima K. Nakanishi Y. Yoshimura K. Tobe T. Clarke J.M. Topping D.L. Suzuki T. Bifidobacteria can protect from enteropathogenic infection through production of acetate Nature 2011 469 543 547 21270894

상세보기
19. Cantarel B.L. Lombard V. Henrissat B. Complex carbohydrate utilization by the healthy human microbiome PLoS One 2012 7 e28742 10.1371/journal.pone.0028742 22719820

상세보기
20. Xu J. Bjursell M.K. Himrod J. Deng S. Carmichael L.K. Chiang H.C. Hooper L.V. Gordon J.I. A genomic view of the human- Bacteroides thetaiotaomicron symbiosis Science 2003 299 2074 2076 10.1126/science.1080029 12663928

상세보기
21. Sandberg A.S. Andlid T. Phytogenic and microbial phytases in human nutrition Int. J. Food Sci. Technol. 2002 37 823 833 10.1046/j.1365-2621.2002.00641.x

상세보기
22. Morvan B. Bonnemoy F. Fonty G. Gouet P. Quantitative determination of H2-utilizing acetogenic and sulfate-reducing bacteria and methanogenic archaea from digestive tract of different mammals Curr. Microbiol. 1996 32 129 133 10.1007/s002849900023 8704656

상세보기
23. Carbonero F. Benefiel A.C. Alizadeh-Ghamsari A.H. Gaskins H.R. Microbial pathways in colonic sulphur metabolism and links with health and disease Front. Physiol. 2012 3 448 10.3389/fphys.2012.00448 23226130

상세보기
24. Chatterjee S. Park S. Low K. Kong Y. Pimentel M. The degree of breath methane production in IBS correlates with the severity of constipation Am. J. Gastroenterol. 2007 102 837 841 10.1111/j.1572-0241.2007.01072.x 17397408

상세보기
25. Sokol H. Pigneur B. Watterlot L. Lakhdari O. Bermudez-Humaran L.G. Gratadoux J.-J. Blugeon S. Bridonneau C. Furet J.-P. Corthier G. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients Proc. Natl. Acad. Sci. USA 2008 105 16731 16736 18936492

상세보기
26. Huurre A. Kalliomaki M. Rautava S. Rinne M. Salminen S. Isolauri E. Mode of delivery—Effects on gut microbiota and humoral immunity Neonatology 2008 93 236 240 10.1159/000111102 18025796

상세보기
27. Kelly D. King T. Aminov R. Importance of microbial colonization of the gut in early life to the development of immunity Mutat. Res. 2007 622 58 69 10.1016/j.mrfmmm.2007.03.011 17612575

상세보기
28. Harmsen H.J. Wildeboer-Veloo A.C.M. Raangs G.C. Wagendorp A.A. Klijn N. Bindels J.G. Welling G.W. Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods J. Pediatr. Gastroenterol. Nutr. 2000 30 61 67 10.1097/00005176-200001000-00019 10630441

상세보기
29. Coppa G.V. Zampini L. Galeazzi T. Gabrielli O. Prebiotics in human milk: A review Dig. Liver Dis. 2006 38 S291 S294 10.1016/S1590-8658(07)60013-9 17259094

상세보기
30. Arslanoglu S. Moro G.E. Schmitt J. Tandoi L. Rizzardi S. Boehm G. Early dietary intervention with a mixture of prebiotic oligosaccharides reduces the incidence of allergic manifestations and infections during the first two years of life J. Nutr. 2008 138 1091 1095 18492839

상세보기
31. Barrett M.J. Donoghue V. Mooney E.E. Slevin M. Persaud T. Twomey E. Ryan S. Laffan E. Twomey A. Isolated acute non-cystic white matter injury in term infants presenting with neonatal encephalopathy Arch. Dis. Child. Fetal Neonatal Ed. 2013 98 F158 F160 10.1136/archdischild-2011-301505 22813533

상세보기
32. Sghir A. Gramet G. Suau A. Rochet V. Pochart P. Dore J. Quantification of bacterial groups within human fecal flora by oligonucleotide probe hybridization Appl. Environ. Microbiol. 2000 66 2263 2266 10.1128/AEM.66.5.2263-2266.2000 10788414

상세보기
33. Pokusaeva K. Fitzgerald G.F. van Sinderen D. Carbohydrate metabolism in Bifidobacteria Genes Nutr. 2011 6 285 306 10.1007/s12263-010-0206-6 21484167

상세보기
34. Yatsunenko T. Rey F.E. Manary M.J. Trehan I. Dominguez-Bello M.G. Contreras M. Magris M. Hidalgo G. Baldassano R.N. Anokhin A.P. Human gut microbiome viewed across age and geography Nature 2012 486 222 227 22699611

상세보기
35. Lakshminarayanan B. Harris H.M.B. Coakley M. O’Sullivan O. Stanton C. Pruteanu M. Shanahan F. O’Toole P.W. Ross R.P. Consortium E. Prevalence and characterization of Clostridium perfringens from the faecal microbiota of elderly Irish subjects J. Med. Microbiol. 2013 62 457 466 23222860

상세보기
36. Claesson M.J. Jeffery I.B. Conde S. Power S.E. O’Connor E.M. Cusack S. Harris H.M.B. Coakley M. Lakshminarayanan B. O’Sulliva O. Gut microbiota composition correlates with diet and health in the elderly Nature 2012 488 178 184 22797518

상세보기
37. Huxley R.R. Ansary-Moghaddam A. Clifton P. Czernichow S. Parr C.L. Woodward M. The impact of dietary and lifestyle risk factors on risk of colorectal cancer: A quantitative overview of the epidemiological evidence Int. J. Cancer 2009 125 171 180 10.1002/ijc.24343 19350627

