최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기Annals of the New York Academy of Sciences, v.1350 no.1, 2015년, pp.61 - 65
Lee, Myung‐Shik (Severans Biomedical Research Institute and Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea)
In our studies investigating the role of autophagy in systemic metabolism, we found that mitochondrial dysfunction due to autophagy deficiency in insulin target tissues, such as skeletal muscle or liver, leads to the induction of fibroblast growth factor (FGF)21 as a mitokine and protection against ...
Mizushima , N. & M. Komatsu . 2011 . Autophagy: renovation of cells and tissues . Cell 147 : 728 – 741 .
Inagaki , T. , et?al . 2007 . Endocrine regulation of the fasting response by PPARalpha‐mediated induction of fibroblast growth factor 21 . Cell Metab. 5 : 415 – 425 .
Kharitonenkov , A. , et?al . 2005 . FGF‐21 as a novel metabolic regulator . J. Clin. Invest. 115 : 1627 – 1635 .
Kim , K.H. , et?al . 2013 . Autophagy deficiency leads to protection from obesity and insulin resistance by inducing FGF21 as a ‘mitokine .’ Nat. Med. 19 : 83 – 92 .
Petersen , K.F. , et?al . 2003 . Mitochondrial dysfunction in the elderly: possible role in insulin resistance . Science 300 : 1140 – 1142 .
Petersen , K.F. , et?al . 2004 . Impaired mitochondrial activity in the insulin‐resistant offspring of patients with type 2 diabetes . N. Engl. J. Med. 350 : 664 – 671 .
Owen , M.R. , E. Doran & A.P. Halestrap . 2000 . Evidence that metformin exerts its anti‐diabetic effects through inhibition of complex I of the mitochondrial respiratory chain . Biochem. J. 348 : 607 – 614 .
Shah , V.O. , et?al . 2009 . Mitochondrial DNA deletion and sarcopoenia . Genet. Med. 11 : 147 – 152 .
Suomalainen , A. , et?al . 2011 . FGF‐21 as a biomarker for muscle‐manifesting mitochondrial respiratory chain deficiencies: a diagnostic study . Lancet Neurol. 10 : 806 – 818 .
Tyynismaa , H. , et?al . 2010 . Mitochondrial myopathy induces a starvation‐like response . Hum. Mol. Genet. 19 : 3948 – 3958 .
Pospisilik , J.A. , et?al . 2007 . Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes . Cell 131 : 476 – 491 .
Wredenberg , A. , et?al . 2006 . Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance . Biochem. Biophys. Res. Com. 350 : 202 – 207 .
Silva , J. P. , et?al . 2000 . Impaired insulin secretion and beta‐cell loss in tissue‐specific knockout mice with mitochondrial . Nature 26 : 336 – 340 .
Kanki , T. , et?al . 2009 . Atg32 is a mitochondrial protein that confers selectivity during mitophagy . Dev. Cell 17 : 98 – 109 .
Okamoto , K. , N. Kondo‐Okamoto & Y. Ohsumi . 2009 . Mitochondria‐anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy . Dev. Cell 17 : 87 – 97 .
Narendra , D. , et?al . 2008 . Parkin is recruited selectively to impaired mitochondria and promotes their autophagy . J. Cell Biol. 183 : 795 – 803 .
Liu , L. , et?al . 2012 . Mitochondrial outer‐membrane protein FUNDC1 mediates hypoxia‐induced mitophagy in mammalian cells . Nature Cell Biol. 14 : 177 – 185 .
Lupfer , C. , et?al . 2013 . Receptor interacting protein kinase 2‐mediated mitophagy regulates inflammasome activation during virus infection . Nat. Immunol. 14 : 480 – 488 .
Sandoval , H. , et?al . 2008 . Essential role for Nix in autophagic maturation of erythroid cells . Nature 454 : 232 – 235 .
Zhang , Q. , et?al . 2015 . The kinase Jnk2 promotes stress‐induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation . Nat. Immunol. 16 : 458 – 466 .
