다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기
BioMed research international, v.2014, 2014년, pp.540292 -
Zutz, Christoph (Institute for Milk Hygiene, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria) , Bandian, Dragana (AIT-Austrian Institute of Technology GmbH, University and Research Campus Tulln, Konrad Lorenz Straße 24, 3430 Tulln on the Danube, Austria) , Neumayer, Bernhard (Institute for Milk Hygiene, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria) , Speringer, Franz (Fungal Genetics and Genomics Unit, Department of Applied Genetics and Cell Biology, BOKU University of Natural Resources and Life Sciences Vienna, Konrad Lorenz Straße 24, 3430 Tulln on the Danube, Austria) , Gorfer, Markus (AIT-Austrian Institute of Technology GmbH, University and Research Campus Tulln, Konrad Lorenz Straße 24, 3430 Tulln on the Danube, Austria) , Wagner, Martin (Institute for Milk Hygiene, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria) , Strauss, Joseph (AIT-Austrian Institute of Technology GmbH, University and Research Campus Tulln, Konrad Lorenz Straße 24, 3430 Tulln on the Danube, Austria) , Rychli, Kathrin (Institute for Milk Hyg)
AI-Helper
For decades, fungi have been the main source for the discovery of novel antimicrobial drugs. Recent sequencing efforts revealed a still high number of so far unknown “cryptic” secondary metabolites. The production of these metabolites is presumably epigenetically silenced under standard laboratory c...
1 Molinari G Natural products in drug discovery: present status and perspectives Advances in Experimental Medicine and Biology 2009 655 13 27 2-s2.0-77953382502 20047031
2 Newman DJ Cragg GM Natural products as sources of new drugs over the 30 years from 1981 to 2010 Journal of Natural Products 2012 75 3 311 335 2-s2.0-84858308226 22316239
3 Taylor PW Alternative natural sources for a new generation of antibacterial agents International Journal of Antimicrobial Agents 2013 42 3 195 201 2-s2.0-84883454500 23796893
4 Winter JM Behnken S Hertweck C Genomics-inspired discovery of natural products Current Opinion in Chemical Biology 2011 15 1 22 31 2-s2.0-79851507787 21111667
5 Walsh CT Fischbach MA Natural products version 2.0: connecting genes to molecules Journal of the American Chemical Society 2010 132 8 2469 2493 2-s2.0-77649305354 20121095
6 Keller NP Turner G Bennett JW Fungal secondary metabolism-from biochemistry to genomics Nature Reviews Microbiology 2005 3 12 937 947 2-s2.0-30544434099 16322742
7 Fisch KM Gillaspy AF Gipson M Chemical induction of silent biosynthetic pathway transcription in Aspergillus niger Journal of Industrial Microbiology & Biotechnology 2009 36 9 1199 1213 2-s2.0-69249214114 19521728
8 Bergmann S Funk AN Scherlach K Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene cluster Applied and Environmental Microbiology 2010 76 24 8143 8149 2-s2.0-78650356368 20952652
9 Chiang Y Oakley CE Ahuja M An efficient system for heterologous expression of secondary metabolite genes in Aspergillus nidulans Journal of the American Chemical Society 2013 135 20 7720 7731 2-s2.0-84878214376 23621425
10 Nützmann HW Reyes-Dominguez Y Scherlach K Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation Proceedings of the National Academy of Sciences of the United States of America 2011 108 34 14282 14287 2-s2.0-80052154073 21825172
11 Reyes-Dominguez Y Boedi S Sulyok M Heterochromatin influences the secondary metabolite profile in the plant pathogen Fusarium graminearum Fungal Genetics and Biology 2012 49 1 39 47 2-s2.0-84856432508 22100541
12 Gacek A Strauss J The chromatin code of fungal secondary metabolite gene clusters Applied Microbiology and Biotechnology 2012 95 6 1389 1404 2-s2.0-84872042007 22814413
13 Brosch G Loidl P Graessle S Histone modifications and chromatin dynamics: a focus on filamentous fungi The FEMS Microbiology Reviews 2008 32 3 409 439 2-s2.0-42149147377 18221488
14 Cole PA Chemical probes for histone-modifying enzymes Nature Chemical Biology 2008 4 10 590 597 2-s2.0-51949111451 18800048
15 Cichewicz RH Epigenome manipulation as a pathway to new natural product scaffolds and their congeners. Natural product reports 2010 27 1 11 22 2-s2.0-73949102298 20024091
16 Zutz C Gacek A Sulyok M Wagner M Strauss J Rychli K Small chemical chromatin effectors alter secondary metabolite production in Aspergillus clavatus Toxins 2013 5 10 1723 1741 24105402
17 Göttlicher M Minucci S Zhu P Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells The EMBO Journal 2002 20 24 6969 6978 2-s2.0-18244383806
18 Krämer OH Zhu P Ostendorff HP The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2 EMBO Journal 2003 22 13 3411 3420 2-s2.0-0037925520 12840003