상세보기
38. Benjamin J.L. Hedin C.R.H. Koutsoumpas A. Ng S.C. McCarthy N.E. Prescott N.J. Pessoa-Lopes P. Mathew C.G. Sanderson J. Hart A.L. Smokers with active Crohn’s disease have a clinically relevant dysbiosis of the gastrointestinal microbiota Inflamm. Bowel Dis. 2012 18 1092 1100 22102318
39. Beamish L.A. Osornio-Vargas A.R. Wine E. Air pollution: An environmental factor contributing to intestinal disease J. Crohns Colitis 2011 5 279 286 10.1016/j.crohns.2011.02.017 21683297

상세보기
40. Lutgendorff F. Akkermans L.M.A. Soderholm J.D. The role of microbiota and probiotics in stress-induced gastrointestinal damage Curr. Mol. Med. 2008 8 282 298 10.2174/156652408784533779 18537636

상세보기
41. Grenham S. Clarke G. Cryan J.F. Dinan T.G. Brain-gut-microbe communication in health and disease Front. Physiol. 2011 2 94 10.3389/fphys.2011.00094 22162969

상세보기
42. Clarke G. Grenham S. Scully P. Fitzgerald P. Moloney R.D. Shanahan F. Dinan T.G. Cryan J.F. The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner Mol. Psychiatry 2013 18 666 673 10.1038/mp.2012.77 22688187

상세보기
43. Finegold S.M. Dowd S.E. Gontcharova V. Liu C. Henley K.E. Wolcott R.D. Youn E. Summanen P.H. Granpeesheh D. Dixon D. Pyrosequencing study of fecal microflora of autistic and control children Anaerobe 2010 16 444 453 20603222

상세보기
44. Parracho H. Bingham M.O. Gibson G.R. McCartney A.L. Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children J. Med. Microbiol. 2005 54 987 991 10.1099/jmm.0.46101-0 16157555

상세보기
45. Wang L. Christophersen C.T. Sorich M.J. Gerber J.P. Angley M.T. Conlon M.A. Low relative abundances of the mucolytic bacterium Akkermansia muciniphila and Bifidobacterium spp. in feces of children with autism Appl. Environ. Microbiol. 2011 77 6718 6721 10.1128/AEM.05212-11 21784919

상세보기
46. Clarke S.F. Murphy E.F. O’Sullivan O. Lucy A.J. Humphreys M. Hogan A. Hayes P. O’Reilly M. Jeffery I.B. Wood-Martin R. Exercise and associated dietary extremes impact on gut microbial diversity Gut 2014 63 1913 1920 25021423

상세보기
47. Ley R.E. Backhed F. Turnbaugh P. Lozupone C.A. Knight R.D. Gordon J.I. Obesity alters gut microbial ecology Proc. Natl. Acad. Sci. USA 2005 102 11070 11075 10.1073/pnas.0504978102 16033867

상세보기
48. Ley R.E. Turnbaugh P.J. Klein S. Gordon J.I. Microbial ecology: human gut microbes associated with obesity Nature 2006 444 1022 1023 10.1038/4441022a 17183309

상세보기
49. Turnbaugh P.J. Ley R.E. Mahowald M.A. Magrini V. Mardis E.R. Gordon J.I. An obesity-associated gut microbiome with increased capacity for energy harvest Nature 2006 444 1027 1031 10.1038/nature05414 17183312

상세보기
50. Delzenne N.M. Cani P.D. Interaction between obesity and the gut microbiota: Relevance in nutrition Ann. Rev. Nutr. 2011 31 15 31 10.1146/annurev-nutr-072610-145146 21568707

상세보기
51. Lin H.V. Frassetto A. Kowalik E.J. Jr. Nawrocki A.R. Lu M.M. Kosinski J.R. Hubert J.A. Szeto D. Yao X. Forrest G. Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms PLoS One 2012 7 e35240 10.1371/journal.pone.0035240. 22506074

상세보기
52. Collado M.C. Isolauri E. Laitinen K. Salminen S. Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women Am. J. Clin. Nutr. 2008 88 894 899 18842773

상세보기
53. Kalliomaki M. Collado M.C. Salminen S. Isolauri E. Early differences in fecal microbiota composition in children may predict overweight Am. J. Clin. Nutr. 2008 87 534 538 18326589

상세보기
54. Devkota S. Wang Y. Musch M.W. Leone V. Fehlner-Peach H. Nadimpalli A. Antonopoulos D.A. Jabri B. Chang E.B. Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10 −/− mice Nature 2012 487 104 108 22722865

상세보기
55. De Filippo C. Cavalieri D. di Paola M. Ramazzotti M. Poullet J.B. Massart S. Collini S. Pieraccini G. Lionetti P. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa Proc. Natl. Acad. Sci. USA 2010 107 14691 14696 10.1073/pnas.1005963107 20679230

상세보기
56. Verdu E.F. Riddle M.S. Chronic gastrointestinal consequences of acute infectious diarrhea: Evolving concepts in epidemiology and pathogenesis Am. J. Gastroenterol. 2012 107 981 989 10.1038/ajg.2012.65 22508147

상세보기
57. Voigt R.M. Forsyth C.B. Green S.J. Mutlu E. Engen P. Vitaterna M.H. Turek F.W. Keshavarzian A. Circadian disorganization alters intestinal microbiota PLoS One 2014 9 e97500 10.1371/journal.pone.0097500 24848969