Jung , H.S. , et?al . 2008 . Loss of autophagy diminishes pancreatic b‐cell mass and function with resultant hyperglycemia . Cell Metab. 8 : 318 – 324 .
Masiero , E. , et?al . 2009 . autophagy is required to maintain muscle mass . Cell Metab. 10 : 507 – 515 .
Markan , K.R. , et?al . 2014 . Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding . Diabetes 63 : 4057 – 4063 .
Gaich , G. , et?al . 2013 . The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes . Cell Metab. 18 : 333 – 340 .
Mu , J. , et?al . 2012 . FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents . Diabetes 61 : 505 – 512 .
Wu , A.L. , et?al . 2011 . Amelioration of type 2 diabetes by antibody‐mediated activation of fibroblast growth factor receptor 1 . Sci. Transl. Med. 3 : 113 – 126 .
Harding , H.P. , et?al . 2003 . An integrated stress response regulates amino acid metabolism and resistance to oxidative stress . Mol. Cell 11 : 629 – 633 .
Durieux , J. , S. Wolff & A. Dillin . 2011 . The cell‐non‐autonomous nature of elecdtron transport chain‐mediated longevity . Cell 144 : 79 – 91 .
Chen , H. , et?al . 2010 . Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations . Cell 141 : 280 – 289 .
Kim , K.H. , et?al . 2013 . Metformin‐induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation . Biochem. Biophys. Res. Com. 440 : 76 – 81 .
Fujita , Y. , et?al . 2015 . GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases . Mitochondrion 20 : 34 – 42 .
Lee , C. , et?al . 2015 . The mitochondrial‐derived peptide MOTS‐C promotes metabolic homeostasis and reduces obesity and insulin resistance . Cell Metab. 21 : 443 – 454 .
Yen , K. , et?al . 2013 . The emerging role of the mitochondrial‐derived peptide humanin in stress resistance . J. Mol. Endocrinol. 50 : R11 – R19 .
Fisher , F.M. , et?al . 2012 . FGF21 regulates PGC‐1α and browning of white adipose tissues in adaptive thermogenesis . Genes Dev. 126 : 271 – 281 .
Kim , K.H. , et?al . 2013 . Acute exercise induces FGF21 expression in mice and in healthy humans . PLoS One 8 : e63517 .
Kim , S.H. , et?al . 2015 . Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity‐induced hepatic metabolic stress . Diabetologia 58 : 809 – 818 .
Izumiya , Y. , et?al . 2008 . FGF21 is an Akt‐regulated myokine . FEBS Lett. 582 : 3805 – 3810 .
Laeger , T. , et?al . 2014 . FGF21 is an endocrine signal of protein restriction . J. Clin. Invest. 124 : 3913 – 3922 .
Suzuki , S.W. , J. Onodera & Y. Ohsumi . 2011 . Starvation induced cell death in autophagy‐defective yeast mutants is caused by mitochondria dysfunction . PLoS One 6 : e17412 .
De Sousa‐Coelho , A.L. , P.F. Marrero & D. Haro . 2012 . Activating transcription factor 4‐dependent induction of FGF21 during amino acid deprivation . Biochem. J. 443 : 165 – 172 .
Ezaki , J. , et?al . 2011 . Liver autophagy contributes to the maintenance of blood glucose and amino acid levels . Autophagy 7 : 1 – 10 .
Zhang , Y. , et?al . 2012 . The starvation hormone, fibroblast growth factor‐21, extends lifespan in mice . eLife 1 : 1 – 14 .
Martin‐Montalvo , A. , et?al . 2013 . Metformin improves healthspan and lifespan in mice . Nat. Commun. 4 : 2192 .
Houtkooper , R.H. , et?al . 2013 . Mitonuclear protein imbalance as a conserved longevity mechanism . Nature 497 : 451 – 459 .
Mouchiroud , L. , et?al . 2013 . The NAD + /Sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling . Cell 154 : 430 – 441 .
Schinzel , R. & A. Dillin . 2015 . Endocrine aspects of organelle stress – cell non‐autonomous signaling of mitochondria and ER . Curr. Opin. Cell Biol. 33 : 102 – 110 .
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.