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BioMed research international, v.2015, 2015년, pp.987404 -
Chen, Lin (Department of Medical Oncology, East Hospital, Tongji University, 150 Jimo Road, Shanghai 200120, China) , Chen, Feng (Department of Cardiology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China) , Zhao, Mengxin (International Joint Cancer Institute, The Second Military Medical University, Shanghai 200433, China) , Zhu, Xiandi (International Joint Cancer Institute, The Second Military Medical University, Shanghai 200433, China) , Ke, Changhong (International Joint Cancer Institute, The Second Military Medical University, Shanghai 200433, China) , Yu, Jiangming (Department of Orthopaedics, Changzheng Hospital, The Second Military Medical University, No. 415 Fengyang Road, Shanghai 200003, China) , Yan, Zhiqiang (Institute of Biomedical Engineering and Technology, Shanghai Engineering Research Center of Molecular Therapeutics, Shanghai 200062, China) , Zhang, Fulei (International Joint Cancer Institute, The Second Military Medical University, Shanghai 200433, China) , Sun, Yun (International Joint Cancer Institute, The Second Military Medical University, Shanghai 200433,) , Chen, Di , Jiang, Cheng , Zhao, Xianxian , Gao, Yong , Guo, Shangjing , Li, Wei
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The application of chemotherapeutic drug adriamycin (ADR) in cancer therapy is limited by its side effects like high toxicity and insolubility. Nanomedicine offers new hope for overcoming the shortcomings. But how to increase in vivo stability and to control intracellular drug release is a key issue...
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