상세보기
58. Hill M.J. Bacterial fermentation of complex carbohydrate in the human colon Eur. J. Cancer Prev. 1995 4 353 358 10.1097/00008469-199510000-00004 7496323

상세보기
59. Payne A.N. Chassard C. Lacroix C. Gut microbial adaptation to dietary consumption of fructose, artificial sweeteners and sugar alcohols: Implications for host-microbe interactions contributing to obesity Obes. Rev. 2012 13 799 809 10.1111/j.1467-789X.2012.01009.x 22686435

상세보기
60. Touvier M. Druesne-Pecollo N. Kesse-Guyot E. Andreeva V.A. Fezeu L. Galan P. Hercberg S. Latino-Martel P. Dual association between polyphenol intake and breast cancer risk according to alcohol consumption level: A prospective cohort study Breast Cancer Res. Treat. 2013 137 225 236 10.1007/s10549-012-2323-y 23132534

상세보기
61. Tuohy K.M. Conterno L. Gasperotti M. Viola R. Up-regulating the human intestinal microbiome using whole plant foods, polyphenols, and/or fiber J. Agric. Food Chem. 2012 60 8776 8782 10.1021/jf2053959 22607578

상세보기
62. Lee H.C. Jenner A.M. Low C.S. Lee Y.K. Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota Res. Microbiol. 2006 157 876 884 10.1016/j.resmic.2006.07.004 16962743

상세보기
63. Tzounis X. Rodriguez-Mateos A. Vulevic J. Gibson G.R. Kwik-Uribe C. Spencer J.P.E. Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study Am. J. Clin. Nutr. 2011 93 62 72 10.3945/ajcn.110.000075 21068351

상세보기
64. Martin F.-P.J. Montoliu I. Nagy K. Moco S. Collino S. Guy P. Redeuil K. Scherer M. Rezzi S. Kochhar S. Specific dietary preferences are linked to differing gut microbial metabolic activity in response to dark chocolate intake J. Proteome Res. 2012 11 6252 6263 23163751

상세보기
65. Gill S.R. Pop M. DeBoy R.T. Eckburg P.B. Turnbaugh P.J. Samuel B.S. Gordon J.I. Relman D.A. Fraser-Liggett C.M. Nelson K.E. Metagenomic analysis of the human distal gut microbiome Science 2006 312 1355 1359 16741115

상세보기
66. Baghurst P.A. Baghurst K.I. Record S.J. Dietary fibre, non-starch polysaccharides and resistant starch—A review Food Aust. 1996 48 S3 S35
67. Murphy N. Norat T. Ferrari P. Jenab M. Bueno-de-Mesquita B. Skeie G. Dahm C.C. Overvad K. Olsen A. Tjønneland A. Dietary fibre intake and risks of cancers of the colon and rectum in the European Prospective Investigation into Cancer and Nutrition (EPIC) PLoS One 2012 7 e39361 10.1371/journal.pone.0039361. 22761771

상세보기
68. Aune D. Chan D.S.M. Lau R. Vieira R. Greenwood D.C. Kampman E. Norat T. Dietary fibre, whole grains, and risk of colorectal cancer: Systematic review and dose-response meta-analysis of prospective studies BMJ 2011 343 d6617 10.1136/bmj.d6617 22074852

상세보기
69. Bodinham C.L. Smith L. Wright J. Frost G.S. Robertson M.D. Dietary fibre improves first-phase insulin secretion in overweight individuals PloS One 2012 7 e40834 10.1371/journal.pone.0040834 22815837

상세보기
70. Hauner H. Bechthold A. Boeing H. Broenstrup A. Buyken A. Leschik-Bonnet E. Linseisen J. Schulze M. Strohm D. Wolfram G. Evidence-based guideline of the German Nutrition Society: Carbohydrate Intake and prevention of nutrition-related diseases Ann. Nutr. MeTab. 2012 60 1 58 22286913

상세보기
71. Sleeth M. Psichas A. Frost G. Weight gain and insulin sensitivity: A role for the glycaemic index and dietary fibre? Br. J. Nutr. 2013 109 1539 1541 10.1017/S0007114512005016 23181986

상세보기
72. Windey K. de Preter V. Verbeke K. Relevance of protein fermentation to gut health Mol. Nutr. Food Res. 2012 56 184 196 10.1002/mnfr.201100542 22121108

상세보기
73. Mitchell B.L. Lawson M.J. Davies M. Grant A.K. Roediger W.E.W. Illman R.J. Topping D.L. Volatile fatty-acids in the human intestine—Studies in surgical patients Nutr. Res. 1985 5 1089 1092 10.1016/S0271-5317(85)80140-8

상세보기
74. Spiller G.A. Chernoff M.C. Hill R.A. Gates J.E. Nassar J.J. Shipley E.A. Effect of purified cellulose, pectin, and a low-residue diet on fecal volatile fatty-acids, transit-time, and fecal weight in humans Am. J. Clin. Nutr. 1980 33 754 759 7361693

상세보기
75. Roediger W.E.W. Role of anaerobic-bacteria in the metabolic welfare of the colonic mucosa in man Gut 1980 21 793 798 10.1136/gut.21.9.793 7429343

상세보기
76. Fung K.Y.C. Cosgrove L. Lockett T. Head R. Topping D.L. A review of the potential mechanisms for the lowering of colorectal oncogenesis by butyrate Br. J. Nutr. 2012 108 820 831 10.1017/S0007114512001948 22676885

상세보기
77. Binder H.J. Role of colonic short-chain fatty acid transport in diarrhea Ann. Rev. Physiol. 2010 72 297 313 10.1146/annurev-physiol-021909-135817 20148677