19 Smith WL Edlind TD Histone deacetylase inhibitors enhance Candida albicans sensitivity to azoles and related antifungals: correlation with reduction in CDR and ERG upregulation Antimicrobial Agents and Chemotherapy 2002 46 11 3532 3539 2-s2.0-0036841830 12384361
20 Candido EP Reeves R Davie JR Sodium butyrate inhibits histone deacetylation in cultured cells Cell 1978 14 1 105 113 2-s2.0-0017886958 667927
21 Vrba J Trtkova K Ulrichova J HDAC inhibitors sodium butyrate and sodium valproate do not affect human ncor1 and ncor2 gene expression in HL-60 cells Biomedical Papers 2011 155 3 259 262 2-s2.0-80054099532
22 Davie JR Inhibition of histone deacetylase activity by butyrate Journal of Nutrition 2003 133 supplement 7 2485S 2493S 2-s2.0-0038676409 12840228
23 Fritz EL Papavasiliou FN Cytidine deaminases: AIDing DNA demethylation? Genes & Development 2010 24 19 2107 2114 2-s2.0-77957659555 20889711
24 Hagemann S Heil O Lyko F Brueckner B Azacytidine and decitabine induce gene-specific and non-random DNA demethylation in human cancer cell lines PLoS ONE 2011 6 3 e17388 2-s2.0-79952328162
26 Schinko T Berger H Lee W Transcriptome analysis of nitrate assimilation in Aspergillus nidulans reveals connections to nitric oxide metabolism Molecular Microbiology 2010 78 3 720 738 2-s2.0-77958536252 20969648
27 Baidya S Cary JW Grayburn WS Calvo AM Role of nitric oxide and flavohemoglobin homolog genes in Aspergillus nidulans sexual development and mycotoxin production Applied and Environmental Microbiology 2011 77 15 5524 5528 2-s2.0-79961076133 21642398
28 Klaubauf S Inselsbacher E Zechmeister-Boltenstern S Molecular diversity of fungal communities in agricultural soils from Lower Austria Fungal Diversity 2010 44 1 65 75 2-s2.0-79955830682 23794962
29 Reed GF Lynn F Meade BD Use of coefficient of variation in assessing variability of quantitative assays Clinical and Diagnostic Laboratory Immunology 2002 9 6 1235 1239 2-s2.0-0036844185 12414755
30 Lakhssassi N Elhajoui N Lodter J-P Pineill J-L Sixou M Antimicrobial susceptibility variation of 50 anaerobic periopathogens in aggressive periodontitis: an interindividual variability study Oral Microbiology and Immunology 2005 20 4 244 252 2-s2.0-20944444632 15943770
31 Andersen MR Nielsen JB Klitgaard A Accurate prediction of secondary metabolite gene clusters in filamentous fungi Proceedings of the National Academy of Sciences of the United States of America 2013 110 1 E99 E107 2-s2.0-84871997235 23248299
32 Khaldi N Collemare J Lebrun M Wolfe KH Evidence for horizontal transfer of a secondary metabolite gene cluster between fungi Genome Biology 2008 9 1, article R18 2-s2.0-44649170477
33 Pettit RK Small-molecule elicitation of microbial secondary metabolites Microbial Biotechnology 2011 4 4 471 478 2-s2.0-79960105974 21375710
34 Talbot GH What is in the pipeline for gram-negative pathogens? Expert Review of Anti-Infective Therapy 2008 6 1 39 49 2-s2.0-40649119273 18251663
35 Varga J Due M Frisvad JC Samson RA Taxonomic revision of Aspergillus section Clavati based on molecular, morphological and physiological data Studies in Mycology 2007 59 89 106 2-s2.0-38549125567 18490946
36 Boyd EM Patulin Canadian Medical Association Journal 1944 50 2 p. 159
37 Parker SR Cutler HG Schreiner PR Koninginin C: a biologically active natural product from Trichoderma koningii Bioscience, Biotechnology, and Biochemistry 1995 59 6 1126 1127 2-s2.0-0029315842
38 Dunlop RW Simon A Sivasithamparam K Ghisalberti EL An antibiotic from Trichoderma koningii active against soilborne plant pathogens Journal of Natural Products 1989 52 1 67 74 2-s2.0-0024599302
39 Zhang B Zheng LP Wang JW Nitric oxide elicitation for secondary metabolite production in cultured plant cells Applied Microbiology and Biotechnology 2012 93 2 455 466 2-s2.0-84856289242 22089384
40 Yu JH Keller N Regulation of secondary metabolism in filamentous fungi Annual Review of Phytopathology 2005 43 437 458
41 Calvo AM Wilson RA Bok JW Keller NP Relationship between secondary metabolism and fungal development Microbiology and Molecular Biology Reviews 2002 66 3 447 459 2-s2.0-0036712096 12208999
42 Birkinshaw JH Bracken A Michael SE Raistrick H Studies in the biochemistry of micro-organisms; fuscin, a metabolic product of Oidiodendron fuscum Robak. Part 2. Derivatives and degradation products The Biochemical Journal 1951 48 1 67 74 2-s2.0-45249091408 14820786
43 Jackson M Karwowski JP Humphrey PE Kohl WL Barlow GJ Tanaka SK Calbistrins, novel antifungal agents produced by Penicillium restrictum . I: production, taxonomy of the producing organism and biological activity Journal of Antibiotics 1993 46 1 34 38 2-s2.0-0027472365 8436557
44 Koehn FE High impact technologies for natural products screening Natural Compounds as Drugs Volume I 2008 65 175 210 2-s2.0-38449122425
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.