상세보기
78. Wycherley T.P. Noakes M. Clifton P.M. Cleanthous X. Keogh J.B. Brinkworth G.D. A high-protein diet with resistance exercise training improves weight loss and body composition in overweight and obese patients with type 2 diabetes Diabetes Care 2010 33 969 976 10.2337/dc09-1974 20150293

상세보기
79. Chao A. Thun M.J. Connell C.J. McCullough M.L. Jacobs E.J. Flanders W.D. Rodriguez C. Sinha R. Calle E.E. Meat consumption and risk of colorectal cancer JAMA 2005 97 906 916
80. Norat T. Bingham S. Ferrari P. Slimani N. Jenab M. Mazuir M. Overvad K. Olsen A. Tjonneland A. Clavel F. Meat, fish, and colorectal cancer risk: The European Prospective Investigation into Cancer and Nutrition J. Natl. Cancer Inst. 2005 97 906 916 15956652

상세보기
81. World Cancer Research Fund Food, Nutrition, Physical Activity, and the Prevention of Colon Cancer: A Global Perspective American Institute for Cancer Research Washington, DC, USA 2007
82. World Cancer Research Fund Food, Nutrition, Physical Activity, and the Prevention of Colorectal Cancer Continuous Update Project Report American Institute for Cancer Research Washington, DC, USA 2011
83. Alexander D.D. Cushing C.A. Red meat and colorectal cancer: A critical summary of prospective epidemiological studies Obes. Rev. 2011 12 e472 e493 10.1111/j.1467-789X.2010.00785.x 20663065

상세보기
84. Oostindjer M. Alexander J. Vang G. Andersen G. Bryan N.S. Chen D. Corpet D.E. de Smet S. Dragsted L.O. Haug A. The role of red and processed meat in colorectal cancer development: A perspective Meat Sci. 2014 97 583 596 24769880

상세보기
85. Silvester K.R. Cummings J.H. Does digestibility of meat protein help explain large-bowel cancer risk Nutr. Cancer 1995 24 279 288 10.1080/01635589509514417 8610047

상세보기
86. Macfarlane G.T. Macfarlane S. Bacteria, colonic fermentation, and gastrointestinal health J. AOAC Int. 2012 95 50 60 10.5740/jaoacint.SGE_Macfarlane 22468341

상세보기
87. Hughes R. Magee E.A. Bingham S. Protein degradation in the large intestine: Relevance to colorectal cancer Curr. Issues Intest. Microbiol. 2000 1 51 58 11709869

상세보기
88. Toden S. Bird A.R. Topping D.L. Conlon M.A. Resistant starch attenuates colonic DNA damage induced by higher dietary protein in rats Nutr. Cancer 2005 51 45 51 10.1207/s15327914nc5101_7 15749629

상세보기
89. Toden S. Bird A.R. Topping D.L. Conlon M.A. Differential effects of dietary whey, casein and soya on colonic DNA damage and large bowel SCFA in rats fed diets low and high in resistant starch Br. J. Nutr. 2007 97 535 543 10.1017/S0007114507336817 17313716

상세보기
90. Toden S. Bird A.R. Topping D.L. Conlon M.A. Dose-dependent reduction of dietary protein-induced colonocyte DNA damage by resistant starch in rats correlates more highly with caecal butyrate than with other short chain fatty acids Cancer Biol. Ther. 2007 6 253 258 10.4161/cbt.6.2.3627 17218781

상세보기
91. Toden S. Bird A.R. Topping D.L. Conlon M.A. High red meat diets induce greater numbers of colonic DNA double-strand breaks than white meat in rats: Attenuation by high-amylose maize starch Carcinogenesis 2007 28 2355 2362 10.1093/carcin/bgm216 17916911

상세보기
92. Russell W.R. Gratz S.W. Duncan S.H. Holtrop G. Ince J. Scobbie L. Duncan G. Johnstone A.M. Lobley G.E. Wallace R.J. High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health Am. J. Clin. Nutr. 2011 93 1062 1072 21389180

상세보기
93. Shaughnessy D.T. Gangarosa L.M. Schliebe B. Umbach D.M. Xu Z. MacIntosh B. Knize M.G. Matthews P.P. Swank A.E. Sandler R.S. Inhibition of fried meat-induced colorectal DNA damage and altered systemic genotoxicity in humans by crucifera, chlorophyllin, and yogurt PLoS One 2011 6 e18707 10.1371/journal.pone.0018707. 21541030

상세보기
94. Humphreys K.J. Conlon M.A. Young G.P. Topping D.L. Hu Y. Winter J.M. Bird A.R. Cobiac L. Kennedy N.A. Michael M.A. Dietary manipulation of oncogenic microRNA expression in human rectal mucosa: A randomized trial Cancer Prev. Res. 2014 7 786 795

상세보기
95. Brinkworth G.D. Noakes M. Clifton P.M. Bird A.R. Comparative effects of very low-carbohydrate, high-fat and high-carbohydrate, low-fat weight-loss diets on bowel habit and faecal short-chain fatty acids and bacterial populations Br. J. Nutr. 2009 101 1493 1502 10.1017/S0007114508094658 19224658

상세보기
96. Windey K. de Preter V. Iouat T. Schuit F. Herman J. Vansant G. Verbeke K. Modulation of protein fermentation does not affect fecal water toxicity: A randomized cross-over study in healthy subjects PLoS One 2012 7 e52387 10.1371/journal.pone.0052387 23285019

상세보기
97. Lin H.C. Visek W.J. Colon mucosal cell damage by ammonia in rats J. Nutr. 1991 121 887 893 2033472

상세보기
98. Kramer H. Dietary patterns, calories, and kidney disease Adv. Chronic Kidney Dis. 2013 20 135 140 10.1053/j.ackd.2012.12.004 23439372

상세보기
99. Koeth R.A. Wang Z. Levison B.S. Buffa J.A. Org E. Sheehy B.T. Britt E.B. Fu X. Wu Y. Li L. Intestinal microbiota metabolism of l -carnitine, a nutrient in red meat, promotes atherosclerosis Nat. Med. 2013 19 576 585 23563705
100. Moreira A.P.B. Texeira T.F.S. Ferreira A.B. Peluzio Mdo C. Alfenas Rde C. Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia Br. J. Nutr. 2012 108 801 809 10.1017/S0007114512001213 22717075

상세보기
101. Ou J. de Lany J.P. Zhang M. Sharma S. O’Keefe S.J.D. Association between low colonic short-chain fatty acids and high bile acids in high colon cancer risk populations Nutr. Cancer 2012 64 34 40 10.1080/01635581.2012.630164 22136517

상세보기
102. Ridlon J.M. Kang D.-J. Hylemon P.B. Bile salt biotransformations by human intestinal bacteria J. Lipid Res. 2006 47 241 259 10.1194/jlr.R500013-JLR200 16299351

상세보기
103. Soto-Vaca A. Gutierrez A. Losso J.N. Xu Z. Finley J.W. Evolution of phenolic compounds from color and flavor problems to health benefits J. Agric. Food Chem. 2012 60 6658 6677 10.1021/jf300861c 22568556

상세보기
104. Manach C. Williamson G. Morand C. Scalbert A. Remesy C. Bioavailability and bioefficacy of polyphenols in humans I. Review of 97 bioavailability studies Am. J. Clin. Nutr. 2005 81 230S 242S 15640486

상세보기
105. Selma M.V. Espin J.C. Tomas-Barberan F.A. Interaction between phenolics and gut microbiota: Role in human health J. Agric. Food Chem. 2009 57 6485 6501 10.1021/jf902107d 19580283

상세보기
106. Forester S.C. Waterhouse A.L. Metabolites are key to understanding health effects of wine polyphenolics J. Nutr. 2009 139 1824S 1831S 10.3945/jn.109.107664 19640966

상세보기
107. Grün C.H. van Dorsten F.A. Jacobs D.M. le Belleguic M. van Velzen E.J.J. Bingham M.O. Janssen H.-G. van Duynhoven J.P.M. GC-MS methods for metabolic profiling of microbial fermentation products of dietary polyphenols in human and in vitro intervention studies J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2008 871 212 219 10.1016/j.jchromb.2008.04.039 18502705

상세보기
108. Lee C.Y. Challenges in providing credible scientific evidence of health benefits of dietary polyphenols J. Funct. Foods 2013 5 524 526 10.1016/j.jff.2012.10.018

상세보기
109. Gross G. Jacobs D.M. Peters S. Possemiers S. van Duynhoven J. Vaughan E.E. van de Wiele T. In vitro bioconversion of polyphenols from black tea and red wine/grape juice by human intestinal microbiota displays strong interindividual variability J. Agric. Food Chem. 2010 58 10236 10246 10.1021/jf101475m 20726519

상세보기
110. Van Nuenen M. Venema K. van der Woude J.C.J. Kuipers E.J. The metabolic activity of fecal microbiota from healthy individuals and patients with inflammatory bowel disease Dig. Dis. Sci. 2004 49 485 491 10.1023/B:DDAS.0000020508.64440.73 15139503

상세보기
111. Cordain L. Eaton S.B. Sebastian A. Mann N. Lindeberg S. Watkins B.A. O’Keefe J.H. Brand-Miller J. Origins and evolution of the Western diet: Health implications for the 21st century Am. J. Clin. Nutr. 2005 81 341 354 15699220

상세보기
112. Qin J. Li R. Raes J. Arumugam M. Burgdorf K.S. Manichanh C. Nielsen T. Pons N. Levenez F. Yamada T. A human gut microbial gene catalogue established by metagenomic sequencing Nature 2010 464 59 65 20203603

상세보기
113. Jeffery I.B. Claesson M.J. O’Toole P.W. Shanahan F. Categorization of the gut microbiota: Enterotypes or gradients? Nat. Rev. Microbiol. 2012 10 591 592 10.1038/nrmicro2859 23066529

상세보기
114. Wu G.D. Chen J. Hoffmann C. Bittinger K. Chen Y.-Y. Keilbaugh S.A. Bewtra M. Knights D. Walters W.A. Knight R. Linking long-term dietary patterns with gut microbial enterotypes Science 2011 334 105 108 21885731

상세보기
115. Lin A. Bik E.M. Costello E.K. Dethlefsen L. Haque R. Relman D.A. Singh U. Distinct distal gut microbiome diversity and composition in healthy children from Bangladesh and the United States PLoS One 2013 8 e53838 10.1371/journal.pone.0053838 23349750

상세보기
116. Purushe J. Fouts D.E. Morrison M. White B.A. Mackie R.I. North American Consortium for Rumen Bacteria Coutinho P.M. Henrissat B. Nelson K.E. Comparative genome analysis of Prevotella ruminicola and Prevotella bryantii : Insights into their environmental niche Microb. Ecol. 2010 60 721 729 10.1007/s00248-010-9692-8 20585943

상세보기
117. Liszt K. Zwielehner J. Handschur M. Hippe B. Thaler R. Haslberger A.G. Characterization of bacteria, clostridia and Bacteroides in faeces of vegetarians using qPCR and PCR-DGGE fingerprinting Ann. Nutr. Metab. 2009 54 253 257 10.1159/000229505 19641302

상세보기
118. Kabeerdoss J. Devi R.S. Mary R.R. Ramakrishna B.S. Faecal microbiota composition in vegetarians: Comparison with omnivores in a cohort of young women in southern India Br. J. Nutr. 2012 108 953 957 10.1017/S0007114511006362 22182464

상세보기
119. Frank D.N. Amand A.L.S. Feldman R.A. Boedeker E.C. Harpaz N. Pace N.R. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases Proc. Natl. Acad. Sci. USA 2007 104 13780 13785 10.1073/pnas.0706625104 17699621

상세보기
120. Gore C. Munro K. Lay C. Bibiloni R. Morris J. Woodcock A. Custovic A. Tannock G.W. Bifidobacterium pseudocatenulatum is associated with atopic eczema: A nested case-control study investigating the fecal microbiota of infants J. Allergy Clin. Immunol. 2008 121 135 140 10.1016/j.jaci.2007.07.061 17900682

상세보기
121. Schwiertz A. Taras D. Schaefer K. Beijer S. Bos N.A. Donus C. Hardt P.D. Microbiota and SCFA in lean and overweight healthy subjects Obesity 2010 18 190 195 10.1038/oby.2009.167 19498350

상세보기
122. Lozupone C.A. Stombaugh J.I. Gordon J.I. Jansson J.K. Knight R. Diversity, stability and resilience of the human gut microbiota Nature 2012 489 220 230 10.1038/nature11550 22972295

상세보기
123. Nava G.M. Carbonero F. Ou J. Benefiel A.C. O’Keefe S.J. Gaskins H.R. Hydrogenotrophic microbiota distinguish native Africans from African and European Americans Environ. Microbiol. Rep. 2012 4 307 315 10.1111/j.1758-2229.2012.00334.x 23760794

상세보기
124. Magee E.A. Richardson C.J. Hughes R. Cummings J.H. Contribution of dietary protein to sulfide production in the large intestine: An in vitro and a controlled feeding study in humans Am. J. Clin. Nutr. 2000 72 1488 1494 11101476

상세보기
125. O’Keefe S.J.D. Kidd M. Espitalier-Noel G. Owira P. Rarity of colon cancer in Africans is associated with low animal product consumption, not fiber Am. J. Gastroenterol. 1999 94 1373 1380 10.1111/j.1572-0241.1999.01089.x 10235221

상세보기
126. Jumpertz R. Duc Son L. Turnbaugh P.J. Trinidad C. Bogardus C. Gordon J.I. Krakoff J. Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans Am. J. Clin. Nutr. 2011 94 58 65 10.3945/ajcn.110.010132 21543530

상세보기
127. Hildebrandt M.A. Hoffmann C. Sherrill-Mix S.A. Keilbaugh S.A. Hamady M. Chen Y.-Y. Knight R. Ahima R.S. Bushman F. Wu G.D. High-fat diet determines the composition of the murine gut microbiome independently of obesity Gastroenterology 2009 137 1716 1724 19706296
128. Cani P.D. Neyrinck A.M. Fava F. Knauf C. Burcelin R.G. Tuohy K.M. Gibson G.R. Delzenne N.M. Selective increases of Bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia Diabetologia 2007 50 2374 2383 10.1007/s00125-007-0791-0 17823788

상세보기
129. Cani P.D. Amar J. Iglesias M.A. Poggi M. Knauf C. Bastelica D. Neyrinck A.M. Fava F. Tuohy K.M. Chabo C. Metabolic endotoxemia initiates obesity and insulin resistance Diabetes 2007 56 1761 1772 17456850

상세보기
130. Neyrinck A.M. Possemiers S. Verstraete W. de Backer F. Cani P.D. Delzenne N.M. Dietary modulation of clostridial cluster XIVa gut bacteria ( Roseburia spp.) by chitin-glucan fiber improves host metabolic alterations induced by high-fat diet in mice J. Nutr. Biochem. 2012 23 51 59 21411304

상세보기
131. Deplancke B. Gaskins H.R. Microbial modulation of innate defense: Goblet cells and the intestinal mucus layer Am. J. Clin. Nutr. 2001 73 1131S 1141S 11393191
132. Kim Y.S. Ho S.B. Intestinal goblet cells and mucins in health and disease: Recent insights and progress Curr. Gastroenterol. Rep. 2010 12 319 330 10.1007/s11894-010-0131-2 20703838

상세보기
133. Hedemann M.S. Theil P.K. Knudsen K.E.B. The thickness of the intestinal mucous layer in the colon of rats fed various sources of non-digestible carbohydrates is positively correlated with the pool of SCFA but negatively correlated with the proportion of butyric acid in digesta Br. J. Nutr. 2009 102 117 125 10.1017/S0007114508143549 19138435

상세보기
134. Femia A.P. Giannini A. Fazi M. Tarquini E. Salvadori M. Roncucci L. Tonelli F. Dolara P. Caderni G. Identification of mucin depleted foci in the human colon Cancer Prev. Res. 2008 1 562 567 10.1158/1940-6207.CAPR-08-0125

상세보기
135. Femia A.P. Swidsinski A. Dolara P. Salvadori M. Amedei A. Caderni G. Mucin depleted foci, colonic preneoplastic lesions lacking Muc2, show up-regulation of Tlr2 but not bacterial infiltration PLoS One 2012 7 e29918 10.1371/journal.pone.0029918 22242189

상세보기
136. Johansson M.E.V. Phillipson M. Petersson J. Velcich A. Holm L. Hansson G.C. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria Proc. Natl. Acad. Sci. USA 2008 105 15064 15069 10.1073/pnas.0803124105 18806221

상세보기
137. Png C.W. Linden S.K. Gilshenan K.S. Zoetendal E.G. McSweeney C.S. Sly L.I. McGuckin M.A. Florin T.H.J. Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria Am. J. Gastroenterol. 2010 105 2420 2428 10.1038/ajg.2010.281 20648002

상세보기
138. Collado M.C. Derrien M. Isolauri E. de Vos W.M. Salminen S. Intestinal integrity and Akkermansia muciniphila , a mucin-degrading member of the intestinal microbiota present in infants, adults, and the elderly Appl. Environ. Microbiol. 2007 73 7767 7770 10.1128/AEM.01477-07 17933936

상세보기
139. Kerr C.A. Grice D.M. Tran C.D. Bauer D.C. Li D. Hendry P. Hannan G.N. Early life events influence whole-of-life metabolic health via gut microflora and gut permeability Crit. Rev. Microbiol. 2014 in press
140. Hooper L.V. Littman D.R. Macpherson A.J. Interactions between the microbiota and the immune system Science 2012 336 1268 1273 10.1126/science.1223490 22674334

상세보기
141. Lebouvier T. Chaumette T. Paillusson S. Duyckaerts C. des Varannes S.B. Neunlist M. Derkinderen P. The second brain and Parkinson’s disease Eur. J. Neurosci. 2009 30 735 741 10.1111/j.1460-9568.2009.06873.x 19712093

상세보기
142. Awad R.A. Neurogenic bowel dysfunction in patients with spinal cord injury, myelomeningocele, multiple sclerosis and Parkinson’s disease World J. Gastroenterol. 2011 17 5035 5048 10.3748/wjg.v17.i46.5035 22171138

상세보기
143. Forsyth C.B. Shannon K.M. Kordower J.H. Voigt R.M. Shaikh M. Jaglin J.A. Estes J.D. Dodiya H.B. Keshavarzian A. Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson’s Disease PLoS One 2011 6 e28032 10.1371/journal.pone.0028032 22145021

상세보기
144. Braak H. Rub U. Gai W.P. del Tredici K. Idiopathic Parkinson’s disease: Possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen J. Neural Transm. 2003 110 517 536 10.1007/s00702-002-0808-2 12721813

상세보기
145. Esteve E. Ricart W. Fernandez-Real J.-M. Gut microbiota interactions with obesity, insulin resistance and type 2 diabetes: Did gut microbiote co-evolve with insulin resistance? Curr. Opin. Clin. Nutr. Metab. Care 2011 14 483 490 10.1097/MCO.0b013e328348c06d 21681087

상세보기
146. Frazier T.H. DiBaise J.K. McClain C.J. Gut microbiota, intestinal permeability, obesity-induced inflammation, and liver injury J. Parenter. Enter. Nutr. 2011 35 14S 20S 10.1177/0148607111413772

상세보기
147. Cani P.D. Osto M. Geurts L. Everard A. Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity Gut Microbes 2012 3 279 288 10.4161/gmic.19625 22572877

상세보기
148. Anders H.-J. Andersen K. Stecher B. The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease Kidney Int. 2013 83 1010 1016 10.1038/ki.2012.440 23325079

상세보기
149. Piya M.K. Harte A.L. McTernan P.G. Metabolic endotoxaemia: Is it more than just a gut feeling? Curr. Opin. Lipidol. 2013 24 78 85 10.1097/MOL.0b013e32835b4431 23298961

상세보기
150. Arumugam M. Raes J. Pelletier E. le Paslier D. Yamada T. Mende D.R. Fernandes G.R. Tap J. Bruls T. Batto J.M. Enterotypes of the human gut microbiome Nature 2011 473 174 180 21508958

상세보기
151. McOrist A.L. Miller R.B. Bird A.R. Keogh J.B. Noakes M. Topping D.L. Conlon M.A. Fecal butyrate levels vary widely among individuals but are usually increased by a diet high in resistant starch J. Nutr. 2011 141 883 889 10.3945/jn.110.128504 21430242

상세보기
152. Abell G.C.J. Cooke C.M. Bennett C.N. Conlon M.A. McOrist A.L. Phylotypes related to Ruminococcus bromii are abundant in the large bowel of humans and increase in response to a diet high in resistant starch FEMS Microbiol. Ecol. 2008 66 505 515 10.1111/j.1574-6941.2008.00527.x 18616586

상세보기
153. Walker A.W. Ince J. Duncan S.H. Webster L.M. Holtrop G. Ze X. Brown D. Stares M.D. Scott P. Bergerat A. Dominant and diet-responsive groups of bacteria within the human colonic microbiota ISME J. 2011 5 220 230 20686513

상세보기
154. Gibson G.R. Roberfroid M.B. Dietary modulation of the human colonic microbiota—Introducing the concept of prebiotics J. Nutr. 1995 125 1401 1412 7782892

상세보기
155. Gibson G.R. Scott K.P. Rastall R.A. Tuohy K.M. Hotchkiss A. Dubert-Ferrandon A. Gareau M. Murphy E.F. Saulnier D. Loh G. Dietary prebiotics: Current status and new definition Food Sci. Technol. Bull. Funct. Foods 2010 7 1 19 10.1616/1476-2137.15880

상세보기
156. Bird A.R. Topping D.L. Resistant starch as a prebiotic Therapeutic Microbiology: Probiotics and Related Strategies Versalovic J. Wilson M. ASM Press Washington, DC, USA 2008 159 173
157. Clark M.J. Robien K. Slavin J.L. Effect of prebiotics on biomarkers of colorectal cancer in humans: A systematic review Nutr. Rev. 2012 70 436 443 10.1111/j.1753-4887.2012.00495.x 22835137

상세보기
158. Roberfroid M. Gibson G.R. Hoyles L. McCartney A.L. Rastall R. Rowland I. Wolvers D. Watzl B. Szajewska H. Stahl B. Prebiotic effects: Metabolic and health benefits Br. J. Nutr. 2010 104 S1 S63 20920376
159. Brownawell A.M. Caers W. Gibson G.R. Kendall C.W.C. Lewis K.D. Ringel Y. Slavin J.L. Prebiotics and the health benefits of fiber: Current regulatory status, future research, and goals J. Nutr. 2012 142 962 974 10.3945/jn.112.158147 22457389

상세보기
160. Saad N. Delattre C. Urdaci M. Schmitter J.M. Bressollier P. An overview of the last advances in probiotic and prebiotic field LWT Food Sci. Technol. 2013 50 1 16 10.1016/j.lwt.2012.05.014

상세보기
161. Delzenne N.M. Neyrinck A.M. Backhed F. Cani P.D. Targeting gut microbiota in obesity: Effects of prebiotics and probiotics Nat. Rev. Endocrinol. 2011 7 639 646 10.1038/nrendo.2011.126 21826100

상세보기
162. Van Loo J. Coussement P. de Leenheer L. Hoebregs H. Smits G. On the presence of inulin and oligofructose as natural ingredients in the western diet Crit. Rev. Food Sci. Nutr. 1995 35 525 552 10.1080/10408399509527714 8777017

상세보기
163. Bird A.R. Conlon M.A. Christophersen C.T. Topping D.L. Resistant starch, large bowel fermentation and a broader perspective of prebiotics and probiotics Benef. Microbes 2010 1 423 431 10.3920/BM2010.0041 21831780

상세보기
164. Conlon M.A. Bird A.R. Regina A. Morell M.K. Lockett T. Kang S. Molloy P. Kerr C.A. Shaw J. McSweeney C. Resistant starches protect against colonic DNA damage and alter microbiota and gene expression in rats fed a western diet J. Nutr. 2012 142 832 840 22457395

상세보기
165. Roberfroid M. Prebiotics: The concept revisited J. Nutr. 2007 137 830S 837S 17311983
166. Bird A.R. Lopez-Rubio A. Shrestha A.K. Gidley M.J. Resistant starch in vitro and in vivo : Factors determining yield, structure, and physiological relevance Modern Biopolymer Science: Bridging the Divide between Fundamental Treatise and Industrial Application Kasapsis S. Norton I.T. Ubbink J.B. Academic Press Burlington, MA, USA 2009 449 510
167. Tremaroli V. Backhed F. Functional interactions between the gut microbiota and host metabolism Nature 2012 489 242 249 10.1038/nature11552 22972297

상세보기
168. Crittenden R. Bird A.R. Gopal P. Henriksson A. Lee Y.K. Payne M.J. Probiotic research in Australia, New Zealand and the Asia-Pacific region Curr. Pharm. Des. 2005 11 37 53 10.2174/1381612053382304 15638751

상세보기
169. Floch M.H. Walker W.A. Madsen K. Sanders M.E. Macfarlane G.T. Flint H.J. Dieleman L.A. Ringel Y. Guandalini S. Kelley C.P. Recommendations for probiotic use—2011 update J. Clin. Gastroenterol. 2011 45 S168 S171 21992958

상세보기
170. Khani S. Hosseini H.M. Taheri M. Nourani M.R. Imani Fooladi A.A. Probiotics as an alternative strategy for prevention and treatment of human diseases: A review Inflamm. Allergy Drug Targets 2012 11 79 89 10.2174/187152812800392832 22280243

상세보기
171. Mugambi M.N. Musekiwa A. Lombard M. Young T. Blaauw R. Probiotics, prebiotics infant formula use in preterm or low birth weight infants: A systematic review Nutr. J. 2012 11 58 10.1186/1475-2891-11-58 22928998

상세보기
172. Johnston B.C. Ma S.S.Y. Goldenberg J.Z. Thorlund K. Vandvik P.O. Loeb M. Guyatt G.H. Probiotics for the prevention of Clostridium difficile -associated diarrhea: A systematic review and meta-analysis Ann. Intern. Med. 2012 157 878 888 10.7326/0003-4819-157-12-201212180-00563 23362517

상세보기
173. Hosseini A. Nikfar S. Abdollahi M. Probiotics use to treat irritable bowel syndrome Expert Opin. Biol. Ther. 2012 12 1323 1334 10.1517/14712598.2012.707179 22897430

상세보기
174. Augustin M.A. Sanguansri L. Lockett T. Nano- and micro-encapsulated systems for enhancing the delivery of resveratrol Ann. N. Y. Acad. Sci. 2013 1290 107 112 10.1111/nyas.12130 23855472

상세보기
175. Cook M.T. Tzortzis G. Charalampopoulos D. Khutoryanskiy V.V. Microencapsulation of probiotics for gastrointestinal delivery J. Control. Release 2012 162 56 67 10.1016/j.jconrel.2012.06.003 22698940

상세보기

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
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The Impact of Diet and Lifestyle on Gut Microbiota and Human Health 원문보기

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